-
1
-
-
0034120178
-
Fty720 immunosup-pression impairs effector t cell peripheral homing without affecting induction, expansion, and memory
-
Pinschewer DD, Ochsenbein AF, Odermatt B, Brinkmann V, Hengartner H, Zinkernagel RM: Fty720 immunosup-pression impairs effector t cell peripheral homing without affecting induction, expansion, and memory. J Immunol 2000;164:5761-5770.
-
(2000)
J Immunol
, vol.164
, pp. 5761-5770
-
-
Pinschewer, D.D.1
Ochsenbein, A.F.2
Odermatt, B.3
Brinkmann, V.4
Hengartner, H.5
Zinkernagel, R.M.6
-
2
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C, Rosenbach M, Hale J, Lynch CL, Rupprecht K, Parsons W, Rosen H: Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002;296:346-349.
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
Thornton, R.7
Shei, G.J.8
Card, D.9
Keohane, C.10
Rosenbach, M.11
Hale, J.12
Lynch, C.L.13
Rupprecht, K.14
Parsons, W.15
Rosen, H.16
-
3
-
-
0037077308
-
The immune modulator fty720 targets sphin-gosine 1-phosphate receptors
-
Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR: The immune modulator fty720 targets sphin-gosine 1-phosphate receptors. J Biol Chem 2002;277:21453-21457.
-
(2002)
J Biol Chem
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
Zollinger, M.12
Lynch, K.R.13
-
4
-
-
2442679391
-
The immunosup-pressant fty720 down-regulates sphingo-sine 1-phosphate g-protein-coupled receptors
-
Gräler MH, Goetzl EJ: The immunosup-pressant fty720 down-regulates sphingo-sine 1-phosphate g-protein-coupled receptors. Faseb J 2004;18:551-553.
-
(2004)
Faseb J
, vol.18
, pp. 551-553
-
-
Gräler, M.H.1
Goetzl, E.J.2
-
5
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lym-phoid organs is dependent on s1p receptor 1
-
Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG: Lymphocyte egress from thymus and peripheral lym-phoid organs is dependent on s1p receptor 1. Nature 2004;427:355-360.
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
Lo, C.G.2
Cinamon, G.3
Lesneski, M.J.4
Xu, Y.5
Brinkmann, V.6
Allende, M.L.7
Proia, R.L.8
Cyster, J.G.9
-
6
-
-
2442561611
-
Expression of the sphingosine 1-phosphate receptor, s1p1, on t-cells controls thymic emigration
-
Allende ML, Dreier JL, Mandala S, Proia RL: Expression of the sphingosine 1-phosphate receptor, s1p1, on t-cells controls thymic emigration. J Biol Chem 2004;279:15396-15401.
-
(2004)
J Biol Chem
, vol.279
, pp. 15396-15401
-
-
Allende, M.L.1
Dreier, J.L.2
Mandala, S.3
Proia, R.L.4
-
7
-
-
34247379074
-
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
-
Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR: Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 2007;316:295-298.
-
(2007)
Science
, vol.316
, pp. 295-298
-
-
Pappu, R.1
Schwab, S.R.2
Cornelissen, I.3
Pereira, J.P.4
Regard, J.B.5
Xu, Y.6
Camerer, E.7
Zheng, Y.W.8
Huang, Y.9
Cyster, J.G.10
Coughlin, S.R.11
-
8
-
-
28544437478
-
Essential role for sphingosine kinases in neural and vascular development
-
Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL: Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 2005;25:11113-11121.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 11113-11121
-
-
Mizugishi, K.1
Yamashita, T.2
Olivera, A.3
Miller, G.F.4
Spiegel, S.5
Proia, R.L.6
-
9
-
-
41449112571
-
Vascular en-dothelium as a contributor of plasma sphingosine 1-phosphate
-
Venkataraman K, Lee YM, Michaud J, Thangada S, Ai Y, Bonkovsky HL, Parikh NS, Habrukowich C, Hla T: Vascular en-dothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res 2008;102:669-676.
