-
1
-
-
0029609610
-
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
-
Bridgewater G, Springer CJ, Knox R, Minton N, Michael P, Collins M. Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur J Cancer 1995;31A:2362-2370.
-
(1995)
Eur J Cancer
, vol.31 A
, pp. 2362-2370
-
-
Bridgewater, G.1
Springer, C.J.2
Knox, R.3
Minton, N.4
Michael, P.5
Collins, M.6
-
2
-
-
0029815716
-
Genedirected enzyme prodrug therapy with a mustard prodrug/ carboxypeptidase G2 combination
-
Marais R, Spooner RA, Light Y, Martin J, Springer CJ. Genedirected enzyme prodrug therapy with a mustard prodrug/ carboxypeptidase G2 combination. Cancer Res. 1996;56:4735-4742.
-
(1996)
Cancer Res.
, vol.56
, pp. 4735-4742
-
-
Marais, R.1
Spooner, R.A.2
Light, Y.3
Martin, J.4
Springer, C.J.5
-
3
-
-
0035038479
-
Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques
-
Eaton JL, Perry MJA, Todryk SM, et al. Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques. Gene Therap. 2001;8:557-567.
-
(2001)
Gene Therap.
, vol.8
, pp. 557-567
-
-
Eaton, J.L.1
Perry, M.J.A.2
Todryk, S.M.3
-
4
-
-
0029637158
-
VDEPT; An enzyme/ prodrug gene therapy approach for the treatment of metastatic colorectal cancer
-
Huber BE, Richards CA, Austin EA. VDEPT; An enzyme/ prodrug gene therapy approach for the treatment of metastatic colorectal cancer. Adv Drug Delivery Rev. 1995;17:279-292.
-
(1995)
Adv Drug Delivery Rev.
, vol.17
, pp. 279-292
-
-
Huber, B.E.1
Richards, C.A.2
Austin, E.A.3
-
5
-
-
0034022622
-
Gene-delivery from replication-selective viruses: Arming guided missiles in the war against cancer
-
Hermiston T. Gene-delivery from replication-selective viruses: Arming guided missiles in the war against cancer. J Clin Invest. 2000;105:1169-1172.
-
(2000)
J Clin Invest.
, vol.105
, pp. 1169-1172
-
-
Hermiston, T.1
-
6
-
-
0036901290
-
Adenoviral vectors: Systemic delivery and tumor targeting
-
Green NK, Seymour LW. Adenoviral vectors: Systemic delivery and tumor targeting. Cancer Gene Therap. 2002;9:1036-1042.
-
(2002)
Cancer Gene Therap.
, vol.9
, pp. 1036-1042
-
-
Green, N.K.1
Seymour, L.W.2
-
7
-
-
0035418150
-
Adeno-associated virus for cancer gene therapy
-
Ponnazhagan S, Curiel DT, Shaw DR., Alvarez RD, Siegal GP. Adeno-associated virus for cancer gene therapy. Cancer Res. 2001;61:6313-6321.
-
(2001)
Cancer Res.
, vol.61
, pp. 6313-6321
-
-
Ponnazhagan, S.1
Curiel, D.T.2
Shaw, D.R.3
Alvarez, R.D.4
Siegal, G.P.5
-
8
-
-
0028789833
-
Development and application of herpes simplex virus vector for gene therapy
-
Glorioso JC, De Luca NA, Fink DJ. Development and application of herpes simplex virus vector for gene therapy. Annu Rev Microbiol. 1995;49:675-710.
-
(1995)
Annu Rev Microbiol.
, vol.49
, pp. 675-710
-
-
Glorioso, J.C.1
De Luca, N.A.2
Fink, D.J.3
-
9
-
-
0034202983
-
Adeno-associated viral-mediated gene transfer to hepatoma: Thymidine kinase/interleukin 2 is more effective in tumor killing in non-ganciclovir (GCV)-treated animals
-
Su H, Lu R, Ding R, Kan YW. Adeno-associated viral-mediated gene transfer to hepatoma: Thymidine kinase/interleukin 2 is more effective in tumor killing in non-ganciclovir (GCV)-treated animals. Mol Ther. 2000;1:509-515.
-
(2000)
Mol Ther.
, vol.1
, pp. 509-515
-
-
Su, H.1
Lu, R.2
Ding, R.3
Kan, Y.W.4
-
10
-
-
1642573191
-
Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors
-
Gerolami R, Uch R, Faivre J, et al. Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors. J Hepatol. 2004;40:291-297.
-
(2004)
J Hepatol.
, vol.40
, pp. 291-297
-
-
Gerolami, R.1
Uch, R.2
Faivre, J.3
-
11
-
-
2942592611
-
MIA (melanoma inhibitory activity) promoter-mediated tissue-specific suicide gene therapy of malignant melanoma
-
Schoensiegel F, Paschen A, Sieger S, et al. MIA (melanoma inhibitory activity) promoter-mediated tissue-specific suicide gene therapy of malignant melanoma. Cancer Gene Ther. 2004;11:408-418.
-
(2004)
Cancer Gene Ther.
, vol.11
, pp. 408-418
-
-
Schoensiegel, F.1
Paschen, A.2
Sieger, S.3
-
12
-
-
33749843288
-
Herpes simplex virus 1 (HSV-1) for cancer treatment
-
Shen Y, Nemunaitis J. Herpes simplex virus 1 (HSV-1) for cancer treatment. Cancer Gene Ther. 2006;11:975-992
-
(2006)
Cancer Gene Ther.
, vol.11
, pp. 975-992
-
-
Shen, Y.1
Nemunaitis, J.2
-
13
-
-
2442767029
-
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma
-
Study Group on Gene Therapy for Glioblastoma
-
Klatzmann D, Valery CA, Bensimon G, et al. A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma. Hum Gene Ther. 1998;9:2595-2604.
-
(1998)
Hum Gene Ther.
, vol.9
, pp. 2595-2604
-
-
Klatzmann, D.1
Valery, C.A.2
Bensimon, G.3
-
14
-
-
0037279647
-
Replicative retroviral vectors for cancer gene therapy
-
Solly SK, Trajcevski S, Frisen C, et al. Replicative retroviral vectors for cancer gene therapy. Cancer Gene Ther. 2003:10:30-39.
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 30-39
-
-
Solly, S.K.1
Trajcevski, S.2
Frisen, C.3
-
15
-
-
20044363101
-
Phase i study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma
-
Braybrooke JP, Slade A, Deplanque G, et al. Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma. Clin Cancer Res. 2005;11:1512-1520.
-
(2005)
Clin Cancer Res.
, vol.11
, pp. 1512-1520
-
-
Braybrooke, J.P.1
Slade, A.2
Deplanque, G.3
-
16
-
-
0036140461
-
Genetically engineered vesicular stomatitis virus in gene therapy: Application for treatment of malignant disease
-
Fernandez M, Porosnicu M, Markovic D, Barber GN. Genetically engineered vesicular stomatitis virus in gene therapy: Application for treatment of malignant disease. J Virol. 2002;76:895-904.
-
(2002)
J Virol.
, vol.76
, pp. 895-904
-
-
Fernandez, M.1
Porosnicu, M.2
Markovic, D.3
Barber, G.N.4
-
17
-
-
33747094529
-
Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a sindbis viral vector as a basis for prodrug ganciclovir activation and PET
-
Tseng JC, Zanzonico PB, Levin B, et al. Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a sindbis viral vector as a basis for prodrug ganciclovir activation and PET. J Nucl Med. 2006;47:1136-1143.
-
(2006)
J Nucl Med.
, vol.47
, pp. 1136-1143
-
-
Tseng, J.C.1
Zanzonico, P.B.2
Levin, B.3
-
18
-
-
0033565215
-
Systematic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice
-
Gnant MF, Puhlmann M, Alexander HR, Bartlett DL. Systematic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice. Cancer Res. 1999;59:3396-3403.
-
(1999)
Cancer Res.
, vol.59
, pp. 3396-3403
-
-
Gnant, M.F.1
Puhlmann, M.2
Alexander, H.R.3
Bartlett, D.L.4
-
19
-
-
0033105882
-
Thymidine kinase-deleted vaccinia virus expressing purine nucleoside phosphorylase as a vector for tumor-directed gene therapy
-
Puhlmann M, Gnant M, Brown CK, Alexander HR, Bartlett DL. Thymidine kinase-deleted vaccinia virus expressing purine nucleoside phosphorylase as a vector for tumor-directed gene therapy. Hum Gene Ther. 1999;10:649-657.
-
(1999)
Hum Gene Ther.
, vol.10
, pp. 649-657
-
-
Puhlmann, M.1
Gnant, M.2
Brown, C.K.3
Alexander, H.R.4
Bartlett, D.L.5
-
21
-
-
10844239971
-
Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK
-
Soghomonyan SA, Doubrovin M, Pike J, et al. Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK. Cancer Gene Ther. 2005;12:101-108.
-
(2005)
Cancer Gene Ther.
, vol.12
, pp. 101-108
-
-
Soghomonyan, S.A.1
Doubrovin, M.2
Pike, J.3
-
22
-
-
0032479769
-
Cationic liposomes for gene therapy
-
Miller AD. Cationic liposomes for gene therapy. Angewandte Chem Internatl Ed. 1998;37:1768-1785.
-
(1998)
Angewandte Chem Internatl Ed.
, vol.37
, pp. 1768-1785
-
-
Miller, A.D.1
-
23
-
-
0034997403
-
Non-viral vectors in cancer gene therapy: Principles and progress
-
Schatzlein AG. Non-viral vectors in cancer gene therapy: Principles and progress. Anti-Cancer Drug Design. 2001;12:275-304.
-
(2001)
Anti-Cancer Drug Design.
, vol.12
, pp. 275-304
-
-
Schatzlein, A.G.1
-
24
-
-
0036431478
-
Cationic lipids in gene delivery: Principles, vector design and therapeutical application
-
Ilies MA, Seitz MA, Balaban AT. Cationic lipids in gene delivery: Principles, vector design and therapeutical application. Curr Pharmaceut Design. 2002;8:2441-2474.
-
(2002)
Curr Pharmaceut Design.
, vol.8
, pp. 2441-2474
-
-
Ilies, M.A.1
Seitz, M.A.2
Balaban, A.T.3
-
25
-
-
27144497008
-
Long-term follow-up of patients with malignant pleural mesothelioma receiving highdose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy
-
Sterman DH, Recio A, Vachani A, et al. Long-term follow-up of patients with malignant pleural mesothelioma receiving highdose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy. Clin Cancer Res. 2005;11:7444-7453.
-
(2005)
Clin Cancer Res.
