New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine

Journal of Medicinal Chemistry

Volumn 47, Issue 6, 2004, Pages 1487-1513

  Angehrn, Peter ^a   Buchmann, Stefan ^a   Funk, Christoph ^a   Goetschi, Erwin ^a   Gmuender, Hans ^a,b   Hebeisen, Paul ^a   Kostrewa, Dirk ^a,c   Link, Helmut ^a   Luebbers, Thomas ^a   Masciadri, Raffaello ^a   Nielsen, Joergen ^a   Reindl, Peter ^a   Ricklin, Fabienne ^a   Schmitt Hoffmann, Anne ^a,d   Theil, Frank Peter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b GENEDATA AG   (Switzerland)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

^d BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,4,5,6,7,8,10 OCTAHYDRO 14 HYDROXY 12 METHOXY 11 METHYL 4 (3 METHYL 1,2,4 OXADIAZOL 5 YL) 6 THIOXO 9,2,5 BENZOXATHIAAZACYCLODODECIN 10 ONE; 1,3,4,5,6,7,8,9,10,12 DECAHYDRO 16 HYDROXY 14 METHOXY 13 METHYL 4 (3 METHYL 1,2,4 OXADIAZOL 5 YL) 6 THIOXO 11,2,5 BENZOXATHIAAZACYCLOTETRADECIN 12 ONE; ADENOSINE TRIPHOSPHATASE; ANTIINFECTIVE AGENT; BENZENE DERIVATIVE; CYCLOTHIALIDINE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; LACTONE; NATURAL PRODUCT; NEW DRUG; RO 091437; SULFIDE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; CONTROLLED STUDY; DRUG ISOLATION; DRUG PENETRATION; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MOLECULAR SIZE; MOUSE; NONHUMAN; SEPTICEMIA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; STREPTOMYCES; STREPTOMYCES FILIPINENSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; DNA GYRASE; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-POSITIVE BACTERIA; HELA CELLS; HUMANS; LACTAMS; LACTONES; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; OXADIAZOLES; PEPTIDES, CYCLIC; PROTEIN SUBUNITS; STAPHYLOCOCCAL INFECTIONS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 12144289254     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0310232     Document Type: Article

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