Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: A phase I/II multi-institutional trial

Journal of Neuro-Oncology

Volumn 65, Issue 3, 2003, Pages 269-278

  Prados, Michael D ^a   McDermott, Michael ^a   Chang, Susan M ^a   Wilson, Charles B ^a   Fick, James ^a,e   Culver, Kenneth W ^b,f   Van Gilder, John ^c   Keles, G Evren ^a,d   Spence, Alex ^d   Berger, Mitchel ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IOWA METHODIST MEDICAL CENTER   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Ganciclovir; Gene therapy; Glioblastoma multiforme; Herpes virus; Thymidine kinase gene

Indexed keywords

ANTINEOPLASTIC AGENT; GANCICLOVIR; GLI 328; RETROVIRUS VECTOR; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ACUTE VENTRICULAR MENINGEAL REACTION; ADULT; AGED; ANOREXIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; BLOOD TOXICITY; BRAIN EDEMA; BRAIN HERNIA; BRAIN INJURY; CANCER GROWTH; CANCER SURGERY; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM DISEASE; CHILL; CLINICAL ARTICLE; CLINICAL TRIAL; COCULTURE; DEEP VEIN THROMBOSIS; DROWSINESS; DRUG EFFICACY; DRUG FEVER; DRUG SAFETY; DRUG TOXICITY; DYSPHASIA; FEASIBILITY STUDY; FEMALE; GASTROINTESTINAL SYMPTOM; GENETIC TRANSDUCTION; GLIOBLASTOMA; HEADACHE; HEMIANOPIA; HEMIPARESIS; HEMIPLEGIA; HERPES SIMPLEX VIRUS; HUMAN; HYPERTENSION; HYPONATREMIA; ILEUS; INTRACRANIAL HYPERTENSION; LABORATORY TEST; LEUKOCYTE; LUNG EMBOLISM; LYMPHOCYTE; LYMPHOCYTOPENIA; MALE; MEMORY DISORDER; METABOLIC DISORDER; MULTICENTER STUDY; MUSCLE STIFFNESS; NAUSEA; NEUROTOXICITY; PANCYTOPENIA; PAPILLEDEMA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PNEUMONIA; POLYMERASE CHAIN REACTION; RECURRENT CANCER; RIGOR; SEIZURE; SEPTICEMIA; SOMNOLENCE; SPEECH DISORDER; SUBDURAL HEMATOMA; SURVIVAL TIME; SYSTEMIC DISEASE; TACHYCARDIA; THROMBOCYTOPENIA; THROMBOEMBOLISM; ULCER PERFORATION; VIRAL GENE THERAPY; VIRUS GENE; VIRUS REPLICATION; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; SIMPLEXVIRUS; SURVIVAL ANALYSIS; THYMIDINE KINASE; TREATMENT OUTCOME;

EID: 10744233353     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NEON.0000003588.18644.9c     Document Type: Article

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