, vol.11
, pp. 7444-7453
-
-
Sterman, D.H.1
Recio, A.2
Vachani, A.3
-
26
-
-
7044235842
-
AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomized, controlled study
-
Immonen A, Vapalahti M, Tyynela K, et al. AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomized, controlled study. Mol Ther. 2004;10:967-972.
-
(2004)
Mol Ther.
, vol.10
, pp. 967-972
-
-
Immonen, A.1
Vapalahti, M.2
Tyynela, K.3
-
27
-
-
31644447744
-
Response of retinoblastoma with vitreous tumor seeding to adenovirusmediated delivery of thymidine kinase followed by ganciclovir
-
Chevez-Barrios P, Chintagumpala M, Mieler W, et al. Response of retinoblastoma with vitreous tumor seeding to adenovirusmediated delivery of thymidine kinase followed by ganciclovir. J Clin Oncol. 2005;23:7927-7935.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 7927-7935
-
-
Chevez-Barrios, P.1
Chintagumpala, M.2
Mieler, W.3
-
28
-
-
0034628523
-
A phase i study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (Adv.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma
-
Morris JC, Ramsey WJ, Wildner O, et al. A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (Adv.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma. Hum Gene Ther. 2000;11:487-503.
-
(2000)
Hum Gene Ther.
, vol.11
, pp. 487-503
-
-
Morris, J.C.1
Ramsey, W.J.2
Wildner, O.3
-
29
-
-
16944365155
-
Phase i study of direct administration of a replication deficient adenovirus vector containing the e coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine
-
Crystal RG, Hirschowitz E, Lieberman M, et al. Phase I study of direct administration of a replication deficient adenovirus vector containing the E coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Hum Gene Ther. 1997;8:985-1001.
-
(1997)
Hum Gene Ther.
, vol.8
, pp. 985-1001
-
-
Crystal, R.G.1
Hirschowitz, E.2
Lieberman, M.3
-
30
-
-
0034841686
-
Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: Results of a phase i clinical trial
-
Sung MW, Yeh HC, Thung SN, et al. Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: Results of a phase I clinical trial. Mol Ther. 2001;4:182-191.
-
(2001)
Mol Ther.
, vol.4
, pp. 182-191
-
-
Sung, M.W.1
Yeh, H.C.2
Thung, S.N.3
-
31
-
-
0035205990
-
Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up
-
Hasenburg A, Tong XW, Fischer DC, et al. Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up. Gynecol Oncol. 2001;83:549-554.
-
(2001)
Gynecol Oncol.
, vol.83
, pp. 549-554
-
-
Hasenburg, A.1
Tong, X.W.2
Fischer, D.C.3
-
32
-
-
0037429003
-
Phase i dose escalation clinical trial of adenovirus vector carrying osteocalcin promoterdriven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer
-
Kubo H, Gardner TA, Wada Y, et al. Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoterdriven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer. Hum Gene Ther. 2003;14:227-241.
-
(2003)
Hum Gene Ther.
, vol.14
, pp. 227-241
-
-
Kubo, H.1
Gardner, T.A.2
Wada, Y.3
-
33
-
-
0025899005
-
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene
-
Ezzeddine ZD, Martuza RL. Platika D, et al. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol. 1991;3:608-614.
-
(1991)
New Biol.
, vol.3
, pp. 608-614
-
-
Ezzeddine, Z.D.1
Martuza, R.L.2
Platika, D.3
-
34
-
-
0027378976
-
Thymidine kinase-mediated killing of rat brain tumors
-
Barba D, Hardin J, Ray J, Gage FH. Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg. 1993;79:729-735.
-
(1993)
J Neurosurg.
, vol.79
, pp. 729-735
-
-
Barba, D.1
Hardin, J.2
Ray, J.3
Gage, F.H.4
-
35
-
-
0034329438
-
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
-
Sandmair AM, Loimas S, Puranen P, et al. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. Hum Gene Ther. 2000;11:2197-2205.
-
(2000)
Hum Gene Ther.
, vol.11
, pp. 2197-2205
-
-
Sandmair, A.M.1
Loimas, S.2
Puranen, P.3
-
36
-
-
0034963065
-
Reduced growth in response to ganciclovir treatment of subcutaneous xenografts expressing HSV-tk in the vascular compartment
-
Mavria G, Porter CD. Reduced growth in response to ganciclovir treatment of subcutaneous xenografts expressing HSV-tk in the vascular compartment. Gene Ther. 2001;8:913-920.
-
(2001)
Gene Ther.
, vol.8
, pp. 913-920
-
-
Mavria, G.1
Porter, C.D.2
-
37
-
-
0036847436
-
Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer
-
Barzon L, Bonaguro R, Castagliuolo I, et al. Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer. J Clin Endocrinol Metab. 2002;87:5304-5311.
-
(2002)
J Clin Endocrinol Metab.
, vol.87
, pp. 5304-5311
-
-
Barzon, L.1
Bonaguro, R.2
Castagliuolo, I.3
-
38
-
-
0034909829
-
Direct retroviral delivery of human cytochrome P450 2B6 for gene-directed enzyme prodrug therapy of cancer
-
Kan O, Griffiths L, Baban D, et al. Direct retroviral delivery of human cytochrome P450 2B6 for gene-directed enzyme prodrug therapy of cancer. Cancer Gene Ther. 2001;8:473-482.
-
(2001)
Cancer Gene Ther.
, vol.8
, pp. 473-482
-
-
Kan, O.1
Griffiths, L.2
Baban, D.3
-
39
-
-
17944377598
-
Hepatic intraarterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases
-
Humphreys MJ, Ghaneh P, Greenhalf W, et al. Hepatic intraarterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases. Gene Ther. 2001;8:1241-1247.
-
(2001)
Gene Ther.
, vol.8
, pp. 1241-1247
-
-
Humphreys, M.J.1
Ghaneh, P.2
Greenhalf, W.3
-
40
-
-
0033588816
-
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir
-
Shand N, Weber F, Mariani L, et al. A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. Hum Gene Ther. 1999;10:2325-2335.
-
(1999)
Hum Gene Ther.
, vol.10
, pp. 2325-2335
-
-
Shand, N.1
Weber, F.2
Mariani, L.3
-
41
-
-
10744233353
-
Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: A phase I/II multi-institutional trial
-
Rados MD, McDermott M, Chang SM, et al. Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: A phase I/II multi-institutional trial. J Neurooncol. 2003;65:269-278.
-
(2003)
J Neurooncol.
, vol.65
, pp. 269-278
-
-
Rados, M.D.1
McDermott, M.2
Chang, S.M.3
-
42
-
-
0034694011
-
A phase III clinical evaluation of herpes simplex virus type i thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
-
Rainov NG. A phase III clinical evaluation of herpes simplex virus type I thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther. 2000;11:2389-2401.
-
(2000)
Hum Gene Ther.
, vol.11
, pp. 2389-2401
-
-
Rainov, N.G.1
-
43
-
-
0031183754
-
Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma
-
Miyatake S, Martuza RL, Rabkin SD. Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma. Cancer Gene Ther. 1997;4:222-228.
-
(1997)
Cancer Gene Ther.
, vol.4
, pp. 222-228
-
-
Miyatake, S.1
Martuza, R.L.2
Rabkin, S.D.3
-
44
-
-
0035076462
-
Combination suicide/cytokine gene therapy gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine
-
Toda M, Martuza RL, Rabkin SD. Combination suicide/cytokine gene therapy gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine. Gene Ther. 2001;8:332-339.
-
(2001)
Gene Ther.
, vol.8
, pp. 332-339
-
-
Toda, M.1
Martuza, R.L.2
Rabkin, S.D.3
-
45
-
-
0036262606
-
Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model
-
Moriuchi S, Wolfe D, Tamura M, et al, Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model. Gene Ther. 2002;9:584-591.
-
(2002)
Gene Ther.
, vol.9
, pp. 584-591
-
-
Moriuchi, S.1
Wolfe, D.2
Tamura, M.3
-
46
-
-
18244372933
-
Combination gene therapy for glioblastoma involving herpes simplex virus vectormediated codelivery of mutant IkappaBalpha and HSV thymidine kinase
-
Moriuchi S, Glorioso JC, Maruno M, et al. Combination gene therapy for glioblastoma involving herpes simplex virus vectormediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. Cancer Gene Ther. 2005;12:487-496.
-
(2005)
Cancer Gene Ther.
, vol.12
, pp. 487-496
-
-
Moriuchi, S.1
Glorioso, J.C.2
Maruno, M.3
-
47
-
-
0034036536
-
Conditionally replicating herpes vector for gene therapy
-
Martuza RL. Conditionally replicating herpes vector for gene therapy. J Clin Invest. 2000;105:841-846.
-
(2000)
J Clin Invest.
, vol.105
, pp. 841-846
-
-
Martuza, R.L.1
-
49
-
-
0034077666
-
Replication-selective adenoviruses as oncolytic agents
-
Heise C, Kirn HD. Replication-selective adenoviruses as oncolytic agents. J Clin Investig. 2000;105:847-851.
-
(2000)
J Clin Investig.
, vol.105
, pp. 847-851
-
-
Heise, C.1
Kirn, H.D.2
-
50
-
-
0036903141
-
Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes
-
Hermiston TV, Kuhn I. Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes. Cancer Gene Therap. 2002;9:1022-1035.
-
(2002)
Cancer Gene Therap.
, vol.9
, pp. 1022-1035
-
-
Hermiston, T.V.1
Kuhn, I.2
-
51
-
-
0035878847
-
Comparative analyses of transgene delivery and expression in tumors inoculated with a replicationconditional or-defective viral vector
-
Ichikawa T, Chiocca EA. Comparative analyses of transgene delivery and expression in tumors inoculated with a replicationconditional or-defective viral vector. Cancer Res. 2001;61:5336-5339.
-
(2001)
Cancer Res.
, vol.61
, pp. 5336-5339
-
-
Ichikawa, T.1
Chiocca, E.A.2
-
52
-
-
0034722892
-
Replication-selective oncolytic adenoviruses: Virotherapy aimed at genetic targets in cancer
-
Kirn D. Replication-selective oncolytic adenoviruses: Virotherapy aimed at genetic targets in cancer. Oncogene. 2000;19:6660-6669.
-
(2000)
Oncogene.
, vol.19
, pp. 6660-6669
-
-
Kirn, D.1
-
53
-
-
0025864440
-
Experimental therapy of human glioma by means of a generically engineered virus mutant
-
Martuza RL, Malick A, Markert JM, Ruffner KL, Coen DM. Experimental therapy of human glioma by means of a generically engineered virus mutant. Sci. 1991;252:854-856.
