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Volumn 11, Issue 9, 2011, Pages 799-809

Regulation of sphingosine kinase in hematological malignancies and other cancers

Author keywords

Cancer; Ceramide; Chronic myeloid leukemia; Hematological malignacy; Sphingosine; Sphingosine 1 phosphate; Sphingosine kinase

Indexed keywords

2 (4 HYDROXYANILINO) 4 (4 CHLOROPHENYL)THIAZOLE; 3 (4 CHLOROPHENYL)ADAMANTANE 1 CARBOXYLIC ACID (PYRIDIN 4 YLMETHYL)AMIDE; ABC 294640; ANTINEOPLASTIC AGENT; BORTEZOMIB; CAMPTOTHECIN; CELL SURFACE RECEPTOR; CERAMIDE; DACTINOMYCIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FINGOLIMOD; G PROTEIN COUPLED RECEPTOR; GEMCITABINE; IDRONOXIL; IMATINIB; N,N DIMETHYLSPHINGOSINE; RESVERATROL; SPHINGOSINE; SPHINGOSINE KINASE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 80054082629     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/187152011797655078     Document Type: Article
Times cited : (22)

References (178)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell, 2000, 100(1), 57-70.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 77953966511 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and cancer
    • Pyne, N.J.; Pyne, S. Sphingosine 1-phosphate and cancer. Nat. Rev. Cancer, 2010, 10(7), 489-503.
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.7 , pp. 489-503
    • Pyne, N.J.1    Pyne, S.2
  • 5
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Hannun, Y.A.; Obeid, L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol., 2008, 9(2), 139-150.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 7
    • 58149277751 scopus 로고    scopus 로고
    • Roles of bioactive sphingolipids in cancer biology and therapeutics
    • Saddoughi, S.A.; Song, P.; Ogretmen, B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem., 2008, 49, 413-440.
    • (2008) Subcell Biochem , vol.49 , pp. 413-440
    • Saddoughi, S.A.1    Song, P.2    Ogretmen, B.3
  • 8
    • 77954605766 scopus 로고    scopus 로고
    • Tumor necrosis factorinduced neutrophil adhesion occurs via sphingosine kinase-1- dependent activation of endothelial {alpha}5{beta}1 integrin
    • Sun, W.Y.; Pitson, S.M.; Bonder, C.S. Tumor necrosis factorinduced neutrophil adhesion occurs via sphingosine kinase-1- dependent activation of endothelial {alpha}5{beta}1 integrin. Am. J. Pathol., 2010, 177(1), 436-446.
    • (2010) Am. J. Pathol , vol.177 , Issue.1 , pp. 436-446
    • Sun, W.Y.1    Pitson, S.M.2    Bonder, C.S.3
  • 11
    • 2442561611 scopus 로고    scopus 로고
    • Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration
    • Allende, M.L.; Dreier, J.L.; Mandala, S.; Proia, R.L. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem., 2004, 279(15), 15396-15401.
    • (2004) J. Biol. Chem , vol.279 , Issue.15 , pp. 15396-15401
    • Allende, M.L.1    Dreier, J.L.2    Mandala, S.3    Proia, R.L.4
  • 12
    • 43049171400 scopus 로고    scopus 로고
    • Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions
    • Oskeritzian, C.A.; Alvarez, S.E.; Hait, N.C.; Price, M.M.; Milstien, S.; Spiegel, S. Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. Blood, 2008, 111(8), 4193-4200.
    • (2008) Blood , vol.111 , Issue.8 , pp. 4193-4200
    • Oskeritzian, C.A.1    Alvarez, S.E.2    Hait, N.C.3    Price, M.M.4    Milstien, S.5    Spiegel, S.6
  • 14
    • 42549148380 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages
    • Hughes, J.E.; Srinivasan, S.; Lynch, K.R.; Proia, R.L.; Ferdek, P.; Hedrick, C.C. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ. Res., 2008, 102(8), 950-958.
    • (2008) Circ. Res , vol.102 , Issue.8 , pp. 950-958
    • Hughes, J.E.1    Srinivasan, S.2    Lynch, K.R.3    Proia, R.L.4    Ferdek, P.5    Hedrick, C.C.6
  • 15
    • 0141920626 scopus 로고    scopus 로고
    • Transduction of multiple effects of sphingosine 1- phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor
    • Dorsam, G.; Graeler, M.H.; Seroogy, C.; Kong, Y.; Voice, J.K.; Goetzl, E.J. Transduction of multiple effects of sphingosine 1- phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. J. Immunol., 2003, 171(7), 3500-3507.
    • (2003) J. Immunol , vol.171 , Issue.7 , pp. 3500-3507
    • Dorsam, G.1    Graeler, M.H.2    Seroogy, C.3    Kong, Y.4    Voice, J.K.5    Goetzl, E.J.6
  • 16
    • 79551614173 scopus 로고    scopus 로고
    • Regulation of sphingosine kinase and sphingolipid signaling
    • Pitson, S.M. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci., 2011, 36(2), 97-107.
    • (2011) Trends Biochem Sci , vol.36 , Issue.2 , pp. 97-107
    • Pitson, S.M.1
  • 17
    • 1542723736 scopus 로고    scopus 로고
    • The structural requirements for ceramide activation of serinethreonine protein phosphatases
    • Chalfant, C.E.; Szulc, Z.; Roddy, P.; Bielawska, A.; Hannun, Y.A. The structural requirements for ceramide activation of serinethreonine protein phosphatases. J Lipid Res., 2004, 45(3), 496-506.
    • (2004) J Lipid Res , vol.45 , Issue.3 , pp. 496-506
    • Chalfant, C.E.1    Szulc, Z.2    Roddy, P.3    Bielawska, A.4    Hannun, Y.A.5
  • 18
    • 0029003788 scopus 로고
    • PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
    • Muller, G.; Ayoub, M.; Storz, P.; Rennecke, J.; Fabbro, D.; Pfizenmaier, K. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. EMBO J., 1995, 14(9), 1961-1969.
    • (1995) EMBO J , vol.14 , Issue.9 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, D.5    Pfizenmaier, K.6
  • 21
    • 77953694599 scopus 로고    scopus 로고
    • Sphingosine and FTY720 directly bind prosurvival 14-3-3 proteins to regulate their function
    • Woodcock, J.M.; Ma, Y.; Coolen, C.; Pham, D.; Jones, C.; Lopez, A.F.; Pitson, S.M. Sphingosine and FTY720 directly bind prosurvival 14-3-3 proteins to regulate their function. Cell Signal, 2010, 22(9), 1291-1299.
    • (2010) Cell Signal , vol.22 , Issue.9 , pp. 1291-1299
    • Woodcock, J.M.1    Ma, Y.2    Coolen, C.3    Pham, D.4    Jones, C.5    Lopez, A.F.6    Pitson, S.M.7
  • 22
    • 0033792671 scopus 로고    scopus 로고
    • Effects of sphingosine and other sphingolipids on protein kinase C
    • Smith, E.R.; Merrill, A.H.; Obeid, L.M.; Hannun, Y.A. Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol., 2000, 312, 361-373.
    • (2000) Methods Enzymol , vol.312 , pp. 361-373
    • Smith, E.R.1    Merrill, A.H.2    Obeid, L.M.3    Hannun, Y.A.4
  • 23
    • 33747603712 scopus 로고    scopus 로고
    • Sphingosine and ceramide signalling in apoptosis
    • Woodcock, J. Sphingosine and ceramide signalling in apoptosis. IUBMB Life, 2006, 58(8), 462-466.
    • (2006) IUBMB Life , vol.58 , Issue.8 , pp. 462-466
    • Woodcock, J.1
  • 24
    • 77956259768 scopus 로고    scopus 로고
    • Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells
    • Habrukowich, C.; Han, D.K.; Le, A.; Rezaul, K.; Pan, W.; Ghosh, M.; Li, Z.; Dodge-Kafka, K.; Jiang, X.; Bittman, R.; Hla, T. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. J. Biol. Chem., 2010, 285(35), 26825-26831.