-
(2008)
Circ Res
, vol.102
, pp. 669-676
-
-
Venkataraman, K.1
Lee, Y.M.2
Michaud, J.3
Thangada, S.4
Ai, Y.5
Bonkovsky, H.L.6
Parikh, N.S.7
Habrukowich, C.8
Hla, T.9
-
10
-
-
33947634013
-
Eryth-rocytes store and release sphingosine 1-phosphate in blood
-
Hänel P, Andréani P, Gräler MH: Eryth-rocytes store and release sphingosine 1-phosphate in blood. Faseb J 2007;21:1202-1209.
-
(2007)
Faseb J
, vol.21
, pp. 1202-1209
-
-
Hänel, P.1
Andréani, P.2
Gräler, M.H.3
-
11
-
-
62449300643
-
Accumulation of fingolimod (fty720) in lym-phoid tissues contributes to prolonged efficacy
-
Sensken SC, Bode C, Gräler MH: Accumulation of fingolimod (fty720) in lym-phoid tissues contributes to prolonged efficacy. J Pharmacol Exp Ther 2009;328:963-969.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 963-969
-
-
Sensken, S.C.1
Bode, C.2
Gräler, M.H.3
-
12
-
-
28244456527
-
Sphingosine-1-phos-phate agonists increase macrophage homing, lymphocyte contacts, and en-dothelial junctional complex formation in murine lymph nodes
-
Singer, II, Tian M, Wickham LA, Lin J, Matheravidathu SS, Forrest MJ, Mandala S, Quackenbush EJ: Sphingosine-1-phos-phate agonists increase macrophage homing, lymphocyte contacts, and en-dothelial junctional complex formation in murine lymph nodes. J Immunol 2005;175:7151-7161.
-
(2005)
J Immunol
, vol.175
, pp. 7151-7161
-
-
Singer, I.I.1
Tian, M.2
Wickham, L.A.3
Lin, J.4
Matheravidathu, S.S.5
Forrest, M.J.6
Mandala, S.7
Quackenbush, E.J.8
-
13
-
-
30044441314
-
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary t cells to lymphatic sinuses
-
Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD: Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary t cells to lymphatic sinuses. Nat Immunol 2005;6:1228-1235.
-
(2005)
Nat Immunol
, vol.6
, pp. 1228-1235
-
-
Wei, S.H.1
Rosen, H.2
Matheu, M.P.3
Sanna, M.G.4
Wang, S.K.5
Jo, E.6
Wong, C.H.7
Parker, I.8
Cahalan, M.D.9
-
14
-
-
33746365908
-
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral s1p1 antagonist in vivo
-
Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H: Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral s1p1 antagonist in vivo. Nat Chem Biol 2006;2:434-441.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 434-441
-
-
Sanna, M.G.1
Wang, S.K.2
Gonzalez-Cabrera, P.J.3
Don, A.4
Marsolais, D.5
Matheu, M.P.6
Wei, S.H.7
Parker, I.8
Jo, E.9
Cheng, W.C.10
Cahalan, M.D.11
Wong, C.H.12
Rosen, H.13
-
15
-
-
68849122050
-
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
-
Camerer E, Regard JB, Cornelissen I, Srinivasan Y, Duong DN, Palmer D, Pham TH, Wong JS, Pappu R, Coughlin SR: Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 2009;119:1871-1879.
-
(2009)
J Clin Invest
, vol.119
, pp. 1871-1879
-
-
Camerer, E.1
Regard, J.B.2
Cornelissen, I.3
Srinivasan, Y.4
Duong, D.N.5
Palmer, D.6
Pham, T.H.7
Wong, J.S.8
Pappu, R.9
Coughlin, S.R.10
-
16
-
-
33845296479
-
Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists
-
Foss FW, Jr., Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TL: Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem 2007;15:663-677.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 663-677
-
-
Foss FW, Jr.1
Snyder, A.H.2
Davis, M.D.3
Rouse, M.4
Okusa, M.D.5
Lynch, K.R.6
MacDonald, T.L.7
-
17
-
-
70350399322
-
Production and characterization of monoclonal anti-sphingosine-1- phosphate antibodies
-
O'Brien N, Jones ST, Williams DG, Cunningham HB, Moreno K, Visentin B, Gentile A, Vekich J, Shestowsky W, Hiraiwa M, Matteo R, Cavalli A, Grotjahn D, Grant M, Hansen G, Campbell MA, Sabbadini R: Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res 2009;50:2245-2257.
