Quinolone-binding pocket of DNA gyrase: Role of GyrB

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 6, 2002, Pages 1805-1815

  Heddle, Jonathan ^a   Maxwell, Anthony ^a  

^a JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; ASPARTIC ACID; DNA TOPOISOMERASE (ATP HYDROLYSING); GLUTAMIC ACID; LYSINE; MUTANT PROTEIN; QUINOLONE DERIVATIVE; TYROSINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CONFORMATIONAL TRANSITION; DNA BINDING; DRUG MECHANISM; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

ADENOSINE TRIPHOSPHATASES; ANTI-INFECTIVE AGENTS; BINDING SITES; CIPROFLOXACIN; DNA; DNA GYRASE; DNA, SUPERHELICAL; DRUG RESISTANCE, MICROBIAL; MODELS, MOLECULAR; MUTATION; OFLOXACIN; PROTEIN CONFORMATION;

EID: 0036093581     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.6.1805-1815.2002     Document Type: Article

References (48)

1. The 43-kDa N-terminal fragment of the gyrase B protein hydrolyses ATP and binds coumarin drugs
2. Toprim - A conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins
3. 87
4. In vitro assays used to measure the activity of topoisomerases
5. Structure at 2.7 Å resolution of a 92K yeast DNA topoisomerase II fragment
6. DNA topoisomerases: Structure, function, and mechanism
7. DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs
8. DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex
9. Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones
10. Mechanisms of fluoroquinolone action
11. DNA gyrase, topoisomerase IV, and the 4-quinolones
12. Quaternary changes in topoisomerase II may direct orthogonal movements of two DNA strands
13. Site-specific interaction of DNA gyrase with DNA
14. Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity
15. In the presence of subunit A inhibitors DNA gyrase cleaves DNA fragments as short as 20 bp at specific sites
16. Cloning of the DNA gyrase genes under tac promoter control: Overproduction of the gyrase A and B proteins
17. The interaction of drugs with DNA gyrase: A model for the molecular basis of quinolone action
18. Conformational changes in DNA gyrase revealed by limited proteolysis
19. Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerases
20. The DNA dependence of the ATPase activity of DNA gyrase
21. Overexpression and purification of bacterial DNA gyrase
22. Mechanistic studies of DNA gyrase
23. Structure of the DNA breakage-reunion domain of DNA gyrase
24. Interaction between DNA gyrase and its cleavage site on DNA
25. Quinolone resistance mutations in DNA gyrase
26. Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo 11
27. The role of GyrB in the DNA cleavagereligation reaction of DNA gyrase: A two-metal-ion mechanism
28. Evidence for a conformational change in the DNA gyrase-DNA complex from hydroxyl radical footprinting
29. The chemistry of the quinolones: Chemistry in the periphery of the quinolones
30. DNA gyrase: Structure and function
31. Tryptic fragments of the Escherichia coli DNA gyrase A protein
32. Mechanism of inhibition of DNA gyrase by quinolone antibacterials: Specificity and cooperativity of drug binding to DNA
33. Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: The target of the drugs is DNA
34. Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme
35. Slow interaction of 5′-adenylyl-β, γ-imidodiphosphate with Escherichia coli DNA gyrase
36. DNA unwinding induced by nalidixic acid binding to DNA
37. Studies on the interaction of 4-quinolones with DNA by DNA unwinding experiments
38. Crystal structure of an N-terminal fragment of the DNA gyrase B protein
39. Locking the ATP-operated clamp of DNA gyrase: Probing the mechanism of strand passage
40. A single point mutation in the DNA gyrase A protein greatly reduces the binding of fluoroquinolones to the gyrase-DNA complex
41. New nalidixic acid resistance mutations related to deoxyribonucleic acid gyrase activity
42. Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli
43. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli
44. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli
45. Quinolone-resistant mutations of the gyrA gene of Escherichia coli
46. Mechanism of action of quinolones against Escherichia coli DNA gyrase
47. DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance