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Volumn 10, Issue 7, 2011, Pages 849-862

Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: Focus on recent discoveries

Author keywords

Cyclooxygenase 2; Neurodegenerative diseases; Neuroinflammation; Nuclear factor kB; Resveratrol; Resveratrol analogues; Sirtuin

Indexed keywords

4 (3 METHYL BUTYL 1 ENYL) 3,5,3',4' TETRAHYDROXYSTILBENE; ALPHA SYNUCLEIN; C REACTIVE PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; PICEATANNOL; PINOSTILBENE; PROSTAGLANDIN E2; PTEROSTILBENE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SIRTUIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 81155123332     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/187152711798072310     Document Type: Review
Times cited : (53)

References (139)
  • 1
    • 0037775809 scopus 로고    scopus 로고
    • Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity
    • Vallieres, L.; Sawchenko, P.E. Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity. J. Neurosci., 2003, 23, 5197-5207.
    • (2003) J. Neurosci , vol.23 , pp. 5197-5207
    • Vallieres, L.1    Sawchenko, P.E.2
  • 2
    • 77955088481 scopus 로고    scopus 로고
    • Resveratrol as a therapeutic agent for neurodegenerative diseases
    • Sun, A.Y.; Wang, Q.; Simonyi, A.; Sun, G.Y. Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol. Neurobiol., 2010, 41, 375-383.
    • (2010) Mol. Neurobiol , vol.41 , pp. 375-383
    • Sun, A.Y.1    Wang, Q.2    Simonyi, A.3    Sun, G.Y.4
  • 3
    • 34648830916 scopus 로고    scopus 로고
    • Anti-inflammatory responses of resveratrol
    • Das, S.; Das, D.K. Anti-inflammatory responses of resveratrol. Inflamm. Allergy Drug Targets, 2007, 6, 168-173.
    • (2007) Inflamm. Allergy Drug Targets , vol.6 , pp. 168-173
    • Das, S.1    Das, D.K.2
  • 4
    • 0035112495 scopus 로고    scopus 로고
    • Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
    • Lovell, M.A.; Xie, C.; Markesbery, W.R. Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures. Neurobiol. Aging, 2001, 22, 187-194.
    • (2001) Neurobiol. Aging , vol.22 , pp. 187-194
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 5
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg, G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci., 1996, 19, 312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 6
    • 33847785649 scopus 로고    scopus 로고
    • Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    • Lalancette-Hebert, M.; Gowing, G.; Simard, A.; Weng, Y.C.; Kriz, J. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J. Neurosci., 2007, 27, 2596-2605.
    • (2007) J. Neurosci , vol.27 , pp. 2596-2605
    • Lalancette-Hebert, M.1    Gowing, G.2    Simard, A.3    Weng, Y.C.4    Kriz, J.5
  • 7
    • 77956537707 scopus 로고    scopus 로고
    • Microglia and neuroprotection: From in vitro studies to therapeutic applications
    • Polazzi, E.; Monti, B. Microglia and neuroprotection: from in vitro studies to therapeutic applications. Prog. Neurobiol., 2010, 92, 293-315.
    • (2010) Prog. Neurobiol , vol.92 , pp. 293-315
    • Polazzi, E.1    Monti, B.2
  • 8
    • 53449090280 scopus 로고    scopus 로고
    • Inhibition of transcriptional activity of c-JUN by SIRT1
    • Gao, Z.; Ye, J. Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem. Biophys. Res. Commun., 2008, 376, 793-796.
    • (2008) Biochem. Biophys. Res. Commun , vol.376 , pp. 793-796
    • Gao, Z.1    Ye, J.2
  • 9
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • Minghetti, L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J. Neuropathol. Exp. Neurol., 2004, 63, 901-910.
    • (2004) J. Neuropathol. Exp. Neurol , vol.63 , pp. 901-910
    • Minghetti, L.1
  • 10
    • 42949146053 scopus 로고    scopus 로고
    • Inhibition of cholinesterase and amyloid-beta aggregation by resveratrol oligomers from Vitis amurensis
    • Jang, M.H.; Piao, X.L.; Kim, J.M.; Kwon, S.W.; Park, J.H. Inhibition of cholinesterase and amyloid-beta aggregation by resveratrol oligomers from Vitis amurensis. Phytother. Res., 2008, 22, 544-549.
    • (2008) Phytother. Res , vol.22 , pp. 544-549
    • Jang, M.H.1    Piao, X.L.2    Kim, J.M.3    Kwon, S.W.4    Park, J.H.5
  • 11
    • 26244449524 scopus 로고    scopus 로고
    • Lipid signaling in experimental epilepsy
    • Cole-Edwards, K.K.; Bazan, N.G. Lipid signaling in experimental epilepsy. Neurochem. Res., 2005, 30, 847-853.
    • (2005) Neurochem. Res , vol.30 , pp. 847-853
    • Cole-Edwards, K.K.1    Bazan, N.G.2
  • 12
    • 0030747128 scopus 로고    scopus 로고
    • NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules
    • Baeuerle, P.A.; Baichwal, V.R. NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv. Immunol., 1997, 65, 111-137.
    • (1997) Adv. Immunol , vol.65 , pp. 111-137
    • Baeuerle, P.A.1    Baichwal, V.R.2
  • 13
    • 77949540912 scopus 로고    scopus 로고
    • Emerging roles of PGE2 receptors in models of neurological disease
    • Andreasson, K. Emerging roles of PGE2 receptors in models of neurological disease. Prostaglandins Other Lipid Mediat., 2010, 91, 104-112.
    • (2010) Prostaglandins Other Lipid Mediat , vol.91 , pp. 104-112
    • Andreasson, K.1
  • 14
    • 4143107932 scopus 로고    scopus 로고
    • Cyclooxygenase isozymes: The biology of prostaglandin synthesis and inhibition
    • Simmons, D.L.; Botting, R.M.; Hla, T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol. Rev., 2004, 56, 387-437.