-
(2009)
J Lipid Res
, vol.50
, pp. 2245-2257
-
-
O'Brien, N.1
Jones, S.T.2
Williams, D.G.3
Cunningham, H.B.4
Moreno, K.5
Visentin, B.6
Gentile, A.7
Vekich, J.8
Shestowsky, W.9
Hiraiwa, M.10
Matteo, R.11
Cavalli, A.12
Grotjahn, D.13
Grant, M.14
Hansen, G.15
Campbell, M.A.16
Sabbadini, R.17
-
18
-
-
33750456153
-
Targeting sphingosine-1-phosphate for cancer therapy
-
Sabbadini RA: Targeting sphingosine-1-phosphate for cancer therapy. Br J Cancer 2006;95:1131-1135.
-
(2006)
Br J Cancer
, vol.95
, pp. 1131-1135
-
-
Sabbadini, R.A.1
-
19
-
-
40749087537
-
Plasma sphingosine 1-phos-phate metabolism and analysis
-
Yatomi Y: Plasma sphingosine 1-phos-phate metabolism and analysis. Biochim Biophys Acta 2008;1780:606-611.
-
(2008)
Biochim Biophys Acta
, vol.1780
, pp. 606-611
-
-
Yatomi, Y.1
-
20
-
-
37349013401
-
Follicular shuttling of marginal zone b cells facilitates antigen transport
-
Cinamon G, Zachariah MA, Lam OM, Foss FW, Jr., Cyster JG: Follicular shuttling of marginal zone b cells facilitates antigen transport. Nat Immunol 2008;9:54-62.
-
(2008)
Nat Immunol
, vol.9
, pp. 54-62
-
-
Cinamon, G.1
Zachariah, M.A.2
Lam, O.M.3
Foss FW, Jr.4
Cyster, J.G.5
-
21
-
-
3242796768
-
Sphingosine 1-phosphate receptor 1 promotes b cell localization in the splenic marginal zone
-
Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG: Sphingosine 1-phosphate receptor 1 promotes b cell localization in the splenic marginal zone. Nat Immunol 2004;5:713-720.
-
(2004)
Nat Immunol
, vol.5
, pp. 713-720
-
-
Cinamon, G.1
Matloubian, M.2
Lesneski, M.J.3
Xu, Y.4
Low, C.5
Lu, T.6
Proia, R.L.7
Cyster, J.G.8
-
22
-
-
65549089187
-
Thymic progenitor homing and lymphocyte homeostasis are linked via s1p-control-led expression of thymic p-selectin/ccl25
-
Gossens K, Naus S, Corbel SY, Lin S, Rossi FM, Kast J, Ziltener HJ: Thymic progenitor homing and lymphocyte homeostasis are linked via s1p-control-led expression of thymic p-selectin/ccl25. J Exp Med 2009;206:761-778.
-
(2009)
J Exp Med
, vol.206
, pp. 761-778
-
-
Gossens, K.1
Naus, S.2
Corbel, S.Y.3
Lin, S.4
Rossi, F.M.5
Kast, J.6
Ziltener, H.J.7
-
23
-
-
67649185215
-
The receptor s1p1 overrides regulatory t cell-mediated immune suppression through akt-mtor
-
Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H: The receptor s1p1 overrides regulatory t cell-mediated immune suppression through akt-mtor. Nat Immunol 2009;10:769-777.
-
(2009)
Nat Immunol
, vol.10
, pp. 769-777
-
-
Liu, G.1
Burns, S.2
Huang, G.3
Boyd, K.4
Proia, R.L.5
Flavell, R.A.6
Chi, H.7
-
24
-
-
24644469502
-
Lymphocyte sequestration through s1p lyase inhibition and disruption of s1p gradients
-
Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG: Lymphocyte sequestration through s1p lyase inhibition and disruption of s1p gradients. Science 2005;309:1735-1739.
-
(2005)
Science
, vol.309
, pp. 1735-1739
-
-
Schwab, S.R.1
Pereira, J.P.2
Matloubian, M.3
Xu, Y.4
Huang, Y.5
Cyster, J.G.6
-
25
-
-
13244270031
-
Cyclical modulation of sphingosine-1-phos-phate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit
-
Lo CG, Xu Y, Proia RL, Cyster JG: Cyclical modulation of sphingosine-1-phos-phate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med 2005;201:291-301.
