Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives

Applied Microbiology and Biotechnology

Volumn 92, Issue 3, 2011, Pages 479-497

  Collin, Frédéric ^a   Karkare, Shantanu ^a,b   Maxwell, Anthony ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Aminocoumarins; DNA gyrase; DNA topoisomerase; NBTIs; Quinolones; Supercoiling

Indexed keywords

AMINOCOUMARINS; DNA GYRASE; DNA TOPOISOMERASE; NBTIS; QUINOLONES; SUPERCOILING;

ENZYME INHIBITION;

DNA;

ADENOSINE TRIPHOSPHATASE; ALBICIDIN; AMINOCOUMARIN DERIVATIVE; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; CCDB PROTEIN; CINODINE; CIPROFLOXACIN; CLEROCIDIN; COUMAMYCIN A1; CYCLOTHIALIDINE; DNA TOPOISOMERASE (ATP HYDROLYSING); GEMIFLOXACIN; GSK 299423; GYRASE INHIBITOR; GYRI PROTEIN; LEVOFLOXACIN; MICROCIN B17; MOXIFLOXACIN; NALIDIXIC ACID; NORFLOXACIN; NOVOBIOCIN; OXOLINIC ACID; PD 0305970; QUINOLONE DERIVATIVE; SIMOCYCLINONE DERIVATIVE; TETRAHYDROINDAZOLE; UNCLASSIFIED DRUG;

BACTERIUM; DNA; DRUG; ENZYME ACTIVITY; HYDROLYSIS; INHIBITION;

ANTIBACTERIAL ACTIVITY; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; CATALYSIS; DNA CLEAVAGE; DNA SUPERCOILING; DRUG DNA BINDING; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PROTEIN HYDROLYSIS; PROTEIN TARGETING; REVIEW;

ADENOSINE TRIPHOSPHATE; ANTI-BACTERIAL AGENTS; BACTERIA; DNA GYRASE; DNA, BACTERIAL; MODELS, BIOLOGICAL; MODELS, MOLECULAR; QUINOLONES;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 82355173219     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3557-z     Document Type: Review

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