A phase I/II study of herpes simplex virus type 1 thymidine kinase 'Suicide' gene therapy for recurrent glioblastoma

Human Gene Therapy

Volumn 9, Issue 17, 1998, Pages 2595-2604

  Klatzmann, David ^a   Valéry, Charles A ^a   Bensimon, Gilbert ^a   Marro, Beatrice ^a   Boyer, Olivier ^a   Mokhtari, Karima ^a   Diquet, Bertrand ^a   Salzmann, Jean Loup ^b   Philippon, Jacques ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b AVICENNE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADULT; ARTICLE; BRAIN; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; GENE THERAPY; GENE TRANSFER; GLIOBLASTOMA; HERPES SIMPLEX VIRUS 1; HUMAN; INJECTION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; QUALITY OF LIFE; RECURRENT CANCER; SUICIDE GENE;

ADULT; BRAIN NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; GANCICLOVIR; GLIOBLASTOMA; HERPESVIRUS 1, HUMAN; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RECURRENCE; THYMIDINE KINASE;

DNA VIRUSES; HERPES; HUMAN HERPESVIRUS 1; UNIDENTIFIED RETROVIRUS;

EID: 2442767029     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349850019436     Document Type: Article

References (32)

1. ALBERT, F.K., FORSTING, M., SARTOR, K., ADAMS, H.P., and KUNZE, S. (1994). Early postoperative magnetic resonance imaging after resection of malignant glioma: Objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 34, 45-60.
2. AMMIRATI, M., GALICICH, J.H., ARBIT, E., and LIAO, Y. (1987). Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery 21, 607-614.
3. ANONYMOUS. (1997). Human gene marker/therapy clinical protocols. Hum. Gene Ther. 8, 629-658.
4. BARBA, D., HARDIN, J., JASODHARA, R., and GAGAE, F. (1993). Thymidine kinase-mediated killing of rat brain tumors. J. Neurosurg. 79, 729-735.
5. BREM, H., PIANTADOSI, S., BURGER, P.C., WALKER, M., SELKER, R., VICK, N.A., BLACK, K., SISTI, M., BREM, S., MOHR, G., MULLER, P., MORAWETZ, R., and SCHULD, S.C. (1995). Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet 345, 1008-1012.
6. CARUSO, M., PANIS, Y., GAGANDEEP, S., HOUSSIN, D., SALZMANN, J., and KLATZMANN, D. (1993). Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. U.S.A. 90, 7024-7028.
7. CHOUCAIR, A.K., LEVIN, V.A., GUTIN, P.H., DAVIS, R.L., SILVER, P., EDWARDS, M.S., and WILSON, C.B. (1986). Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J. Neurosurg. 65, 654-658.
8. CULVER, K., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E., and BLAESE, R. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
9. DAUMAS-DUPORT, C., SCHEITHAUER, B., O'FALLON, J., and KELLY, P. (1988). Grading of astrocytomas. A simple and reproducible method. Cancer 62, 2152-2165.
10. EZZEDDINE, Z., MARTUZA, R., PLATIKA, D., SHORT, M., MALICK, M., CHOI, A., and BREAKEFIELD, X. (1991). Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol. 3, 608-614.
11. FREEMAN, S.M., ABBOUD, C.N., and WHARTENBY, K.A. (1993). The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
12. GAGANDEEP, S., BREW, R., GREEN, B., CHRISTMAS, S.E., KLATZMANN, D., POSTON, G.J. and KINSELLA, A.R. (1996). Prodrug-activated gene therapy: Involvement of an immunological component in the "bystander effect." Cancer Gene Ther. 3, 83-88.
13. HARSH, G.R., LEVIN, V.A., GUTIN, P.H., SEAGER, M., SILVER, P., and WILSON, C.B. (1987). Reoperation for recurrent glioblastoma and anaplastic astrocytoma. Neurosurgery 21, 615-621.
14. INNIS, M.A., and GELFAND, D.H. (1990). Optimization of PCRs. In PCR Protocols M.A. Innis, D.H. Gelfand, J.J. Sninsky, and T.J. White, eds. (Academic Press, San Diego, CA) pp. 3-12.