-
(2005)
J Exp Med
, vol.201
, pp. 291-301
-
-
Lo, C.G.1
Xu, Y.2
Proia, R.L.3
Cyster, J.G.4
-
26
-
-
58149474166
-
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lym-phoid lesions
-
Vogel P, Donoviel MS, Read R, Hansen GM, Hazlewood J, Anderson SJ, Sun W, Swaffield J, Oravecz T: Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lym-phoid lesions. PLoS One 2009;4:e4112.
-
(2009)
PLoS One
, vol.4
-
-
Vogel, P.1
Donoviel, M.S.2
Read, R.3
Hansen, G.M.4
Hazlewood, J.5
Anderson, S.J.6
Sun, W.7
Swaffield, J.8
Oravecz, T.9
-
27
-
-
70449700288
-
Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice
-
Weber C, Krueger A, Münk A, Bode C, Van Veldhoven PP, Gräler MH: Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice. J Immunol 2009;183:4292-4301.
-
(2009)
J Immunol
, vol.183
, pp. 4292-4301
-
-
Weber, C.1
Krueger, A.2
Münk, A.3
Bode, C.4
Van Veldhoven, P.P.5
Gräler, M.H.6
-
28
-
-
76449120437
-
Phase ii study of oral fingolimod (fty720) in multiple sclerosis: 3-year results
-
Comi G, O'Connor P, Montalban X, Antel J, Radue EW, Karlsson G, Pohlmann H, Aradhye S, Kappos L: Phase ii study of oral fingolimod (fty720) in multiple sclerosis: 3-year results. Mult Scler 2010;16:197-207.
-
(2010)
Mult Scler
, vol.16
, pp. 197-207
-
-
Comi, G.1
O'Connor, P.2
Montalban, X.3
Antel, J.4
Radue, E.W.5
Karlsson, G.6
Pohlmann, H.7
Aradhye, S.8
Kappos, L.9
-
29
-
-
54449099880
-
Fty720 therapy exerts differential effects on t cell subsets in multiple sclerosis
-
Mehling M, Brinkmann V, Antel J, Bar-Or A, Goebels N, Vedrine C, Kristofic C, Kuhle J, Lindberg RL, Kappos L: Fty720 therapy exerts differential effects on t cell subsets in multiple sclerosis. Neurology 2008;71:1261-1267.
-
(2008)
Neurology
, vol.71
, pp. 1261-1267
-
-
Mehling, M.1
Brinkmann, V.2
Antel, J.3
Bar-Or, A.4
Goebels, N.5
Vedrine, C.6
Kristofic, C.7
Kuhle, J.8
Lindberg, R.L.9
Kappos, L.10
-
30
-
-
70849086174
-
Fty720 (fingolimod) in multiple sclerosis: Therapeutic effects in the immune and the central nervous system
-
Brinkmann V: Fty720 (fingolimod) in multiple sclerosis: Therapeutic effects in the immune and the central nervous system. Br J Pharmacol 2009;158:1173-1182.
-
(2009)
Br J Pharmacol
, vol.158
, pp. 1173-1182
-
-
Brinkmann, V.1
-
31
-
-
33846021925
-
Essential roles of sphingosine 1-phosphate/s1p1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury
-
Kimura A, Ohmori T, Ohkawa R, Madoiwa S, Mimuro J, Murakami T, Kobayashi E, Hoshino Y, Yatomi Y, Sakata Y: Essential roles of sphingosine 1-phosphate/s1p1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells 2007;25:115-124.
-
(2007)
Stem Cells
, vol.25
, pp. 115-124
-
-
Kimura, A.1
Ohmori, T.2
Ohkawa, R.3
Madoiwa, S.4
Mimuro, J.5
Murakami, T.6
Kobayashi, E.7
Hoshino, Y.8
Yatomi, Y.9
Sakata, Y.10
-
32
-
-
13844271705
-
Edg8/s1p5: An oligodendroglial receptor with dual function on process retraction and cell survival
-
Jaillard C, Harrison S, Stankoff B, Aigrot MS, Calver AR, Duddy G, Walsh FS, Pangalos MN, Arimura N, Kaibuchi K, Zalc B, Lubetzki C: Edg8/s1p5: An oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci 2005;25:1459-1469.
-
(2005)
J Neurosci
, vol.25
, pp. 1459-1469
-
-
Jaillard, C.1
Harrison, S.2
Stankoff, B.3
Aigrot, M.S.4
Calver, A.R.5
Duddy, G.6
Walsh, F.S.7
Pangalos, M.N.8
Arimura, N.9
Kaibuchi, K.10
Zalc, B.11
Lubetzki, C.12
-
33
-
-
0142241216
-
Common signaling pathways link activation of murine par-1, lpa, and s1p receptors to proliferation of astrocytes
-
Sorensen SD, Nicole O, Peavy RD, Montoya LM, Lee CJ, Murphy TJ, Traynelis SF, Hepler JR: Common signaling pathways link activation of murine par-1, lpa, and s1p receptors to proliferation of astrocytes. Mol Pharmacol 2003;64:1199-1209.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1199-1209
-
-
Sorensen, S.D.1
Nicole, O.2
Peavy, R.D.3
Montoya, L.M.4
Lee, C.J.5
Murphy, T.J.6
Traynelis, S.F.7
Hepler, J.R.8
-
34
-
-
48049096529
-
Sphingosine kinase 1/s1p receptor signaling axis controls glial proliferation in mice with sandhoff disease
-
Wu YP, Mizugishi K, Bektas M, Sandhoff R, Proia RL: Sphingosine kinase 1/s1p receptor signaling axis controls glial proliferation in mice with sandhoff disease. Hum Mol Genet 2008;17:2257-2264.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2257-2264
-
-
Wu, Y.P.1
Mizugishi, K.2
Bektas, M.3
Sandhoff, R.4
Proia, R.L.5
-
35
-
-
11144353922
-
Sphingosine 1-phosphate (s1p) receptor subtypes s1p1 and s1p3, respectively, regulate lymphocyte recirculation and heart rate
-
Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, Rosen H: Sphingosine 1-phosphate (s1p) receptor subtypes s1p1 and s1p3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 2004;279:13839-13848.
-
(2004)
J Biol Chem
, vol.279
, pp. 13839-13848
-
-
Sanna, M.G.1
Liao, J.2
Jo, E.3
Alfonso, C.4
Ahn, M.Y.5
Peterson, M.S.6
Webb, B.7
Lefebvre, S.8
Chun, J.9
Gray, N.10
Rosen, H.11
-
36
-
-
23844552403
-
Sphingosine-1-phos-phate mediates migration of mature dendritic cells
-
Czeloth N, Bernhardt G, Hofmann F, Genth H, Forster R: Sphingosine-1-phos-phate mediates migration of mature dendritic cells. J Immunol 2005;175:2960-2967.
-
(2005)
J Immunol
, vol.175
, pp. 2960-2967
-
-
Czeloth, N.1
Bernhardt, G.2
Hofmann, F.3
Genth, H.4
Forster, R.5
-
37
-
-
36248966560
-
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phos-phate receptor
-
Walzer T, Chiossone L, Chaix J, Calver A, Carozzo C, Garrigue-Antar L, Jacques Y, Baratin M, Tomasello E, Vivier E: Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phos-phate receptor. Nat Immunol 2007;8:1337-1344.
-
(2007)
Nat Immunol
, vol.8
, pp. 1337-1344
-
-
Walzer, T.1
Chiossone, L.2
Chaix, J.3
Calver, A.4
Carozzo, C.5
Garrigue-Antar, L.6
Jacques, Y.7
Baratin, M.8
Tomasello, E.9
Vivier, E.10
-
38
-
-
38449105053
-
Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen
-
Czeloth N, Schippers A, Wagner N, Muller W, Kuster B, Bernhardt G, Forster R: Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen. J Immunol 2007;179:5855-5863.
-
(2007)
J Immunol
, vol.179
, pp. 5855-5863
-
-
Czeloth, N.1
Schippers, A.2
Wagner, N.3
Muller, W.4
Kuster, B.5
Bernhardt, G.6
Forster, R.7
-
39
-
-
33750589822
-
Local application of fty720 to the lung abrogates experimental asthma by altering dendritic cell function
-
Idzko M, Hammad H, van Nimwegen M, Kool M, Muller T, Soullie T, Willart MA, Hijdra D, Hoogsteden HC, Lambrecht BN: Local application of fty720 to the lung abrogates experimental asthma by altering dendritic cell function. J Clin Invest 2006;116:2935-2944.
