RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis

Journal of Neurochemistry

Volumn 102, Issue 5, 2007, Pages 1585-1594

  Murakami, Masashi ^a   Ichihara, Masatoshi ^a   Sobue, Sayaka ^a   Kikuchi, Ryosuke ^a   Ito, Hiromi ^a   Kimura, Ami ^a   Iwasaki, Takashi ^a   Takagi, Akira ^a   Kojima, Tetsuhito ^a   Takahashi, Masahide ^b   Suzuki, Motoshi ^c   Banno, Yoshiko ^d   Nozawa, Yoshinori ^e   Murate, Takashi ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d GIFU UNIVERSITY   (Japan)

^e GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

Author keywords

Cellular function; Gene expression; Glial cell line derived neurotrophic factor; Multiple endocrine neoplasia type 2; RET; SPHK1

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROMODULIN; PROTEIN RET; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL STRAIN 3T3; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NEURITE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; SIPPLE SYNDROME; TUMOR DIFFERENTIATION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MICE; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A; MUTATION; NEUROBLASTOMA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-RET; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 34547867758     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04673.x     Document Type: Article

References (36)

1. Akao Y., Banno Y., Nakagawa Y., Hasegawa N., Kim T. J., Murate T., Igarashi Y. Nozawa Y. (2006) High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptotecin-induced up-regulation. Biochem. Biophys. Res. Commun. 342, 1284 1290.
2. Bonhoure E., Pchejetski D., Aouali N., Morjani H., Levade T., Kohama T. Cuvillier O. (2006) Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia 20, 95 102.
3. Chen Z. Y., Chai Y. F., Cao L., Huang A. J., Cui R. Y., Lu C. L. He C. (2001) Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells. Neuroscience 104, 593 598.
4. Chiariello M., Visconti R., Carlomagno F. et al. (1998) Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene 16, 2435 2445.
5. Donati C. Bruni P. (2006) Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. Biochim. Biophys. Acta 1758, 2037 2048.
6. Edsall L. C. Spiegel S. (1999) Enzymatic measurement of sphingosine 1-phosphate. Anal. Biochem. 272, 80 86.
7. French K. J., Schrecengost R. S., Lee B. D., Zhuang Y., Smith S. N., Eberly J. L., Yun J. K. Smith C. D. (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63, 5962 5969.
8. Ichihara M., Murakumo Y. Takahashi M. (2004) RET and neuroendocrine tumors. Cancer Lett. 204, 197 211.
9. Iwashita T., Asai N., Murakami H., Matsuyama M. Takahashi M. (1996) Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation. Oncogene 12, 481 487.
10. Johnson K. R., Becker K. P., Facchinetti M. M., Hannun Y. A. Obeid L. M. (2002) PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J. Biol. Chem. 277, 35257 35262.
11. Kawamori T., Osta W., Johnson K. R. et al. (2006) Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 20, 386 388.
12. Koda M., Murate T., Wang S., Ohguchi K., Sobue S., Ikeda M., T-Koizumi K., Igarashi Y., Nozawa Y. Banno Y. (2005) Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granulocytic differentiation through the upregulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells. Biochim. Biophys. Acta 1733, 101 110.
13. Kodama Y., Murakumo Y., Ichihara M., Kawal K., Shimono Y. Takahashi M. (2004) Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region. Biochem. Biophys. Res. Commun. 320, 108 115.
14. Kohama T., Olivera A., Edsall L., Nagiec M. M., Dickson R. Spiegel S. (1998) Molecular cloning and functional characterization of murine sphingosine kinase. J. Biol. Chem. 273, 23722 23728.
15. Kohno M., Momoi M., Oo M. L. et al. (2006) Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol. Cell Biol. 26, 7211 7223.
16. Le Scolan E., Pchejetski D., Banno Y., Denis N., Mayeux P., Vainchenker W., Levade T. Moreau-Gachelin F. (2005) Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood 106, 1808 1816.
17. Morinaga T., Enomoto A., Shimono Y. et al. (2005) GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region. Nucleic Acids Res. 33, 4191 4201.
18. Murate T., Banno Y., T-Koizumi K. et al. (2001) Cell type-specific localization of sphingosine kinase 1a in human tissues. J. Histochem. Cytochem. 49, 845 855.
19. Nakade Y., Banno Y., T-Koizumi K. et al. (2003) Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1. Biochim. Biophys. Acta 1635, 104 116.
20. Nava V. E., Hobson J. P., Murthy S., Milstien S. Spiegel S. (2002) Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp. Cell Res. 281, 115 127.
21. Pezeshki G., Franke B. Engele J. (2003) GDNF elicits distinct immediate-early gene responses in cultured cortical and mesencephalic neurons. J. Neurosci. Res. 71, 478 484.
22. Pitson S. M., Xia P., Leclercg T. M., Moretti P. A., Zebol J. R., Lynn H. E., Wattenberg B. W. Vadas M. A. (2005) Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogeneic signalling. J. Exp. Med. 201, 49 54.
23. Riboni L., Prinetti A., Bassi R., Caminiti A. Tettamanti G. (1995) A mediator role of ceramide in the regulation of neuroblastoma Neuro2a cell differentiation. J. Biol. Chem. 270, 26868 26875.
24. Saini H. S., Coelho R. P., Goparaju S. K., Jolly P. S., Maceyka M., Spiegel S. Sato-Bigbee C. (2005) Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. J. Neurochem. 95, 1298 1310.
25. Schultz A. Larsson C. (2004) Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. J. Neurochem. 89, 1427 1435.
26. Shu X., Wu W., Mosteller R. D. Broek D. (2002) Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell Biol. 22, 7758 7768.
27. Sobue S., Hagiwara K., Banno Y., T-Koizumi K., Suzuki M., Takagi A., Kojima T., Asano H., Nozawa Y. Murate T. (2005) Transcription factor specificity proein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. J. Neurochem. 95, 940 949.
28. Sobue S., Iwasaki T., Sugisaki C. et al. (2006) Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes. Leukemia 20, 2042 2046.
29. Taha T. A., Hannun Y. A. Obeid L. M. (2006) Sphingosine kinase: biochemical and cellular regulation and role in disease. J. Biochem. Mol. Biol. 39, 113 131.
30. Takahashi M. (2001) The GDNF/RET signaling pathway and human diseases. Cytokine Growth Factor Rev. 12, 361 373.
31. Takahashi M., Ritz J. Cooper G. M. (1985) Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 42, 581 588.
32. Toman R. E., Payne S. G., Watterson K. R., Maceyka M., Lee N. H., Milstien S., Bigbee J. W. Siegel S. (2004) Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. J. Cell Biol. 166, 381 392.
33. Treanor J. J., Goodman L., de Sauvage F. et al. (1996) Characterization of a multicomponent receptor for GDNF. Nature 382, 80 83.
34. Van Hooff C. O., Holthuis J. C., Oestreicher A. B., Boonstra J., De Graan P. N. Gispen W. H. (1989) Nerve growth factor-induced changes in the intracellular localization of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells. J. Cell Biol. 108, 1115 1125.
35. Van Weering D. H. Bos J. L. (1998) Signal transduction by the receptor tyrosine kinase Ret. Recent Results Cancer Res. 154, 271 281.
36. Worby C. A., Vega Q. C., Zhao Y., Chao H. H-J., Seasholtz A. F. Dixon J. E. (1996) Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J. Biol. Chem. 271, 23619 23622.