The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

Proteins: Structure, Function and Genetics

Volumn 28, Issue 1, 1997, Pages 41-52

  Tsai, Francis T F ^a   Singh, Onkar M P ^b   Skarzynski, Tadeusz ^b   Wonacott, Alan J ^b   Weston, Simon ^c   Tucker, Alec ^c   Pauptit, Richard A ^c   Breeze, Alexander L ^c   Poyser, J Philip ^c   O'Brien, Ronan ^d   Ladbury, John E ^d   Wigley, Dale B ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

clorobiocin; coumarin inhibitor; gyrase; type II topoisomerase

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; CLOROBIOCIN; DNA TOPOISOMERASE (ATP HYDROLYSING); GAG PROTEIN; NOVOBIOCIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FOLDING; THERMODYNAMICS;

EID: 0030893658     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(199705)28:1<41::AID-PROT4>3.0.CO;2-M     Document Type: Article

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