-
(1991)
Sci.
, vol.252
, pp. 854-856
-
-
Martuza, R.L.1
Malick, A.2
Markert, J.M.3
Ruffner, K.L.4
Coen, D.M.5
-
54
-
-
0036903141
-
Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes
-
Herminston T. Khun I. Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes. Cancer Gene Therap. 2002;9:1022-1035.
-
(2002)
Cancer Gene Therap.
, vol.9
, pp. 1022-1035
-
-
Herminston, T.1
Khun, I.2
-
55
-
-
0034927057
-
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
-
Kirn D, Martuza RL, Zwiebel J. Replication-selective virotherapy for cancer: Biological principles, risk management and future directions. Nat Med. 2001;7:781-787.
-
(2001)
Nat Med.
, vol.7
, pp. 781-787
-
-
Kirn, D.1
Martuza, R.L.2
Zwiebel, J.3
-
56
-
-
12944315014
-
Conditionally replicating herpes simplex virus mutant, G207, for the treatment of malignant glioma: Results of a phase i trial
-
Markert JM, Medlock MD, Rabkin SD, et al. Conditionally replicating herpes simplex virus mutant, G207, for the treatment of malignant glioma: Results of a phase I trial. Gene Ther. 2000;7:867-874.
-
(2000)
Gene Ther.
, vol.7
, pp. 867-874
-
-
Markert, J.M.1
Medlock, M.D.2
Rabkin, S.D.3
-
57
-
-
0033556003
-
Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase
-
Wildner O, Blaese RM, Morris JC. Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase. Cancer Res. 1999;59: 410-413.
-
(1999)
Cancer Res.
, vol.59
, pp. 410-413
-
-
Wildner, O.1
Blaese, R.M.2
Morris, J.C.3
-
58
-
-
0033895515
-
The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virustk: Assessment of antitumor efficacy and toxicity
-
Wildner O, Morris JC. The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virustk: Assessment of antitumor efficacy and toxicity. Cancer Res. 2000;60:4167-4174.
-
(2000)
Cancer Res.
, vol.60
, pp. 4167-4174
-
-
Wildner, O.1
Morris, J.C.2
-
59
-
-
0035893397
-
Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase
-
Nanda D, Vogels R, Havenga M, Avezaat CJ, Bout A, Smitt PS. Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase. Caner Res. 2001;61:8743-8750.
-
(2001)
Caner Res.
, vol.61
, pp. 8743-8750
-
-
Nanda, D.1
Vogels, R.2
Havenga, M.3
Avezaat, C.J.4
Bout, A.5
Smitt, P.S.6
-
60
-
-
0033643594
-
Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tK
-
Morris JC, Wildner O. Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tK. Mol Ther. 2000;1:56-62.
-
(2000)
Mol Ther.
, vol.1
, pp. 56-62
-
-
Morris, J.C.1
Wildner, O.2
-
61
-
-
0034279442
-
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses
-
Wildner O, Morris JC. Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses. J Gene Med. 2000;2:353-360.
-
(2000)
J Gene Med.
, vol.2
, pp. 353-360
-
-
Wildner, O.1
Morris, J.C.2
-
62
-
-
0034956825
-
Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy
-
Lambright ES, Amin K, Wiewrodt R, et al. Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy. Gene Ther. 2001;8:946-953.
-
(2001)
Gene Ther.
, vol.8
, pp. 946-953
-
-
Lambright, E.S.1
Amin, K.2
Wiewrodt, R.3
-
63
-
-
2342641762
-
Replicative oncolytic herpes simplex viruses in combination cancer therapies
-
Post DE, Fulci G, Chiocca EA, Van Meir EG. Replicative oncolytic herpes simplex viruses in combination cancer therapies. Curr Gene Ther. 2004;4:41-51.
-
(2004)
Curr Gene Ther.
, vol.4
, pp. 41-51
-
-
Post, D.E.1
Fulci, G.2
Chiocca, E.A.3
Van Meir, E.G.4
-
64
-
-
10844256740
-
Tumor-specific intravenous gene delivery using oncolytic adenoviruses
-
Zhan J, Gao Y, Wang W, et al. Tumor-specific intravenous gene delivery using oncolytic adenoviruses. Cancer Gene Ther. 2005;12:19-25.
-
(2005)
Cancer Gene Ther.
, vol.12
, pp. 19-25
-
-
Zhan, J.1
Gao, Y.2
Wang, W.3
-
65
-
-
33746896895
-
Oncolytic adenoviral vector carrying the cytosine deaminase gene for melanoma gene therapy
-
Liu Y, Deisseroth A. Oncolytic adenoviral vector carrying the cytosine deaminase gene for melanoma gene therapy. Cancer Gen Ther. 2006;13:845-855.
-
(2006)
Cancer Gen Ther.
, vol.13
, pp. 845-855
-
-
Liu, Y.1
Deisseroth, A.2
-
66
-
-
4243164553
-
Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector
-
Chen MJ, Green NK, Reynolds GM, et al. Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector. Gene Ther. 2004;11:1126-1136.
-
(2004)
Gene Ther.
, vol.11
, pp. 1126-1136
-
-
Chen, M.J.1
Green, N.K.2
Reynolds, G.M.3
-
67
-
-
29244455327
-
Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954
-
Lukashev AN, Fuerer C, Chen MJ, Searle P, Iggo R. Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954. Hum Gene Ther. 2005;16:1473-1483.
-
(2005)
Hum Gene Ther.
, vol.16
, pp. 1473-1483
-
-
Lukashev, A.N.1
Fuerer, C.2
Chen, M.J.3
Searle, P.4
Iggo, R.5
-
68
-
-
20444467322
-
Systemic genedirected enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2
-
Schepelmann S, Hallenbeck P, Ogilvie LM, et al. Systemic genedirected enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005;65:5003-5008.
-
(2005)
Cancer Res.
, vol.65
, pp. 5003-5008
-
-
Schepelmann, S.1
Hallenbeck, P.2
Ogilvie, L.M.3
-
69
-
-
0142219877
-
A prodrug strategy using ONYX-0150-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38
-
Stubdal H, Perin N, Lemmon M, et al. A prodrug strategy using ONYX-0150-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38. Cancer Res. 2003;63:6900-6908.
-
(2003)
Cancer Res.
, vol.63
, pp. 6900-6908
-
-
Stubdal, H.1
Perin, N.2
Lemmon, M.3
-
70
-
-
0032503659
-
A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy
-
Freytag SO, Rogulski KR, Paielli DL, Gilbert JD, Kim JH. A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy. Human Gene Therap. 1998;9:1323-1333.
-
(1998)
Human Gene Therap.
, vol.9
, pp. 1323-1333
-
-
Freytag, S.O.1
Rogulski, K.R.2
Paielli, D.L.3
Gilbert, J.D.4
Kim, J.H.5
-
71
-
-
0036733759
-
Phase i study of replication-competent adenvovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
-
Freytag SO, Khil M, Stricker H, et al. Phase I study of replication-competent adenvovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res. 2002;62:4968-4976.
-
(2002)
Cancer Res.
, vol.62
, pp. 4968-4976
-
-
Freytag, S.O.1
Khil, M.2
Stricker, H.3
-
72
-
-
0036644845
-
Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: Potential relevance to gene therapy
-
Rauen KA, Sudilovsky D, Le JL, et al. Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: Potential relevance to gene therapy. Cancer Res. 2002;62:3812-3818.
-
(2002)
Cancer Res.
, vol.62
, pp. 3812-3818
-
-
Rauen, K.A.1
Sudilovsky Le, D.J.L.2
-
73
-
-
0034671907
-
Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity
-
Krasnykh V, Dmitriev I, Navarro J-G, et al. Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity. Cancer Res. 2000;60:6784-6787.
-
(2000)
Cancer Res.
, vol.60
, pp. 6784-6787
-
-
Krasnykh, V.1
Dmitriev, I.2
Navarro, J.-G.3
-
74
-
-
33645020031
-
Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increase the infectivity and therapeutic effect for breast cancer gene therapy
-
Liu Y, Ye T, Maynard J, Akbulut H, Deisseroth A. Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increase the infectivity and therapeutic effect for breast cancer gene therapy. Cancer Gene Ther. 2006;13:346-356.
-
(2006)
Cancer Gene Ther.
, vol.13
, pp. 346-356
-
-
Liu, Y.1
Ye, T.2
Maynard, J.3
Akbulut, H.4
Deisseroth, A.5
-
75
-
-
0035418558
-
Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228
-
Kitazono M, Goldsmith ME, Aikou T, Bates S, Fojo T. Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228. Cancer Res. 2001;61:6328-6330.
-
(2001)
Cancer Res.
, vol.61
, pp. 6328-6330
-
-
Kitazono, M.1
Goldsmith, M.E.2
Aikou, T.3
Bates, S.4
Fojo, T.5
-
76
-
-
0038066634
-
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells
-
Anders M, Christian C, McMahon M, McCormick F, Korn WM. Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer Res. 2003;63:2088-2095.
-
(2003)
Cancer Res.
, vol.63
, pp. 2088-2095
-
-
Anders, M.1
Christian, C.2
McMahon, M.3
McCormick, F.4
Korn, W.M.5
-
77
-
-
0028034286
-
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
-
Boviatsis EJ, Park JS, Sena-Esteves M, et al. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res. 1994;54:5745-5751.
-
(1994)
Cancer Res.
, vol.54
, pp. 5745-5751
-
-
Boviatsis, E.J.1
Park, J.S.2
Sena-Esteves, M.3
-
78
-
-
0035878715
-
Multimodality therapy with a replicationconditional herpes simplex virus 1 mutant that express yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine tom 5-fluorouracil
-
Nakamura H, Mullen JT, Chanrasekhar S, Pawlik TM, Yoon SS, Tanabe KK. Multimodality therapy with a replicationconditional herpes simplex virus 1 mutant that express yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine tom 5-fluorouracil. Cancer Res. 2001;61:5447-5452.
-
(2001)
Cancer Res.
, vol.61
, pp. 5447-5452
-
-
Nakamura, H.1
Mullen, J.T.2
Chanrasekhar, S.3
Pawlik, T.M.4
Yoon, S.S.5
Tanabe, K.K.6
-
79
-
-
0036721374
-
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus i mutant that expresses the CYP2B1 transgene
-
Pawlik TM, Nakamura H, Mullen JT, et al. Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus I mutant that expresses the CYP2B1 transgene. Cancer. 2002;95:1171-1181.
-
(2002)
Cancer.
, vol.95
, pp. 1171-1181
-
-
Pawlik, T.M.1
Nakamura, H.2
Mullen, J.T.3
-
80
-
-
0344200002
-
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies
-
Aghi M, Chou TC, Suling K, Breakefield XO, Chiocca IA. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 1999;59:3861-3865.