    • (2004) Pharmacol. Rev , vol.56 , pp. 387-437
    • Simmons, D.L.1    Botting, R.M.2    Hla, T.3
  • 15
    • 0032838324 scopus 로고    scopus 로고
    • Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation
    • Zhang, J.; Rivest, S. Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur. J. Neurosci., 1999, 11, 2651-2668.
    • (1999) Eur. J. Neurosci , vol.11 , pp. 2651-2668
    • Zhang, J.1    Rivest, S.2
  • 17
    • 0028130213 scopus 로고
    • Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase
    • Westwick, J.K.; Weitzel, C.; Minden, A.; Karin, M.; Brenner, D.A. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J. Biol. Chem., 1994, 269, 26396-26401.
    • (1994) J. Biol. Chem , vol.269 , pp. 26396-26401
    • Westwick, J.K.1    Weitzel, C.2    Minden, A.3    Karin, M.4    Brenner, D.A.5
  • 18
    • 0030254341 scopus 로고    scopus 로고
    • Polymerase chain reaction analysis of TNF-alpha and IL-6 mRNA levels in whole blood from cattle naturally or experimentally infected with Mycobacterium paratuberculosis
    • Adams, J.L.; Collins, M.T.; Czuprynski, C.J. Polymerase chain reaction analysis of TNF-alpha and IL-6 mRNA levels in whole blood from cattle naturally or experimentally infected with Mycobacterium paratuberculosis. Can. J. Vet. Res., 1996, 60, 257-262.
    • (1996) Can. J. Vet. Res , vol.60 , pp. 257-262
    • Adams, J.L.1    Collins, M.T.2    Czuprynski, C.J.3
  • 19
    • 63249088045 scopus 로고    scopus 로고
    • Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: Comparison of preand post-ischemic administration
    • Wang, Q.; Sun, A.Y.; Simonyi, A.; Miller, D.K.; Smith, R.E.; Luchtefeld, R.G.; Korthuis, R.J.; Sun, G.Y. Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of preand post-ischemic administration. J. Nutr. Biochem., 2009, 20, 369-377.
    • (2009) J. Nutr. Biochem , vol.20 , pp. 369-377
    • Wang, Q.1    Sun, A.Y.2    Simonyi, A.3    Miller, D.K.4    Smith, R.E.5    Luchtefeld, R.G.6    Korthuis, R.J.7    Sun, G.Y.8
  • 20
    • 69549127950 scopus 로고    scopus 로고
    • JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease
    • Wang, Y.; Zhang, Y.; Wei, Z.; Li, H.; Zhou, H.; Zhang, Z.; Zhang, Z. JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease. J. Neurol. Sci., 2009, 285, 172-177.
    • (2009) J. Neurol. Sci , vol.285 , pp. 172-177
    • Wang, Y.1    Zhang, Y.2    Wei, Z.3    Li, H.4    Zhou, H.5    Zhang, Z.6    Zhang, Z.7
  • 21
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edged sword
    • Aggarwal, B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol., 2003, 3, 745-756.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 22
    • 78649733057 scopus 로고    scopus 로고
    • Reduced Alzheimer's disease ss-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin
    • Meckler, X.; Roseman, J.; Das, P.; Cheng, H.; Pei, S.; Keat, M.; Kassarjian, B.; Golde, T.E.; Parent, A.T.; Thinakaran, G. Reduced Alzheimer's disease ss-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. J. Neurosci., 2010, 30, 16160-16169.
    • (2010) J. Neurosci , vol.30 , pp. 16160-16169
    • Meckler, X.1    Roseman, J.2    Das, P.3    Cheng, H.4    Pei, S.5    Keat, M.6    Kassarjian, B.7    Golde, T.E.8    Parent, A.T.9    Thinakaran, G.10
  • 23
    • 27544484846 scopus 로고    scopus 로고
    • Are mitochondria critical in the pathogenesis of Alzheimer's disease?
    • Reddy, P.H.; Beal, M.F. Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res. Brain Res. Rev., 2005, 49, 618-632.
    • (2005) Brain Res. Brain Res. Rev , vol.49 , pp. 618-632
    • Reddy, P.H.1    Beal, M.F.2
  • 25
    • 77956302879 scopus 로고    scopus 로고
    • Inflammation in neurological disorders: A help or a hindrance?
    • Wee Yong, V. Inflammation in neurological disorders: a help or a hindrance? Neuroscientist, 2010, 16, 408-420.
    • (2010) Neuroscientist , vol.16 , pp. 408-420
    • Wee, Y.V.1
  • 27
    • 46749087854 scopus 로고    scopus 로고
    • Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
    • Maier, M.; Peng, Y.; Jiang, L.; Seabrook, T.J.; Carroll, M.C.; Lemere, C.A. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J. Neurosci., 2008, 28, 6333-6341.
    • (2008) J. Neurosci , vol.28 , pp. 6333-6341
    • Maier, M.1    Peng, Y.2    Jiang, L.3    Seabrook, T.J.4    Carroll, M.C.5    Lemere, C.A.6
  • 28
    • 0030961544 scopus 로고    scopus 로고
    • Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
    • McDonald, D.R.; Brunden, K.R.; Landreth, G.E. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J. Neurosci., 1997, 17, 2284-2294.
    • (1997) J. Neurosci , vol.17 , pp. 2284-2294
    • McDonald, D.R.1    Brunden, K.R.2    Landreth, G.E.3
  • 29
    • 0032891880 scopus 로고    scopus 로고
    • Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with betaamyloid[25-35]
    • Meda, L.; Baron, P.; Prat, E.; Scarpini, E.; Scarlato, G.; Cassatella, M.A.; Rossi, F. Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with betaamyloid[25-35]. J. Neuroimmunol., 1999, 93, 45-52.
