Impaired replication dynamics at the FRA3B common fragile site

Human Molecular Genetics

Volumn 19, Issue 1, 2009, Pages 99-110

  Palakodeti, Aparna ^a   Lucas, Isabelle ^a   Jiang, Yanwen ^a   Young, David J ^a   Fernald, Anthony A ^a   Karrison, Theodore ^a   Le Beau, Michelle M ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; CHROMOSOME PROTEIN; PROTEIN FRA3B; UNCLASSIFIED DRUG; ACID ANHYDRIDE HYDROLASE; DNA; FRAGILE HISTIDINE TRIAD PROTEIN; TUMOR PROTEIN;

ARTICLE; CELL CYCLE S PHASE; CHROMOSOME BAND; CHROMOSOME FRAGILE SITE; CONTROLLED STUDY; DNA REPLICATION; DNA STRAND; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; THEORETICAL MODEL; DNA REPLICATION ORIGIN; DRUG EFFECT; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

ACID ANHYDRIDE HYDROLASES; APHIDICOLIN; CHROMOSOME FRAGILE SITES; DNA; DNA REPLICATION; NEOPLASM PROTEINS; REPLICATION ORIGIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S PHASE; TIME FACTORS;

EID: 77649290673     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp470     Document Type: Article

References (28)

1. Glover, T.W., Arlt, M.F., Casper, A.M. and Durkin, S.G. (2005) Mechanisms of common fragile site instability. Hum. Mol. Genet., 14 (Spec. No. 2), R197-R205.
2. Glover, T.W. (2006) Common fragile sites. Cancer Lett., 232, 4-12.
3. Cox, C., Bignell, G., Greenman, C., Stabenau, A., Warren, W., Stephens, P., Davies, H., Watt, S., Teague, J., Edkins, S. et al. (2005) A survey of homozygous deletions in human cancer genomes. Proc. Natl. Acad. Sci. USA, 102, 4542-4547.
4. Gorgoulis, V.G., Vassiliou, L.V., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., Ditullio, R.A. Jr, Kastrinakis, N.G., Levy, B. et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature, 434, 907-913.
5. Smith, D.I., McAvoy, S., Zhu, Y. and Perez, D.S. (2007) Large common fragile site genes and cancer. Semin. Cancer Biol., 17, 31-41.
6. Glover, T.W., Berger, C., Coyle, J. and Echo, B. (1984) DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet., 67, 136-142.
7. Matsuyama, A., Shiraishi, T., Trapasso, F., Kuroki, T., Alder, H., Mori, M., Huebner, K. and Croce, C.M. (2003) Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic. Proc. Natl. Acad. Sci. U S A, 100, 14988-14993.
8. Zlotorynski, E., Rahat, A., Skaug, J., Ben-Porat, N., Ozeri, E., Hershberg, R., Levi, A., Scherer, S.W., Margalit, H. and Kerem, B. (2003) Molecular basis for expression of common and rare fragile sites. Mol. Cell. Biol., 23, 7143-7151.
9. Toledo, F., Coquelle, A., Svetlova, E. and Debatisse, M. (2000) Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility. Nucleic Acids Res., 28, 4805-4813.
10. Laird, C., Jaffe, E., Karpen, G., Lamb, M. and Nelson, R. (1987) Fragile sites in human chromosomes as regions of late-replicating DNA. Trends Genet., 3, 274-281.
11. Lucas, I., Palakodeti, A. and Le Beau, M.M. (2007) The Implications of DNA Replication in Common Fragile Site Expression. Arrieta, I., Penagarikano, O. and Télez, M. (eds), Fragile Sites: New Discoveries and Changing Perspectives, Nova Science Publishers, Inc., Hauppauge, NY, pp. 67-98.
12. Casper, A.M., Nghiem, P., Arlt, M.F. and Glover, T.W. (2002) ATR regulates fragile site stability. Cell, 111, 779-789.
13. Durkin, S.G. and Glover, T.W. (2007) Chromosome fragile sites. Annu. Rev. Genet., 41, 169-192.
14. Le Beau, M.M., Rassool, F.V., Neilly, M.E., Espinosa, R. III, Glover, T.W., Smith, D.I. and McKeithan, T.W. (1998) Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum. Mol. Genet., 7, 755-761.
15. Giacca, M., Pelizon, C. and Falaschi, A. (1997) Mapping replication origins by quantifying relative abundance of nascent DNA strands using competitive polymerase chain reaction. Methods, 13, 301-312.
16. Lucas, I., Palakodeti, A., Jiang, Y., Young, D.J., Jiang, N., Fernald, A.A. and Le Beau, M.M. (2007) High-throughput mapping of origins of replication in human cells. EMBO Rep., 8, 770-777.
17. Trivedi, A., Waltz, S.E., Kamath, S. and Leffak, M. (1998) Multiple initiations in the c-myc replication origin independent of chromosomal location. DNA Cell Biol., 17, 885-896.
18. Brylawski, B.P., Cohen, S.M., Longmire, J.L., Doggett, N.A., Cordeiro-Stone, M. and Kaufman, D.G. (2000) Construction of a cosmid library of DNA replicated early in the S phase of normal human fibroblasts. J. Cell. Biochem., 78, 509-517.
19. White, E.J., Emanuelsson, O., Scalzo, D., Royce, T., Kosak, S., Oakeley, E.J., Weissman, S., Gerstein, M., Groudine, M., Snyder, M. et al. (2004) DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states. Proc. Natl. Acad. Sci. U S A, 101, 17771-17776.
20. Hellman, A., Rahat, A., Scherer, S.W., Darvasi, A., Tsui, L.C. and Kerem, B. (2000) Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability. Mol. Cell Biol., 20, 4420-4427.
21. Hellman, A., Zlotorynski, E., Scherer, S.W., Cheung, J., Vincent, J.B., Smith, D.I., Trakhtenbrot, L. and Kerem, B. (2002) A role for common fragile site induction in amplification of human oncogenes. Cancer Cell, 1, 89-97.
22. Gilbert, D.M. (2007) Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress. Chromosoma, 116, 341-347.
23. Hansen, R.S., Canfield, T.K., Lamb, M.M., Gartler, S.M. and Laird, C.D. (1993) Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell, 73, 1403-1409.
24. Howell, R.T. and McDermott, A. (1982) Replication status of the fragile X chromosome, fra(X)(q27), in three heterozygous females. Hum. Genet., 62, 282-284.
25. Rahat, A., Hellman, A. and Kerem, B. (2007) A Common Replication Pattern Underlies the Fragility at Gragile Site Regions. Arrieta, I., Penagarikano, O. and Télez, M. (Eds), Fragile Sites: New Discoveries and Changing Perspectives, Nova Science Publishers, Inc., Hauppauge, NY, pp. 99-115.
26. Woodward, A.M., Gohler, T., Luciani, M.G., Oehlmann, M., Ge, X., Gartner, A., Jackson, D.A. and Blow, J.J. (2006) Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J. Cell Biol., 173, 673-683.
27. Ge, X.Q., Jackson, D.A. and Blow, J.J. (2007) Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev., 21, 3331-3341.
28. Selzer, R.R., Richmond, T.A., Pofahl, N.J., Green, R.D., Eis, P.S., Nair, P., Brothman, A.R. and Stallings, R.L. (2005) Analysis of chromosome breakpoints in neuroblastoma at sub-kilobase resolution using fine-tiling oligonucleotide array CGH. Genes Chromosomes Cancer, 44, 305-319.