-
(1999)
Cancer Res.
, vol.59
, pp. 3861-3865
-
-
Aghi, M.1
Chou, T.C.2
Suling, K.3
Breakefield, X.O.4
Chiocca, I.A.5
-
81
-
-
23044450359
-
Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan
-
2005
-
Tyminski E, LeRoy S, Terada K, et al. (2005) Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan. Cancer Res. 2005;65:6850-6857.
-
(2005)
Cancer Res.
, vol.65
, pp. 6850-6857
-
-
Tyminski, E.1
Leroy, S.2
Terada, K.3
-
82
-
-
0036827801
-
Enzyme-activated prodrug therapy enhances tumor-specific replication of adenovirus vectors
-
Bernt KM, Steinwaerder DS, Ni S, Li ZY, Roffler SR, Lieber A. Enzyme-activated prodrug therapy enhances tumor-specific replication of adenovirus vectors. Cancer Res. 2002;62:6089-6098.
-
(2002)
Cancer Res.
, vol.62
, pp. 6089-6098
-
-
Bernt, K.M.1
Steinwaerder, D.S.2
Ni, S.3
Li, Z.Y.4
Roffler, S.R.5
Lieber, A.6
-
83
-
-
0346365365
-
The oncolytic effect of recombinant vesicular stomatitis virus is enhanced by expression of the fusion cytosine deaminase/uracil phosphorbiosylltransferase suicide gene
-
Porosnicu M, Mian A, Barber GN. The oncolytic effect of recombinant vesicular stomatitis virus is enhanced by expression of the fusion cytosine deaminase/uracil phosphorbiosylltransferase suicide gene. Cancer Res. 2003;63:8366-8376.
-
(2003)
Cancer Res.
, vol.63
, pp. 8366-8376
-
-
Porosnicu, M.1
Mian, A.2
Barber, G.N.3
-
84
-
-
0033567895
-
Sensitization of tumor necrosis factor alpha-resistant human melanoma by tumorspecific in vivo transfer of the gene encoding endothelial monocyte-activating polypeptide II using recombinant vaccinia virus
-
Gnant MF, Berger AC, Huang J, et al. Sensitization of tumor necrosis factor alpha-resistant human melanoma by tumorspecific in vivo transfer of the gene encoding endothelial monocyte-activating polypeptide II using recombinant vaccinia virus. Cancer Res. 1999;59:4668-4674.
-
(1999)
Cancer Res.
, vol.59
, pp. 4668-4674
-
-
Gnant, M.F.1
Berger, A.C.2
Huang, J.3
-
85
-
-
0034128881
-
Replication-selective microbiological agents: Fighting cancer with targeted germ warfare
-
Kirn D. Replication-selective microbiological agents: Fighting cancer with targeted germ warfare. J Clin Invest. 2000;105:837-839.
-
(2000)
J Clin Invest.
, vol.105
, pp. 837-839
-
-
Kirn, D.1
-
86
-
-
0030854392
-
Tumor-targeted Salmonella as a novel anticancer vector
-
Pawelek JM, Low KB, Bermudes D. Tumor-targeted Salmonella as a novel anticancer vector. Cancer Res. 1997;57:4537-4544.
-
(1997)
Cancer Res.
, vol.57
, pp. 4537-4544
-
-
Pawelek, J.M.1
Low, K.B.2
Bermudes, D.3
-
87
-
-
0035816147
-
Salmonella-based tumor-targeted cancer therapy: Tumor amplified protein expression therapy (TAPET) for diagnostic imaging
-
Tjuvaev J, Blasberg R, Luo X, Zheng LM, King I, Bermudes D. Salmonella-based tumor-targeted cancer therapy: Tumor amplified protein expression therapy (TAPET) for diagnostic imaging. J Control Release. 2001;74:313-315.
-
(2001)
J Control Release.
, vol.74
, pp. 313-315
-
-
Tjuvaev, J.1
Blasberg, R.2
Luo, X.3
Zheng, L.M.4
King, I.5
Bermudes, D.6
-
88
-
-
0034032620
-
Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors
-
Yazawa K, Fujimori M, Amano J, Kano Y, Taniguchi S. Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors. Cancer Gene Ther. 2000;7:269-274
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 269-274
-
-
Yazawa, K.1
Fujimori, M.2
Amano, J.3
Kano, Y.4
Taniguchi, S.5
-
89
-
-
0035013495
-
Increasing specificity of anti-tumour therapy: Cytotoxic proteins delivery by non-pathogenic Clostridia under regulation of radioinduced promoter
-
Nuyts S, Theys J, Landuyt W, Van Mellaert L, Lambin P, Anne J. Increasing specificity of anti-tumour therapy: Cytotoxic proteins delivery by non-pathogenic Clostridia under regulation of radioinduced promoter. Anticancer Res. 2001;21:857-862.
-
(2001)
Anticancer Res.
, vol.21
, pp. 857-862
-
-
Nuyts, S.1
Theys, J.2
Landuyt, W.3
Van Mellaert, L.4
Lambin, P.5
Anne, J.6
-
90
-
-
0035014279
-
The use of radiation-induced bacterial promoters in anaerobicconditions: A means to control gene expression in Clostridiummediated gene therapy
-
Nuyts S, Van Mellaert L, Theys J, Landuyt W, Lambin P, Anne J. The use of radiation-induced bacterial promoters in anaerobicconditions: A means to control gene expression in Clostridiummediated gene therapy. Radiation Res. 2001;155:716-723.
-
(2001)
Radiation Res.
, vol.155
, pp. 716-723
-
-
Nuyts, S.1
Van Mellaert, L.2
Theys, J.3
Landuyt, W.4
Lambin, P.5
Anne, J.6
-
91
-
-
85047697737
-
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis
-
Liu S-C, Minton NP, Giaccia AJ, Brown JM. Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Therap. 2002;9:291-296.
-
(2002)
Gene Therap.
, vol.9
, pp. 291-296
-
-
Liu, S.-C.1
Minton, N.P.2
Giaccia, A.J.3
Brown, J.M.4
-
92
-
-
0003008343
-
Synthetic DNA delivery systems
-
Luo D, Salzman WM. Synthetic DNA delivery systems. Nature Biotech. 2000;18:33-37.
-
(2000)
Nature Biotech.
, vol.18
, pp. 33-37
-
-
Luo, D.1
Salzman, W.M.2
-
93
-
-
0034109287
-
Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of CB1954
-
Djeha AH, Hulme A, Dexter MT, et al. Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of CB1954. Cancer Gene Ther. 2000;7:721-731.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 721-731
-
-
Djeha, A.H.1
Hulme, A.2
Dexter, M.T.3
-
94
-
-
0035870252
-
Effective tumor therapy with plasmid cytokines combined with in vivo electroporation
-
Lohr F, Lo DY, Zaharoff DA, et al. Effective tumor therapy with plasmid cytokines combined with in vivo electroporation. Cancer Res. 2001;61:3281-3284.
-
(2001)
Cancer Res.
, vol.61
, pp. 3281-3284
-
-
Lohr, F.1
Lo, D.Y.2
Zaharoff, D.A.3
-
95
-
-
0033950759
-
Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis
-
Bentires-Alj M, Helin A-C, Lechanteur C, et al. Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis. Cancer Gene Ther. 2000;7:20-26.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 20-26
-
-
Bentires-Alj, M.1
Helin, A.-C.2
Lechanteur, C.3
-
96
-
-
0033961768
-
Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer
-
Harada Y, Iwai M, Tanaka S, et al. Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer. Cancer Gene Ther. 2000;7:27-36.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 27-36
-
-
Harada, Y.1
Iwai, M.2
Tanaka, S.3
-
97
-
-
0035138403
-
Usefulness of repeated intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy
-
Kanyama H, Tomita N, Yamano T, et al. Usefulness of repeated intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy. Cancer Res. 2001;61:14-18, 100.
-
(2001)
Cancer Res.
, vol.61
, Issue.14-18
, pp. 100
-
-
Kanyama, H.1
Tomita, N.2
Yamano, T.3
-
98
-
-
0034102551
-
Widespread gene transfection into the central nervous system of primates
-
Hagihara Y, Saitoh Y, Kaneda Y, Kohmura E, Yoshimine T. Widespread gene transfection into the central nervous system of primates. Gene Ther. 2000;7:759-763.
-
(2000)
Gene Ther.
, vol.7
, pp. 759-763
-
-
Hagihara, Y.1
Saitoh, Y.2
Kaneda, Y.3
Kohmura, E.4
Yoshimine, T.5
-
99
-
-
12944260697
-
Selective in vivo transfection of murine biliary epithelia using polycationenhanced adenovirus
-
Mc Kay TR, MacVinish LJ, Carpenter B, et al. Selective in vivo transfection of murine biliary epithelia using polycationenhanced adenovirus. Gene Ther. 2000;7:644-652.
-
(2000)
Gene Ther.
, vol.7
, pp. 644-652
-
-
Mc Kay, T.R.1
MacVinish, L.J.2
Carpenter, B.3
-
100
-
-
0032857639
-
Systemic p53 gene therapy in combination with radiation results in human tumor regression
-
Xu L, Pirollo KF, Rait A, Murray AL, Chang EH. Systemic p53 gene therapy in combination with radiation results in human tumor regression. Tumor Targeting. 1999;4:92-104.
-
(1999)
Tumor Targeting.
, vol.4
, pp. 92-104
-
-
Xu, L.1
Pirollo, K.F.2
Rait, A.3
Murray, A.L.4
Chang, E.H.5
-
102
-
-
85047698036
-
Alternative splicing as a novel means of regulating the expression of therapeutic genes
-
Hayes GM, Carpenito C, Davis PD, Dougherty ST, Dirks GF, Dougherty GH. Alternative splicing as a novel means of regulating the expression of therapeutic genes. Cancer Gene Ther. 2002;9:133-141.
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 133-141
-
-
Hayes, G.M.1
Carpenito, C.2
Davis, P.D.3
Dougherty, S.T.4
Dirks, G.F.5
Dougherty, G.H.6
-
103
-
-
0036019373
-
Selective killing of cancer cells based on translational control of suicide gene therapy
-
De Fatta RJ, Li Y, De Benedetti A. Selective killing of cancer cells based on translational control of suicide gene therapy. Cancer Gene Ther. 2002;9:573-578.
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 573-578
-
-
De Fatta, R.J.1
Li, Y.2
De Benedetti, A.3
-
104
-
-
0036270720
-
A cancer gene therapy approach through translational control of a suicide gene
-
De Fatta RJ, Chervenack RP, De Benedetti A. A cancer gene therapy approach through translational control of a suicide gene. Cancer Gene Ther. 2002;9:502-505.