-
(2006)
J Clin Invest
, vol.116
, pp. 2935-2944
-
-
Idzko, M.1
Hammad, H.2
Van Nimwegen, M.3
Kool, M.4
Muller, T.5
Soullie, T.6
Willart, M.A.7
Hijdra, D.8
Hoogsteden, H.C.9
Lambrecht, B.N.10
-
40
-
-
70449732610
-
T-bet-dependent s1p5 expression in nk cells promotes egress from lymph nodes and bone marrow
-
Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J: T-bet-dependent s1p5 expression in nk cells promotes egress from lymph nodes and bone marrow. J Exp Med 2009;206:2469-2481.
-
(2009)
J Exp Med
, vol.206
, pp. 2469-2481
-
-
Jenne, C.N.1
Enders, A.2
Rivera, R.3
Watson, S.R.4
Bankovich, A.J.5
Pereira, J.P.6
Xu, Y.7
Roots, C.M.8
Beilke, J.N.9
Banerjee, A.10
Reiner, S.L.11
Miller, S.A.12
Weinmann, A.S.13
Goodnow, C.C.14
Lanier, L.L.15
Cyster, J.G.16
Chun, J.17
-
41
-
-
33645289121
-
Cd69 acts downstream of interferon-alpha/beta to inhibit s1p1 and lymphocyte egress from lymphoid organs
-
Shiow LR, Rosen DB, Brdickova N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M: Cd69 acts downstream of interferon-alpha/beta to inhibit s1p1 and lymphocyte egress from lymphoid organs. Nature 2006;440:540-544.
-
(2006)
Nature
, vol.440
, pp. 540-544
-
-
Shiow, L.R.1
Rosen, D.B.2
Brdickova, N.3
Xu, Y.4
An Lanier, L.L.5
Cyster, J.G.6
Matloubian, J.M.7
-
42
-
-
0025311299
-
An abundant transcript induced in differentiating human endothe-lial cells encodes a polypeptide with structural similarities to g-protein-coupled receptors
-
Hla T, Maciag T: An abundant transcript induced in differentiating human endothe-lial cells encodes a polypeptide with structural similarities to g-protein-coupled receptors. J Biol Chem 1990;265:9308-9313.
-
(1990)
J Biol Chem
, vol.265
, pp. 9308-9313
-
-
Hla, T.1
MacIag, T.2
-
43
-
-
0033600839
-
Differential coupling of the sphingosine 1-phosphate receptors edg-1, edg-3, and h218/edg-5 to the g(i), g(q), and g(12) families of heterotrimeric g proteins
-
Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR: Differential coupling of the sphingosine 1-phosphate receptors edg-1, edg-3, and h218/edg-5 to the g(i), g(q), and g(12) families of heterotrimeric g proteins. J Biol Chem 1999;274:27351-27358.
-
(1999)
J Biol Chem
, vol.274
, pp. 27351-27358
-
-
Windh, R.T.1
Lee, M.J.2
Hla, T.3
An, S.4
Barr, A.J.5
Manning, D.R.6
-
44
-
-
42249096282
-
Selective activation of g alpha i mediated signal ling of s1p3 by fty720-phosphate
-
Sensken SC, Stäubert C, Keul P, Levkau B, Schöneberg T, Gräler MH: Selective activation of g alpha i mediated signal ling of s1p3 by fty720-phosphate. Cell Signal 2008;20:1125-1133.
-
(2008)
Cell Signal
, vol.20
, pp. 1125-1133
-
-
Sensken, S.C.1
Stäubert, C.2
Keul, P.3
Levkau, B.4
Schöneberg, T.5
Gräler, M.H.6
-
45
-
-
4644261120
-
Small interfering rna-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in en-dothelial cells
-
Gonzalez E, Nagiel A, Lin AJ, Golan DE, Michel T: Small interfering rna-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in en-dothelial cells. J Biol Chem 2004;279:40659-40669.
