Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 16, Issue 1, 2011, Pages 87-95

  Spurney, Christopher F ^a,b   Sali, Arpana ^b   Guerron, Alfredo D ^b   Iantorno, Micaela ^b   Yu, Qing ^b   Gordish Dressman, Heather ^b   Rayavarapu, Sree ^b   Van Der Meulen, Jack ^b   Hoffman, Eric P ^b   Nagaraju, Kanneboyina ^b  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

angiotensin; cardiomyopathy; Duchenne muscular dystrophy; dystrophin; echocardiography; mice

Indexed keywords

DRINKING WATER; DYSTROPHIN; LOSARTAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DIAPHRAGM; ECHOCARDIOGRAPHY; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; FORCE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GRIP STRENGTH; HEART FUNCTION; HEART MUSCLE FIBROSIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; ROTAROD TEST; SKELETAL MUSCLE; STAINING; SYSTOLIC BLOOD PRESSURE; TREADMILL EXERCISE; TREATMENT DURATION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOOD PRESSURE; CARDIOMYOPATHIES; CELL ADHESION MOLECULES; DYSTROPHIN; FEMALE; FIBROSIS; GENE EXPRESSION REGULATION; HEART; LOSARTAN; MICE; MICE, INBRED MDX; MUSCLE WEAKNESS; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE; MYOCARDIUM; RNA, MESSENGER; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

EID: 79951479823     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248410381757     Document Type: Article

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