Increasing specificity of anti-tumor therapy: Cytotoxic protein delivery by non-pathogenic clostridia under regulation of radio-induced promoters

Anticancer Research

Volumn 21, Issue 2 A, 2001, Pages 857-862

  Nuyts, S ^a   Theys, J ^a   Landuyt, W ^a   Van Mellaert, L ^a   Lambin, P ^a   Anne J ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Clostridium; Cytosine deaminase; Gene therapy; Radio induced promoters; Tumor necrosis factor

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOSINE DEAMINASE; FLUOROURACIL; PLASMID DNA; RECA PROTEIN; RECN PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CLOSTRIDIUM; DNA MODIFICATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SPECIFICITY; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC ENGINEERING; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; BACTERIAL PROTEINS; CELLULASE; CLOSTRIDIUM; CYTOSINE DEAMINASE; DEOXYRIBONUCLEASES; DNA RESTRICTION ENZYMES; DRUG DELIVERY SYSTEMS; FLUCYTOSINE; FLUOROURACIL; GENE THERAPY; GENETIC VECTORS; MALE; NUCLEOSIDE DEAMINASES; PROMOTER REGIONS (GENETICS); RATS; REC A RECOMBINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035013495     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Gene therapy for cancer: What have we done and where are we going
2. Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours
3. Anaerobic bacteria as delivery system for cancer gene therapy: In vitro activation of 5-fluorocytosine by genetically engineered clostridia
4. Identification of the Escherichia coli recN gene product as a major SOS protein
5. General microbiology of recA: Environmental and evolutionary significance
6. Introduction of plasmids into whole cells of Clostridium acetobutylicum by electroporation
7. Stable Escherichia coli-Clostridium acetobutylicum shuttle vectors for secretion of murine tumor necrosis factor alpha
8. Electroporation of, plasmid isolation from and plasmid conservation in Clostridium acetobutylicum DSM792
9. Efficient secretion of biologically active mouse tumour necrosis factor alpha by Streptomyces lividans
10. Interferon gamma, a mediator of lethal lipopolyaccharide-induced Shwartzman-like shock reactions in mice
11. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: A negative selection system
12. Distribution and cloning of eukaryotic mRNAs by means of differential display: Refinements and optimization
13. Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries
14. Differential display using one-base anchored oligo-dT primers
15. The X-ray induction of SOS repair activity in E. coli: Euoxic vs. anoxic DNA damage
16. Tumor colonisation with anaerobic bacteria following vascular targeting treatment: Improvement for anaerobic vector gene therapy developments