Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained antitumor immunity prolongs animal survival

Cancer Research

Volumn 56, Issue 16, 1996, Pages 3758-3762

  Chen, Shu Hsia ^a   Kosai, Ken Ichiro ^a   Xu, Bisong ^a   Pham Nguyen, Khiem ^a   Contant, Charles ^a   Finegold, Milton J ^a   Woo, Savio L C ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; THYMIDINE KINASE; TUMOR CELL VACCINE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CANCER RECURRENCE; CANCER REGRESSION; CELLULAR IMMUNITY; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENE THERAPY; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SURVIVAL TIME; TUMOR IMMUNITY; VIRUS RECOMBINANT;

ANIMALS; COLONIC NEOPLASMS; GENE THERAPY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES; THYMIDINE KINASE;

EID: 0029740524     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Dreben, J A , and Niederhuber, J E. Colon Cancer. In: J E Niederhuber (ed), Current Therapy in Oncology, pp 426-431, St. Louis: B. C. Decker, Inc., 1993.
2. Lebovic, G. S., and Niederhuber, J. E. Colorectal cancer metastatic to the liver, hepatic arterial infusion. In: J. E Niederhuber (ed.), Current Therapy in Oncology, pp. 389-395. Niederhuber, J E., ed. B C. Decker, St. Louis , 1993
3. Chen, S-H , Li Chen, X. H., Wang, Y , Kosai, K-i, Finegold, M. J , Rich, S. S., and Woo, S L C Combination gene therapy for liver metastasis of colon carcinoma in vivo. Proc. Natl. Acad Sci. USA. 92: 2577-2581, 1995.
4. Gansbacher, B , Zier, K , Daniels, B , Cronin, K., Bannerji, R., and Gilboa, E. Interleukin 2 gene transfer into tumor cells abrogates tumorigenictly and induces protective immunity. J Exp Med., 172: 1217-1224, 1990.
5. Steinman, R. M The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol., 9: 271-296, 1991
6. Dranoff, G., Jaffee, E. Lazenby, A , Golumbek, P , Levitsky, H., Brose, K., Jackson, V., Hamada, H , Pardoll, D., and Mulligan, R C. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent: specific, and long-lasting anti-tumor immunity Proc. Natl. Acad. Sci. USA, 90: 3539-3543, 1993.
7. Chen, S. H., Shine, H. D , Goodman, J C., Grossman, R G., and Woo, S L. C. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo Proc. Natl. Acad Sci USA, 91: 3054-3057, 1994
8. Corbeit, T H., Griswold, D. P., Roberts, B. J., Peckham, J. C., and Schabel, F M., Jr. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res., 35: 2434-2439, 1975
9. Cox, D. R , and Oakes, D Analysis of survival data, pp. 91-139. New York: Chapman and Hall, Inc , 1984
10. Coligan, J E., Kruisbeck, A. M., Marguiles, D. H., Shevach, E. M , and Strober, W. Current protocols in immunology. New York: Wiley-Interscience, 1991.
11. Ezzeddine, Z. D , Martuza, R. L., Platika, D , Short, M. P., Malick, A., Choi, B , and Breakfield, X. O. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the Herpes simplex virus thymidine kinase gene. New Biol., 3: 608-614, 1991
12. Culver, K. W., Ram, Z , Walbridge, S., Ishii, H., Oldfield, E H., and Blaese, R M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (Washington DC), 256: 1550-1552, 1992.
13. Pardoll, D M Paracrine cytokine adjuvants in cancer immunotherapy. Annu Rev. Immunol, 13: 399-415, 1995
14. Pak, A S., Ip, G., Wright, M. A , and Young, M. R. I. Treating tumor-bearing mice with low-dose γ-interferon plus tumor necrosis factor a to diminish immune suppressive granulocyte-macrophage progenitor cells increase responsiveness to interleukin-2 immunotherapy Cancer Res., 55 885-890, 1995.
15. Pappo, I , Tahara, H., Robbins, P D., Gately, M. K , Wolf, S. F., Barhea, A , and Lotze, M. T., Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy. J. Surg. Res., 58: 218-226, 1995
16. Tanaka, N., Sivanandham, M , and Wallack, M. K. Immunotherapy of a vaccinia colon oncolysate prepared with interleukin 2 gene-encoded vaccinia virus and interferon α increases the survival of mice bearing syngenic colon adenocarcinoma. J. Immunother Emphasis Tumor Immunol , 16, 283-293, 1994.
17. Schuurman, B , Heuff, G., Beelen, R. H., and Meyer, S. Immunotherapy of human Kupffer cells after activation with human granulocyte/macrophage-colony-stimulating factor and interferon γ. Cancer Immunol. Immunother., 39: 179-184, 1994.
18. Jones, T. C. The effects of rhGM-CSF on macrophage function Eur J Cancer, 29A(Suppl. 3): S10-S13, 1993.
19. Allison, J. P , Hurwitz, A. A, and Leaach, D. R. Manipulation of costimulatory signals to enhance antitumor T-cell responses Curr Opin. Immunol. 7: 682-686, 1995.
20. Grabbe, S., Geissent, S , Schwartz, T., and Granstein, R. D. Dendritic cells as initiators of tumor immune response: a possible strategy for tumor immunotherapy? Immunol. Today. 16: 117-121, 1995.
21. Fearon, E. R , Pardoll, D. M., Itaya, T., Golumbek, P., Levitsky, H. I., Simons, J W , Karasuyama, H , Vogelstein, B , and Frost, P Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell, 60: 397-403, 1990.
22. Schmidt, W , Schweighoffer, T., Herbst, E , Maasi, G , Berger, M , Schilcher, F, Schaffner, G , and Birnstiel, M L Cancer vaccines the interleukin 2 dosage effect. Proc Natl. Acad. Sci. USA, 92: 4711-4714, 1995.