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 502-505
-
-
De Fatta, R.J.1
Chervenack, R.P.2
De Benedetti, A.3
-
105
-
-
0035134629
-
Clinical research results with di 1520 (ONYX-015), a replication selective adenovirus for the treatment of cancer: What have we learned?
-
Kirn D. Clinical research results with dI 1520 (ONYX-015), a replication selective adenovirus for the treatment of cancer: What have we learned? Gene Ther. 2001;8:89-98.
-
(2001)
Gene Ther.
, vol.8
, pp. 89-98
-
-
Kirn, D.1
-
106
-
-
0031761897
-
Gene therapy of gliomas: Receptors and transcriptional targeting
-
Spear MA. Gene therapy of gliomas: Receptors and transcriptional targeting. Anticancer Research. 1998;18:3223-3232.
-
(1998)
Anticancer Research.
, vol.18
, pp. 3223-3232
-
-
Spear, M.A.1
-
107
-
-
0034652614
-
Evaluation of HSV-tk gene therapy in rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes
-
Gerolami R, Cardoso J, Lewin M, et al. Evaluation of HSV-tk gene therapy in rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes. Cancer Res. 2000;60:993-1001.
-
(2000)
Cancer Res.
, vol.60
, pp. 993-1001
-
-
Gerolami, R.1
Cardoso, J.2
Lewin, M.3
-
108
-
-
0033805534
-
Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC-1 antigen
-
Kurihara T, Brough DE, Kovesti I, Kufe DW. Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC-1 antigen. J Clin Invest. 2000;106:763-771.
-
(2000)
J Clin Invest.
, vol.106
, pp. 763-771
-
-
Kurihara, T.1
Brough, D.E.2
Kovesti, I.3
Kufe, D.W.4
-
109
-
-
0032150507
-
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus
-
Siders WM, Halloran PJ, Fenton RG. Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus. Cancer Gene Ther. 1998;5:281-291.
-
(1998)
Cancer Gene Ther.
, vol.5
, pp. 281-291
-
-
Siders, W.M.1
Halloran, P.J.2
Fenton, R.G.3
-
110
-
-
0034213449
-
Therapeutic efficacy of the suicide gene driven the promoter of vascular endothelial growth factor gene against hypoxic tumor cells
-
Koshikawa N, Takenaga K, Tagawa M, Sakiyama S. Therapeutic efficacy of the suicide gene driven the promoter of vascular endothelial growth factor gene against hypoxic tumor cells. Cancer Res. 2000;60:2936-2941.
-
(2000)
Cancer Res.
, vol.60
, pp. 2936-2941
-
-
Koshikawa, N.1
Takenaga, K.2
Tagawa, M.3
Sakiyama, S.4
-
111
-
-
0034650401
-
Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: Construction and testing of a tissue specific adenovirus vector
-
Latham JPF, Searle PF, Mautner V, James ND. Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: Construction and testing of a tissue specific adenovirus vector. Cancer Res. 2000;60:334-341.
-
(2000)
Cancer Res.
, vol.60
, pp. 334-341
-
-
Latham, J.P.F.1
Searle, P.F.2
Mautner, V.3
James, N.D.4
-
112
-
-
0035300474
-
Gene therapy targeting for hepatocellular carcinoma: Selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human a-fetoprotein promoter
-
Ido A, Uto H, Moriuchi A, et al. Gene therapy targeting for hepatocellular carcinoma: Selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human a-fetoprotein promoter. Cancer Res. 2001;61:3016-3021.
-
(2001)
Cancer Res.
, vol.61
, pp. 3016-3021
-
-
Ido, A.1
Uto, H.2
Moriuchi, A.3
-
113
-
-
0035361401
-
The use of L-plastin promoter for adenoviral-mediated , tumor-specific gene-expression in ovarian and bladder cancer cell lines
-
Peng XY, Won JH, Rutherford T, et al. The use of L-plastin promoter for adenoviral-mediated , tumor-specific gene-expression in ovarian and bladder cancer cell lines. Cancer Res. 2001;61:4405-4413.
-
(2001)
Cancer Res.
, vol.61
, pp. 4405-4413
-
-
Peng, X.Y.1
Won, J.H.2
Rutherford, T.3
-
114
-
-
0034798205
-
Latency associated promoter transgene expression in the central nervous system after stereotaxic delivery of replication-defective HSV-1-based vectors
-
Scarpini CG, May J, Lachman RH, et al. Latency associated promoter transgene expression in the central nervous system after stereotaxic delivery of replication-defective HSV-1-based vectors. Gene Ther. 2001;8:1057-1071.
-
(2001)
Gene Ther.
, vol.8
, pp. 1057-1071
-
-
Scarpini, C.G.1
May, J.2
Lachman, R.H.3
-
115
-
-
0035869668
-
Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a myc-max binding motif
-
Nishino K, Osaki T, Kumagai T, et al. Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a myc-max binding motif. Internatl J Cancer. 2001;91:851-856.
-
(2001)
Internatl J Cancer.
, vol.91
, pp. 851-856
-
-
Nishino, K.1
Osaki, T.2
Kumagai, T.3
-
116
-
-
0035881303
-
Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/ 5-fluoro-cytosine enhanced by the Cre/loxP system in the orthotopic gastric carcinoma model
-
Ueda K, Iwahashi M, Nakamori M, et al. Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/ 5-fluoro-cytosine enhanced by the Cre/loxP system in the orthotopic gastric carcinoma model. Cancer Res. 2001;61:6158-6162.
-
(2001)
Cancer Res.
, vol.61
, pp. 6158-6162
-
-
Ueda, K.1
Iwahashi, M.2
Nakamori, M.3
-
117
-
-
0035881263
-
A conditional replication-competent vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis
-
Matsubara S, Wada Y, Gardner TA, et al. A conditional replication-competent vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Res. 2001;61:6012-6019.
-
(2001)
Cancer Res.
, vol.61
, pp. 6012-6019
-
-
Matsubara, S.1
Wada, Y.2
Gardner, T.A.3
-
119
-
-
33746056891
-
Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy
-
Yoon KJ, Qi J, Remack JS, et al. Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy. Mol Cancer Ther. 2006;5:1577-1584.
-
(2006)
Mol Cancer Ther.
, vol.5
, pp. 1577-1584
-
-
Yoon, K.J.1
Qi, J.2
Remack, J.S.3
-
120
-
-
0034803673
-
A novel parasite-derived suicide gene for cancer gene therapy with specificity for lung cancer cells
-
Trudeau C, Yuan S, Galipeau J, Benlimame N, Alaoui-Jamali MA, Batist G. A novel parasite-derived suicide gene for cancer gene therapy with specificity for lung cancer cells. Human Gene Ther. 2001;12:1673-1680.
-
(2001)
Human Gene Ther.
, vol.12
, pp. 1673-1680
-
-
Trudeau, C.1
Yuan, S.2
Galipeau, J.3
Benlimame, N.4
Alaoui-Jamali, M.A.5
Batist, G.6
-
121
-
-
0033664464
-
Development of a novel enzyme/prodrug combination for gene therapy of cancer: Horseradish peroxidase/indole-3-acetic acid
-
Greco O, Folkes LK, Wardman P, Tozer GM, Dachs GU. Development of a novel enzyme/prodrug combination for gene therapy of cancer: Horseradish peroxidase/indole-3-acetic acid. Cancer Gene Ther. 2000;7:1414-1420.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 1414-1420
-
-
Greco, O.1
Folkes, L.K.2
Wardman, P.3
Tozer, G.M.4
Dachs, G.U.5
-
122
-
-
3142602957
-
Analysis of the horseradish peroxidase/indole-3-acetic acid combination in a threedimensional tumor model
-
Tupper J, Greco O, Tozer GM, Dachs GU. Analysis of the horseradish peroxidase/indole-3-acetic acid combination in a threedimensional tumor model. Cancer Gene Ther. 2004;11:508-513.
-
(2004)
Cancer Gene Ther.
, vol.11
, pp. 508-513
-
-
Tupper, J.1
Greco, O.2
Tozer, G.M.3
Dachs, G.U.4
-
123
-
-
0034541169
-
Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells
-
Simonova M, Wall A, Weissleder R, Bogdanov A. Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells. Cancer Res. 2000;60:6656-6662.
-
(2000)
Cancer Res.
, vol.60
, pp. 6656-6662
-
-
Simonova, M.1
Wall, A.2
Weissleder, R.3
Bogdanov, A.4
-
124
-
-
0031796794
-
Successful use of a plant gene in the treatment of cancer in vivo
-
Cortes ML, de Felipe P, Martin V, Hughes MA, Izquierdo M. Successful use of a plant gene in the treatment of cancer in vivo. Gene Ther. 1998;5:1499-1507.
-
(1998)
Gene Ther.
, vol.5
, pp. 1499-1507
-
-
Cortes, M.L.1
De Felipe, P.2
Martin, V.3
Hughes, M.A.4
Izquierdo, M.5
-
125
-
-
0034186366
-
Prodrug activation enzymes in cancer gene therapy
-
Aghi M, Hochberg F, Breakfield XO. Prodrug activation enzymes in cancer gene therapy. J Gene Med. 2000;2:148-164.
-
(2000)
J Gene Med.
, vol.2
, pp. 148-164
-
-
Aghi, M.1
Hochberg, F.2
Breakfield, X.O.3
-
126
-
-
33646779548
-
Tumor-selective drug activation: A GDEPT approach utilizing cytochromeP450 1A1 and AQ4N
-
Yakkundi A, McErlane V, Murray M, et al. Tumor-selective drug activation: A GDEPT approach utilizing cytochromeP450 1A1 and AQ4N. Cancer Gene Ther. 2006;13:598-605.
-
(2006)
Cancer Gene Ther.
, vol.13
, pp. 598-605
-
-
Yakkundi, A.1
McErlane, V.2
Murray, M.3
-
127
-
-
18344372908
-
The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by cytochrome P450 enzyme 1B1
-
Potter GA, Patterson LH, Wanogho E. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by cytochrome P450 enzyme 1B1. Br J Cancer. 2002;86:774-778.
-
(2002)
Br J Cancer.
, vol.86
, pp. 774-778
-
-
Potter, G.A.1
Patterson, L.H.2
Wanogho, E.3
-
128
-
-
4444223732
-
Cytochrome P450 enzymes: Novel options for cancer therapeutics
-
McFadyen MCE, Melvin WT, Murray GI. Cytochrome P450 enzymes: Novel options for cancer therapeutics. Mol Cancer Ther. 2004;3:363-371.