    • (1999) J. Neuroimmunol , vol.93 , pp. 45-52
    • Meda, L.1    Baron, P.2    Prat, E.3    Scarpini, E.4    Scarlato, G.5    Cassatella, M.A.6    Rossi, F.7
  • 30
    • 0025801468 scopus 로고
    • Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?
    • Vandenabeele, P.; Fiers, W. Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain? Immunol. Today, 1991, 12, 217-219.
    • (1991) Immunol. Today , vol.12 , pp. 217-219
    • Vandenabeele, P.1    Fiers, W.2
  • 31
    • 0036323485 scopus 로고    scopus 로고
    • Cyclin D1 and cyclin E are colocalized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
    • Hoozemans, J.J.; Bruckner, M.K.; Rozemuller, A.J.; Veerhuis, R.; Eikelenboom, P.; Arendt, T. Cyclin D1 and cyclin E are colocalized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex. J. Neuropathol. Exp. Neurol., 2002, 61, 678-688.
    • (2002) J. Neuropathol. Exp. Neurol , vol.61 , pp. 678-688
    • Hoozemans, J.J.1    Bruckner, M.K.2    Rozemuller, A.J.3    Veerhuis, R.4    Eikelenboom, P.5    Arendt, T.6
  • 33
    • 34250784090 scopus 로고    scopus 로고
    • Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice
    • Cakala, M.; Malik, A.R.; Strosznajder, J.B. Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice. Pharmacol. Rep., 2007, 59, 164-172.
    • (2007) Pharmacol. Rep , vol.59 , pp. 164-172
    • Cakala, M.1    Malik, A.R.2    Strosznajder, J.B.3
  • 34
    • 0035693794 scopus 로고    scopus 로고
    • Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease
    • Yermakova, A.V.; O'Banion, M.K. Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol. Aging, 2001, 22, 823-836.
    • (2001) Neurobiol. Aging , vol.22 , pp. 823-836
    • Yermakova, A.V.1    O'Banion, M.K.2
  • 35
    • 0033526660 scopus 로고    scopus 로고
    • Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs
    • Yasojima, K.; Schwab, C.; McGeer, E.G.; McGeer, P.L. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res., 1999, 830, 226-236.
    • (1999) Brain Res , vol.830 , pp. 226-236
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4
  • 37
    • 80053212816 scopus 로고    scopus 로고
    • The Role of Tau in Alzheimer's Disease and Related Disorders
    • Medeiros, R.; Baglietto-Vargas, D.; Laferla, F.M. The Role of Tau in Alzheimer's Disease and Related Disorders. CNS Neurosci. Ther., 2011, 17(5), 514-524.
    • (2011) CNS Neurosci. Ther , vol.17 , Issue.5 , pp. 514-524
    • Medeiros, R.1    Baglietto-Vargas, D.2    Laferla, F.M.3
  • 38
    • 57149101898 scopus 로고    scopus 로고
    • Chronic neuron-specific tumor necrosis factor alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
    • Janelsins, M.C.; Mastrangelo, M.A.; Park, K.M.; Sudol, K.L.; Narrow, W.C.; Oddo, S.; LaFerla, F.M.; Callahan, L.M.; Federoff, H.J.; Bowers, W.J. Chronic neuron-specific tumor necrosis factor alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am. J. Pathol., 2008, 173, 1768-1782.
    • (2008) Am. J. Pathol , vol.173 , pp. 1768-1782
    • Janelsins, M.C.1    Mastrangelo, M.A.2    Park, K.M.3    Sudol, K.L.4    Narrow, W.C.5    Oddo, S.6    Laferla, F.M.7    Callahan, L.M.8    Federoff, H.J.9    Bowers, W.J.10
  • 39
    • 0032621790 scopus 로고    scopus 로고
    • TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs
    • Blasko, I.; Marx, F.; Steiner, E.; Hartmann, T.; Grubeck-Loebenstein, B. TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J., 1999, 13, 63-68.
    • (1999) FASEB J , vol.13 , pp. 63-68
    • Blasko, I.1    Marx, F.2    Steiner, E.3    Hartmann, T.4    Grubeck-Loebenstein, B.5
  • 40
    • 10344238086 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha, interleukin-1beta, and interferon gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
    • Liao, Y.F.; Wang, B.J.; Cheng, H.T.; Kuo, L.H.; Wolfe, M.S. Tumor necrosis factor-alpha, interleukin-1beta, and interferon gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J. Biol. Chem., 2004, 279, 49523-49532.
    • (2004) J. Biol. Chem , vol.279 , pp. 49523-49532
    • Liao, Y.F.1    Wang, B.J.2    Cheng, H.T.3    Kuo, L.H.4    Wolfe, M.S.5
  • 41
    • 0035696328 scopus 로고    scopus 로고
    • Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice
    • DiCarlo, G.; Wilcock, D.; Henderson, D.; Gordon, M.; Morgan, D. Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice. Neurobiol. Aging, 2001, 22, 1007-1012.
    • (2001) Neurobiol. Aging , vol.22 , pp. 1007-1012
    • Dicarlo, G.1    Wilcock, D.2    Henderson, D.3    Gordon, M.4    Morgan, D.5
  • 42
    • 34447644067 scopus 로고    scopus 로고
    • Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model
    • Butovsky, O.; Kunis, G.; Koronyo-Hamaoui, M.; Schwartz, M. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur. J. Neurosci., 2007, 26, 413-416.
    • (2007) Eur. J. Neurosci , vol.26 , pp. 413-416
    • Butovsky, O.1    Kunis, G.2    Koronyo-Hamaoui, M.3    Schwartz, M.4
  • 45
    • 37049028157 scopus 로고    scopus 로고
    • Neuroprotective effects of resident microglia following acute brain injury
    • Simard, A.R.; Rivest, S. Neuroprotective effects of resident microglia following acute brain injury. J. Comp. Neurol., 2007, 504, 716-729.
