Lectin-like oxidized LDL receptor-1 (LOX-1) expression in the tubulointerstitial area likely plays an important role in human diabetic nephropathy

Internal Medicine

Volumn 48, Issue 4, 2009, Pages 189-194

  Yamamoto, Naoyuki ^a   Toyoda, Masao ^a   Abe, Makiko ^a   Kobayashi, Takako ^a   Kobayashi, Keiko ^a   Kato, Mayuko ^a   Miyauchi, Masaaki ^a   Kimura, Moritsugu ^a   Umezono, Tomoya ^a   Suzuki, Daisuke ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetic nephropathy; In situ hybridization; LOX 1; Proteinuria; Tubulointerstitium

Indexed keywords

MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE LOCATION; GLOMERULUS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; KIDNEY TUBULE; MALE; MEMBRANOUS GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; RISK FACTOR;

ADULT; CASE-CONTROL STUDIES; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; IN SITU HYBRIDIZATION; KIDNEY; MALE; MIDDLE AGED; NEPHROSIS, LIPOID; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS E;

EID: 61749090032     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.48.1251     Document Type: Article

References (26)

1. Moorhead JF, Chan MK, El-Nahas M, Varghese Z. Lipid nephrotoxity in chronic progressive glomerular and tublo-interstitial disease. Lancet 2: 1309-1311, 1982.
2. Avram MM. Similarities between glomerular sclerosis and atherosclerosis in human renal biopsy specimens: a role for lipoprotein glomerulopathy. Am J Med 87: 39N-41N, 1989.
3. Moorhead JF, Brunton C, Fernando RL, Burns A, Varghese Z. Do glomerular atherosclerosis and lipid-mediated tubulo-interstitial disease cause progressive renal failure in man? Blood Purif 14: 58-66, 1996.
4. Kasiske BL, Cleary MP, O'Donnell MP, Keane WF. Effects of genetic obesity on renal structure and function in the Zucker rat. J Lab Clin Med 106: 598-604, 1985.
5. Kasiske BL, O'Donnell MP, Schmitz PG, Kim Y, Keane WF. Renal injury of diet-induced hypercholesterolemia in rats. Kidney Int 37: 880-891, 1990.
6. Lee HS, Kim YS. Identification of oxidized low density lipoprotein in human renal biopsies. Kidney Int 54: 848-856, 1998.
7. Laakso M, Pyörälä K, Sarlund H, Voutilainen E. Lipid and lipoprotein abnormalities associated with coronary heart disease in patients with insulin-dependent diabetes mellitus. Arteriosclerosis 6: 679-684, 1986.
8. Reaven GM. Non-insulin-dependent diabetes mellitus, abnormal lipoprotein metabolism, and atherosclerosis. Metabolism 36 (suppl 1): 1-8, 1987.
9. Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature 386: 73-77, 1997.
10. Nagase M, Kaname S, Nagase T, et al. Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis. J Am Soc Nephrol 11: 1826-1836, 2000.
11. Wilson SH, Chade AR, Feldstein A, et al. Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia. Nephrol Dial Transplant 18: 703-709, 2003.
12. Kosaka H, Yoneyama H, Zhang L, Fujii S, Yamamoto A, Igarashi J. Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine. FASEB J 17: 636-643, 2003.
13. Suzuki D, Miyazaki M, Naka R, et al. In situ hybridization of interleukin 6 in diabetic nephropathy. Diabetes 44: 1233-1238, 1995.
14. Suzuki D, Miyazaki M, Jinde K, et al. In situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1 and type IV collagen in diabetic nephropathy. Kidney Int 52: 111-119, 1997.
15. Kataoka H, Kume N, Minami M, et al. Expression of lectin-like oxidized LDL receptor-1 in human atherosclerotic lesions. Ann N Y Acad Sci 902: 328-335, 2000.
16. Chen M, Kakutani M, Naruko T, et al. Activation-dependent surface expression of LOX-1 in human platelets. Biochem Biophys Res Commun 282: 153-158, 2001.
17. Eddy AA, Giachelli CM. Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney Int 47: 1546-1557, 1995.
18. D'Amico G, Ferrario F, Rastaldi MP. Tubulointerstitial damage in glomerular diseases: its role in the progression of renal damage. Am J Kidney Dis 26: 124-132, 1995.
19. Klahr S, Tripathy K, Bolanos O. Qualitative and quantitative analysis of urinary lipids in the nephrotic syndrome. J Clin Invest 46: 1475-1481, 1967.
20. Jüngst D, Wallner J, Karl HJ. Correlation of total cholesterol and protein in urine in patients with the nephrotic syndrome. Klin Wochenschr 58: 1215-1216, 1980.
21. Kume N, Moriwaki H, Kataoka H, et al. Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells. Ann N Y Acad Sci 902: 323-327, 2000.
22. Kita T, Kume N, Ishii K, Horiuchi H, Arai H, Yokode M. Oxidized LDL and expression of monocyte adhesion molecules. Diabetes Res Clin Pract 45: 123-126, 1999.
23. Chen H, Li D, Saldeen T, Mehta JL. Transforming growth factor-beta (1) modulates oxidatively modified LDL-induced expression of adhesion molecules: role of LOX-1. Circ Res 89: 1155-1160, 2001.
24. Li DY, Zhang YC, Philips MI, Sawamura T, Mehta JL. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation. Circ Res 84: 1043-1049, 1999.
25. Paniagua JA, López-Miranda J, Pérez-Martínez P, et al. Oxidized-LDL levels are changed during short-term serum glucose variations and lowered with statin treatment in early Type 2 diabetes: a study of endothelial function and microalbuminuria. Diabet Med 22: 1647-1656, 2005.
26. Farhangkhoee H, Khan ZA, Barbin Y, Chakrabarti S. Glucose-induced up-regulation of CD36 mediates oxidative stress and microvascular endothelial cell dysfunction. Diabetologia 48: 1401-1410, 2005.