Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

Nature Structural and Molecular Biology

Volumn 17, Issue 9, 2010, Pages 1152-1153

  Wohlkonig, Alexandre ^a   Chan, Pan F ^b   Fosberry, Andrew P ^a   Homes, Paul ^a   Huang, Jianzhong ^b   Kranz, Michael ^a   Leydon, Vaughan R ^a   Miles, Timothy J ^c   Pearson, Neil D ^b   Perera, Rajika L ^a   Shillings, Anthony J ^a   Gwynn, Michael N ^b   Bax, Benjamin D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c Cell Biology Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; DNA TOPOISOMERASE IIA; DNA TOPOISOMERASE IV; MAGNESIUM ION; MOXIFLOXACIN; QUINOLONE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; QUINOLONE DERIVATIVE;

ACINETOBACTER BAUMANNII; ARTICLE; DNA CLEAVAGE; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ACINETOBACTER BAUMANNII; DNA TOPOISOMERASE IV; ENZYME INHIBITORS; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; QUINOLONES;

ACINETOBACTER BAUMANNII; BACTERIA (MICROORGANISMS);

EID: 77956343814     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1892     Document Type: Article

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