    • (2010) J. Biol. Chem , vol.285 , Issue.35 , pp. 26825-26831
    • Habrukowich, C.1    Han, D.K.2    Le, A.3    Rezaul, K.4    Pan, W.5    Ghosh, M.6    Li, Z.7    Dodge-Kafka, K.8    Jiang, X.9    Bittman, R.10    Hla, T.11
  • 26
    • 66349136253 scopus 로고    scopus 로고
    • Lysophospholipid receptors in vertebrate development, physiology, and pathology
    • Skoura, A.; Hla, T. Lysophospholipid receptors in vertebrate development, physiology, and pathology. J. Lipid Res., 2009, 50 Suppl, S293-298.
    • (2009) J. Lipid Res , vol.50 , Issue.SUPPL.
    • Skoura, A.1    Hla, T.2
  • 27
    • 66349124729 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: The Swiss army knife of sphingolipid signaling
    • Maceyka, M.; Milstien, S.; Spiegel, S. Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. J. Lipid Res., 2009, 50 Suppl, S272-276.
    • (2009) J. Lipid Res , vol.50 , Issue.SUPPL
    • Maceyka, M.1    Milstien2    Spiegel, S.3
  • 31
    • 77953680582 scopus 로고    scopus 로고
    • Inhibitors of the sphingosine kinase pathway as potential therapeutics
    • Pitman, M.R.; Pitson, S.M. Inhibitors of the sphingosine kinase pathway as potential therapeutics. Curr. Cancer Drug Targets, 2010, 10(4), 354-367.
    • (2010) Curr. Cancer Drug Targets , vol.10 , Issue.4 , pp. 354-367
    • Pitman, M.R.1    Pitson, S.M.2
  • 32
    • 33747588567 scopus 로고    scopus 로고
    • Cellular signalling by sphingosine kinase and sphingosine 1-phosphate
    • Leclercq, T.M.; Pitson, S.M. Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. IUBMB Life, 2006, 58(8), 467-472.
    • (2006) IUBMB Life , vol.58 , Issue.8 , pp. 467-472
    • Leclercq, T.M.1    Pitson, S.M.2
  • 33
    • 0034733556 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
    • Liu, H.; Sugiura, M.; Nava, V.E.; Edsall, L.C.; Kono, K.; Poulton, S.; Milstien, S.; Kohama, T.; Spiegel, S. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem., 2000, 275(26), 19513-19520.
    • (2000) J. Biol. Chem , vol.275 , Issue.26 , pp. 19513-19520
    • Liu, H.1    Sugiura, M.2    Nava, V.E.3    Edsall, L.C.4    Kono, K.5    Poulton, S.6    Milstien, S.7    Kohama, T.8    Spiegel, S.9
  • 34
  • 35
    • 0142215631 scopus 로고    scopus 로고
    • The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
    • Paugh, S.W.; Payne, S.G.; Barbour, S.E.; Milstien, S.; Spiegel, S. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett., 2003, 554(1-2), 189-193.
    • (2003) FEBS Lett , vol.554 , Issue.1-2 , pp. 189-193
    • Paugh, S.W.1    Payne, S.G.2    Barbour, S.E.3    Milstien, S.4    Spiegel, S.5
  • 37
  • 40
    • 68149124148 scopus 로고    scopus 로고
    • Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis
    • Lai, W.Q.; Irwan, A.W.; Goh, H.H.; Melendez, A.J.; McInnes, I.B.; Leung, B.P. Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis. J. Immunol., 2009, 183(3), 2097-2103.
    • (2009) J. Immunol , vol.183 , Issue.3 , pp. 2097-2103
    • Lai, W.Q.1    Irwan, A.W.2    Goh, H.H.3    Melendez, A.J.4    McInnes, I.B.5    Leung, B.P.6
  • 43
    • 0142091073 scopus 로고    scopus 로고
    • Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
    • Igarashi, N.; Okada, T.; Hayashi, S.; Fujita, T.; Jahangeer, S.; Nakamura, S. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J. Biol. Chem., 2003, 278(47), 46832-46839.
    • (2003) J. Biol. Chem , vol.278 , Issue.47 , pp. 46832-46839
    • Igarashi, N.1    Okada, T.2    Hayashi, S.3    Fujita, T.4    Jahangeer, S.5    Nakamura, S.6
  • 45
    • 56549085199 scopus 로고    scopus 로고
    • Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner
    • Hofmann, L.P.; Ren, S.; Schwalm, S.; Pfeilschifter, J.; Huwiler, A. Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Bio.l Chem., 2008, 389(11), 1399-1407.
    • (2008) Bio.l Chem , vol.389 , Issue.11 , pp. 1399-1407
    • Hofmann, L.P.1    Ren, S.2    Schwalm, S.3    Pfeilschifter, J.4    Huwiler, A.5
  • 47
    • 27744479194 scopus 로고    scopus 로고
    • Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis
    • Okada, T.; Ding, G.; Sonoda, H.; Kajimoto, T.; Haga, Y.; Khosrowbeygi, A.; Gao, S.; Miwa, N.; Jahangeer, S.; Nakamura, S. Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis. J. Biol. Chem., 2005, 280(43), 36318-36325.
    • (2005) J. Biol. Chem , vol.280 , Issue.43 , pp. 36318-36325
    • Okada, T.1    Ding, G.2    Sonoda, H.3    Kajimoto, T.4    Haga, Y.5    Khosrowbeygi, A.6    Gao, S.7    Miwa, N.8    Jahangeer, S.9    Nakamura, S.10
  • 48
    • 23844498431 scopus 로고    scopus 로고
    • Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
    • Van Brocklyn, J.R.; Jackson, C.A.; Pearl, D.K.; Kotur, M.S.; Snyder, P.J.; Prior, T.W. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J. Neuropathol. Exp. Neurol., 2005, 64(8), 695-705.
    • (2005) J. Neuropathol. Exp. Neurol , vol.64 , Issue.8 , pp. 695-705
    • van Brocklyn, J.R.1    Jackson, C.A.2    Pearl, D.K.3    Kotur, M.S.4    Snyder, P.J.5    Prior, T.W.6
  • 49
    • 67449098149 scopus 로고    scopus 로고
    • Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation
    • Nemoto, S.; Nakamura, M.; Osawa, Y.; Kono, S.; Itoh, Y.; Okano, Y.; Murate, T.; Hara, A.; Ueda, H.; Nozawa, Y.; Banno, Y. Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. J. Biol. Chem., 2009, 284(16), 10422-10432.
    • (2009) J. Biol. Chem , vol.284 , Issue.16 , pp. 10422-10432
    • Nemoto, S.1    Nakamura, M.2    Osawa, Y.3    Kono, S.4    Itoh, Y.5    Okano, Y.6    Murate, T.7    Hara, A.8    Ueda, H.9    Nozawa, Y.10    Banno, Y.11
  • 50
    • 35948936347 scopus 로고    scopus 로고
    • Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin
    • Sankala, H.M.; Hait, N.C.; Paugh, S.W.; Shida, D.; Lepine, S.; Elmore, L.W.; Dent, P.; Milstien, S.; Spiegel, S. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res., 2007, 67(21), 10466-10474.
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10466-10474
    • Sankala, H.M.1    Hait, N.C.2    Paugh, S.W.3    Shida, D.4    Lepine, S.5    Elmore, L.W.6    Dent, P.7    Milstien, S.8    Spiegel, S.9
  • 51
    • 62549143484 scopus 로고    scopus 로고
    • Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1- phosphate-mediated chemoresistance in A549 lung cancer cells
    • Schnitzer, S.E.; Weigert, A.; Zhou, J.; Brune, B. Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1- phosphate-mediated chemoresistance in A549 lung cancer cells. Mol. Cancer Res., 2009, 7(3), 393-401.
