LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: Implications in endothelial dysfunction and atherosclerosis

Pharmacology and Therapeutics

Volumn 95, Issue 1, 2002, Pages 89-100

  Chen, Mingyi ^a   Masaki, Tomoh ^a   Sawamura, Tatsuya ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Atherosclerosis; Endothelial cell dysfunction; LOX 1; Oxidized low density lipoproteins; Scavenger receptor

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; CELL ADHESION MOLECULE; COMPLEMENTARY DNA; ENDOTHELIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; LOW DENSITY LIPOPROTEIN; OLR1 PROTEIN, HUMAN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR;

APOPTOSIS; ATHEROSCLEROSIS; CARBOXY TERMINAL SEQUENCE; DIABETES MELLITUS; ESCHERICHIA COLI; GENE ASSIGNMENT; GLOMERULOSCLEROSIS; GLYCOSYLATION; HEMODYNAMICS; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LIGAND BINDING; MACROPHAGE; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVIEW; SEQUENCE HOMOLOGY; SMOOTH MUSCLE FIBER; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; THROMBOCYTE ACTIVATION; AMINO ACID SEQUENCE; ANIMAL; ARTERIOSCLEROSIS; CELL CULTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; ANIMAL; ARTERIOSCLEROSIS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMAN; LIPOPROTEINS, LDL; MOLECULAR SEQUENCE DATA; MYOCYTES, SMOOTH MUSCLE; RECEPTORS, LDL; SEQUENCE ALIGNMENT; SUPPORT, NON-U.S. GOV'T; ANIMALS; HUMANS; RECEPTORS, OXIDIZED LDL; SCAVENGER RECEPTORS, CLASS E;

EID: 0035993485     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00236-X     Document Type: Review

References (58)

1. Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells
2. Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene
3. LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells
4. The centromeric part of the human NK gene complex: Linkage of LOX-1 and LY49L with the CD94/NKG2 region
5. Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: Modulation by losartan
6. Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits
7. Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein
8. Activation-dependent surface expression of lox-1 in human platelets
9. Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: Possible role of LOX-1 ligand and age
10. Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding
11. PPARγ ligands inhibit TNF-α-induced LOX-1 expression in cultured endothelial cells
12. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species
13. The binding of oxidized low-density lipoprotein (ox-LDL) to ox-LDL receptor-1 in endothelial cells reduces the intracellular concentration of nitric oxide through an increased production of superoxide
14. Focal and segmental glomerulosclerosis: Analogies to atherosclerosis
15. TGF-β1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages
16. The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin
17. Localization of atherosclerosis: Role of hemodynamics
18. 2α increases expression of LOX-1 in JAR cells
19. High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1)
20. Advanced glycation end products-induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages
21. A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1
22. Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits: Identification by a novel enzyme immunoassay
23. Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions
24. Biosynthesis and post-translational processing of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). N-linked glycosylation affects cell-surface expression and ligand binding
25. Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells
26. LOX-1, a possible clue to the missing link between hypertension and atherogenesis
27. Roles of lectin-like oxidized LDL receptor-1 and its soluble forms in atherogenesis
28. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells
29. Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells
30. Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells
31. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: Evidence from use of antisense LOX-1 mRNA and chemical inhibitors
32. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation
33. Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1→p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene
34. Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells
35. Identification and autoregulation of receptor for ox-LDL in cultured human coronary artery endothelial cells
36. 1 increases the expression of lectin-like oxidized low-density lipoprotein receptor-1
37. Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein
38. Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells
39. Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: Upregulated expression by TNF-α
40. Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein
41. Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells
42. Identification of soluble forms of lectin-like oxidized LDL receptor-1
43. Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats
44. Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene
45. Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1)
46. Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis
47. Redox-sensitive regulation of LOX-1 gene expression in vascular endothelium
48. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells
49. Atherosclerosis-an inflammatory disease
50. An endothelial receptor for oxidized low-density lipoprotein
51. Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor
52. LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria
53. Low density lipoprotein oxidation and its pathobiological significance
54. Receptors for oxidized low density lipoprotein
55. Hepatic and extrahepatic scavenger receptors: Function in relation to disease
56. Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model
57. The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile
58. Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor