-
1
-
-
0029815716
-
Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination
-
Marais, R., Spooner, R.A., Light, Y., Martin, J., and Springer, C.J. 1996. Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination. Cancer Res. 56:4735-4742.
-
(1996)
Cancer Res.
, vol.56
, pp. 4735-4742
-
-
Marais, R.1
Spooner, R.A.2
Light, Y.3
Martin, J.4
Springer, C.J.5
-
2
-
-
0029609610
-
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
-
Bridgewater, J.A., et al. 1995. Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur. J. Cancer. 31A:2362-2370.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 2362-2370
-
-
Bridgewater, J.A.1
-
3
-
-
0029637158
-
VDEPT: An enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer
-
Huber, B.E., Richards, C.A., and Austin, E.A. 1995. VDEPT: an enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer. Advanced Drug Delivery Reviews. 17:279-292.
-
(1995)
Advanced Drug Delivery Reviews
, vol.17
, pp. 279-292
-
-
Huber, B.E.1
Richards, C.A.2
Austin, E.A.3
-
4
-
-
0034022622
-
Gene delivery from replication-selective viruses: Arming guided missiles in the war against cancer
-
Hermiston, T. 2000. Gene delivery from replication-selective viruses: arming guided missiles in the war against cancer. J. Clin. Invest. 105:1169-1172.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 1169-1172
-
-
Hermiston, T.1
-
5
-
-
0028108469
-
Metabolism of 5-fluorocytidine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
-
Huber, B.E., Austin, E.A., Richards, C.A., Davis, S.T., and Good, S.S. 1994. Metabolism of 5-fluorocytidine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc. Natl. Acad. Sci. USA. 91:8302-8306.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8302-8306
-
-
Huber, B.E.1
Austin, E.A.2
Richards, C.A.3
Davis, S.T.4
Good, S.S.5
-
6
-
-
0031437780
-
A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy
-
Marais, R., et al. 1997. A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy. Nat. Biotechnol. 15:1373-1377.
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 1373-1377
-
-
Marais, R.1
-
7
-
-
0031956262
-
The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme prodrug therapies
-
Denny, W.A., and Wilson, W.R. 1998. The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme prodrug therapies. J. Pharm. Pharmacol. 50:387-394.
-
(1998)
J. Pharm. Pharmacol.
, vol.50
, pp. 387-394
-
-
Denny, W.A.1
Wilson, W.R.2
-
8
-
-
0031983448
-
Gene-directed enzyme prodrug therapy
-
Niculescu-Duvaz, I., Spooner, R., Marais, R., and Springer, C.J. 1998. Gene-directed enzyme prodrug therapy. Bioconjug. Chem. 9:4-22.
-
(1998)
Bioconjug. Chem.
, vol.9
, pp. 4-22
-
-
Niculescu-Duvaz, I.1
Spooner, R.2
Marais, R.3
Springer, C.J.4
-
9
-
-
0032966050
-
Improving enzymes for gene therapy
-
Encell, L.P., Landis, D.M., and Loeb, L.A. 1999. Improving enzymes for gene therapy. Nat. Biotechnol. 17:143-147.
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 143-147
-
-
Encell, L.P.1
Landis, D.M.2
Loeb, L.A.3
-
11
-
-
0034026546
-
Immunomodulation of cancer: Potential use of selectively replicating agents
-
Agha-Mohammadi, S., and Lotze, M.T. 2000. Immunomodulation of cancer: potential use of selectively replicating agents. J. Clin. Invest. 105:1173-1176.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 1173-1176
-
-
Agha-Mohammadi, S.1
Lotze, M.T.2
-
12
-
-
0032542264
-
Self-immolative nitrogen mustard prodrugs for suicide gene therapy
-
Niculescu-Duvaz, D., et al. 1998. Self-immolative nitrogen mustard prodrugs for suicide gene therapy. J. Med. Chem. 41:5297-5309.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 5297-5309
-
-
Niculescu-Duvaz, D.1
-
13
-
-
0033168032
-
Self-immolative anthracycline prodrugs for suicide gene therapy
-
Niculescu-Duvaz, I., et al. 1999. Self-immolative anthracycline prodrugs for suicide gene therapy. J. Med. Chem. 42:2485-2489.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 2485-2489
-
-
Niculescu-Duvaz, I.1
-
14
-
-
0033119291
-
Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer
-
Kievit, E., et al. 1999. Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer. Cancer Res. 59:1417-1421.