-
(2004)
Mol Cancer Ther.
, vol.3
, pp. 363-371
-
-
McFadyen, M.C.E.1
Melvin, W.T.2
Murray, G.I.3
-
129
-
-
10444290057
-
Suicide gene therapy: Conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase
-
Savage P, Cowburn P, Clemen D, et al. Suicide gene therapy: Conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase. Cancer Gene Ther. 2004;11:774-781.
-
(2004)
Cancer Gene Ther.
, vol.11
, pp. 774-781
-
-
Savage, P.1
Cowburn, P.2
Clemen, D.3
-
130
-
-
0035399802
-
Appropriate subcellular location of prodrugactivating enzymes has important consequences for suicide gene therapy
-
Spooner RA, Maycroft KA, Paterson H, Friedlos F, Springer CJ, Marais R. Appropriate subcellular location of prodrugactivating enzymes has important consequences for suicide gene therapy. Internatl J Cancer. 2001;93:123-130.
-
(2001)
Internatl J Cancer.
, vol.93
, pp. 123-130
-
-
Spooner, R.A.1
Maycroft, K.A.2
Paterson, H.3
Friedlos, F.4
Springer, C.J.5
Marais, R.6
-
131
-
-
0033961881
-
Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-a-peptide prodrugs
-
Hamstra DA, Page M, Maybaum J, Rehemtulla A. Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-a-peptide prodrugs. Cancer Res. 2000;60:657-665.
-
(2000)
Cancer Res.
, vol.60
, pp. 657-665
-
-
Hamstra, D.A.1
Page, M.2
Maybaum, J.3
Rehemtulla, A.4
-
132
-
-
0034947012
-
Cell surface display of a lysosomal enzyme for extra-cellular gene-directed enzyme prodrug therapy
-
Heine D, Muller R, Brusselbach S. Cell surface display of a lysosomal enzyme for extra-cellular gene-directed enzyme prodrug therapy. Gene Ther. 2001;8:1005-1010.
-
(2001)
Gene Ther.
, vol.8
, pp. 1005-1010
-
-
Heine, D.1
Muller, R.2
Brusselbach, S.3
-
133
-
-
0031437780
-
A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy
-
Marais R, Spooner RA, Stribbling SM, Light Y, Martin J, Springer CJ. A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy. Nature Biotech. 1997;15:1373-1377.
-
(1997)
Nature Biotech.
, vol.15
, pp. 1373-1377
-
-
Marais, R.1
Spooner, R.A.2
Stribbling, S.M.3
Light, Y.4
Martin, J.5
Springer, C.J.6
-
134
-
-
0033993506
-
Secreted human β-glucuronidase: A novel tool for gene-directed enzyme prodrug therapy
-
Weyel D, Sedlacek HH, Muller R, Brusselbach S. Secreted human β-glucuronidase: A novel tool for gene-directed enzyme prodrug therapy. Gene Ther. 2000;7:224-231.
-
(2000)
Gene Ther.
, vol.7
, pp. 224-231
-
-
Weyel, D.1
Sedlacek, H.H.2
Muller, R.3
Brusselbach, S.4
-
135
-
-
0032526239
-
Isolation and partial characterization of a cDNA encoding rabbit liver carboxyl esterase that activates the prodrug irinotecan (CPT-11)
-
Potter PM, Pawlick CA, Morton CL, Naeve CV, Danks MK. Isolation and partial characterization of a cDNA encoding rabbit liver carboxyl esterase that activates the prodrug irinotecan (CPT-11). Cancer Res. 1998;58:2646-2651.
-
(1998)
Cancer Res.
, vol.58
, pp. 2646-2651
-
-
Potter, P.M.1
Pawlick, C.A.2
Morton, C.L.3
Naeve, C.V.4
Danks, M.K.5
-
136
-
-
0035392963
-
Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase
-
Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM. Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase. Cancer Res. 2001;61:5078-5082.
-
(2001)
Cancer Res.
, vol.61
, pp. 5078-5082
-
-
Wierdl, M.1
Morton, C.L.2
Weeks, J.K.3
Danks, M.K.4
Harris, L.C.5
Potter, P.M.6
-
137
-
-
33645466808
-
Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydrxylase P450 2B11
-
Jounaidi Y, Chen C-S, Veal GJ, Waxman DJ. Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydrxylase P450 2B11. Mol Cancer Ther. 2006;5:541-555.
-
(2006)
Mol Cancer Ther.
, vol.5
, pp. 541-555
-
-
Jounaidi, Y.1
Chen, C.-S.2
Veal, G.J.3
Waxman, D.J.4
-
138
-
-
0036708008
-
Characterization of herpes simplex virus type 1 kinase mutants engineered for improved ganciclovir and acyclovir activity
-
Kokoris MS, Black ME. Characterization of herpes simplex virus type 1 kinase mutants engineered for improved ganciclovir and acyclovir activity. Protein Sci. 2002;11:2267-2272.
-
(2002)
Protein Sci.
, vol.11
, pp. 2267-2272
-
-
Kokoris, M.S.1
Black, M.E.2
-
139
-
-
0029588221
-
The choice of prodrugs for gene directed enzyme prodrug therapy of cancer
-
Connors TA. The choice of prodrugs for gene directed enzyme prodrug therapy of cancer. Gene Ther. 1995;2:702-709.
-
(1995)
Gene Ther.
, vol.2
, pp. 702-709
-
-
Connors, T.A.1
-
140
-
-
0035123128
-
Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives
-
Greco O, Dachs GU. Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives. J Cellular Physiol. 2001;187:22-36.
-
(2001)
J Cellular Physiol.
, vol.187
, pp. 22-36
-
-
Greco, O.1
Dachs, G.U.2
-
142
-
-
0038685423
-
Prodrugs for gene-directed enzyme prodrug therapy (GDEPT)
-
Denny WA. Prodrugs for gene-directed enzyme prodrug therapy (GDEPT). Biomed Biotechnol. 2003;1:48-70.
-
(2003)
Biomed Biotechnol.
, vol.1
, pp. 48-70
-
-
Denny, W.A.1
-
143
-
-
0030593879
-
A novel nitro-substituted seco-Cl: Application as a reductively activated ADEPT prodrug
-
Tercel M, Denny WA, Wilson WR. A novel nitro-substituted seco-Cl: Application as a reductively activated ADEPT prodrug. Bioorg Med Chem Let. 1996;6:2741-2744.
-
(1996)
Bioorg Med Chem Let.
, vol.6
, pp. 2741-2744
-
-
Tercel, M.1
Denny, W.A.2
Wilson, W.R.3
-
144
-
-
0029897684
-
Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P-450 gene
-
Chen L, Waxman DJ, Chen D, Kufe DC. Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P-450 gene. Cancer Res. 1996;56:1331-1340.
-
(1996)
Cancer Res.
, vol.56
, pp. 1331-1340
-
-
Chen, L.1
Waxman, D.J.2
Chen, D.3
Kufe, D.C.4
-
145
-
-
0032523096
-
In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors
-
Kojima A, Hackett NR, Ohwada A, Crystal RG. In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors. J Clin Invest. 1998;101:1789-1796.
-
(1998)
J Clin Invest.
, vol.101
, pp. 1789-1796
-
-
Kojima, A.1
Hackett, N.R.2
Ohwada, A.3
Crystal, R.G.4
-
146
-
-
0034105702
-
Prodrug-activating systems in suicide gene therapy
-
Springer CJ, Niculescu-Duvaz I. Prodrug-activating systems in suicide gene therapy. J Clin Invest. 2000;105:1161-1167.
-
(2000)
J Clin Invest.
, vol.105
, pp. 1161-1167
-
-
Springer, C.J.1
Niculescu-Duvaz, I.2
-
147
-
-
18544405495
-
Bystander effect of purine nucleoside analogues in HSV-tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues
-
Degreve B. De Clerq E, Balzarini J. Bystander effect of purine nucleoside analogues in HSV-tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues. Gene Ther. 1999;6:162-170.
-
(1999)
Gene Ther.
, vol.6
, pp. 162-170
-
-
Degreve, B.1
De Clerq, E.2
Balzarini, J.3
-
148
-
-
0032510381
-
Intensely potent doxorubicin analgoues: Structure-activity relationships
-
Farquhar D, Cherif A, Bakina E, Nelson GA. Intensely potent doxorubicin analgoues: Structure-activity relationships. J Med Chem. 1998;41:965-972.
-
(1998)
J Med Chem.
, vol.41
, pp. 965-972
-
-
Farquhar, D.1
Cherif, A.2
Bakina, E.3
Nelson, G.A.4
-
149
-
-
0033998433
-
The macrophage a novel system to deliver gene therapy to pathological hypoxia
-
Griffiths L, Binley K, Iqball S, et al. The macrophage-a novel system to deliver gene therapy to pathological hypoxia. Gene Ther. 2000;7:255-262.
-
(2000)
Gene Ther.
, vol.7
, pp. 255-262
-
-
Griffiths, L.1
Binley, K.2
Iqball, S.3
-
150
-
-
0033929022
-
Complex interaction between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression
-
McCart JA, Puhlmann M, Lee J, et al. Complex interaction between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression. Gene Ther. 2000;7:1217-1223.
-
(2000)
Gene Ther.
, vol.7
, pp. 1217-1223
-
-
McCart, J.A.1
Puhlmann, M.2
Lee, J.3
-
151
-
-
0031956262
-
The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and genedirected enzyme prodrugs therapies
-
Denny WA, Wilson WR. The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and genedirected enzyme prodrugs therapies. J Pharmaceut Pharmacol. 1998;50:387-394.
-
(1998)
J Pharmaceut Pharmacol.
, vol.50
, pp. 387-394
-
-
Denny, W.A.1
Wilson, W.R.2
-
152
-
-
0002742642
-
Alkylating agents
-
(ed. DEV Wilman), Blackie, London
-
Niculescu-Duvaz I, Baracu I, Balaban AT. (1990). Alkylating agents. In Chemistry of Antitumour Agents (ed. DEV Wilman), pp. 63-131. Blackie, London.
-
(1990)
Chemistry of Antitumour Agents
, pp. 63-131
-
-
Niculescu-Duvaz, I.1
Baracu, I.2
Balaban, A.T.3
-
153
-
-
0033027043
-
Gene therapy of cancer: Activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase
-
Secrist JA, Parker WB, Allan PW, et al. Gene therapy of cancer: Activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase. Nucleosides Nucleotides. 1999;18:745-757.
-
(1999)
Nucleosides Nucleotides.