    • (2009) Mol Cancer Res , vol.7 , Issue.3 , pp. 393-401
    • Schnitzer, S.E.1    Weigert, A.2    Zhou, J.3    Brune, B.4
  • 53
    • 0033230364 scopus 로고    scopus 로고
    • Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
    • Olivera, A.; Kohama, T.; Edsall, L.; Nava, V.; Cuvillier, O.; Poulton, S.; Spiegel, S. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J. Cell Biol., 1999, 147(3), 545-558.
    • (1999) J. Cell Biol , vol.147 , Issue.3 , pp. 545-558
    • Olivera, A.1    Kohama, T.2    Edsall, L.3    Nava, V.4    Cuvillier, O.5    Poulton, S.6    Spiegel, S.7
  • 54
    • 0035089286 scopus 로고    scopus 로고
    • Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
    • Edsall, L.C.; Cuvillier, O.; Twitty, S.; Spiegel, S.; Milstien, S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J. Neurochem., 2001, 76(5), 1573-1584.
    • (2001) J. Neurochem , vol.76 , Issue.5 , pp. 1573-1584
    • Edsall, L.C.1    Cuvillier, O.2    Twitty, S.3    Spiegel, S.4    Milstien, S.5
  • 56
    • 73649132258 scopus 로고    scopus 로고
    • Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival
    • Gamble, J.R.; Sun, W.Y.; Li, X.; Hahn, C.N.; Pitson, S.M.; Vadas, M.A.; Bonder, C.S. Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. Am. J. Pathol., 2009, 175(5), 2217-2225.
    • (2009) Am. J. Pathol , vol.175 , Issue.5 , pp. 2217-2225
    • Gamble, J.R.1    Sun, W.Y.2    Li, X.3    Hahn, C.N.4    Pitson, S.M.5    Vadas, M.A.6    Bonder, C.S.7
  • 57
    • 0142056955 scopus 로고    scopus 로고
    • Sphingosine kinase transmits estrogen signaling in human breast cancer cells
    • Sukocheva, O.A.; Wang, L.; Albanese, N.; Pitson, S.M.; Vadas, M.A.; Xia, P. Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol. Endocrinol., 2003, 17(10), 2002-2012.
    • (2003) Mol. Endocrinol , vol.17 , Issue.10 , pp. 2002-2012
    • Sukocheva, O.A.1    Wang, L.2    Albanese, N.3    Pitson, S.M.4    Vadas, M.A.5    Xia, P.6
  • 58
    • 0036436697 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
    • Nava, V.E.; Hobson, J.P.; Murthy, S.; Milstien, S.; Spiegel, S. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp. Cell Res., 2002, 281(1), 115-127.
    • (2002) Exp. Cell Res , vol.281 , Issue.1 , pp. 115-127
    • Nava, V.E.1    Hobson, J.P.2    Murthy, S.3    Milstien, S.4    Spiegel, S.5
  • 65
    • 58149231552 scopus 로고    scopus 로고
    • Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival
    • Li, J.; Guan, H.Y.; Gong, L.Y.; Song, L.B.; Zhang, N.; Wu, J.; Yuan, J.; Zheng, Y.J.; Huang, Z.S.; Li, M. Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival. Clin. Cancer Res., 2008, 14(21), 6996-7003.
    • (2008) Clin. Cancer Res , vol.14 , Issue.21 , pp. 6996-7003
    • Li, J.1    Guan, H.Y.2    Gong, L.Y.3    Song, L.B.4    Zhang, N.5    Wu, J.6    Yuan, J.7    Zheng, Y.J.8    Huang, Z.S.9    Li, M.10
  • 68
    • 77956589444 scopus 로고    scopus 로고
    • Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy
    • Liu, G.; Zheng, H.; Zhang, Z.; Wu, Z.; Xiong, H.; Li, J.; Song, L. Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy. BMC Cancer, 2010, 10, 495.
    • (2010) BMC Cancer , vol.10 , pp. 495
    • Liu, G.1    Zheng, H.2    Zhang, Z.3    Wu, Z.4    Xiong, H.5    Li, J.6    Song, L.7
  • 71
    • 78149348826 scopus 로고    scopus 로고
    • High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptorpositive breast cancer patients
    • Watson, C.; Long, J.S.; Orange, C.; Tannahill, C.L.; Mallon, E.; McGlynn, L.M.; Pyne, S.; Pyne, N.J.; Edwards, J. High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptorpositive breast cancer patients. Am. J. Pathol., 2010, 177(5), 2205-2215.
    • (2010) Am. J. Pathol , vol.177 , Issue.5 , pp. 2205-2215
    • Watson, C.1    Long, J.S.2    Orange, C.3    Tannahill, C.L.4    Mallon, E.5    McGlynn, L.M.6    Pyne, S.7    Pyne, N.J.8    Edwards, J.9
  • 73
    • 78751544538 scopus 로고    scopus 로고
    • Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition
    • Sinha, U.K.; Schorn, V.J.; Hochstim, C.; Chinn, S.B.; Zhu, S.; Masood, R. Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head Neck, 2011, 33(2), 178-188.
    • (2011) Head Neck , vol.33 , Issue.2 , pp. 178-188
    • Sinha, U.K.1    Schorn, V.J.2    Hochstim, C.3    Chinn, S.B.4    Zhu, S.5    Masood, R.6
  • 75
    • 0025756765 scopus 로고
    • Cell membrane signaling as target in cancer therapy: Inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice
    • Endo, K.; Igarashi, Y.; Nisar, M.; Zhou, Q.H.; Hakomori, S. Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res., 1991, 51(6), 1613-1618.
    • (1991) Cancer Res , vol.51 , Issue.6 , pp. 1613-1618
    • Endo, K.1    Igarashi, Y.2    Nisar, M.3    Zhou, Q.H.4    Hakomori, S.5
  • 77
    • 79954625512 scopus 로고    scopus 로고
    • A phase I clinical trial of safingol in combination with Cisplatin in advanced solid tumors
    • Dickson, M.A.; Carvajal, R.D.; Merrill, A.H., Jr.; Gonen, M.; Cane, L.M.; Schwartz, G.K. A phase I clinical trial of safingol in combination with Cisplatin in advanced solid tumors. Clin. Cancer Res., 2011, 17(8), 2484-2492.
    • (2011) Clin. Cancer Res , vol.17 , Issue.8 , pp. 2484-2492
    • Dickson, M.A.1    Carvajal, R.D.2    Merrill Jr., A.H.3    Gonen, M.4    Cane, L.M.5    Schwartz, G.K.6
  • 79
    • 79953324725 scopus 로고    scopus 로고
    • Sphingosine kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-{kappa}B Pathway in Human Nonsmall Cell Lung Cancer
    • Song, L.; Xiong, H.; Li, M.; Liao, W.T.; Wang, L.; Wu, J. Sphingosine kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-{kappa}B Pathway in Human Nonsmall Cell Lung Cancer. Clin. Cancer Res., 2011.
    • (2011) Clin. Cancer Res
    • Song, L.1    Xiong, H.2    Li, M.3    Liao, W.T.4    Wang, L.5    Wu, J.6
  • 80
    • 78650407629 scopus 로고    scopus 로고
    • Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage
    • Huwiler, A.; Kotelevets, N.; Xin, C.; Pastukhov, O.; Pfeilschifter, J.; Zangemeister-Wittke, U. Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. Br. J. Pharmacol., 2011, 162(2), 532-543.
    • (2011) Br. J. Pharmacol , vol.162 , Issue.2 , pp. 532-543
    • Huwiler, A.1    Kotelevets, N.2    Xin, C.3    Pastukhov, O.4    Pfeilschifter, J.5    Zangemeister-Wittke, U.6
  • 81
    • 70349333252 scopus 로고    scopus 로고
    • Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
    • Sukocheva, O.; Wang, L.; Verrier, E.; Vadas, M.A.; Xia, P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology, 2009, 150(10), 4484-4492.