    • (2007) J. Comp. Neurol , vol.504 , pp. 716-729
    • Simard, A.R.1    Rivest, S.2
  • 46
    • 34247366072 scopus 로고    scopus 로고
    • Inflammation as a causative factor in the aetiology of Parkinson's disease
    • Whitton, P.S. Inflammation as a causative factor in the aetiology of Parkinson's disease. Br. J. Pharmacol., 2007, 150, 963-976.
    • (2007) Br. J. Pharmacol , vol.150 , pp. 963-976
    • Whitton, P.S.1
  • 47
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration
    • Hirsch, E.C.; Hunot, S.; Damier, P.; Faucheux, B. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann. Neurol., 1998, 44, S115-S120.
    • (1998) Ann. Neurol , vol.44 , pp. 115-120
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 48
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • McGeer, P.L.; McGeer, E.G. Glial reactions in Parkinson's disease. Mov. Disord., 2008, 23, 474-483.
    • (2008) Mov. Disord , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 50
    • 84863116750 scopus 로고    scopus 로고
    • Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease
    • Gao, H.M.; Liu, B.; Zhang, W.; Hong, J.S. Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J., 2003, 17, 1954-1956.
    • (2003) FASEB J , vol.17 , pp. 1954-1956
    • Gao, H.M.1    Liu, B.2    Zhang, W.3    Hong, J.S.4
  • 51
    • 0346463000 scopus 로고    scopus 로고
    • NADPH oxidase mediates lipopolysaccharide induced neurotoxicity and proinflammatory gene expression in activated microglia
    • Qin, L.; Liu, Y.; Wang, T.; Wei, S.J.; Block, M.L.; Wilson, B.; Liu, B.; Hong, J.S. NADPH oxidase mediates lipopolysaccharide induced neurotoxicity and proinflammatory gene expression in activated microglia. J. Biol. Chem., 2004, 279, 1415-1421.
    • (2004) J. Biol. Chem , vol.279 , pp. 1415-1421
    • Qin, L.1    Liu, Y.2    Wang, T.3    Wei, S.J.4    Block, M.L.5    Wilson, B.6    Liu, B.7    Hong, J.S.8
  • 52
  • 53
    • 79955921784 scopus 로고    scopus 로고
    • Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of parkinson's disease
    • Gao, H.M.; Zhang, F.; Zhou, H.; Kam, W.; Wilson, B.; Hong, J.S. Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of parkinson's disease. Environ. Health Perspect., 2011, 119, 807-814.
    • (2011) Environ. Health Perspect , vol.119 , pp. 807-814
    • Gao, H.M.1    Zhang, F.2    Zhou, H.3    Kam, W.4    Wilson, B.5    Hong, J.S.6
  • 55
    • 14744296610 scopus 로고    scopus 로고
    • Inflammatory process in Parkinson's disease: Role for cytokines
    • Nagatsu, T.; Sawada, M. Inflammatory process in Parkinson's disease: role for cytokines. Curr. Pharm. Des., 2005, 11, 999-1016.
    • (2005) Curr. Pharm. Des , vol.11 , pp. 999-1016
    • Nagatsu, T.1    Sawada, M.2
  • 56
    • 0028178281 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
    • Mogi, M.; Harada, M.; Riederer, P.; Narabayashi, H.; Fujita, K.; Nagatsu, T. Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci. Lett., 1994, 165, 208-210.
    • (1994) Neurosci. Lett , vol.165 , pp. 208-210
    • Mogi, M.1    Harada, M.2    Riederer, P.3    Narabayashi, H.4    Fujita, K.5    Nagatsu, T.6
  • 57
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson's disease: INOS, lipocortin-1, and cyclooxygenases-1 and -2
    • Knott, C.; Stern, G.; Wilkin, G.P. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol. Cell. Neurosci., 2000, 16, 724-739.
    • (2000) Mol. Cell. Neurosci , vol.16 , pp. 724-739
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 58
    • 41949108084 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells
    • Chae, S.W.; Kang, B.Y.; Hwang, O.; Choi, H.J. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neurosci. Lett., 2008, 436, 205-209.
    • (2008) Neurosci. Lett , vol.436 , pp. 205-209
    • Chae, S.W.1    Kang, B.Y.2    Hwang, O.3    Choi, H.J.4
  • 59
    • 61649109455 scopus 로고    scopus 로고
    • Identification of the amino acid sequence motif of alpha-synuclein responsible for macrophage activation
    • Lee, S.B.; Park, S.M.; Ahn, K.J.; Chung, K.C.; Paik, S.R.; Kim, J. Identification of the amino acid sequence motif of alpha-synuclein responsible for macrophage activation. Biochem. Biophys. Res. Commun., 2009, 381, 39-43.
    • (2009) Biochem. Biophys. Res. Commun , vol.381 , pp. 39-43
    • Lee, S.B.1    Park, S.M.2    Ahn, K.J.3    Chung, K.C.4    Paik, S.R.5    Kim, J.6
  • 60
    • 0036719568 scopus 로고    scopus 로고
    • Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease
    • Sriram, K.; Matheson, J.M.; Benkovic, S.A.; Miller, D.B.; Luster, M.I.; O'Callaghan, J.P. Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. FASEB J., 2002, 16, 1474-1476.
    • (2002) FASEB J , vol.16 , pp. 1474-1476
    • Sriram, K.1    Matheson, J.M.2    Benkovic, S.A.3    Miller, D.B.4    Luster, M.I.5    O'Callaghan, J.P.6
  • 61
    • 77952291438 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction
    • Park, K.M.; Bowers, W.J. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal., 2010, 22, 977-983.
