In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 5, 2009, Pages 2110-2119

  Oppegard, Lisa M ^a   Hamann, Bree L ^b   Streck, Kathryn R ^a   Ellis, Keith C ^c,d   Fiedler, Hans Peter ^e   Khodursky, Arkady B ^b   Hiasa, Hiroshi ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGUCYCLINE DERIVATIVE; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SIMOCYCLINONE D8; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; STAPHYLOCOCCUS AUREUS; STREPTOMYCES ANTIBIOTICUS; UPREGULATION;

ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; COUMARINS; CULTURE MEDIA; DNA GYRASE; DNA TOPOISOMERASES, TYPE II, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLYCOSIDES; MICROBIAL SENSITIVITY TESTS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS; STREPTOMYCES ANTIBIOTICUS;

EID: 66149137945     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01440-08     Document Type: Article

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