The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography

EMBO Journal

Volumn 15, Issue 6, 1996, Pages 1412-1420

  Lewis, Richard J ^a,d   Singh, Onkar M P ^b   Smith, Clare V ^c   Skarzynski, Tadeusz ^b   Maxwell, Anthony ^c   Wonacott, Alan J ^b   Wigley, Dale B ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Antibiotic; Coumarin; Cyclothialidine; DNA gyrase; X ray crystallography

Indexed keywords

ADENYLYLIMIDODIPHOSPHATE; ANTIBIOTIC AGENT; COUMARIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; GR 122222X; NOVOBIOCIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

EID: 0029978822     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00483.x     Document Type: Article

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