    • (2009) Endocrinology , vol.150 , Issue.10 , pp. 4484-4492
    • Sukocheva, O.1    Wang, L.2    Verrier, E.3    Vadas, M.A.4    Xia, P.5
  • 83
    • 0033517823 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces angiogenesis: Its angiogenic action and signaling mechanism in human umbilical vein endothelial cells
    • Lee, O.H.; Kim, Y.M.; Lee, Y.M.; Moon, E.J.; Lee, D.J.; Kim, J.H.; Kim, K.W.; Kwon, Y.G. Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun., 1999, 264(3), 743-750.
    • (1999) Biochem. Biophys. Res. Commun , vol.264 , Issue.3 , pp. 743-750
    • Lee, O.H.1    Kim, Y.M.2    Lee, Y.M.3    Moon, E.J.4    Lee, D.J.5    Kim, J.H.6    Kim, K.W.7    Kwon, Y.G.8
  • 84
    • 77955801617 scopus 로고    scopus 로고
    • Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis
    • Anelli, V.; Gault, C.R.; Snider, A.J.; Obeid, L.M. Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J., 2010, 24(8), 2727-2738.
    • (2010) In Vitro. FASEB J , vol.24 , Issue.8 , pp. 2727-2738
    • Anelli, V.1    Gault, C.R.2    Snider, A.J.3    Obeid, L.M.4
  • 86
    • 77955769300 scopus 로고    scopus 로고
    • Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis
    • Tengood, J.E.; Kovach, K.M.; Vescovi, P.E.; Russell, A.J.; Little, S.R. Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. Biomaterials, 2010, 31(30), 7805-7812.
    • (2010) Biomaterials , vol.31 , Issue.30 , pp. 7805-7812
    • Tengood, J.E.1    Kovach, K.M.2    Vescovi, P.E.3    Russell, A.J.4    Little, S.R.5
  • 88
    • 70249125866 scopus 로고    scopus 로고
    • Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype
    • Weigert, A.; Schiffmann, S.; Sekar, D.; Ley, S.; Menrad, H.; Werno, C.; Grosch, S.; Geisslinger, G.; Brune, B. Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. Int. J. Cancer, 2009, 125(9), 2114-2121.
    • (2009) Int. J. Cancer , vol.125 , Issue.9 , pp. 2114-2121
    • Weigert, A.1    Schiffmann, S.2    Sekar, D.3    Ley, S.4    Menrad, H.5    Werno, C.6    Grosch, S.7    Geisslinger, G.8    Brune, B.9
  • 90
    • 77951085269 scopus 로고    scopus 로고
    • A novel sphingosine kinase inhibitor induces autophagy in tumor cells
    • Beljanski, V.; Knaak, C.; Smith, C.D. A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J. Pharmacol. Exp Ther., 2010, 333(2), 454-464.
    • (2010) J. Pharmacol. Exp Ther , vol.333 , Issue.2 , pp. 454-464
    • Beljanski, V.1    Knaak, C.2    Smith, C.D.3
  • 91
    • 84861642085 scopus 로고    scopus 로고
    • Combined anticancer effects of sphingosine kinase inhibitors and sorafenib
    • Beljanski, V.; Knaak, C.; Zhuang, Y.; Smith, C.D. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest. New Drugs, 2010.
    • (2010) Invest. New Drugs
    • Beljanski, V.1    Knaak, C.2    Zhuang, Y.3    Smith, C.D.4
  • 92
    • 77957770455 scopus 로고    scopus 로고
    • Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase
    • Chumanevich, A.A.; Poudyal, D.; Cui, X.; Davis, T.; Wood, P.A.; Smith, C.D.; Hofseth, L.J. Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis, 2010, 31(10), 1787-1793.
    • (2010) Carcinogenesis , vol.31 , Issue.10 , pp. 1787-1793
    • Chumanevich, A.A.1    Poudyal, D.2    Cui, X.3    Davis, T.4    Wood, P.A.5    Smith, C.D.6    Hofseth, L.J.7
  • 94
    • 79952343738 scopus 로고    scopus 로고
    • Antitumor activity of Sphingosine Kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts
    • Beljanski, V.; Lewis, C.S.; Smith, C.D. Antitumor activity of Sphingosine Kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biol. Ther., 2011, 11(5).
    • (2011) Cancer Biol. Ther , vol.11 , Issue.5
    • Beljanski, V.1    Lewis, C.S.2    Smith, C.D.3
  • 95
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • Deininger, M.W.; Goldman, J.M.; Melo, J.V. The molecular biology of chronic myeloid leukemia. Blood, 2000, 96(10), 3343-3356.
    • (2000) Blood , vol.96 , Issue.10 , pp. 3343-3356
    • Deininger, M.W.1    Goldman, J.M.2    Melo, J.V.3
  • 96
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo, T.G.; Pendergast, A.M.; Muller, A.J.; Witte, O.N. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science, 1990, 247(4946), 1079-1082.
    • (1990) Science , vol.247 , Issue.4946 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 98
    • 37149032222 scopus 로고    scopus 로고
    • Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells
    • Li, Q.F.; Huang, W.R.; Duan, H.F.; Wang, H.; Wu, C.T.; Wang, L.S. Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells. Oncogene, 2007, 26(57), 7904-7908.
    • (2007) Oncogene , vol.26 , Issue.57 , pp. 7904-7908
    • Li, Q.F.1    Huang, W.R.2    Duan, H.F.3    Wang, H.4    Wu, C.T.5    Wang, L.S.6
  • 99
    • 43749123266 scopus 로고    scopus 로고
    • Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells
    • Bonhoure, E.; Lauret, A.; Barnes, D.J.; Martin, C.; Malavaud, B.; Kohama, T.; Melo, J.V.; Cuvillier, O. Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. Leukemia, 2008, 22(5), 971-979.
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 971-979
    • Bonhoure, E.1    Lauret, A.2    Barnes, D.J.3    Martin, C.4    Malavaud, B.5    Kohama, T.6    Melo, J.V.7    Cuvillier, O.8
  • 101
    • 78651337547 scopus 로고    scopus 로고
    • Seeking the causes and solutions to imatinibresistance in chronic myeloid leukemia
    • Bixby, D.; Talpaz, M. Seeking the causes and solutions to imatinibresistance in chronic myeloid leukemia. Leukemia, 2011, 25(1), 7-22.
    • (2011) Leukemia , vol.25 , Issue.1 , pp. 7-22
    • Bixby, D.1    Talpaz, M.2
  • 102
    • 34249737950 scopus 로고    scopus 로고
    • Alterations of ceramide/sphingosine 1- phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
    • Baran, Y.; Salas, A.; Senkal, C.E.; Gunduz, U.; Bielawski, J.; Obeid, L.M.; Ogretmen, B. Alterations of ceramide/sphingosine 1- phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J. Biol. Chem., 2007, 282(15), 10922-10934.
    • (2007) J. Biol. Chem , vol.282 , Issue.15 , pp. 10922-10934
    • Baran, Y.1    Salas, A.2    Senkal, C.E.3    Gunduz, U.4    Bielawski, J.5    Obeid, L.M.6    Ogretmen, B.7
  • 104
    • 70450193142 scopus 로고    scopus 로고
    • Imatinib and beyond--exploring the full potential of targeted therapy for CML
    • Quintas-Cardama, A.; Kantarjian, H.; Cortes, J. Imatinib and beyond--exploring the full potential of targeted therapy for CML. Nat. Rev. Clin. Oncol., 2009, 6(9), 535-543.