    • (2010) Cell Signal , vol.22 , pp. 977-983
    • Park, K.M.1    Bowers, W.J.2
  • 62
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • Gil, J.M.; Rego, A.C. Mechanisms of neurodegeneration in Huntington's disease. Eur. J. Neurosci., 2008, 27, 2803-2820.
    • (2008) Eur. J. Neurosci , vol.27 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 63
    • 77955089391 scopus 로고    scopus 로고
    • Targeting glial cells to elucidate the pathogenesis of Huntington's disease
    • Hsiao, H.Y.; Chern, Y. Targeting glial cells to elucidate the pathogenesis of Huntington's disease. Mol. Neurobiol., 2010, 41, 248-255.
    • (2010) Mol. Neurobiol , vol.41 , pp. 248-255
    • Hsiao, H.Y.1    Chern, Y.2
  • 64
    • 77957993152 scopus 로고    scopus 로고
    • Mitochondrial associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench
    • Rosenstock, T.R.; Duarte, A.I.; Rego, A.C. Mitochondrial associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench. Curr. Drug Targets, 2010, 11, 1218-1236.
    • (2010) Curr. Drug Targets , vol.11 , pp. 1218-1236
    • Rosenstock, T.R.1    Duarte, A.I.2    Rego, A.C.3
  • 69
    • 77955649302 scopus 로고    scopus 로고
    • Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis
    • Meissner, F.; Molawi, K.; Zychlinsky, A. Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Proc. Natl. Acad. Sci. USA, 2010, 107, 13046-13050.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 13046-13050
    • Meissner, F.1    Molawi, K.2    Zychlinsky, A.3
  • 71
    • 77955506963 scopus 로고    scopus 로고
    • Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis
    • Sanagi, T.; Yuasa, S.; Nakamura, Y.; Suzuki, E.; Aoki, M.; Warita, H.; Itoyama, Y.; Uchino, S.; Kohsaka, S.; Ohsawa, K. Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. J. Neurosci. Res., 2010, 88, 2736-2746.
    • (2010) J. Neurosci. Res , vol.88 , pp. 2736-2746
    • Sanagi, T.1    Yuasa, S.2    Nakamura, Y.3    Suzuki, E.4    Aoki, M.5    Warita, H.6    Itoyama, Y.7    Uchino, S.8    Kohsaka, S.9    Ohsawa, K.10
  • 72
    • 1842471942 scopus 로고    scopus 로고
    • Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: An [11C](R)-PK11195 positron emission tomography study
    • Turner, M.R.; Cagnin, A.; Turkheimer, F.E.; Miller, C.C.; Shaw, C.E.; Brooks, D.J.; Leigh, P.N.; Banati, R.B. Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol. Dis., 2004, 15, 601-609.
    • (2004) Neurobiol. Dis , vol.15 , pp. 601-609
    • Turner, M.R.1    Cagnin, A.2    Turkheimer, F.E.3    Miller, C.C.4    Shaw, C.E.5    Brooks, D.J.6    Leigh, P.N.7    Banati, R.B.8
  • 75
    • 0030656388 scopus 로고    scopus 로고
    • Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds
    • Orsini, F.; Pelizzoni, F.; Verotta, L.; Aburjai, T.; Rogers, C.B. Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds. J. Nat. Prod., 1997, 60, 1082-1087.
    • (1997) J. Nat. Prod , vol.60 , pp. 1082-1087
    • Orsini, F.1    Pelizzoni, F.2    Verotta, L.3    Aburjai, T.4    Rogers, C.B.5
  • 76
    • 0037189214 scopus 로고    scopus 로고
    • Convenient preparation of transarylalkenes via palladium(II)-catalyzed isomerization of cisarylalkenes
    • Yu, J.; Gaunt, M.J.; Spencer, J.B. Convenient preparation of transarylalkenes via palladium(II)-catalyzed isomerization of cisarylalkenes. J. Org. Chem., 2002, 67, 4627-4629.
    • (2002) J. Org. Chem , vol.67 , pp. 4627-4629
    • Yu, J.1    Gaunt, M.J.2    Spencer, J.B.3
  • 77
    • 73449100838 scopus 로고    scopus 로고
    • Resveratrol: Its biologic targets and functional activity
    • Pervaiz, S.; Holme, A.L. Resveratrol: its biologic targets and functional activity. Antioxid. Redox Signal., 2009, 11, 2851-2897.
    • (2009) Antioxid. Redox Signal , vol.11 , pp. 2851-2897
    • Pervaiz, S.1    Holme, A.L.2
  • 78
    • 43549088782 scopus 로고    scopus 로고
    • Resveratrol: A multitargeted agent for age-associated chronic diseases
    • Harikumar, K.B.; Aggarwal, B.B. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle, 2008, 7, 1020-1035.
    • (2008) Cell Cycle , vol.7 , pp. 1020-1035
    • Harikumar, K.B.1    Aggarwal, B.B.2
  • 79
    • 77956242222 scopus 로고    scopus 로고
    • Resveratrol protects dopamine neurons against lipopolysaccharideinduced neurotoxicity through its anti-inflammatory actions
    • Zhang, F.; Shi, J.S.; Zhou, H.; Wilson, B.; Hong, J.S.; Gao, H.M. Resveratrol protects dopamine neurons against lipopolysaccharideinduced neurotoxicity through its anti-inflammatory actions. Mol. Pharmacol., 2010, 78, 466-477.
    • (2010) Mol. Pharmacol , vol.78 , pp. 466-477
    • Zhang, F.1    Shi, J.S.2    Zhou, H.3    Wilson, B.4    Hong, J.S.5    Gao, H.M.6
  • 80
    • 56149119401 scopus 로고    scopus 로고
    • Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats
    • Jin, F.; Wu, Q.; Lu, Y.F.; Gong, Q.H.; Shi, J.S. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur. J. Pharmacol., 2008, 600, 78-82.