, vol.18
, pp. 745-757
-
-
Secrist, J.A.1
Parker, W.B.2
Allan, P.W.3
-
154
-
-
0001687859
-
The design of selectively-activated prodrugs for cancer chemotherapy
-
Denny WA. The design of selectively-activated prodrugs for cancer chemotherapy. Curr Pharma Design. 1996;2:281-294.
-
(1996)
Curr Pharma Design.
, vol.2
, pp. 281-294
-
-
Denny, W.A.1
-
155
-
-
33751141247
-
Prodrugs of the cytostatic CC-1065 that can be activated in a tumor selective manner
-
Tietze L, Hanemann R, Buhr W, Logers M, Menningem P. Prodrugs of the cytostatic CC-1065 that can be activated in a tumor selective manner. Angewante Chemie International Edition. 1996;35:2674-2677.
-
(1996)
Angewante Chemie International Edition.
, vol.35
, pp. 2674-2677
-
-
Tietze, L.1
Hanemann, R.2
Buhr, W.3
Logers, M.4
Menningem, P.5
-
156
-
-
0036495569
-
Proof of principle in the selective treatment of cancer by antibody-directed enzyme prodrug therapy: The development of highly potent prodrugs
-
Tietze LF, Feuerstein T, Feher A, Haunbert F, Pranknin O. Proof of principle in the selective treatment of cancer by antibody-directed enzyme prodrug therapy: The development of highly potent prodrugs. Angewante Chemie International Edition. 2003;41:759-761.
-
(2003)
Angewante Chemie International Edition
, vol.41
, pp. 759-761
-
-
Tietze, L.F.1
Feuerstein, T.2
Feher, A.3
Haunbert, F.4
Pranknin, O.5
-
157
-
-
0141809797
-
The design of prodrugs for antibody directed enzyme prodrug therapy
-
R Begent and A Hamlin editors; London, The Royal Society of Medicine Press
-
Springer CJ, Niculescu-Duvaz I, Mauger AB, et al. The design of prodrugs for antibody directed enzyme prodrug therapy. IN: R Begent and A Hamlin, editors; New Antibody Technology and Emergence of Useful Cancer Therapy. 1995; London, The Royal Society of Medicine Press; 75-79.
-
(1995)
New Antibody Technology and Emergence of Useful Cancer Therapy
, pp. 75-79
-
-
Springer, C.J.1
Niculescu-Duvaz, I.2
Mauger, A.B.3
-
158
-
-
0034536263
-
Metabolism of selenoamino acids and contribution of selenium methylation to their toxicity
-
Nakamuro K, Okuno T, Hasegawa T. Metabolism of selenoamino acids and contribution of selenium methylation to their toxicity. J Health Sci. 2000;46:418-421.
-
(2000)
J Health Sci.
, vol.46
, pp. 418-421
-
-
Nakamuro, K.1
Okuno, T.2
Hasegawa, T.3
-
159
-
-
0020441192
-
The relationship between the catalytic activities of rabbit pulmonary cytochrome P-450 isozymes and the lungspecific toxicity of the furan derivative, 4-ipomeanol
-
Wolf CR, Statham CN, McMenamin MG, Bend JR, Boyd MR, Philpot RM. The relationship between the catalytic activities of rabbit pulmonary cytochrome P-450 isozymes and the lungspecific toxicity of the furan derivative, 4-ipomeanol. Molecular Pharmacol. 1982;22:738-744.
-
(1982)
Molecular Pharmacol.
, vol.22
, pp. 738-744
-
-
Wolf, C.R.1
Statham, C.N.2
McMenamin, M.G.3
Bend, J.R.4
Boyd, M.R.5
Philpot, R.M.6
-
160
-
-
0027504795
-
A comparative study of the use of primary Chinese-hamster liver cultures and genetically-engineered immortal V79 Chinese-hamster cell-lines expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays
-
Ellard S, Parry JM. A comparative study of the use of primary Chinese-hamster liver cultures and genetically-engineered immortal V79 Chinese-hamster cell-lines expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays. Toxicol. 1993;82:131-149.
-
(1993)
Toxicol.
, vol.82
, pp. 131-149
-
-
Ellard, S.1
Parry, J.M.2
-
161
-
-
0030907756
-
Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy
-
Friedlos F, Denny WA, Palmer BD, Springer CJ. Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. J Med Chem. 1997;40:1270-1275.
-
(1997)
J Med Chem.
, vol.40
, pp. 1270-1275
-
-
Friedlos, F.1
Denny, W.A.2
Palmer, B.D.3
Springer, C.J.4
-
162
-
-
33144455024
-
Nitrobenzylcarbamate prodrugs of cytotoxic acridines for potential use with nitroreductase gene-directed enzyme prodrug therapy
-
Asche C, Dumy P, Carrez D, Croisy A, Demeunynk M. Nitrobenzylcarbamate prodrugs of cytotoxic acridines for potential use with nitroreductase gene-directed enzyme prodrug therapy. Bioorg Med Chem Lett. 2006;1990-1994.
-
(2006)
Bioorg Med Chem Lett.
, pp. 1990-1994
-
-
Asche, C.1
Dumy, P.2
Carrez, D.3
Croisy, A.4
Demeunynk, M.5
-
163
-
-
33745827010
-
Design, synthesis and biological evaluation of cyclic and acyclic nitrobenzylphophoramide mustards for E. coli nitroreductase activation
-
Jiang Y, Han J, Yu C, et al. Design, synthesis and biological evaluation of cyclic and acyclic nitrobenzylphophoramide mustards for E. coli nitroreductase activation. J Med Chem. 2006;49:4333-4343.
-
(2006)
J Med Chem.
, vol.49
, pp. 4333-4343
-
-
Jiang, Y.1
Han, J.2
Yu, C.3
-
164
-
-
0033168032
-
Selfimmolative anthracycline prodrugs for suicide gene therapy
-
Niculescu-Duvaz I, Niculescu-Duvaz D, Friedlos,F, et al. Selfimmolative anthracycline prodrugs for suicide gene therapy. J Med Chem. 1999;42:2485-2489.
-
(1999)
J Med Chem.
, vol.42
, pp. 2485-2489
-
-
Niculescu-Duvaz, I.1
Niculescu-Duvaz, D.2
Friedlos, F.3
-
165
-
-
0033168032
-
Self-immolative anthracycline prodrugs for suicide gene therapy
-
Niculescu-Duvaz I, Niculescu-Duvaz D, Friedlos F. Niculescu-Duvaz I, Niculescu-Duvaz D, Friedlos,F, et al. Self-immolative anthracycline prodrugs for suicide gene therapy. J Med Chem. 1999;42:2485-2489.
-
(1999)
J Med Chem.
, vol.42
, pp. 2485-2489
-
-
Niculescu-Duvaz, I.1
Niculescu-Duvaz, D.2
Friedlos, F.3
Niculescu-Duvaz, I.4
Niculescu-Duvaz, D.5
Friedlos, F.6
-
166
-
-
0037464457
-
Selfimmolative nitrogen mustards prodrugs cleavable by carboxypeptidase Ge (CPG2) showing large cytotoxicity differential in GDEPT
-
Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, et al. Selfimmolative nitrogen mustards prodrugs cleavable by carboxypeptidase Ge (CPG2) showing large cytotoxicity differential in GDEPT. J Med Chem. 2003;46:1690-1705.
-
(2003)
J Med Chem.
, vol.46
, pp. 1690-1705
-
-
Niculescu-Duvaz, D.1
Niculescu-Duvaz, I.2
Friedlos, F.3
-
167
-
-
2342519428
-
Significant differences in biological parameters between prodrugs cleavable by carbozypeptidase G2 that generate 3,5-diflurophenol and aniline mustards in gene-directed enzyme prodrug therapy
-
Niculescu-Duvaz I, Scanlon I, Niculescu-Duvaz D, et al. Significant differences in biological parameters between prodrugs cleavable by carbozypeptidase G2 that generate 3,5-diflurophenol and aniline mustards in gene-directed enzyme prodrug therapy. J Med Chem. 2004:47-2651-2658.
-
(2004)
J Med Chem.
, vol.47
, pp. 2651-2658
-
-
Niculescu-Duvaz, I.1
Scanlon, I.2
Niculescu-Duvaz, D.3
-
168
-
-
23444457117
-
Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy
-
Davies LC, Friedlos F, Hedley D, et al. Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy. J Med Chem. 2005;48:5321-5328.
-
(2005)
J Med Chem.
, vol.48
, pp. 5321-5328
-
-
Davies, L.C.1
Friedlos, F.2
Hedley, D.3
-
169
-
-
0034686261
-
A daunorubicin b-galactoside prodrug for use in conjunction with gene-directed enzyme prodrug therapy
-
Ghosh AK, Khan S, Marini F, Nelson JA, Farquhar D. A daunorubicin b-galactoside prodrug for use in conjunction with gene-directed enzyme prodrug therapy. Tetrahedron Lett. 2000;41:4871-4874.
-
(2000)
Tetrahedron Lett.
, vol.41
, pp. 4871-4874
-
-
Ghosh, A.K.1
Khan, S.2
Marini, F.3
Nelson, J.A.4
Farquhar, D.5
-
170
-
-
0034085228
-
Two-drug combinations that increase apoptosis and modulate Bak and Bcl-Xl expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase
-
McMasters RA, Wilbert TN, Jones KE, et al. Two-drug combinations that increase apoptosis and modulate Bak and Bcl-Xl expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. Cancer Gene Ther. 2000;7:563-573.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 563-573
-
-
McMasters, R.A.1
Wilbert, T.N.2
Jones, K.E.3
-
171
-
-
0036045454
-
Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy
-
Boucher PD, Ostruszka LJ, Murphy PJM, Shewach DS. Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy. Gene Ther. 2002;9:1023-1030.
-
(2002)
Gene Ther.
, vol.9
, pp. 1023-1030
-
-
Boucher, P.D.1
Ostruszka, L.J.2
Murphy, P.J.M.3
Shewach, D.S.4
-
172
-
-
0034885956
-
Modulation of cyclophosphamide-based cytochrome p450 gene therapy using liver P450 inhibitors
-
Huang Z, Waxman DJ. Modulation of cyclophosphamide-based cytochrome p450 gene therapy using liver P450 inhibitors. Cancer Gene Ther. 2001;8:450-458.
-
(2001)
Cancer Gene Ther.
, vol.8
, pp. 450-458
-
-
Huang, Z.1
Waxman, D.J.2
-
173
-
-
0034660849
-
Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy
-
Jounaidi Y, Waxman DJ. Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Cancer Res. 2000;60:3761-3769.
-
(2000)
Cancer Res.
