Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 3, 2003, Pages 1037-1046

  Gross, Christian H ^a   Parsons, Jonathan D ^a   Grossman, Trudy H ^a   Charifson, Paul S ^a   Bellon, Steven ^a   Jernee, James ^a   Dwyer, Maureen ^a   Chambers, Stephen P ^a   Markland, William ^a   Botfield, Martyn ^a   Raybuck, Scott A ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); NOVOBIOCIN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CELL VIABILITY; CRYSTAL STRUCTURE; DNA SUPERCOILING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION; GENETIC COMPLEMENTATION; HYDROLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TEMPERATURE SENSITIVE MUTANT;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALLELES; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BINDING SITES; CLONING, MOLECULAR; DNA GYRASE; DNA, SUPERHELICAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NOVOBIOCIN; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 0037416980     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.3.1037-1046.2003     Document Type: Article

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