Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats

Journal of Hypertension

Volumn 16, Issue 12 SUPPL., 1998, Pages 2039-2043

  Gigante, Bruna ^a   Piras, Ornella ^a   De Paolis, Paola ^b   Porcellini, Antonio ^b   Natale, Armando ^a   Volpe, Massimo ^b,c,d  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRCSS Ist Neurologico M   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

Angiotensin II receptors; Blood pressure; Losartan; PD123319

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; LOSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; BLOOD PRESSURE REGULATION; CONFERENCE PAPER; CONTROLLED STUDY; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEPHRECTOMY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM RESTRICTION;

EID: 0032421733     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816121-00027     Document Type: Conference Paper

References (29)

1. De Gasparo M, Bottari SP, Levens NR. Characteristics of Angiotensin II receptors and their role in and organ physiology. In: Laragh JH, Brenner BM (editors). Hypertension: Pathophysiology, Diagnosis and Management. New York: Raven Press; 1995. pp. 1695-1718.
2. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE. Isolation of a cDNA encoding the vascular type 1 angiotensin II receptor. Nature 1991; 351:233-236.
3. Sasaki K, Yamano Y, Bardhan S, Iwai N, Murray JJ, Hasegawa M, et al. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type 1 receptor. Nature 1991; 351:230-232.
4. Kobayashi S, Ohuishi J, Nibu Y, Nishimatsu S, Umemura S, Ishiu M, et al. Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter. BBA 1995; 1262:155-158.
5. Kakar SS, Seller JC, Devor DC, Musgrow LC, Neill JD. Angiotensin II type 1 receptor cDNAs: differential tissue expression and hormonal regulation. BBRC 1992; 183 (part 3):1090-1096.
6. Dzau VJ, Mukoyama M, Pratt RE. Molecular biology of angiotensin receptors: target for drug research? J Hypertens 1994; 2 (suppl 2):S1-S5.
7. Timmermans PBMWM, Chiu AT, Herblin WF, Wong PC, Smith RD. Angiotensin II receptor subtypes. Am J Hypertens 1992; 5:406-410.
8. Clauser E, Curnow KM, Davies E, Conchon S, Teutsch B, Vianello B, et al. Angiotensin II receptors:protein and gene structures, expression and potential pathological involvments. Eur J Endocrinol 1996; 134:403-411.
9. Pieruzzi F, Abassi Z, Kaiser HR. Expression of renin angiotensin system components in the heart, kidneys and lungs of rats with experimental heart failure. Circulation 1995; 92:3105-3112.
10. 2 subtype receptors prevents the effects of angiotensin II on rat vascular structure. J Clin Invest 1996; 98:418-425.
11. Lo M, Liu KL, Lantelme P, Sassard J. Subtype 2 of angiotensin II receptors controls pressure natriuresis in rats. JCI 1995; 95:1394-1397.
12. 2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. BBRC 1992; 183:206-211.
13. 2 receptor mediates inhibition of cell proliferation in coronary endothelial cells. JCI 1995; 95:651-657.
14. Kajstura J, Cigola E, Malhotra A, Li P, Cheng W, Meggs LG, Anversa P. Angiotensin II induces apoptosis of adult ventricular myocites in vitro. J Mol Cell Cardiol 1997; 29:859-870.
15. The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 1997; 157:2413-2445.
16. Gradman AH, Arcuri KE, Goldberg Al, Ikeda LS, Nelson EB, Snavely DB, et al. A randomized placebo-controlled, double blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension. Hypertension 1995; 25:1345-1350.
17. Critchley JAJH, Gilchist N, Ikeda L A randomized double-masked comparison of the anti-hypertensive efficacy and safety of combination therapy with losartan and hydrochlorothiazide versus captopril and hydrochlorothiazide in elderly and younger patients. Curr Ther Res 1996; 57:392-407.
18. Tofovic SP, Pong AS, Jackson EK. Effects of angiotensin subtype 1 and sutype 2 receptor antagonists in normotensive versus hypertensive rats. Hypertension 1991; 18:774-782.
19. Ichichi T, Labosky P, Shiota C, Okuyama S, Imagawa Y, Fogo A. et al. Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type 2 receptor. Nature 1995; 377:748-750.
20. Wong PC, Price WA, Chiu AT, Duncia JV, Carin DJ, Wexler RR, et al. In vivo pharmacology of DuP753. Am J Hypertens 1991; 4:2885-2985.
21. Volpe M, Gigante B, Enea I, Porcellini A, Russo R, Magri P, et al. Role of tissue renin in the regulation of aldosterone biosynthesis in the adrenal cortex of nephrectomized rats. Circ Res 1997; 81:857-864.
22. Timmermans PBMWM, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993; 45:205-251.
23. 2 receptor ligands CGP 42112B and PD123319 in the sodium depleted rat. Eur J Pharmacol 1993; 249:85-93.
24. 1-receptor antagonist, EXP3174. Br J Pharmacol 1992; 107:873-880.
25. Eskay R, Zukowska-Grojec Z, Haas M, Dave JR, Zamir N. Circulating atrial natriuretic peptides in conscious rats: regulation of release by multiple factors. Science 1986; 232:636-639.
26. 2 receptor in renal vascular hypertension [abstract]. Hypertension 1997; 30 (3 part 1):477.
27. 1 subtype receptors. Hypertension 1997; 30 (3 part 2):563-568.
28. Zhuo J, Alcorn D, Harris PJ, Mendelsohn FAO. Localization and properties of angiotensin II receptors in rat kidney. Kidney Int 1993; 44 (suppl 42):S40-S46.
29. 2 receptor stimulation increases aortic cyclic GMP in stroke prone spontaneously hypertensive rats by a kinindependent mechanism. Hypertension 1998; 31 (II):349-355.