GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 4, 1996, Pages 1060-1062

  Stieger, Martin ^a   Angehen, Peter ^b   Wohlgensinger, Beatrice ^a   Gmünder, Hans ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b F Hoffmann La Roche   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CIPROFLOXACIN; COUMAMYCIN; CYCLOTHIALIDINE; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; ERYTHROMYCIN; NOVOBIOCIN; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; DNA STRAND BREAKAGE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; NOTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 0030005040     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.4.1060     Document Type: Note

References (37)

1. Ali, J. A., A. P. Jackson, A. J. Howells, and A. Maxwell. 1993. The 43 kDa N-terminal fragment of the gyrase B protein hydrolyses ATP and binds coumarin drugs. Biochemistry 24:2717-2724
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1990. Current protocols in molecular biology. John Wiley & Sons, New York.
3. Brockbank, S. M. V., and P. T. Barth. 1993. Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus attreus. J. Bacteriol. 175:3269-3277.
4. Contreras, A., and A. Maxwell. 1992. gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase Mol. Microbiol 6:1617-1624.
5. Cullen, M. E., A. W. Wyke, R. Kuroda, and L. M. Fisher. 1989. Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones. Antimicrob. Agents Chemother. 33:886-894.
6. 1. Proc. Natl. Acad. Sci. USA 88:8860-8864.
7. Drlica, K., and S. Cough lin. 1989. Inhibitors of DNA gyrase. Pharmacol. Ther. 44:107-121.
8. Gellert, M., K. Mizuuchi, M. H. O'Dea, and H. A. Nash. 1976. DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc. Natl. Acad. Sci. USA 73:3872-3876.
9. Gellert, M., M. H. O'Dea, T. Itoh, and J.-I. Tomizawa. 1976. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc. Natl. Acad. Sci. USA 73:4474-4478.
10. Gilbert, E. J., and A. Maxwell. 1994. The 24kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs. Mol. Microbiol. 12:365-373.
11. Goetschi, E., P. Angehrn, H. Gmunder, P. Hebeisen, H. Link, R. Masciadri, and J. Nielsen. 1994. Cyclothialidine and its congeners: a new class of DNA gyrase inhibitors. Pharmacol. Ther. 60:367-380.
12. Holmes, M. L., and M.-L. Dyall-Smith. 1991. Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteria J. Bacteriol. 173: 642-648.
13. Hooper, D. C., and J. S. Wolfson. 1991. Fluoroquinolone antimicrobial agents. N. Engl. J. Med. 324:384-394.
14. Horowitz, D. S., and J. C. Wang. 1987. Mapping the active site tyrosine of Escherichia coli DNA gyrase. J. Biol. Chem. 262:5339-5344.
15. Jackson, A. P., A. Maxwell, and D. B. Wigley. 1991. Preliminary crystallographic analysis of the ATP-hydrolysing domain of the Escherichia coli DNA gyrase B protein. J. Mol. Biol. 217:15-17.
16. Kamiyama, T., N. Shimma, T. Ohtsuka, N. Nakayama, Y. Itezono, N. Nakada, J. Watanabe, and K. Yokose. 1994. Cyclothialidine, a novel E. coli DNA gyrase inhibitor. H. Isolation, characterization and structure elucidation. J. Antibiot. 47:37-45.
17. 2 protein core. Biochemistry 19:5229-5234.
18. Lewis, R. J., O. M. P. Singh, C. V. Smith, A. Maxwell, T. Skarzynski, A. J. Wonacott, and D. B. Wigley. 1994. Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein. J. Mol. Biol. 241:128-130.
19. Margerrison, E. E. C, R. Hopewell, and L. M. Fisher. 1992. Nucleotide sequence of the Staphylococcus aureus gyrB-gyrA locus encoding the DNA gyrase A and B proteins. J. Bacteriol. 174:1596-1603.
20. Mizuuchi, K., M. H. O'Dea, and M. Gellert. 1978. DNA gyrase: subunit structure and ATPase activity of the purified enzyme. Proc. Natl. Acad. Sci USA 74:5960-5963
21. Muñoz, R., M. Bustamante, and A. de la Campa. 1995. Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance. J Bacteriol. 177:4166-4170.
22. Nakada, N., H. Gmünder, T. Hirata, and M. Arisawa. 1995. Characterization of the binding site for cyclothialidine on the B subunit of DNA gyrase. J. Biol Chem. 270:14286-14291
23. Nakada, N., H. Shimada, T. Hirata, Y. Aoki, T. Kamiyama, J. Watanabe, and M. Arisawa. 1993. Cyclothialidine, a new DNA gyrase inhibitor: biological characterization. Antimicrob. Agents Chemother. 37:2656-2661.
24. Oram, M., and L. M. Fisher. 1991. 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. Antimicrob. Agents Chemother. 35:387-389.
25. Radi, S. 1990. Structure-activity relationships in DNA gyrase inhibitors. Pharmacol. Ther. 48:1-17.
26. Recce, R. J., and A. Maxwell. 1991. DNA gyrase: structure and function. Crit. Rev. Biochem. Mol. Biol. 26:335-375.
27. Reece, R. J., and A. Maxwell. 1991. Probing the limits of the DNA breakage-reunion domain of the Escherichia coli DNA gyrase A protein. J. Biol. Chem. 266:3540-3546.
28. Sreedharan, S., M. Oram, B. Jensen, L. R. Petersen, and L. M. Fisher. 1990. DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. J. Bacteriol. 172:7260-7262.
29. Stein, D. C., R. J. Danaher, and T. M. Cook. 1991. Characterization of a gvrB mutation responsible for low-level nalidixic acid resistance in Neisseria gonorrhoeae. Antimicrob. Agents Chemother. 35:622-626.
30. Sugino, A. N., N. P. Higgins, P. O. Brown, C. L. Peebles, and N. R. Cozzarelli. 1978. Energy coupling in DNA gyrase and the mechanism of action of novobiocin Proc. Natl. Acad. Sci. USA 75:4838-4842
31. Thiara, A. S., and E. Cundliffe. 1988. Cloning and characterization of a DNA gyrase B gene from Streptomyces sphaeroides that confers resistance to novobiocin. EMBO J 7:2255-2259.
32. Wang, J. C. 1985. DNA topoisomerases. Annu. Rev. Biochem. 54:665-697
33. Wang, Y., W. M. Huang, and D. E. Taylor. 1993. Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. Antimicrob. Agents Chemother. 37:457-463
34. Watanabe, J., N. Nakada, S. Swairi, H. Shimada, S. Ohshima, T. Kamiyama, and M. Arisawa. 1994. Cyclothialidine, a novel DNA gyrase inhibitor. I. Screening, taxonomy, fermentation and biological activity. J. Antibiot. 47: 32-36.
35. Wigley, D. B., G. J. Davies, E. J. Dodson, A. Maxwell, and G. Dodson. 1991 Crystal structure of the N-terminal domain of the DNA gyrase B protein. Nature (London) 351:624-629.
36. Willmott, C. J. R., and A. Maxwell. 1993. A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex. Antimicrob. Agents Chemother. 37:126-127.
37. Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Qninolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.