    • (2008) Eur. J. Pharmacol , vol.600 , pp. 78-82
    • Jin, F.1    Wu, Q.2    Lu, Y.F.3    Gong, Q.H.4    Shi, J.S.5
  • 81
    • 70450285045 scopus 로고    scopus 로고
    • Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model
    • Long, J.; Gao, H.; Sun, L.; Liu, J.; Zhao-Wilson, X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Res., 2009, 12, 321-331.
    • (2009) Rejuvenation Res , vol.12 , pp. 321-331
    • Long, J.1    Gao, H.2    Sun, L.3    Liu, J.4    Zhao-Wilson, X.5
  • 82
    • 34447136104 scopus 로고    scopus 로고
    • Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine
    • Lee, M.K.; Kang, S.J.; Poncz, M.; Song, K.J.; Park, K.S. Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine. Exp. Mol. Med., 2007, 39, 376-384.
    • (2007) Exp. Mol. Med , vol.39 , pp. 376-384
    • Lee, M.K.1    Kang, S.J.2    Poncz, M.3    Song, K.J.4    Park, K.S.5
  • 85
    • 0037446328 scopus 로고    scopus 로고
    • Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death
    • Jang, J.H.; Surh, Y.J. Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic. Biol. Med., 2003, 34, 1100-1110.
    • (2003) Free Radic. Biol. Med , vol.34 , pp. 1100-1110
    • Jang, J.H.1    Surh, Y.J.2
  • 87
    • 1942472491 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: Involvement of protein kinase C
    • Han, Y.S.; Zheng, W.H.; Bastianetto, S.; Chabot, J.G.; Quirion, R. Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C. Br. J. Pharmacol., 2004, 141, 997-1005.
    • (2004) Br. J. Pharmacol , vol.141 , pp. 997-1005
    • Han, Y.S.1    Zheng, W.H.2    Bastianetto, S.3    Chabot, J.G.4    Quirion, R.5
  • 88
    • 34548755196 scopus 로고    scopus 로고
    • Neuroprotective effects of natural products: Interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin
    • Bastianetto, S.; Brouillette, J.; Quirion, R. Neuroprotective effects of natural products: interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin. Neurochem. Res., 2007, 32, 1720-1725.
    • (2007) Neurochem. Res , vol.32 , pp. 1720-1725
    • Bastianetto, S.1    Brouillette, J.2    Quirion, R.3
  • 90
    • 33644854620 scopus 로고    scopus 로고
    • Comparative studies of the antioxidant effects of cis and trans-resveratrol
    • Orallo, F. Comparative studies of the antioxidant effects of cis and trans-resveratrol. Curr. Med. Chem., 2006, 13, 87-98.
    • (2006) Curr. Med. Chem , vol.13 , pp. 87-98
    • Orallo, F.1
  • 91
    • 77950189559 scopus 로고    scopus 로고
    • NF-kappaB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy
    • Kumar, A.; Sharma, S.S. NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy. Biochem. Biophys. Res. Commun., 2010, 394, 360-365.
    • (2010) Biochem. Biophys. Res. Commun , vol.394 , pp. 360-365
    • Kumar, A.1    Sharma, S.S.2
  • 92
    • 79952084201 scopus 로고    scopus 로고
    • Effects of resveratrol on nuclear factor-kappaB and pro-inflammatory factors from lipopolysaccharide activated murine peritoneal macrophages
    • Zhang, S.; Li, S.; Wei, T. Effects of resveratrol on nuclear factor-kappaB and pro-inflammatory factors from lipopolysaccharide activated murine peritoneal macrophages. Wei Sheng Yan Jiu, 2009, 38, 465-467.
    • (2009) Wei Sheng Yan Jiu , vol.38 , pp. 465-467
    • Zhang, S.1    Li, S.2    Wei, T.3
  • 93
    • 0038474039 scopus 로고    scopus 로고
    • Different short and long-term effects of resveratrol on nuclear factor-kappaB phosphorylation and nuclear appearance in human endothelial cells
    • Pellegatta, F.; Bertelli, A.A.; Staels, B.; Duhem, C.; Fulgenzi, A.; Ferrero, M.E. Different short and long-term effects of resveratrol on nuclear factor-kappaB phosphorylation and nuclear appearance in human endothelial cells. Am. J. Clin. Nutr., 2003, 77, 1220-1228.
    • (2003) Am. J. Clin. Nutr , vol.77 , pp. 1220-1228
    • Pellegatta, F.1    Bertelli, A.A.2    Staels, B.3    Duhem, C.4    Fulgenzi, A.5    Ferrero, M.E.6
  • 95
    • 27844497059 scopus 로고    scopus 로고
    • Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides
    • Marambaud, P.; Zhao, H.; Davies, P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J. Biol. Chem., 2005, 280, 37377-37382.
    • (2005) J. Biol. Chem , vol.280 , pp. 37377-37382
    • Marambaud, P.1    Zhao, H.2    Davies, P.3
  • 98
    • 2542445157 scopus 로고    scopus 로고
    • Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: A mechanistic approach to the design of COX-1 selective agents
    • Szewczuk, L.M.; Forti, L.; Stivala, L.A.; Penning, T.M. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J. Biol. Chem., 2004, 279, 22727-22737.
    • (2004) J. Biol. Chem , vol.279 , pp. 22727-22737
    • Szewczuk, L.M.1    Forti, L.2    Stivala, L.A.3    Penning, T.M.4
  • 99
    • 63049135666 scopus 로고    scopus 로고
    • An in vitro screening cascade to identify neuroprotective antioxidants in ALS
    • Barber, S.C.; Higginbottom, A.; Mead, R.J.; Barber, S.; Shaw, P.J. An in vitro screening cascade to identify neuroprotective antioxidants in ALS. Free Radic. Biol. Med., 2009, 46, 1127-1138.
