The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines

Cancer Research

Volumn 61, Issue 11, 2001, Pages 4405-4413

  Peng, Xue Yan ^a   Won, Jong Ho ^a   Rutherford, Thomas ^b   Fujii, Takuma ^a   Zelterman, Daniel ^a   Pizzorno, Giuseppi ^a   Sapi, Eva ^b   Leavitt, John ^a   Kacinski, Barry ^b   Crystal, Ronald ^c   Schwartz, Peter ^b   Deisseroth, Albert ^a  

^a YALE CANCER CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; FLUOROURACIL; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER THERAPY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; CYTOMEGALOVIRUS; CYTOSINE DEAMINASE; FEMALE; FLUCYTOSINE; FLUOROURACIL; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; INHIBITORY CONCENTRATION 50; LAC OPERON; MICE; MICE, NUDE; NUCLEOSIDE DEAMINASES; OVARIAN NEOPLASMS; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035361401     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Strategies for cancer gene therapy using adenoviral vectors
2. Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine
3. Combination immunotherapy for established tumors with engineered tumor vaccines and adenovirus-mediated gene transfer
4. Discovery and characterization of two novel human cancer-related proteins using two-dimensional gel electrophoresis
5. The murine L-plastin gene promoter: Identification and comparison with the human L-plastin gene promoter
6. Activation of the leukocyte plastin gene occurs in most human cancer cells
7. Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cell
8. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine
9. The efficacy of adenovirus-mediated gene therapy of ovarian cancer is enhanced by using the cytomegalovirus promoter
10. Manipulation of adenovirus vectors
11. Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors
12. Histochemical staining following LacZ gene transfer underestimates transfection efficiency
13. Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine
14. "Distant" bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distant transduced tumor
15. Potentiation of the bystander effect by immunization combined with suicide gene therapy
16. Escherichia coli thymidylate synthase expression protects human cells from the cytotoxic effects of 5-fluorodeoxyuridine more effectively than human thymidylate synthase overexpression
17. Expression of CSF-1 and CSF-1 receptor by normal lactating mammary epithelial cells
18. Characterization of a xenograft model of human ovarian carcinoma which produces intraperitoneal carcinomatosis and metastases in mice
19. Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouse
20. Targeting and eradicating cancer cells by a prostate-specific vector carrying the diphtheria toxin A gene
21. Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: A murine study with clinical relevance
22. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
23. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5
24. The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F
25. Cytosine deaminase adenoviral vector and 5-fluorocytosin selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: A potential purging method for autologous transplantation
26. Integrins avb3 and avb5 promoter adenovirus internalization but not virus attachment
27. Integrin avb5 selectively promotes adenovirus mediated cell membrane permeabilization
28. FACS-gal: Flow cytometric analysis and sorting of cells expressing reporter gene constructs