Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3166-3174

  Jung, Jae Chul ^a   Lim, Eunyoung ^b   Lee, Yongnam ^b   Kang, Jun Mo ^a   Kim, Heejeong ^a   Jang, Soyong ^a   Oh, Seikwan ^a   Jung, Mankil ^b  

^a Kyung Hee University Hospital   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Free radical scavenging effects; LPS induced NO generation; Neuroprotective activity; trans Stilbene derivatives; Wittig Horner reaction

Indexed keywords

3,4 DIHYDROXY 4' (N ALLYLAMINOCARBONYL)STILBENE; 3,4 DIHYDROXY 4' [N (2 FLUOROBENZYL)AMINOCARBONYL]STILBENE; 3,4 DIHYDROXY 4' [N (FURAN 2 YLMETHYL)AMINOCARBONYL]STILBENE; FREE RADICAL; GLUTAMIC ACID; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; RESVERATROL; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; HORNER REACTION; IC 50; MICROGLIA; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHASE CONTRAST MICROSCOPY;

ANIMALS; CELL LINE; CEREBRAL CORTEX; DRUG DESIGN; FREE RADICAL SCAVENGERS; KINETICS; L-LACTATE DEHYDROGENASE; MICE; MICE, INBRED ICR; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; STEREOISOMERISM; STILBENES;

EID: 67349183313     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.011     Document Type: Article

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