    • (2009) Clin. Oncol , vol.6 , Issue.9 , pp. 535-543
    • Quintas-Cardama, A.1    Kantarjian, H.2    Cortes, J.3
  • 105
    • 33644974376 scopus 로고    scopus 로고
    • Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
    • Bonhoure, E.; Pchejetski, D.; Aouali, N.; Morjani, H.; Levade, T.; Kohama, T.; Cuvillier, O. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia, 2006, 20(1), 95-102.
    • (2006) Leukemia , vol.20 , Issue.1 , pp. 95-102
    • Bonhoure, E.1    Pchejetski, D.2    Aouali, N.3    Morjani, H.4    Levade, T.5    Kohama, T.6    Cuvillier, O.7
  • 108
    • 46749153415 scopus 로고    scopus 로고
    • Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions
    • Bayerl, M.G.; Bruggeman, R.D.; Conroy, E.J.; Hengst, J.A.; King, T.S.; Jimenez, M.; Claxton, D.F.; Yun, J.K. Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions. Leuk. Lymphoma, 2008, 49(5), 948-954.
    • (2008) Leuk. Lymphoma , vol.49 , Issue.5 , pp. 948-954
    • Bayerl, M.G.1    Bruggeman, R.D.2    Conroy, E.J.3    Hengst, J.A.4    King, T.S.5    Jimenez, M.6    Claxton, D.F.7    Yun, J.K.8
  • 109
    • 34547647448 scopus 로고    scopus 로고
    • Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis
    • Li, Q.F.; Wu, C.T.; Duan, H.F.; Sun, H.Y.; Wang, H.; Lu, Z.Z.; Zhang, Q.W.; Liu, H.J.; Wang, L.S. Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis. Br. J. Haematol., 2007, 138(5), 632-639.
    • (2007) Br. J. Haematol , vol.138 , Issue.5 , pp. 632-639
    • Li, Q.F.1    Wu, C.T.2    Duan, H.F.3    Sun, H.Y.4    Wang, H.5    Lu, Z.Z.6    Zhang, Q.W.7    Liu, H.J.8    Wang, L.S.9
  • 110
    • 77957737922 scopus 로고    scopus 로고
    • Prokineticin-1/endocrine glandderived vascular endothelial growth factor is a survival factor for human multiple myeloma cells
    • Li, Q.F.; Zhu, H.Y.; Yang, Y.F.; Liu, J.; Xiao, F.J.; Zhang, Q.W.; Wu, C.T.; Wang, H.; Wang, L.S. Prokineticin-1/endocrine glandderived vascular endothelial growth factor is a survival factor for human multiple myeloma cells. Leuk. Lymphoma, 2010, 51(10), 1902-1912.
    • (2010) Leuk. Lymphoma , vol.51 , Issue.10 , pp. 1902-1912
    • Li, Q.F.1    Zhu, H.Y.2    Yang, Y.F.3    Liu, J.4    Xiao, F.J.5    Zhang, Q.W.6    Wu, C.T.7    Wang, H.8    Wang, L.S.9
  • 111
    • 34547820916 scopus 로고    scopus 로고
    • Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration
    • Doll, F.; Pfeilschifter, J.; Huwiler, A. Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration. Endocr Relat Cancer, 2007, 14(2), 325-335.
    • (2007) Endocr Relat Cancer , vol.14 , Issue.2 , pp. 325-335
    • Doll, F.1    Pfeilschifter, J.2    Huwiler, A.3
  • 112
    • 31044450344 scopus 로고    scopus 로고
    • The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7
    • Doll, F.; Pfeilschifter, J.; Huwiler, A. The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7. Biochim. Biophys. Acta, 2005, 1738(1-3), 72-81.
    • (2005) Biophys. Acta , vol.1738 , Issue.1-3 , pp. 72-81
    • Doll, F.1    Pfeilschifter, J.2    Huwiler, A.3
  • 113
    • 0035839128 scopus 로고    scopus 로고
    • Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor
    • Kleuser, B.; Maceyka, M.; Milstien, S.; Spiegel, S. Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor. FEBS Lett., 2001, 503(1), 85-90.
    • (2001) FEBS Lett , vol.503 , Issue.1 , pp. 85-90
    • Kleuser, B.1    Maceyka, M.2    Milstien, S.3    Spiegel, S.4
  • 114
    • 28244481494 scopus 로고    scopus 로고
    • Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12
    • Sobue, S.; Hagiwara, K.; Banno, Y.; Tamiya-Koizumi, K.; Suzuki, M.; Takagi, A.; Kojima, T.; Asano, H.; Nozawa, Y.; Murate, T. Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. J. Neurochem., 2005, 95(4), 940-949.
    • (2005) J. Neurochem , vol.95 , Issue.4 , pp. 940-949
    • Sobue, S.1    Hagiwara, K.2    Banno, Y.3    Tamiya-Koizumi, K.4    Suzuki, M.5    Takagi, A.6    Kojima, T.7    Asano, H.8    Nozawa, Y.9    Murate, T.10
  • 116
    • 33646157725 scopus 로고    scopus 로고
    • Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism
    • Huwiler, A.; Doll, F.; Ren, S.; Klawitter, S.; Greening, A.; Romer, I.; Bubnova, S.; Reinsberg, L.; Pfeilschifter, J. Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. Biochim. Biophys. Acta, 2006, 1761(3), 367-376.
    • (2006) Biochim. Biophys. Acta , vol.1761 , Issue.3 , pp. 367-376
    • Huwiler, A.1    Doll, F.2    Ren, S.3    Klawitter, S.4    Greening, A.5    Romer, I.6    Bubnova, S.7    Reinsberg, L.8    Pfeilschifter, J.9
  • 117
    • 33846878942 scopus 로고    scopus 로고
    • Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity
    • Klawitter, S.; Hofmann, L.P.; Pfeilschifter, J.; Huwiler, A. Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Br. J. Pharmacol., 2007, 150(3), 271-280.
    • (2007) Br. J. Pharmacol , vol.150 , Issue.3 , pp. 271-280
    • Klawitter, S.1    Hofmann, L.P.2    Pfeilschifter, J.3    Huwiler, A.4
  • 119
    • 0035542735 scopus 로고    scopus 로고
    • 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate
    • Manggau, M.; Kim, D.S.; Ruwisch, L.; Vogler, R.; Korting, H.C.; Schafer-Korting, M.; Kleuser, B. 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J. Invest. Dermatol., 2001, 117(5), 1241-1249.
    • (2001) J. Invest. Dermatol , vol.117 , Issue.5 , pp. 1241-1249
    • Manggau, M.1    Kim, D.S.2    Ruwisch, L.3    Vogler, R.4    Korting, H.C.5    Schafer-Korting, M.6    Kleuser, B.7
  • 120
    • 0030592536 scopus 로고    scopus 로고
    • Protein kinase Cdependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity
    • Buehrer, B.M.; Bardes, E.S.; Bell, R.M. Protein kinase Cdependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity. Biochim. Biophys. Acta, 1996, 1303(3), 233-242.
    • (1996) Biochim. Biophys. Acta , vol.1303 , Issue.3 , pp. 233-242
    • Buehrer, B.M.1    Bardes, E.S.2    Bell, R.M.3
  • 123
    • 40049096040 scopus 로고    scopus 로고
    • Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells
    • Schwalm, S.; Doll, F.; Romer, I.; Bubnova, S.; Pfeilschifter, J.; Huwiler, A. Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochem. Biophys. Res. Commun., 2008, 368(4), 1020-1025.
    • (2008) Biochem. Biophys. Res. Commun , vol.368 , Issue.4 , pp. 1020-1025
    • Schwalm, S.1    Doll, F.2    Romer, I.3    Bubnova, S.4    Pfeilschifter, J.5    Huwiler, A.6
  • 124
    • 33746396117 scopus 로고    scopus 로고
    • The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells
    • Ahmad, M.; Long, J.S.; Pyne, N.J.; Pyne, S. The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. Prostaglandins Other Lipid Mediat., 2006, 79(3-4), 278-286.
