Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy

Gene Therapy

Volumn 9, Issue 15, 2002, Pages 1023-1030

  Boucher, P D ^a   Ostruszka, L J ^a   Murphy, P J M ^a   Shewach, D S ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Bystander effect; Ganciclovir; Gene therapy; HSVtk; Hydroxyurea

Indexed keywords

APHIDICOLIN; BETA GALACTOSIDASE; CYTOTOXIC AGENT; DNA; GANCICLOVIR; HYDROXYUREA; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE S PHASE; CELL MATURATION; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; DRUG EFFICACY; DRUG MIXTURE; DRUG POTENTIATION; FEMALE; GENE DELIVERY SYSTEM; GENE THERAPY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR MODEL; TUMOR REGRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; VIRAL GENE THERAPY;

ANIMALS; ANTIMETABOLITES; ANTIVIRAL AGENTS; APHIDICOLIN; BYSTANDER EFFECT; CELL CYCLE; CELL LINE; COLONIC NEOPLASMS; DRUG SYNERGISM; FEMALE; GANCICLOVIR; GENE THERAPY; HUMANS; HYDROXYUREA; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SIMPLEXVIRUS; THYMIDINE KINASE;

ANIMALIA; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0036045454     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301730     Document Type: Article

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