Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase-Akt signaling in human breast cancer cells

Acta Biochimica et Biophysica Sinica

Volumn 40, Issue 4, 2008, Pages 304-310

  Zhao, Yanbin ^a   Chen, Xuesong ^a   Cai, Li ^a   Yang, Yanmei ^b   Sui, Guangjie ^a   Wu, Jin ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Forest Protection Institute of Heilongjiang Province   (China)

Author keywords

Angiotensin II; Angiotensin II type 1 receptor; Anti apoptosis; Breast cancer; PI3 kinase Akt

Indexed keywords

ANGIOTENSIN II; DOXORUBICIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; BREAST TUMOR; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANGIOTENSIN II; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; ENZYME ACTIVATION; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 42449131721     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2008.00402.x     Document Type: Article

References (31)

1. Touyz RM, Deng LY, He G, Wu XH, Schiffrin EL. Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: Role of extracellular signal-regulated kinases. J Hypertens 1999, 17 : 907 916.
2. Everett AD, Heller F, Fisher A. AT1 receptor gene regulation in cardiac myocytes and fibroblasts. J Mol Cell Cardiol 1996, 28 : 1727 1736.
3. Brilla CG, Scheer C, Rupp H. Renin-angiotensin system and myo-cardial collagen matrix: modulation of cardiac fibroblast function by angiotensin II type 1 receptor antagonism. J Hypertens Suppl 1997, 15 : S13 S19.
4. Ino K, Uehara C, Kikkawa F, Kajiyama H, Shibata K, Suzuki T, Khin EE et al. Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway. J Clin Endocrinol Metab 2003, 88 : 3973 3982.
5. Muscella A, Greco S, Elia MG, Storelli C, Marsigliante S. Angiotensin II stimulation of Na+-K+ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells. Endocrinology 2002, 173 : 315 323.
6. Suganuma T, Ino K, Shibata K, Kajiyama H, Nagasaka T, Mizutani S, Kikkawa F. Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination. Clin Cancer Res 2005, 11 : 2686 2694.
7. Amaya K, Ohta T, Kitagawa H, Kayahara M, Takamura H, Fujimura T, Nishimura G et al. Angiotensin II activates MAP kinase and NF-kappaB through angiotensin II type I receptor in human pancreatic cancer cells. Int J Oncol 2004, 25 : 849 856.
8. Thomas WG, Mendelsohn FA. Angiotensin receptors: form and distribution. Int J Biochem Cell Biol 2003, 35 : 774 779.
9. Kosugi M, Miyajima A, Kikuchi E, Horiguchi Y, Murai M. Angiotensin II type 1 receptor antagonist candesartan as an angiogenic inhibitor in a xenograft model of bladder cancer. Clin Cancer Res 2006, 12 : 2888 2893.
10. Fujimoto Y, Sasaki T, Tsuchida A, Chayama K. Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist. FEBS Lett 2001, 495 : 197 200.
11. Egami K, Murohara T, Shimada T, Sasaki K, Shintani S, Sugaya T, Ishii M et al. Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth. J Clin Invest 2003, 112 : 67 75.
12. Arrieta O, Guevara P, Escobar E, García-Navarrete R, Pineda B, Sotelo J. Blockage of angiotensin II type 1 receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma. Br J Cancer 2005, 92 : 1247 1252.
13. Greco S, Muscella A, Elia MG, Salvatore P, Storelli C, Mazzotta A, Manca C et al. Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells. J Cell Physiol 2003, 196 : 370 377.
14. Uemura H, Ishiguro H, Nakaigawa N, Nagashima Y, Miyoshi Y, Fujinami K, Sakaguchi A et al. Angiotensin II receptor blocker shows antiproliferative activity in prostate cancer cells: a possibility of tyrosine kinase inhibitor of growth factor. Mol Cancer Ther 2003, 2 : 1139 1147.
15. Takahashi T, Taniguchi T, Konishi H, Kikkawa U, Ishikawa Y, Yokoyama M. Activation of Akt-protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells. Am J Physiol 1999, 276 : H1927 H1934.
16. Brader S, Eccles SA. Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori 2004, 90 : 2 8.
17. Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 2004, 9 : 667 676.
18. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999, 13 : 2905 2927.
19. Kandel ES, Hay N. The regulation and activities of the multifunctional serine-threonine kinase Akt-PKB. Exp Cell Res 1999, 253 : 210 229.
20. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282 : 318 321.
21. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y. Greenberg, ME. Akt phosphorylation of Bad couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91 : 231 241.
22. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999, 98 : 857 866.
23. Inwang ER, Puddefoot JR, Brown CL, Goode AW, Marsigliante S, Ho MM, Payne JG et al. Angiotensin II type 1 receptor expression in human breast tissues. Br J Cancer 1997, 75 : 1279 1283.
24. De Paepe B, Verstraeten VL, De Potter CR, Vakaet LA, Bullock GR. Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma. Histochem Cell Biol 2001, 116 : 247 254.
25. Tahmasebi M, Puddefoot JR, Inwang ER, Goode AW, Carpenter R, Vinson GP. Transcription of the prorenin gene in normal and diseased breast. Eur J Cancer 1998, 34 : 1777 1782.
26. Berry MG, Goode AW, Puddefoot JR, Vinson GP, Carpenter R. Integrin betal upregulation in MCF-7 breast cancer cells by angiotensin II. Eur J Surg Oncol 2000, 26 : 25 29.
27. Ohashi H, Takagi H, Oh H, Suzuma K, Suzuma I, Miyamoto N, Uemura A et al. Phosphatidylinositol 3-kinase-Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothe-lial cells by governing survivin expression and suppression of caspase-3 activity. Circ Res 2004, 94 : 785 793.
28. Dugourd C, Gervais M, Corvol P, Monnot C. Akt is a major downstream target of PI3-kinase involved in angiotensin II-induced proliferation. Hypertension 2003, 41 : 882 890.
29. Liu X, Shi Y, Giranda VL, Luo Y. Inhibition of the phosphatidylinositol 3-kinase-Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. Mol Cancer Ther 2006, 5 : 494 501.
30. Clark AS, West K, Streicher S, Dennis PA. Constitutive and induc-ible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther 2002, 1 : 707 717.
31. Gamen S, Anel A, Pérez-Galán P, Lasierra P, Johnson D, Piñeiro A, Naval J. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res 2000, 258 : 223 235.