Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase

Cancer Research

Volumn 59, Issue 2, 1999, Pages 410-413

  Wildner, Oliver ^a   Blaese, R Michael ^a   Morris, John C ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; TOPOTECAN; VIRUS ENZYME; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG POTENTIATION; EXPERIMENTAL NEOPLASM; FEMALE; GENE THERAPY; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUICIDE GENE;

ADENOVIRIDAE; ANIMALS; COLONIC NEOPLASMS; FEMALE; GANCICLOVIR; GENE THERAPY; HT29 CELLS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SIMPLEXVIRUS; THYMIDINE KINASE; TOPOTECAN; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0033556003     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Cancer Statistics. CA Cancer J. Clin., 48: 6-29, 1998.
2. NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer. J. Am. Med. Assoc., 264: 1444-1450, 1990.
3. Moolten, F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res., 46: 5276-5281, 1986.
4. Moolten, F. L., and Wells, J. M. Curability of tumors hearing herpes thymidine kinase genes transferred by retroviral vectors. J. Natl. Cancer Inst., 82: 297-300, 1990.
5. Chen, S. H., Shine, H. D., Goodman, J. C., Grossman, R. G., and Woo, S. L. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA. 91: 3054-3057, 1994.
6. Smythe, W. R., Hwang, H. C., Amin, K. M., Eck, S. L. Davidson, B. L., Wilson, J. M., Kaiser, L. R., and Albelda, S. M. Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res., 54: 2055-2059, 1994.
7. Colombo, B. M., Benedetti, S., Ottolenghi, S., Mora, M., Pollo, B., Poli, G., and Finocchiaro. G. The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum. Gene Ther., 6: 763-772, 1995.
8. Takamiya, Y., Short, M. P., Ezzeddine, Z. D., Moolten, F. L., Breakefield, X. O., and Martuza, R. L. Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1 -thymidine kinase gene and wild type retrovirus kills other tumor cells. J. Neurosci. Res., 33: 493-503, 1992.
9. Miyatake, S., Martuza, R. L., and Rabkin, S. D. Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma. Cancer Gene Ther., 4: 222-228, 1997.
10. Dion, L. D., Goldsmith, K. T., Strong, T. V., Bilbao, G., Curiel, D. T., and Garver, R. I. J. E1A RNA transcripts amplify adenovirus-mediated tumor reduction. Gene Ther., J: 1021-1025, 1996.
11. Culver, K. W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E. H., and Blaese, R. M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (Washington DC), 256: 1550-1552, 1992.
12. Bischoff, J. R., Kirn, D. H., Williams, A., Heise, C. Horn, S., Muna, M., Ng, L., Nye, J. A., Sampson-Johannes, A., Fattaey, A., and McCormick, F. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (Washington DC), 274: 373-376, 1996.
13. Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D. D., and Kirn, D. H. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med., 3: 639-645, 1997.
14. Wildner, O., Morris, J. C., Vahanian, N. N., Ford, H. J., Ramsey, W. J., and Blaese, R. M. Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene lherapy of cancer. Gene Ther., in press, 1998.
15. Freytag, S. O., Rogulski, K. R., Paielli, D. L., Gilbert, J. D., and Kim, J. H. A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy. Hum. Gene Ther., 9: 1323-1333, 1998.
16. Link, C. J. J., Levy, J. P., McCann, L. Z., and Moorman, D. W. Gene therapy for colon cancer with the herpes simplex thymidine kinase gene. J. Surg. Oncol., 64: 289-294, 1997.
17. Hayashi, S., Emi, N., Yokoyama. I., Uchida, K., and Takagi, H. Effect of gene therapy with the herpes simplex virus-thymidine kinase gene on hepatic metastasis in murine colon cancer. Surg. Today, 27: 40-43, 1997.
18. Coll, J. L., Mesnil, M., Lefebvre, M. F., Lancon, A., and Favrot, M. C. Long-term survival of immunocompetent rats with intraperitoneal colon carcinoma tumors using herpes simplex thymidine kinase/ganciclovir and IL-2 treatments. Gene Ther., 4: 1160-1166, 1997.
19. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
20. Hollstein, M., Sidransky, D., Vogelstein, B., and Hams, C. C. p53 mutations in human cancers. Science (Washington DC), 253: 49-53, 1991.
21. Rothenberg, M. L. Topoisomerase I inhibitors: review and update. Ann. Oncol., 8: 837-855, 1997.
22. Davis, A. R., Kostek, B., Mason, B. B., Hsiao, C. L., Morin. J., Dheer, S. K., and Hung, P. P. Expression of hepatitis B surface antigen with a recombinant adenovirus. Proc. Natl. Acad. Sci. USA, 82: 7560-7564, 1985.
23. Morgan, R. A., Couture, L., Elroy-Stein, O., Ragheb, J., Moss, B., and Anderson, W. F. Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy. Nucleic Acids. Res., 20: 1293-1299, 1992.
24. Barker, D. D., and Berk, A. J. Adenovirus proteins from both K1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection [published erratum appears in Virology 158: 263, 1987]. Virology. 156: 107-121, 1987.
25. Ishii-Morita, H., Agbaria, R., Mullen, C. A., Hirano, H., Koeplin, D. A., Ram, Z., Oldfield, E. H., Johns, D. G., and Blaese, R. M. Mechanism of "bystander effect" killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment. Gene Ther., 4: 244-251, 1997.
26. Dethlefsen, L. A., Prewitt, J. M., and Mendelsohn, M. L. Analysis of tumor growth curves. J. Natl. Cancer Inst., 40: 389-405, 1968.
27. Giovanella, B. C. Stehlin, J. S., Wall, M. E., Wani, M. C., Nicholas, A. W., Liu, L. F., Silber, R., and Potmesil, M. DNA topoisomerase 1-targeted chemotherapy of human colon cancer in xenografts. Science (Washington DC). 246: 1046-1048, 1989.
28. Smith, R. R., Huebner, R. J., Rowe, W. P., Schatten, W. E., and Thomas, L. B. Studies on the use of viruses in the treatment of carcinoma of the cervix. Cancer (Phila.), 9: 1211-1218, 1956.
29. van der Eb, A. J., Mulder, C., Graham, F. L., and Houweling, A. Transformation with specific fragments of adenovirus DNAs. 1. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA. Gene (Amst.), 2: 115-132, 1977.
30. Wei, S. J., Chao, Y., Hung, Y. M., Lin, W., Yang, D. M., Shin, Y. L., Ch'ang, L. Y., Whang-Peng, J., and Yang, W. K. S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase. Exp. Cell Res., 241: 66-75, 1998.
31. Romig, H., and Richter, A. Expression of the type I DNA topoisomerase gene in adenovirus-5 infected human cells. Nucleic Acids Res., 18: 801-808, 1990.
32. Chow, K. C-. and Pearson, G. D. Adenovirus infection elevates levels of cellular topoisomerase I. Proc. Natl. Acad. Sci. USA, 82: 2247-2251, 1985.
33. Eng, W. K., Faucette, L., Johnson, R. K., and Sternglanz, R. Evidence that DNA topoisomerase 1 is necessary for the cytotoxic effects of camptothecin. Mol. Pharmacol., 34: 755-760, 1988.
34. Wong, M. L., and Hsu, M. T. Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome. J. Virol., 64: 691-699, 1990.
35. Schaack, J., Schedl, P., and Shenk, T. Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication. J. Virol., 64: 78-85, 1990.
36. Nagata, K., Guggenheimer, R. A., and Hurwitz, J. Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins. Proc. Natl. Acad. Sci. USA. 80: 4266-4270, 1983.