    • (2009) Free Radic. Biol. Med , vol.46 , pp. 1127-1138
    • Barber, S.C.1    Higginbottom, A.2    Mead, R.J.3    Barber, S.4    Shaw, P.J.5
  • 101
  • 103
    • 14644442917 scopus 로고    scopus 로고
    • Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: Structure activity relationship
    • Murias, M.; Jager, W.; Handler, N.; Erker, T.; Horvath, Z.; Szekeres, T.; Nohl, H.; Gille, L. Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure activity relationship. Biochem. Pharmacol., 2005, 69, 903-912.
    • (2005) Biochem. Pharmacol , vol.69 , pp. 903-912
    • Murias, M.1    Jager, W.2    Handler, N.3    Erker, T.4    Horvath, Z.5    Szekeres, T.6    Nohl, H.7    Gille, L.8
  • 104
    • 2442420057 scopus 로고    scopus 로고
    • The 3,4-dihydroxyl groups are important for transresveratrol analogs to exhibit enhanced antioxidant and apoptotic activities
    • Cai, Y.J.; Wei, Q.Y.; Fang, J.G.; Yang, L.; Liu, Z.L.; Wyche, J.H.; Han, Z. The 3,4-dihydroxyl groups are important for transresveratrol analogs to exhibit enhanced antioxidant and apoptotic activities. Anticancer Res., 2004, 24, 999-1002.
    • (2004) Anticancer Res , vol.24 , pp. 999-1002
    • Cai, Y.J.1    Wei, Q.Y.2    Fang, J.G.3    Yang, L.4    Liu, Z.L.5    Wyche, J.H.6    Han, Z.7
  • 105
    • 4644302857 scopus 로고    scopus 로고
    • Resveratrol analogues as selective cyclooxygenase-2 inhibitors: Synthesis and structure-activity relationship
    • Murias, M.; Handler, N.; Erker, T.; Pleban, K.; Ecker, G.; Saiko, P.; Szekeres, T.; Jager, W. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg. Med. Chem., 2004, 12, 5571-5578.
    • (2004) Bioorg. Med. Chem , vol.12 , pp. 5571-5578
    • Murias, M.1    Handler, N.2    Erker, T.3    Pleban, K.4    Ecker, G.5    Saiko, P.6    Szekeres, T.7    Jager, W.8
  • 106
    • 45849091854 scopus 로고    scopus 로고
    • Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships
    • Meng, X.L.; Yang, J.Y.; Chen, G.L.; Wang, L.H.; Zhang, L.J.; Wang, S.; Li, J.; Wu, C.F. Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships. Chem. Biol. Interact., 2008, 174, 51-59.
    • (2008) Chem. Biol. Interact , vol.174 , pp. 51-59
    • Meng, X.L.1    Yang, J.Y.2    Chen, G.L.3    Wang, L.H.4    Zhang, L.J.5    Wang, S.6    Li, J.7    Wu, C.F.8
  • 107
    • 67349183313 scopus 로고    scopus 로고
    • Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects
    • Jung, J.C.; Lim, E.; Lee, Y.; Kang, J.M.; Kim, H.; Jang, S.; Oh, S.; Jung, M. Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. Eur. J. Med. Chem., 2009, 44, 3166-3174.
    • (2009) Eur. J. Med. Chem , vol.44 , pp. 3166-3174
    • Jung, J.C.1    Lim, E.2    Lee, Y.3    Kang, J.M.4    Kim, H.5    Jang, S.6    Oh, S.7    Jung, M.8
  • 108
    • 25144455677 scopus 로고    scopus 로고
    • Inhibition of cyclo-oxygenase-2 expression in mouse macrophages by 4-(3-methyl-but-1-enyl) 3,5,3',4'-tetrahydroxystilbene, a resveratrol derivative from peanuts
    • Patel, B.; Patel, S.; Hoffman, R. Inhibition of cyclo-oxygenase-2 expression in mouse macrophages by 4-(3-methyl-but-1-enyl) 3,5,3',4'-tetrahydroxystilbene, a resveratrol derivative from peanuts. Phytother. Res., 2005, 19, 552-555.
    • (2005) Phytother. Res , vol.19 , pp. 552-555
    • Patel, B.1    Patel, S.2    Hoffman, R.3
  • 109
    • 0036885057 scopus 로고    scopus 로고
    • Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation
    • Ashikawa, K.; Majumdar, S.; Banerjee, S.; Bharti, A.C.; Shishodia, S.; Aggarwal, B.B. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J. Immunol., 2002, 169, 6490-6497.
    • (2002) J. Immunol , vol.169 , pp. 6490-6497
    • Ashikawa, K.1    Majumdar, S.2    Banerjee, S.3    Bharti, A.C.4    Shishodia, S.5    Aggarwal, B.B.6
  • 110
    • 34247874522 scopus 로고    scopus 로고
    • Protective effects of piceatannol against beta-amyloid-induced neuronal cell death
    • Kim, H.J.; Lee, K.W.; Lee, H.J. Protective effects of piceatannol against beta-amyloid-induced neuronal cell death. Ann. NY Acad. Sci., 2007, 1095, 473-482.
    • (2007) Ann. NY Acad. Sci , vol.1095 , pp. 473-482
    • Kim, H.J.1    Lee, K.W.2    Lee, H.J.3
  • 111
    • 58949095218 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF kappaB
    • Kang, S.S.; Cuendet, M.; Endringer, D.C.; Croy, V.L.; Pezzuto, J.M.; Lipton, M.A. Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF kappaB. Bioorg. Med. Chem., 2009, 17, 1044-1054.