, vol.60
, pp. 3761-3769
-
-
Jounaidi, Y.1
Waxman, D.J.2
-
174
-
-
14644396577
-
Development of hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy
-
Wang D, Ruan H, Hu L, et al. Development of hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy. Cancer Gene Ther. 2005;12:276-283.
-
(2005)
Cancer Gene Ther.
, vol.12
, pp. 276-283
-
-
Wang, D.1
Ruan, H.2
Hu, L.3
-
175
-
-
0033984339
-
Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization
-
Rogulski KR, Wing MS, Paielli DL, Gilbert JD, Kim JH, Freytag SO. Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization. Human Gene Ther. 2000;11:67-76.
-
(2000)
Human Gene Ther.
, vol.11
, pp. 67-76
-
-
Rogulski, K.R.1
Wing, M.S.2
Paielli, D.L.3
Gilbert, J.D.4
Kim, J.H.5
Freytag, S.O.6
-
176
-
-
0034660858
-
In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosporibosyltransgerase fusion gene
-
Erbs P, Regulier E, Kintz J, et al. In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosporibosyltransgerase fusion gene. Cancer Res. 2000;60:3813-3822.
-
(2000)
Cancer Res.
, vol.60
, pp. 3813-3822
-
-
Erbs, P.1
Regulier, E.2
Kintz, J.3
-
177
-
-
0034899009
-
Enhanced growth suppression in esophageal carcinoma cells using adenovirusmediated fusion gene transfer uracil phosphoryl transferase and herpes simplex virus thymidine kinase
-
Shimizu T, Shimada H, Ochiai T, Hamada H. Enhanced growth suppression in esophageal carcinoma cells using adenovirusmediated fusion gene transfer uracil phosphoryl transferase and herpes simplex virus thymidine kinase. Cancer Gene Ther. 2001;8:512-521.
-
(2001)
Cancer Gene Ther.
, vol.8
, pp. 512-521
-
-
Shimizu, T.1
Shimada, H.2
Ochiai, T.3
Hamada, H.4
-
178
-
-
0029740524
-
Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained antitumor immunity prolongs animal survival
-
Chen SH, Kosai K, Xu B, et al. Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained antitumor immunity prolongs animal survival. Cancer Res. 1996;56:3758-3762.
-
(1996)
Cancer Res.
, vol.56
, pp. 3758-3762
-
-
Chen, S.H.1
Kosai, K.2
Xu, B.3
-
179
-
-
0035076462
-
Combination suicide/cytokine gene therapy gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine
-
Toda M, Martuza RL, Rabkin SD. Combination suicide/cytokine gene therapy gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine. Gene Ther. 2001;8:332-339.
-
(2001)
Gene Ther.
, vol.8
, pp. 332-339
-
-
Toda, M.1
Martuza, R.L.2
Rabkin, S.D.3
-
180
-
-
33646044375
-
Cytotoxicity of HSVtk and hrTNF a fusion genes with IRES in treatment of gastric cancer
-
2006
-
Zhang J-H, Wan M-X, Pan B-R, Yu B. (2006) Cytotoxicity of HSVtk and hrTNF-a fusion genes with IRES in treatment of gastric cancer. Cancer Lett. 2006;235:191-201.
-
(2006)
Cancer Lett.
, vol.235
, pp. 191-201
-
-
Zhang, J.-H.1
Wan, M.-X.2
Pan, B.-R.3
Yu, B.4
-
181
-
-
0028108469
-
Metabolism of 5-fluorocytidine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
-
Huber BE, Austin EA, Richards CA, Davis ST, Good SS. Metabolism of 5-fluorocytidine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proceed Natl Acad Sci USA. 1994;91:8302-8306.
-
(1994)
Proceed Natl Acad Sci USA.
, vol.91
, pp. 8302-8306
-
-
Huber, B.E.1
Austin, E.A.2
Richards, C.A.3
Davis, S.T.4
Good, S.S.5
-
182
-
-
0033900009
-
Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communications
-
Mesnil M, Yamasachi H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communications. Cancer Res. 2000;60:3989-3999.
-
(2000)
Cancer Res.
, vol.60
, pp. 3989-3999
-
-
Mesnil, M.1
Yamasachi, H.2
-
183
-
-
0031991630
-
Bystander tumoricidal effect and gap junctional communication in lung cancer cells
-
Imaizumi K, Hasegawa Y, Kawabe T, et al. Bystander tumoricidal effect and gap junctional communication in lung cancer cells. Am J Respir Cell Mol Biol. 1998;18:205-212.
-
(1998)
Am J Respir Cell Mol Biol.
, vol.18
, pp. 205-212
-
-
Imaizumi, K.1
Hasegawa, Y.2
Kawabe, T.3
-
185
-
-
0030916131
-
Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: The Good Samaritan effect
-
Wygoda MR, Wilson MR, Davis MA, Trosko JE, Rehemtulla A, Lawrence TS. Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: The Good Samaritan effect. Cancer Res. 1997;57:1699-1703.
-
(1997)
Cancer Res.
, vol.57
, pp. 1699-1703
-
-
Wygoda, M.R.1
Wilson, M.R.2
Davis, M.A.3
Trosko, J.E.4
Rehemtulla, A.5
Lawrence, T.S.6
-
186
-
-
0032440742
-
The bystander effect in the HSVtk/ganciclovir system and its relation to gap junctional communication
-
Touraine RL, Ishii-Morita H, Ramsey WJ, Blaese RM. The bystander effect in the HSVtk/ganciclovir system and its relation to gap junctional communication. Gene Ther. 1998;5:1705-1711.
-
(1998)
Gene Ther.
, vol.5
, pp. 1705-1711
-
-
Touraine, R.L.1
Ishii-Morita, H.2
Ramsey, W.J.3
Blaese, R.M.4
-
187
-
-
0032213438
-
Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions
-
Touraine RL, Vahanian N, Ramsey WJ, Blaese RM. Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Human Gene Ther. 1998;9:2385-2391.
-
(1998)
Human Gene Ther.
, vol.9
, pp. 2385-2391
-
-
Touraine, R.L.1
Vahanian, N.2
Ramsey, W.J.3
Blaese, R.M.4
-
188
-
-
0033669748
-
The role of cellular-and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy
-
Grignet-Debrus C, Cool V, Baudson N, Velu T, Calberg-Bacq C-M. The role of cellular-and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy. Cancer Gene Ther. 2000:7:1456-1468.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 1456-1468
-
-
Grignet-Debrus, C.1
Cool, V.2
Baudson, N.3
Velu, T.4
Calberg-Bacq, C.-M.5
-
189
-
-
0034033272
-
Comparative in vitro and in vivo cytotoxic activity of BVaraU against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase
-
Grignet-Debrus C, Cool V, Baudson N, et al. Comparative in vitro and in vivo cytotoxic activity of BVaraU against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase. Cancer Gene Ther. 2000;7:215-223.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 215-223
-
-
Grignet-Debrus, C.1
Cool, V.2
Baudson, N.3
-
190
-
-
0030007803
-
In vivo analysis of the "bystander effect": A cytokine cascade
-
Ramesh R, Marrogi AJ, Munshi A, Abboud CN, Freeman SM. In vivo analysis of the "bystander effect": A cytokine cascade. Exp Hematol. 1996;24:829-838.
-
(1996)
Exp Hematol.
, vol.24
, pp. 829-838
-
-
Ramesh, R.1
Marrogi, A.J.2
Munshi, A.3
Abboud, C.N.4
Freeman, S.M.5
-
191
-
-
0035106088
-
Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis
-
Agard C, Ligeza C, Dupas B, et al. Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis. Cancer Gene Ther. 2001;8:128-136.
-
(2001)
Cancer Gene Ther.
, vol.8
, pp. 128-136
-
-
Agard, C.1
Ligeza, C.2
Dupas, B.3
-
192
-
-
0034490547
-
Combined suicide and granulocyte-macrophage colonystimulating factor gene therapy induces complete tumor regression and generates antitumor immunity
-
Jones RK, Pope IM, Kinsella AR, Watson AJM, Christmas SE. Combined suicide and granulocyte-macrophage colonystimulating factor gene therapy induces complete tumor regression and generates antitumor immunity. Cancer Gene Ther. 2000;7:1519-1528.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 1519-1528
-
-
Jones, R.K.1
Pope, I.M.2
Kinsella, A.R.3
Watson, A.J.M.4
Christmas, S.E.5
-
193
-
-
0033914768
-
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model
-
Majumdar A, Zolotorev A, Samuel S, et al. Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model. Cancer Gene Ther. 2000;7:1086-1099.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 1086-1099
-
-
Majumdar, A.1
Zolotorev, A.2
Samuel, S.3
-
194
-
-
0034032940
-
Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte macrophage colony-stimulating factor gene transfer
-
Cao X, Huang X, Ju DW, Zhang WP, Hamada H, Wang J. Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte macrophage colony-stimulating factor gene transfer. Cancer Gene Ther. 2000;7:177-186.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 177-186
-
-
Cao, X.1
Huang, X.2
Ju, D.W.3
Zhang, W.P.4
Hamada, H.5
Wang, J.6
-
195
-
-
0033918251
-
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T-lymphoma
-
Rivas C, Chandler P, Melo JV, Simpson E, Apperley JF. Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T-lymphoma. Cancer Gene Ther. 2000;7:954-962.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 954-962
-
-
Rivas, C.1
Chandler, P.2
Melo, J.V.3
Simpson, E.4
Apperley, J.F.5
-
196
-
-
0035049257
-
Necrotic, rather than apoptotic death caused by cytochrome P450-activated ifosfamide
-
Karle P, Renner M, Salmons B, Gunzburg WH. Necrotic, rather than apoptotic death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001;8:220-230.
-
(2001)
Cancer Gene Ther.
, vol.8
, pp. 220-230
-
-
Karle, P.1
Renner, M.2
Salmons, B.3
Gunzburg, W.H.4
-
200
-
-
33646539513
-
Gene therapy for gastrointestinal tumors
-
Lohr M. Gene therapy for gastrointestinal tumors. Zeitschrift Gastro. 2006;44:333-340.
-
(2006)
Zeitschrift Gastro.
, vol.44
, pp. 333-340
-
-
Lohr, M.1
-
201
-
-
33646763193
-
Clinical trials of gene therapy, virotherapy, and immunotherapy for malignant tumors
-
2006
-
Barzon L, Zanusso M, Columbo F, Palu G. (2006) Clinical trials of gene therapy, virotherapy, and immunotherapy for malignant tumors. Cancer Gene Ther. 2006;13: 539-554.
-
(2006)
Cancer Gene Ther.
, vol.13
, pp. 539-554
-
-
Barzon, L.1
Zanusso, M.2
Columbo, F.3
Palu, G.4
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