    • (2006) Prostaglandins Other Lipid Mediat , vol.79 , Issue.3-4 , pp. 278-286
    • Ahmad, M.1    Long, J.S.2    Pyne, N.J.3    Pyne, S.4
  • 125
    • 41249103991 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2
    • Anelli, V.; Gault, C.R.; Cheng, A.B.; Obeid, L.M. Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J. Biol. Chem., 2008, 283(6), 3365-3375.
    • (2008) J. Biol. Chem , vol.283 , Issue.6 , pp. 3365-3375
    • Anelli, V.1    Gault, C.R.2    Cheng, A.B.3    Obeid, L.M.4
  • 127
    • 77955295887 scopus 로고    scopus 로고
    • Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells
    • Long, J.S.; Edwards, J.; Watson, C.; Tovey, S.; Mair, K.M.; Schiff, R.; Natarajan, V.; Pyne, N.J.; Pyne, S. Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. Mol. Cell Biol., 2010, 30(15), 3827-3841.
    • (2010) Mol. Cell Biol , vol.30 , Issue.15 , pp. 3827-3841
    • Long, J.S.1    Edwards, J.2    Watson, C.3    Tovey, S.4    Mair, K.M.5    Schiff, R.6    Natarajan, V.7    Pyne, N.J.8    Pyne, S.9
  • 128
    • 53649091866 scopus 로고    scopus 로고
    • V-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: Alteration of AU-rich element-binding proteins
    • Sobue, S.; Murakami, M.; Banno, Y.; Ito, H.; Kimura, A.; Gao, S.; Furuhata, A.; Takagi, A.; Kojima, T.; Suzuki, M.; Nozawa, Y.; Murate, T. v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins. Oncogene, 2008, 27(46), 6023-6033.
    • (2008) Oncogene , vol.27 , Issue.46 , pp. 6023-6033
    • Sobue, S.1    Murakami, M.2    Banno, Y.3    Ito, H.4    Kimura, A.5    Gao, S.6    Furuhata, A.7    Takagi, A.8    Kojima, T.9    Suzuki, M.10    Nozawa, Y.11    Murate, T.12
  • 129
    • 79551468923 scopus 로고    scopus 로고
    • Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl(+) cells sensitive and resistant to STI571 through down-regulation Mcl-1
    • Li, Q.F.; Yan, J.; Zhang, K.; Yang, Y.F.; Xiao, F.J.; Wu, C.T.; Wang, H.; Wang, L.S. Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl(+) cells sensitive and resistant to STI571 through down-regulation Mcl-1. Biochem. Biophys. Res. Commun., 2011, 405(1), 31-36.
    • (2011) Biochem. Biophys. Res. Commun , vol.405 , Issue.1 , pp. 31-36
    • Li, Q.F.1    Yan, J.2    Zhang, K.3    Yang, Y.F.4    Xiao, F.J.5    Wu, C.T.6    Wang, H.7    Wang, L.S.8
  • 130
    • 78751642725 scopus 로고    scopus 로고
    • The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60: Acute myeloid leukemia cells
    • Cakir, Z.; Saydam, G.; Sahin, F.; Baran, Y. The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60: acute myeloid leukemia cells. J. Cancer Res. Clin. Oncol., 2010.
    • (2010) J. Cancer Res. Clin. Oncol
    • Cakir, Z.1    Saydam, G.2    Sahin, F.3    Baran, Y.4
  • 131
    • 77957831195 scopus 로고    scopus 로고
    • The sphingosine kinase- 1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer
    • Brizuela, L.; Dayon, A.; Doumerc, N.; Ader, I.; Golzio, M.; Izard, J.C.; Hara, Y.; Malavaud, B.; Cuvillier, O. The sphingosine kinase- 1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer. FASEB J., 2010, 24(10), 3882-3894.
    • (2010) FASEB J , vol.24 , Issue.10 , pp. 3882-3894
    • Brizuela, L.1    Dayon, A.2    Doumerc, N.3    Ader, I.4    Golzio, M.5    Izard, J.C.6    Hara, Y.7    Malavaud, B.8    Cuvillier, O.9
  • 134
    • 20444506408 scopus 로고    scopus 로고
    • Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism
    • Taha, T.A.; Kitatani, K.; Bielawski, J.; Cho, W.; Hannun, Y.A.; Obeid, L.M. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J. Biol. Chem., 2005, 280(17), 17196-17202.
    • (2005) J. Biol. Chem , vol.280 , Issue.17 , pp. 17196-17202
    • Taha, T.A.1    Kitatani, K.2    Bielawski, J.3    Cho, W.4    Hannun, Y.A.5    Obeid, L.M.6
  • 135
    • 33750509678 scopus 로고    scopus 로고
    • Sphingosine kinase-1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease
    • Taha, T.A.; El-Alwani, M.; Hannun, Y.A.; Obeid, L.M. Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease. FEBS Lett., 2006, 580(26), 6047-6054.
    • (2006) FEBS Lett , vol.580 , Issue.26 , pp. 6047-6054
    • Taha, T.A.1    El-Alwani, M.2    Hannun, Y.A.3    Obeid, L.M.4
  • 136
    • 78649876185 scopus 로고    scopus 로고
    • The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)- 4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells
    • Loveridge, C.; Tonelli, F.; Leclercq, T.; Lim, K.G.; Long, J.S.; Berdyshev, E.; Tate, R.J.; Natarajan, V.; Pitson, S.M.; Pyne, N.J.; Pyne, S. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)- 4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J. Biol. Chem., 2010, 285(50), 38841-38852.
    • (2010) J. Biol. Chem , vol.285 , Issue.50 , pp. 38841-38852
    • Loveridge, C.1    Tonelli, F.2    Leclercq, T.3    Lim, K.G.4    Long, J.S.5    Berdyshev, E.6    Tate, R.J.7    Natarajan, V.8    Pitson, S.M.9    Pyne, N.J.10    Pyne, S.11
  • 137
    • 77952907876 scopus 로고    scopus 로고
    • A novel mode of action of the putative sphingosine kinase inhibitor 2-(phydroxyanilino)- 4-(p-chlorophenyl) thiazole (SKI II): Induction of lysosomal sphingosine kinase 1 degradation
    • Ren, S.; Xin, C.; Pfeilschifter, J.; Huwiler, A. A novel mode of action of the putative sphingosine kinase inhibitor 2-(phydroxyanilino)- 4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cell Physiol. Biochem., 2010, 26(1), 97-104.
    • (2010) Cell Physiol. Biochem , vol.26 , Issue.1 , pp. 97-104
    • Ren, S.1    Xin, C.2    Pfeilschifter, J.3    Huwiler, A.4
  • 138
    • 77954535502 scopus 로고    scopus 로고
    • FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
    • Tonelli, F.; Lim, K.G.; Loveridge, C.; Long, J.; Pitson, S.M.; Tigyi, G.; Bittman, R.; Pyne, S.; Pyne, N.J. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal, 2010, 22(10), 1536-1542.
    • (2010) Cell Signal , vol.22 , Issue.10 , pp. 1536-1542
    • Tonelli, F.1    Lim, K.G.2    Loveridge, C.3    Long, J.4    Pitson, S.M.5    Tigyi, G.6    Bittman, R.7    Pyne, S.8    Pyne, N.J.9
  • 141
    • 0034721844 scopus 로고    scopus 로고
    • Expression of a catalytically inactive sphingosine kinase mutant blocks agonistinduced sphingosine kinase activation. A dominant-negative sphingosine kinase
    • Pitson, S.M.; Moretti, P.A.; Zebol, J.R.; Xia, P.; Gamble, J.R.; Vadas, M.A.; D'Andrea, R.J.; Wattenberg, B.W. Expression of a catalytically inactive sphingosine kinase mutant blocks agonistinduced sphingosine kinase activation. A dominant-negative sphingosine kinase. J. Biol. Chem., 2000, 275(43), 33945-33950.
