Characterization of Herpes Simplex Virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity

Protein Science

Volumn 11, Issue 9, 2002, Pages 2267-2272

  Kokoris, Mark S ^b   Black, Margaret E ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b Chiroscience R and D Inc   (United States)

Author keywords

Acyclovir; Ganciclovir; Herpes Simplex Virus type 1 thymidine kinase; Random sequence mutagenesis

Indexed keywords

ACICLOVIR; GANCICLOVIR; PRODRUG; THYMIDINE; THYMIDINE KINASE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT;

AFFINITY CHROMATOGRAPHY; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ANALYSIS; ENZYME ENGINEERING; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; HERPES SIMPLEX VIRUS 1; MICHAELIS CONSTANT; MUTAGENESIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; BINDING SITE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENE THERAPY; GENETICS; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MUTATION;

ACYCLOVIR; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; BINDING SITES; CHROMATOGRAPHY, AFFINITY; GANCICLOVIR; GENE THERAPY; HERPESVIRUS 1, HUMAN; HUMAN; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; PRODRUGS; SUBSTRATE SPECIFICITY; SUPPORT, U.S. GOV'T, P.H.S.; THYMIDINE KINASE; TUMOR CELLS, CULTURED; HUMANS;

DNA VIRUSES; ESCHERICHIA COLI; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0036708008     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.2460102     Document Type: Article

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