Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a sindbis viral vector as a basis for prodrug ganciclovir activation and PET

Journal of Nuclear Medicine

Volumn 47, Issue 7, 2006, Pages 1136-1143

  Tseng, Jen Chieh ^a   Zanzonico, Pat B ^b   Levin, Brandi ^a   Finn, Ronald ^b   Larson, Steven M ^b   Meruelo, Daniel ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Gene directed enzyme prodrug therapy; Herpes simplex virus thymidine kinase type 1; In vivo imaging; PET; Sindbis vector

Indexed keywords

5 ETHYL 2' FLUOROURACIL ARABINOSIDE F 18; GANCICLOVIR; HERPES SIMPLEX VIRUS THYMIDINE KINASE 1; RADIOPHARMACEUTICAL AGENT; RNA; THYMIDINE KINASE 1; UNCLASSIFIED DRUG; VIRUS VECTOR; PRODRUG; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CELL STRAIN BHK; CONTROLLED STUDY; DRUG ACTIVATION; DRUG TARGETING; ELECTROPORATION; FEMALE; GENETIC TRANSFECTION; HAMSTER; HERPES SIMPLEX VIRUS 1; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY TUMOR; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPLICON; SCID MOUSE; SINDBIS VIRUS; THERAPY EFFECT; TUMOR CELL; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CHEMISTRY; GENE TRANSFER; GENETICS; KIDNEY; METABOLISM; METHODOLOGY; MOUSE MUTANT;

ANIMALS; CRICETINAE; FEMALE; GANCICLOVIR; GENE TRANSFER TECHNIQUES; HERPESVIRUS 1, HUMAN; KIDNEY; MICE; MICE, SCID; POSITRON-EMISSION TOMOGRAPHY; PRODRUGS; SINDBIS VIRUS; THYMIDINE KINASE; TRANSFECTION;

EID: 33747094529     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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