A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir

Human Gene Therapy

Volumn 10, Issue 14, 1999, Pages 2325-2335

  Shand, N ^a   Weber, F ^b   Mariani, L ^c   Bernstein, M ^d   Gianella Borradori, A ^a   Long, Z ^a   Sorensen, A G ^e   Barbier, N ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADULT; AGED; ARTICLE; BRAIN TUMOR; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; GENE THERAPY; GENETIC TRANSDUCTION; GLIOBLASTOMA; HERPES SIMPLEX VIRUS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; TREATMENT OUTCOME; TUMOR RECURRENCE;

ADULT; AGED; ANTIVIRAL AGENTS; BRAIN; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; GANCICLOVIR; GENE THERAPY; GLIOBLASTOMA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; SIMPLEXVIRUS; SURVIVAL ANALYSIS; THYMIDINE KINASE;

HERPES; SIMPLEXVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0033588816     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950016979     Document Type: Article

References (22)

1. BERNSTEIN, M., LAPERRIERE, N., GLEN, J., LEUNG, P., THOMASON, C., and LANDON, A.E. (1994). Brachytherapy for recurrent malignant astrocytoma. Int. J. Radiat. Oncol. Biol. Phys. 30, 1213-1217.
2. CHERUKU, R., TAPAZOGLOU, E., ENSLEY, J., KISH, J.A., CUMMINGS, G.D., and AL-SARRAF, M. (1991). The incidence and significance of thromboembolic complications in patients with high-grade gliomas. Cancer 68, 2621-2624.
3. COOL, V., PIROTTE, B., GERARD, C., et al. (1996). Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. Hum. Gene Ther. 7, 627-635.
4. CORNETTA, K., MORGAN, R.A., and ANDERSON, W.F. (1991). Safety issues related to retroviral-mediated gene transfer in humans. Hum. Gene Ther. 2, 5-14.
5. CULVER, K.W., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E.H., and BLAESE, R.M. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
6. DIRKS, P., BERNSTEIN, M., MULLER, P.J. and TUCKER, W.S. (1993). The value of reoperation for recurrent glioblastoma. Can. J. Surg. 36, 271-275.
7. EZZEDDINE, Z.D., MARTUZA, R.L., PLATIKA, D., et al. (1991). Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol. 3, 608-614.
8. FREEMAN, S.M., ABBOUD, C.N., WHARTENBY, K.A., et al. (1993). The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
9. GLINSKI, B., DYMEK, P., and SKOLYSZEWSKI, J. (1998). Altered therapy schedules in postoperative treatment of patients with malignant gliomas. Twenty year experience of the Maria Sklodowska-Curie Memorial Center in Krakow, 1973-1993. J. Neurooncol. 36, 159-165.
10. HILDEBRAND, J., DE WITTE, O., and SAHMOUD, T. (1998). Response of recurrent glioblastoma and anaplastic astrocytoma to dibromodulcitol, BCNU and procarbazine - a phase-II study. J. Neurooncol. 37, 155-160.
11. IZQUIERDO, M., CORTES, M., DE FELIPE, P., et al. (1995). Long-term rat survival after malignant brain tumor regression by retroviral gene therapy. Gene Ther. 2, 66-69.
12. KLEIHUES, P., BURGER, P.C., and SCHEITHAUER, B.W. (1993). Histological typing of tumors of the central nervous system. In World Health Organization Classifications of Tumors. (Springer-Verlag, Berlin).
13. LONG, Z., LI, L.P. GROOMS, T., et al. (1998). Biosafety monitoring of patients receiving intracerebral injections of murine retroviral vector producer cells. Hum. Gene Ther. 9, 1165-1172.
14. LYONS, R., FORRY-SCHAUDIES, S., OTTO, E., et al. (1995). An improved vector encoding the herpes simplex virus thymidine kinase gene increases antitumor efficacy in vivo. Cancer Gene Ther. 2, 273-280.
15. MOOLTEN, F.L. (1986). Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res. 46, 5276-5281.
16. OTTO, E., JONES-TOWER, A., VANIN, E.F., et al. (1994). Characterization of a replication-competent retrovirus resulting from recombination of packaging and vector sequences. Hum. Gene Ther. 5, 567-575.
17. RAM, Z., CULVER, K.W., WALBRIDGE, S., BALEASE, R.M., and OLDFIELD, E.H. (1993). In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res. 53, 83-88.
18. RAM, Z., CULVER, K.W., OSHIRO, E.M., et al. (1997). Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nature Med. 3, 1354-1361.
19. SHORT, M.P., CHOI, B.C., LEE, J.K., MALICK, A., BREAKEFIELD, X.O., and MARTUZA, R.L. (1990). Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J. Neurosci. Res. 27, 427-439.
20. SHRIEVE, D.C., ALEXANDER, E., III, WEN, P.Y., et al. (1995). Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme. Neurosurgery 36, 275-282.
21. SMITH, M.M., THOMPSON, J.E., CASTILLO, M., et al. (1996). MR of recurrent high-grade astrocytomas after intralesional immunotherapy. Am. J. Neuroradiol. 17, 1065-1071.
22. STOCKHAMMER, G., BROTCHI, J., LEBLANC, R., et al. (1997). Gene therapy for glioblastoma multiforme: In vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. J. Mol. Med. 75, 300-304.