    • (2009) Bioorg. Med. Chem , vol.17 , pp. 1044-1054
    • Kang, S.S.1    Cuendet, M.2    Endringer, D.C.3    Croy, V.L.4    Pezzuto, J.M.5    Lipton, M.A.6
  • 112
    • 33845367887 scopus 로고    scopus 로고
    • Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB
    • Heynekamp, J.J.; Weber, W.M.; Hunsaker, L.A.; Gonzales, A.M.; Orlando, R.A.; Deck, L.M.; Jagt, D.L. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. J. Med. Chem., 2006, 49, 7182-7189.
    • (2006) J. Med. Chem , vol.49 , pp. 7182-7189
    • Heynekamp, J.J.1    Weber, W.M.2    Hunsaker, L.A.3    Gonzales, A.M.4    Orlando, R.A.5    Deck, L.M.6    Jagt, D.L.7
  • 113
    • 77952882393 scopus 로고    scopus 로고
    • Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells
    • Chao, J.; Li, H.; Cheng, K.W.; Yu, M.S.; Chang, R.C.; Wang, M. Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J. Nutr. Biochem., 2010, 21, 482-489.
    • (2010) J. Nutr. Biochem , vol.21 , pp. 482-489
    • Chao, J.1    Li, H.2    Cheng, K.W.3    Yu, M.S.4    Chang, R.C.5    Wang, M.6
  • 116
    • 33847060910 scopus 로고    scopus 로고
    • Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging
    • Yang, S.R.; Wright, J.; Bauter, M.; Seweryniak, K.; Kode, A.; Rahman, I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am. J. Physiol. Lung Cell. Mol. Physiol., 2007, 292, L567-L576.
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.292 , pp. 567-576
    • Yang, S.R.1    Wright, J.2    Bauter, M.3    Seweryniak, K.4    Kode, A.5    Rahman, I.6
  • 119
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses beta-amyloid production by activating the alpha secretase gene ADAM10
    • Donmez, G.; Wang, D.; Cohen, D.E.; Guarente, L. SIRT1 suppresses beta-amyloid production by activating the alpha secretase gene ADAM10. Cell, 2010, 142, 320-332.
    • (2010) Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 120
    • 77953421120 scopus 로고    scopus 로고
    • The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology
    • Wang, J.; Fivecoat, H.; Ho, L.; Pan, Y.; Ling, E.; Pasinetti, G.M. The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology. Biochim. Biophys. Acta, 2010, 1804, 1690-1694.
    • (2010) Biochim. Biophys. Acta , vol.1804 , pp. 1690-1694
    • Wang, J.1    Fivecoat, H.2    Ho, L.3    Pan, Y.4    Ling, E.5    Pasinetti, G.M.6
  • 121
    • 28844474597 scopus 로고    scopus 로고
    • SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    • Chen, J.; Zhou, Y.; Mueller-Steiner, S.; Chen, L.F.; Kwon, H.; Yi, S.; Mucke, L.; Gan, L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J. Biol. Chem., 2005, 280, 40364-40374.
    • (2005) J. Biol. Chem , vol.280 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3    Chen, L.F.4    Kwon, H.5    Yi, S.6    Mucke, L.7    Gan, L.8
  • 125
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1alpha: A key regulator of energy metabolism
    • Liang, H.; Ward, W.F. PGC-1alpha: a key regulator of energy metabolism. Adv. Physiol. Educ., 2006, 30, 145-151.
    • (2006) Adv. Physiol. Educ , vol.30 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 128
    • 33845942205 scopus 로고    scopus 로고
    • Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
    • Okawara, M.; Katsuki, H.; Kurimoto, E.; Shibata, H.; Kume, T.; Akaike, A. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem. Pharmacol., 2007, 73, 550-560.
    • (2007) Biochem. Pharmacol , vol.73 , pp. 550-560
    • Okawara, M.1    Katsuki, H.2    Kurimoto, E.3    Shibata, H.4    Kume, T.5    Akaike, A.6
  • 129
    • 33749042331 scopus 로고    scopus 로고
    • Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    • Cui, L.; Jeong, H.; Borovecki, F.; Parkhurst, C.N.; Tanese, N.; Krainc, D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell, 2006, 127, 59-69.
    • (2006) Cell , vol.127 , pp. 59-69
    • Cui, L.1    Jeong, H.2    Borovecki, F.3    Parkhurst, C.N.4    Tanese, N.5    Krainc, D.6
  • 130
    • 77955660387 scopus 로고    scopus 로고
    • Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease
    • Ho, D.J.; Calingasan, N.Y.; Wille, E.; Dumont, M.; Beal, M.F. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Exp. Neurol., 2010, 225, 74-84.
    • (2010) Exp. Neurol , vol.225 , pp. 74-84
    • Ho, D.J.1    Calingasan, N.Y.2    Wille, E.3    Dumont, M.4    Beal, M.F.5
  • 132
    • 40849135481 scopus 로고    scopus 로고
    • The Sirtuin family: Therapeutic targets to treat diseases of aging
    • Milne, J.C.; Denu, J.M. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol., 2008, 12, 11-17.
    • (2008) Curr. Opin. Chem. Biol , vol.12 , pp. 11-17
    • Milne, J.C.1    Denu, J.M.2
  • 135
    • 20444444649 scopus 로고    scopus 로고
    • Mechanism of human SIRT1 activation by resveratrol
    • Borra, M.T.; Smith, B.C.; Denu, J.M. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem., 2005, 280, 17187-17195.
    • (2005) J. Biol. Chem , vol.280 , pp. 17187-17195
    • Borra, M.T.1    Smith, B.C.2    Denu, J.M.3
  • 139
    • 34248146970 scopus 로고    scopus 로고
    • Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat
    • Mokni, M.; Elkahoui, S.; Limam, F.; Amri, M.; Aouani, E. Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat. Neurochem. Res., 2007, 32, 981-987.
    • (2007) Neurochem. Res , vol.32 , pp. 981-987
    • Mokni, M.1    Elkahoui, S.2    Limam, F.3    Amri, M.4    Aouani, E.5


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