Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II

Investigational New Drugs

Volumn 28, Issue 1, 2010, Pages 20-25

  Sadiq, Ahad A ^a   Patel, Manish R ^a   Jacobson, Blake A ^a   Escobedo, Marco ^a   Ellis, Keith ^b   Oppegard, Lisa M ^a   Hiasa, Hiroshi ^a   Kratzke, Robert A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Lung cancer; Mesothelioma; Topoisomerasell

Indexed keywords

CISPLATIN; DNA TOPOISOMERASE INHIBITOR; EPIDERMAL GROWTH FACTOR; ETOPOSIDE; GEMCITABINE; HYDROCORTISONE; KINETOPLAST DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; SIMOCYCLINONE D8; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG EFFECT; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; MALIGNANT MESOTHELIOMA; NONHUMAN; PRIORITY JOURNAL; SERUM;

APOPTOSIS; BIOCATALYSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COUMARINS; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GLYCOSIDES; HUMANS;

EID: 74149092112     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9209-1     Document Type: Article

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