The Role of Late/Slow Replication of the FRA16D in Common Fragile Site Induction

Genes Chromosomes and Cancer

Volumn 39, Issue 1, 2004, Pages 71-76

  Palakodeti, Aparna ^a   Han, Yu ^a   Jiang, Yanwen ^a   Le Beau, Michelle M ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE;

ALLELE; ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; FEMALE; GENE EXPRESSION; GENE REPLICATION; GENE SEQUENCE; GENETIC STRAIN; HUMAN; HUMAN CELL; METAPHASE; MITOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ACID ANHYDRIDE HYDROLASES; ADULT; CARRIER PROTEINS; CELL LINE, TUMOR; CHROMOSOME FRAGILE SITES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 16; DNA REPLICATION; FEMALE; G2 PHASE; HUMANS; LEUKEMIA, B-CELL; NEOPLASM PROTEINS; S PHASE;

EID: 0345283196     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10290     Document Type: Article

References (21)

1. Arlt MF, Miller DE, Beer DG, Glover TW. 2002. Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells. Genes Chromosomes Cancer 33:82-92.
2. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM. 2000. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res 60:2140-2145.
3. Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, Brenner AJ, Aldaz CM. 2001. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res 61:8068-8073.
4. Casper AM, Nghiem P, Arlt MF, Glover TW. 2002. ATR regulates fragile site stability. Cell 111:779-789.
5. Cha RS, Kleckner N. 2002. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297:602-606.
6. Glover TW. 1998. Instability at chromosomal fragile sites. Recent Results Cancer Res 154:185-199.
7. Glover TW, Berger C, Coyle J, Echo B. 1984. DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet 67:136-142.
8. Handr O, Baker E, Dayan S, Gartler SM, Woollatt E, Richards RI, Hansen RS. 2000. Analysis of replication timing at the FRA10B and FRA16B fragile site loci. Chromosome Res 8:677-688.
9. Hansen RS, Canfield TK, Lamb MM, Gartler SM, Laird CD. 1993. Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell 73:1403-1409.
10. Hellman A, Rahat A, Scherer SW, Darvasi A, Tsui L-C, Kerem B. 2000. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability. Mol Cell Biol 20:4420-4427.
11. Huang H, Reed CP, Mordi A, Lomberk G, Wang L, Shridhar V, Hartmann L, Jenkins R, Smith DI. 1999. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer 24:48-55.
12. Huebner K, Garrison PN, Barnes LD, Croce CM. 1998. The role of the FHIT/FRA3B locus in cancer. Ann Rev Genet 32:7-31.
13. Krummel KA, Roberts LR, Kawakami M, Glover TW, Smith DI. 2000. The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations. Genomics 69:37-46.
14. Laird C, Jaffe E, Karpen G, Lamb M, Nelson R. 1987. Fragile sites in human chromosomes as regions of late replicating DNA. Trends Genet 3:274-281.
15. Le Beau MM, Rassool FV, Neilly ME, Espinosa III, R, Glover TW, Smith DI, McKeithan TW. 1998. Replication of a common fragile site, FRA3B, occurs late in S phase, and is delayed further upon induction: Implications for the mechanisms of fragile site induction. Hum Mol Genet 7:755-761.
16. Mangelsdorf M, Ried K, Woollatt E, Dayan S, Eyre H, Finnis M, Hobson L, Nancarrow J, Venter D, Baker E, Richards RI. 2000. Chromosomal fragile site FRA16D and DNA instability in cancer. Cancer Res 60:1683-1689.
17. Paige AJW, Taylor KJ, Stewart A, Sgouros JG, Gabra H, Sellar GC, Smyth JF, Porteous DJ, Watson JEV. 2000. A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D. Cancer Res 60:1690-1697.
18. Richards RI. 2001. Fragile and unstable chromosomes in cancer: Causes and consequences. Trends Genet 17:339-345.
19. Ried K, Finnis M, Hobson L, Mangelsdorf M, Dayan S, Nancarrow JK, Woollatt E, Kremmidiotis G, Gardner A, Venter D, Baker E, Richards RI. 2000. Common chromosomal fragile site FRA16D sequence: Identification of the FOR gene spanning FRA16D and homozygous deletions and translocations breakpoints in cancer cells. Hum Mol Genet 9:1651-1663.
20. Widrow RJ, Hansen RS, Kawame H, Gartler SM, Laird CD. 1998. Very late DNA replication in the human cell cycle. Proc Natl Acad Sci USA 95:11246-11250.
21. Yunis JJ, Soreng AL, Bowe A. 1987. Fragile sites are targets for diverse mutagens and carcinogens. Oncogene 1:59-69.