15. KIANMANESH, A., PERRIN, H., PANIS, Y., FABRE, M., NAGY, H.J., HOUSSIN, D., and KLATZMANN, D. (1997). A "distant" bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distant transduced tumor. Hum. Gene Ther. 8, 1807-1814.
16. KLATZMANN, D., PHILIPPON, J., VALÉRY, C.A., BENSIMON, G., SALZMANN, J.L., and the STUDY GROUP ON THERAPY FOR GLIOBLASTOMA. (1996). Gene therapy for glioblastoma in adult patients: Safety and efficacy evaluation of an in situ injection of recombinant retrovirus-producing cells carrying the thymidine kinase gene of the herpes simplex type 1 virus, to be followed with the administration of ganciclovir. Hum. Gene Ther. 7, 109-126.
17. KLEIHUES, P., BURGER, P.C., and SCHEITHAUER, B.W. (1993). The new WHO classification of brain tumours. Brain Pathol. 3, 255-268.
18. MOOLTEN, F. (1986). Tumor sensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for prospective cancer control strategy. Cancer Res. 46, 5276-5281.
19. NISHIYAMA, Y., and RAPP, F. (1979). Anticellular effects of 9-(2-hydroxyethoxymethyl) guanine against herpes simplex virus-transformed cells. J. Gen. Virol. 45, 227-230.
20. ORDA REPORTS. (1994). Hum. Gene Ther. 5, 1296.
21. RAM, Z., CULVER, K.W., WALBRIDGE, S., FRANK, J.A., BLAESE, R.M., and OLDFIELD, E.H. (1993). Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors. J. Neurosurg. 79, 400-407.
22. RAM, Z., CULVER, K.W., OSHIRO, E.M., VIOLA, J.J., DEVROOM. H.L., OTTO, E., LONG, Z., CHIANG, Y., MCGARRITY, G.J., MUUL, L.M., KATZ, D., BLAESE, R.M., and OLDFIELD E.H. (1997). Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nature Med. 3, 1354-1368.
23. ROSTOMILY, R.C., SPENCE, A.M., DUONG, D., MCCORMICK, K., BLAND, M., and BERGER, M.S. (1994). Multimodality management of recurrent adult malignant gliomas: Results of a phase II multiagent chemotherapy study and analysis of cytoreductive surgery. Neurosurgery 35, 378-388. [Discussion 88]
24. RUSSELL, D.W., BERGER, M.S., and MILLER, A.D. (1995). The effects of human serum and cerebrospinal fluid on retroviral vectors and packaging cell lines. Hum. Gene Ther. 6, 635-641.
25. SALCMAN, M. (1980a). Glioblastoma multiforme. Am. J. Med. Sci. 279, 84-94.
26. SALCMAN, M. (1980b). Survival in glioblastoma: Historical perspective. Neurosurgery 7, 435-439.
27. SHAPIRO, W.R., GREEN, S.B., BURGER, P.C., SELKER, R.G., VANGILDER, J.C., ROBERTSON, J.T., MEALEY, J., JR., RANSOHOFF, J., and MAHALEY, M.S., JR. (1992). A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma. J. Neurosurg. 76, 772-781.
28. SHORT, M.P., CHOI, B.C., LEE, J.K., MALICK, A., BREAKEFIELD, X.O., and MARTUZA, R.L. (1990). Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J. Neurosci. Res. 27, 427-439.
29. ST. CLAIR, M.H., LAMBE, C.U., and FURMAN, P.A. (1987). Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. Antimicrob. Agents Chemother. 31, 844-849.
30. VAN TASSEL, P., BRUNER, J.M., MAOR, M.H., LEEDS, N.B., GLEASON, M.J., YUNG, W.K., and LEVIN, V.A. (1995). MR of toxic effects of accelerated fractionation radiation therapy and carboplatin chemotherapy for malignant gliomas. Am. J. Neuroradiol. 16, 715-726.
31. WALKER, M.D., ALEXANDER, E., JR., HUNT, W.E., MACCARTY, C.S., MAHALEY, M.S., JR., MEALEY, J., JR., NORRELL, H.A., OWENS, G., RANSOHOFF, J., WILSON, C.B., GEHAN, E.A., and STRIKE, T.A. (1978). Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J. Neurosurg. 49, 333-343.
32. WALTER, K.A., TAMARGO, R.J., OLIVI, A., BURGER, P.C., and BREM, H. (1995). Intratumoral chemotherapy. Neurosurgery 37, 1128-1145.