    • (2000) J. Biol. Chem , vol.275 , Issue.43 , pp. 33945-33950
    • Pitson, S.M.1    Moretti, P.A.2    Zebol, J.R.3    Xia, P.4    Gamble, J.R.5    Vadas, M.A.6    D'Andrea, R.J.7    Wattenberg, B.W.8
  • 142
    • 33744807983 scopus 로고    scopus 로고
    • The sphingosine and diacylglycerol kinase superfamily of signaling kinases: Localization as a key to signaling function
    • Wattenberg, B.W.; Pitson, S.M.; Raben, D.M. The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. J. Lipid Res., 2006, 47(6), 1128-1139.
    • (2006) J. Lipid Res , vol.47 , Issue.6 , pp. 1128-1139
    • Wattenberg, B.W.1    Pitson, S.M.2    Raben, D.M.3
  • 144
    • 12344272084 scopus 로고    scopus 로고
    • Phosphorylationdependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
    • Pitson, S.M.; Xia, P.; Leclercq, T.M.; Moretti, P.A.; Zebol, J.R.; Lynn, H.E.; Wattenberg, B.W.; Vadas, M.A. Phosphorylationdependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. J. Exp. Med., 2005, 201(1), 49-54.
    • (2005) J. Exp. Med , vol.201 , Issue.1 , pp. 49-54
    • Pitson, S.M.1    Xia, P.2    Leclercq, T.M.3    Moretti, P.A.4    Zebol, J.R.5    Lynn, H.E.6    Wattenberg, B.W.7    Vadas, M.A.8
  • 145
    • 73649108890 scopus 로고    scopus 로고
    • Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium - and integrin-binding protein 1
    • Jarman, K.E.; Moretti, P.A.; Zebol, J.R.; Pitson, S.M. Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. J. Biol. Chem., 2010, 285(1), 483-492.
    • (2010) J. Biol. Chem , vol.285 , Issue.1 , pp. 483-492
    • Jarman, K.E.1    Moretti, P.A.2    Zebol, J.R.3    Pitson, S.M.4
  • 148
    • 51349102583 scopus 로고    scopus 로고
    • Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration
    • Maceyka, M.; Alvarez, S.E.; Milstien, S.; Spiegel, S. Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol. Cell Biol., 2008, 28(18), 5687-5697.
    • (2008) Mol. Cell Biol , vol.28 , Issue.18 , pp. 5687-5697
    • Maceyka, M.1    Alvarez, S.E.2    Milstien, S.3    Spiegel, S.4
  • 149
    • 58049199390 scopus 로고    scopus 로고
    • Deactivation of sphingosine kinase 1 by protein phosphatase 2A
    • Barr, R.K.; Lynn, H.E.; Moretti, P.A.; Khew-Goodall, Y.; Pitson, S.M. Deactivation of sphingosine kinase 1 by protein phosphatase 2A. J. Biol. Chem., 2008, 283(50), 34994-35002.
    • (2008) J. Biol. Chem , vol.283 , Issue.50 , pp. 34994-35002
    • Barr, R.K.1    Lynn, H.E.2    Moretti, P.A.3    Khew-Goodall, Y.4    Pitson, S.M.5
  • 150
    • 79751529038 scopus 로고    scopus 로고
    • A critical role for the protein phosphatase 2A B'alpha regulatory subunit in dephosphorylation of sphingosine kinase 1
    • Pitman, M.R.; Barr, R.K.; Gliddon, B.L.; Magarey, A.M.; Moretti, P.A.; Pitson, S.M. A critical role for the protein phosphatase 2A B'alpha regulatory subunit in dephosphorylation of sphingosine kinase 1. Int. J. Biochem. Cell Biol., 2011, 43(3), 342-347.
    • (2011) Int. J. Biochem. Cell Biol , vol.43 , Issue.3 , pp. 342-347
    • Pitman, M.R.1    Barr, R.K.2    Gliddon, B.L.3    Magarey, A.M.4    Moretti, P.A.5    Pitson, S.M.6
  • 151
    • 43049121301 scopus 로고    scopus 로고
    • A tumor suppressor role for PP2AB56alpha through negative regulation of c-Myc and other key oncoproteins
    • Arnold, H.K.; Sears, R.C. A tumor suppressor role for PP2AB56alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev., 2008, 27(2), 147-158.
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.2 , pp. 147-158
    • Arnold, H.K.1    Sears, R.C.2
  • 152
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • Kim, E.K.; Choi, E.J. Pathological roles of MAPK signaling pathways in human diseases. Biochim. Biophys. Acta, 2010, 1802(4), 396-405.
    • (2010) Biochim. Biophys. Acta , vol.1802 , Issue.4 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 153
    • 34250787073 scopus 로고    scopus 로고
    • Ras as a therapeutic target in hematologic malignancies
    • Alvarado, Y.; Giles, F.J. Ras as a therapeutic target in hematologic malignancies. Expert Opin. Emerg. Drugs, 2007, 12(2), 271-284.
    • (2007) Expert Opin. Emerg. Drugs , vol.12 , Issue.2 , pp. 271-284
    • Alvarado, Y.1    Giles, F.J.2
  • 154
    • 0037052338 scopus 로고    scopus 로고
    • Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells
    • Melendez, A.J.; Khaw, A.K. Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem., 2002, 277(19), 17255-17262.
    • (2002) J. Biol. Chem , vol.277 , Issue.19 , pp. 17255-17262
    • Melendez, A.J.1    Khaw, A.K.2
  • 155
    • 3242720378 scopus 로고    scopus 로고
    • Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells
    • Duan, H.F.; Wu, C.T.; Lu, Y.; Wang, H.; Liu, H.J.; Zhang, Q.W.; Jia, X.X.; Lu, Z.Z.; Wang, L.S. Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. Exp. Cell Res., 2004, 298(2), 593-601.
    • (2004) Exp. Cell Res , vol.298 , Issue.2 , pp. 593-601
    • Duan, H.F.1    Wu, C.T.2    Lu, Y.3    Wang, H.4    Liu, H.J.5    Zhang, Q.W.6    Jia, X.X.7    Lu, Z.Z.8    Wang, L.S.9
  • 156
    • 0029964454 scopus 로고    scopus 로고
    • Effect of acidic phospholipids on sphingosine kinase
    • Olivera, A.; Rosenthal, J.; Spiegel, S. Effect of acidic phospholipids on sphingosine kinase. J. Cell Biochem., 1996, 60(4), 529-537.
    • (1996) J. Cell Biochem , vol.60 , Issue.4 , pp. 529-537
    • Olivera, A.1    Rosenthal, J.2    Spiegel, S.3
  • 157
    • 0034283195 scopus 로고    scopus 로고
    • Human sphingosine kinase: Purification, molecular cloning and characterization of the native and recombinant enzymes
    • Pitson, S.M.; D'Andrea R, J.; Vandeleur, L.; Moretti, P.A.; Xia, P.; Gamble, J.R.; Vadas, M.A.; Wattenberg, B.W. Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. Biochem. J., 2000, 350 Pt 2, 429-441.
    • (2000) Biochem. J , vol.350 , Issue.Pt 2 , pp. 429-441
    • Pitson, S.M.1    D'Andrea, R.2    Vandeleur, L.3    Moretti, P.A.4    Xia, P.5    Gamble, J.R.6    Vadas, M.A.7    Wattenberg, B.W.8
  • 160
    • 44349185584 scopus 로고    scopus 로고
    • Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity
    • Leclercq, T.M.; Moretti, P.A.; Vadas, M.A.; Pitson, S.M. Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. J Biol Chem, 2008, 283(15), 9606-9614.