-
(1999)
Cancer Res.
, vol.59
, pp. 1417-1421
-
-
Kievit, E.1
-
15
-
-
0029883624
-
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy
-
Black, M.E., Newcomb, T.G., Wilson, H.M., and Loeb, L.A. 1996. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy. Proc. Natl. Acad. Sci. USA. 93:3525-3529
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3525-3529
-
-
Black, M.E.1
Newcomb, T.G.2
Wilson, H.M.3
Loeb, L.A.4
-
16
-
-
0030965992
-
Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate
-
Smith, G.K., et al. 1997. Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate. J. Biol. Chem. 272:15804-15816.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15804-15816
-
-
Smith, G.K.1
-
17
-
-
12944265253
-
-
Rhone-Poulene Rorer. Enzymes combinations for destroying proliferative cells. Patent WO 9735024
-
Blanche, F., Cameron, B., Couder, M., and Crouzet. J. 1997. Rhone-Poulene Rorer. Enzymes combinations for destroying proliferative cells. Patent WO 9735024
-
(1997)
-
-
Blanche, F.1
Cameron, B.2
Couder, M.3
Crouzet, J.4
-
18
-
-
0030810198
-
Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene
-
Chen, L., Yu, L.J., and Waxman, D.J. 1997. Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene. Cancer Res. 57:4830-4837.
-
(1997)
Cancer Res.
, vol.57
, pp. 4830-4837
-
-
Chen, L.1
Yu, L.J.2
Waxman, D.J.3
-
19
-
-
0032169967
-
Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing-cells: A novel paradigm for cell killing
-
Rubsam, L.Z., Davidson, L., and Shewach, D.S. 1998. Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing-cells: a novel paradigm for cell killing. Cancer Res. 58:3873-3882.
-
(1998)
Cancer Res.
, vol.58
, pp. 3873-3882
-
-
Rubsam, L.Z.1
Davidson, L.2
Shewach, D.S.3
-
20
-
-
85038041499
-
-
Trustee of Boston University. Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy. Patent WO 9905299
-
Waxman, D.J., and Goldstein, J.A. 1999. Trustee of Boston University. Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy. Patent WO 9905299.
-
(1999)
-
-
Waxman, D.J.1
Goldstein, J.A.2
-
21
-
-
0032188845
-
Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine
-
Tiraby, M., et al. 1998. Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine. FEMS Microbiol. Lett. 167:41-49.
-
(1998)
FEMS Microbiol. Lett.
, vol.167
, pp. 41-49
-
-
Tiraby, M.1
-
22
-
-
0031907361
-
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells
-
Balzarini, G., et al. 1998. Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells. Gene Ther. 5:419-426.
-
(1998)
Gene Ther.
, vol.5
, pp. 419-426
-
-
Balzarini, G.1
-
23
-
-
0032440742
-
The bystander effect in the HSVtk/ganciclovir system and its relation to gap junctional communication
-
Touraine, R.L., Ishii-Morita, H., Ramsey, W.J., and Blaese, R.M. 1998. The bystander effect in the HSVtk/ganciclovir system and its relation to gap junctional communication. Gene Ther. 5:1705-1711.
-
(1998)
Gene Ther.
, vol.5
, pp. 1705-1711
-
-
Touraine, R.L.1
Ishii-Morita, H.2
Ramsey, W.J.3
Blaese, R.M.4
-
24
-
-
0032213438
-
Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions
-
Touraine, R.L., Vahanian, N., Ramsey, W.J., and Blaese, R.M. 1998. Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum. Gene Ther. 9:2385-2391.
