Identification of the amino acid sequence motif of α-synuclein responsible for macrophage activation

Biochemical and Biophysical Research Communications

Volumn 381, Issue 1, 2009, Pages 39-43

  Lee, Saet byul ^a   Park, Sang Myun ^b   Ahn, Keun Jae ^a   Chung, Kwang Chul ^c   Paik, Seung R ^d   Kim, Jongsun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Yonsei University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Inflammation; Macrophage; Parkinson's disease; Synuclein; TNF

Indexed keywords

ALPHA SYNUCLEIN; BETA SYNUCLEIN; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE 2; GAMMA SYNUCLEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN SECRETION; RNA TRANSCRIPTION;

ALPHA-SYNUCLEIN; AMINO ACID MOTIFS; ANIMALS; CELL LINE; DNA MUTATIONAL ANALYSIS; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE DELETION;

EID: 61649109455     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.02.002     Document Type: Article

References (26)

1. Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A., Kondo J., Ihara Y., and Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 90 (1993) 11282-11286
2. Lavedan C. The synuclein family. Genome Res. 8 (1998) 871-880
3. Kahle P.J., Haass C., Kretzschmar H.A., and Neumann M. Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases. J. Neurochem. 82 (2002) 449-457
4. Jakes R., Spillantini M.G., and Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 345 (1994) 27-32
5. Maroteaux L., Campanelli J.T., and Scheller R.H. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8 (1988) 2804-2815
6. Ji H., Liu Y.E., Jia T., Wang M., Liu J., Xiao G., Joseph B.K., Rosen C., and Shi Y.E. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res. 57 (1997) 759-764
7. Surguchov A., Surgucheva I., Solessio E., and Baehr W. Synoretin-a new protein belonging to the synuclein family. Mol. Cell. Neurosci. 13 (1999) 95-103
8. Borghi R., Marchese R., Negro A., Marinelli L., Forloni G., Zaccheo D., Abbruzzese G., and Tabaton M. Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neurosci. Lett. 287 (2000) 65-67
9. El-Agnaf O.M., Salem S.A., Paleologou K.E., Cooper L.J., Fullwood N.J., Gibson M.J., Curran M.D., Court J.A., Mann D.M., Ikeda S., Cookson M.R., Hardy J., and Allsop D. Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, Including human plasma. FASEB J. 17 (2003) 1945-1947
10. El-Agnaf O.M., Salem S.A., Paleologou K.E., Curran M.D., Gibson M.J., Court J.A., Schlossmacher M.G., and Allsop D. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J. 20 (2006) 419-425
11. Mukaetova-Ladinska E.B., Milne J., Andras A., Abdel-All Z., Cerejeira J., Greally E., Robson J., Jaros E., Perry R., McKeith I.G., Brayne C., Xuereb J., Cleghorn A., Doherty J., McIntosh G., and Milton I. Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Dement. Geriatr. Cogn. Disord. 26 (2008) 32-42
12. Lee H.J., Patel S., and Lee S.J. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J. Neurosci. 25 (2005) 6016-6024
13. Zhang W., Wang T., Pei Z., Miller D.S., Wu X., Block M.L., Wilson B., Zhou Y., Hong J.S., and Zhang J. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 19 (2005) 533-542
14. Klegeris A., Giasson B.I., Zhang H., Maguire J., Pelech S., and McGeer P.L. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. FASEB J. 20 (2006) 2000-2008
15. Klegeris A., Pelech S., Giasson B.I., Maguire J., Zhang H., McGeer E.G., and McGeer P.L. alpha-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiol. Aging 29 (2008) 739-752
16. Su X., Maguire-Zeiss K.A., Giuliano R., Prifti L., Venkatesh K., and Federoff H.J. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol. Aging 29 (2008) 1690-1701
17. Park J.Y., Paik S.R., Jou I., and Park S.M. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease. Glia 56 (2008) 1215-1223
18. Ahn K.J., Paik S.R., Chung K.C., and Kim J. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. J. Neurochem. 97 (2006) 265-279
19. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J.T., Schols L., and Riess O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18 (1998) 106-108
20. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., and Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
21. Zarranz J.J., Alegre J., Gomez-Esteban J.C., Lezcano E., Ros R., Ampuero I., Vidal L., Hoenicka J., Rodriguez O., Atares B., Llorens V., Gomez Tortosa E., del Ser T., Munoz D.G., and de Yebenes J.G. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55 (2004) 164-173
22. Conway K.A., Harper J.D., and Lansbury P.T. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat. Med. 4 (1998) 1318-1320
23. Li J., Uversky V.N., and Fink A.L. Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, Aggregation, and fibrillation of human alpha-synuclein. Biochemistry 40 (2001) 11604-11613
24. Ostrerova-Golts N., Petrucelli L., Hardy J., Lee J.M., Farer M., and Wolozin B. The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. J. Neurosci. 20 (2000) 6048-6054
25. Dong C., Davis R.J., and Flavell R.A. MAP kinases in the immune response. Annu. Rev. Immunol. 20 (2002) 55-72
26. Park S.M., Ahn K.J., Jung H.Y., Park J.H., and Kim J. Effects of novel peptides derived from the acidic tail of synuclein (ATS) on the aggregation and stability of fusion proteins. Protein Eng. Des. Sel. 17 (2004) 251-260