    • (2008) J Biol Chem , vol.283 , Issue.15 , pp. 9606-9614
    • Leclercq, T.M.1    Moretti, P.A.2    Vadas, M.A.3    Pitson, S.M.4
  • 161
    • 0347318051 scopus 로고    scopus 로고
    • Translation factors: In sickness and in health
    • Abbott, C.M.; Proud, C.G. Translation factors: in sickness and in health. Trends Biochem. Sci., 2004, 29(1), 25-31.
    • (2004) Trends Biochem. Sci , vol.29 , Issue.1 , pp. 25-31
    • Abbott, C.M.1    Proud, C.G.2
  • 162
    • 0036359281 scopus 로고    scopus 로고
    • Moonlighting functions of polypeptide elongation factor 1: From actin bundling to zinc finger protein R1-associated nuclear localization
    • Ejiri, S. Moonlighting functions of polypeptide elongation factor 1: from actin bundling to zinc finger protein R1-associated nuclear localization. Biosci. Biotechnol. Biochem., 2002, 66(1), 1-21.
    • (2002) Biosci. Biotechnol. Biochem , vol.66 , Issue.1 , pp. 1-21
    • Ejiri, S.1
  • 163
    • 4143091385 scopus 로고    scopus 로고
    • The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: Review article
    • Lamberti, A.; Caraglia, M.; Longo, O.; Marra, M.; Abbruzzese, A.; Arcari, P. The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article. Amino Acids, 2004, 26(4), 443-448.
    • (2004) Amino Acids , vol.26 , Issue.4 , pp. 443-448
    • Lamberti, A.1    Caraglia, M.2    Longo, O.3    Marra, M.4    Abbruzzese, A.5    Arcari, P.6
  • 164
    • 78751649728 scopus 로고    scopus 로고
    • Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis
    • Leclercq, T.M.; Moretti, P.A.; Pitson, S.M. Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. Oncogene, 2011, 30(3), 372-378.
    • (2011) Oncogene , vol.30 , Issue.3 , pp. 372-378
    • Leclercq, T.M.1    Moretti, P.A.2    Pitson, S.M.3
  • 165
    • 17844364503 scopus 로고    scopus 로고
    • Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: Response to cytokines
    • Mastrandrea, L.D.; Sessanna, S.M.; Laychock, S.G. Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. Diabetes, 2005, 54(5), 1429-1436.
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1429-1436
    • Mastrandrea, L.D.1    Sessanna, S.M.2    Laychock, S.G.3
  • 166
  • 167
    • 33646340969 scopus 로고    scopus 로고
    • IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses
    • Olivera, A.; Urtz, N.; Mizugishi, K.; Yamashita, Y.; Gilfillan, A.M.; Furumoto, Y.; Gu, H.; Proia, R.L.; Baumruker, T.; Rivera, J. IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J. Biol. Chem., 2006, 281(5), 2515-2525.
    • (2006) J. Biol. Chem , vol.281 , Issue.5 , pp. 2515-2525
    • Olivera, A.1    Urtz, N.2    Mizugishi, K.3    Yamashita, Y.4    Gilfillan, A.M.5    Furumoto, Y.6    Gu, H.7    Proia, R.L.8    Baumruker, T.9    Rivera, J.10
  • 168
    • 34249656324 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 activation by ERK-mediated phosphorylation
    • Hait, N.C.; Bellamy, A.; Milstien, S.; Kordula, T.; Spiegel, S. Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J. Biol. Chem., 2007, 282(16), 12058-12065.
    • (2007) J. Biol. Chem , vol.282 , Issue.16 , pp. 12058-12065
    • Hait, N.C.1    Bellamy, A.2    Milstien, S.3    Kordula, T.4    Spiegel, S.5
  • 170
    • 1242317094 scopus 로고    scopus 로고
    • Different roles of p38 MAPK and ERK in STI571-induced multi-lineage differentiation of K562 cells
    • Kohmura, K.; Miyakawa, Y.; Kawai, Y.; Ikeda, Y.; Kizaki, M. Different roles of p38 MAPK and ERK in STI571-induced multi-lineage differentiation of K562 cells. J. Cell Physiol., 2004, 198(3), 370-376.
    • (2004) J. Cell Physiol , vol.198 , Issue.3 , pp. 370-376
    • Kohmura, K.1    Miyakawa, Y.2    Kawai, Y.3    Ikeda, Y.4    Kizaki, M.5
  • 171
    • 3142677459 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells
    • Marley, S.B.; Lewis, J.L.; Schneider, H.; Rudd, C.E.; Gordon, M.Y. Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells. Br. J. Haematol., 2004, 125(4), 500-511.
    • (2004) Br. J. Haematol , vol.125 , Issue.4 , pp. 500-511
    • Marley, S.B.1    Lewis, J.L.2    Schneider, H.3    Rudd, C.E.4    Gordon, M.Y.5
  • 172
    • 68849103758 scopus 로고    scopus 로고
    • Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities
    • Issuree, P.D.; Pushparaj, P.N.; Pervaiz, S.; Melendez, A.J. Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities. FASEB J., 2009, 23(8), 2412-2424.
    • (2009) FASEB J , vol.23 , Issue.8 , pp. 2412-2424
    • Issuree, P.D.1    Pushparaj, P.N.2    Pervaiz, S.3    Melendez, A.J.4
  • 173
    • 33644847833 scopus 로고    scopus 로고
    • Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: Implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways
    • Kang, J.S.; Yoon, Y.D.; Han, M.H.; Han, S.B.; Lee, K.; Lee, K.H.; Park, S.K.; Kim, H.M. Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. Mol. Pharmacol., 2006, 69(3), 941-949.
    • (2006) Mol. Pharmacol , vol.69 , Issue.3 , pp. 941-949
    • Kang, J.S.1    Yoon, Y.D.2    Han, M.H.3    Han, S.B.4    Lee, K.5    Lee, K.H.6    Park, S.K.7    Kim, H.M.8
  • 174
    • 67649619170 scopus 로고    scopus 로고
    • Phenoxodiol: Pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs
    • Silasi, D.A.; Alvero, A.B.; Rutherford, T.J.; Brown, D.; Mor, G. Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs. Expert Opin. Pharmacother., 2009, 10(6), 1059-1067.
    • (2009) Expert Opin. Pharmacother , vol.10 , Issue.6 , pp. 1059-1067
    • Silasi, D.A.1    Alvero, A.B.2    Rutherford, T.J.3    Brown, D.4    Mor, G.5
  • 176
    • 33646426132 scopus 로고    scopus 로고
    • Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects
    • Gamble, J.R.; Xia, P.; Hahn, C.N.; Drew, J.J.; Drogemuller, C.J.; Brown, D.; Vadas, M.A. Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. Int. J. Cancer, 2006, 118(10), 2412-2420.
    • (2006) Int. J. Cancer , vol.118 , Issue.10 , pp. 2412-2420
    • Gamble, J.R.1    Xia, P.2    Hahn, C.N.3    Drew, J.J.4    Drogemuller, C.J.5    Brown, D.6    Vadas, M.A.7
  • 177
    • 33746068256 scopus 로고    scopus 로고
    • NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis
    • De Luca, T.; Morre, D.M.; Zhao, H.; Morre, D.J. NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. Biofactors, 2005, 25(1-4), 43-60.
    • (2005) Biofactors , vol.25 , Issue.1-4 , pp. 43-60
    • de Luca, T.1    Morre, D.M.2    Zhao, H.3    Morre, D.J.4
  • 178
    • 70249089391 scopus 로고    scopus 로고
    • Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol
    • De Luca, T.; Bosneaga, E.; Morre, D.M.; Morre, D.J. Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol. Biofactors, 2008, 34(3), 253-260.
    • (2008) Biofactors , vol.34 , Issue.3 , pp. 253-260
    • de Luca, T.1    Bosneaga, E.2    Morre, D.M.3    Morre, D.J.4


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