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 2385-2391
-
-
Touraine, R.L.1
Vahanian, N.2
Ramsey, W.J.3
Blaese, R.M.4
-
25
-
-
0031991630
-
Bystander tumoricidal effect and gap junctional communication in lung cancer cells
-
Imaizumi, K., et al. 1998. Bystander tumoricidal effect and gap junctional communication in lung cancer cells. Am. J. Respir. Cell Mol. Biol. 18:205-212.
-
(1998)
Am. J. Respir. Cell Mol. Biol.
, vol.18
, pp. 205-212
-
-
Imaizumi, K.1
-
26
-
-
0032502845
-
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase
-
Boucher, P.D., Ruch, R.J., and Shewach, D.S. 1998. Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase. Hum. Gene Ther. 9:801-814.
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 801-814
-
-
Boucher, P.D.1
Ruch, R.J.2
Shewach, D.S.3
-
27
-
-
0031974255
-
Gene-directed enzyme prodrug therapy: Quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase
-
Friedlos, F., Court, S., Ford, M., Denny, W.A., and Springer, C.J. 1998. Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase. Gene Ther. 5:105-112.
-
(1998)
Gene Ther.
, vol.5
, pp. 105-112
-
-
Friedlos, F.1
Court, S.2
Ford, M.3
Denny, W.A.4
Springer, C.J.5
-
28
-
-
0030007803
-
In vivo analysis of the "bystander effect": A cytokine cascade
-
Ramesh, R., Marrogi, A.J., Munshi, A., Abboud, C.N., and Freeman, S.M. 1996. In vivo analysis of the "bystander effect": a cytokine cascade. Exp. Hematol. 24:829-838.
-
(1996)
Exp. Hematol.
, vol.24
, pp. 829-838
-
-
Ramesh, R.1
Marrogi, A.J.2
Munshi, A.3
Abboud, C.N.4
Freeman, S.M.5
-
29
-
-
0029737399
-
Antitumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras (G12V)
-
Pavlovic, J., Nawrath, M., Tu, R., Heinicke, T., and Moelling, K. 1996. Antitumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras (G12V). Gene Ther. 3:635-643.
-
(1996)
Gene Ther.
, vol.3
, pp. 635-643
-
-
Pavlovic, J.1
Nawrath, M.2
Tu, R.3
Heinicke, T.4
Moelling, K.5
-
30
-
-
0029740524
-
Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained antitumor immunity prolongs animal survival
-
Chen, S.H., et al. 1996. Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival. Cancer Res. 56:3758-3762.
-
(1996)
Cancer Res.
, vol.56
, pp. 3758-3762
-
-
Chen, S.H.1
-
31
-
-
0032502844
-
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo
-
Uckert, W., et al. 1998. Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo. Hum. Gene Ther. 9:855-865.
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 855-865
-
-
Uckert, W.1
-
32
-
-
0033218746
-
Efficacy of a replication-competent adenovirus (ONYX-015) after intratumoral injection intratumoral spread and distribution effects
-
Heise, C.C., Williams, A., Olesch, J., and Kirn, D.H. 1999. Efficacy of a replication-competent adenovirus (ONYX-015) after intratumoral injection intratumoral spread and distribution effects. Cancer Gene Ther. 6:499-504.
-
(1999)
Cancer Gene Ther.
, vol.6
, pp. 499-504
-
-
Heise, C.C.1
Williams, A.2
Olesch, J.3
Kirn, D.H.4
-
33
-
-
0034077666
-
Replication-selective adenoviruses as oncolytic agents
-
Heise, C., and Kirn, D.H. 2000. Replication-selective adenoviruses as oncolytic agents. J. Clin. Invest. 105:847-851.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 847-851
-
-
Heise, C.1
Kirn, D.H.2
|