-
(2004)
J Biol Chem
, vol.279
, pp. 40659-40669
-
-
Gonzalez, E.1
Nagiel, A.2
Lin, A.J.3
Golan, D.E.4
Michel, T.5
-
46
-
-
65249113865
-
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants
-
Weis N, Weigert A, von Knethen A, Brune B: Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. Mol Biol Cell 2009;20:1280-1288.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1280-1288
-
-
Weis, N.1
Weigert, A.2
Von Knethen, A.3
Brune, B.4
-
47
-
-
0036905055
-
Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic t cells
-
Gräler M, Goetzl EJ: Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic t cells. Faseb J 2002;16:1874-1878.
-
(2002)
Faseb J
, vol.16
, pp. 1874-1878
-
-
Gräler, M.1
Goetzl, E.J.2
-
48
-
-
15444373513
-
Pten as an effector in the signaling of antimigratory g protein-coupled receptor
-
Sanchez T, Thangada S, Wu MT, Kontos CD, Wu D, Wu H, Hla T: Pten as an effector in the signaling of antimigratory g protein-coupled receptor. Proc Natl Acad Sci USA 2005;102:4312-4317.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4312-4317
-
-
Sanchez, T.1
Thangada, S.2
Wu, M.T.3
Kontos, C.D.4
Wu, D.5
Wu, H.6
Hla, T.7
-
49
-
-
72249096210
-
Targeted disruption of the s1p2 sphingosine 1-phosphate receptor gene leads to diffuse large b-cell lymphoma formation
-
Cattoretti G, Mandelbaum J, Lee N, Chaves AH, Mahler AM, Chadburn A, Dalla-Favera R, Pasqualucci L, MacLennan AJ: Targeted disruption of the s1p2 sphingosine 1-phosphate receptor gene leads to diffuse large b-cell lymphoma formation. Cancer Res 2009;69:8686-8692.
-
(2009)
Cancer Res
, vol.69
, pp. 8686-8692
-
-
Cattoretti, G.1
Mandelbaum, J.2
Lee, N.3
Chaves, A.H.4
Mahler, A.M.5
Chadburn, A.6
Dalla-Favera, R.7
Pasqualucci, L.8
MacLennan, A.J.9
-
50
-
-
33846983547
-
Sphingosine 1-phos-phate (s1p) signaling is required for maintenance of hair cells mainly via activation of s1p2
-
Herr DR, Grillet N, Schwander M, Rivera R, Muller U, Chun J: Sphingosine 1-phos-phate (s1p) signaling is required for maintenance of hair cells mainly via activation of s1p2. J Neurosci 2007;27:1474-1478.
-
(2007)
J Neurosci
, vol.27
, pp. 1474-1478
-
-
Herr, D.R.1
Grillet, N.2
Schwander, M.3
Rivera, R.4
Muller, U.5
Chun, J.6
-
51
-
-
34249845679
-
Deafness and stria vascularis defects in s1p2 receptor-null mice
-
Kono M, Belyantseva IA, Skoura A, Frolenkov GI, Starost MF, Dreier JL, Lidington D, Bolz SS, Friedman TB, Hla T, Proia RL: Deafness and stria vascularis defects in s1p2 receptor-null mice. J Biol Chem 2007;282:10690-10696.
-
(2007)
J Biol Chem
, vol.282
, pp. 10690-10696
-
-
Kono, M.1
Belyantseva, I.A.2
Skoura, A.3
Frolenkov, G.I.4
Starost, M.F.5
Dreier, J.L.6
Lidington, D.7
Bolz, S.S.8
Friedman, T.B.9
Hla, T.10
Proia, R.L.11
-
52
-
-
62049084843
-
B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis
-
Sinha RK, Park C, Hwang IY, Davis MD, Kehrl JH: B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. Immunity 2009;30:434-446.
-
(2009)
Immunity
, vol.30
, pp. 434-446
-
-
Sinha, R.K.1
Park, C.2
Hwang, I.Y.3
Davis, M.D.4
Kehrl, J.H.5
-
53
-
-
10644289345
-
The sphingosine-1-phosphate (s1p) lysophospholipid receptor s1p3 regulates madcam-1+ endothelial cells in splenic marginal sinus organization
-
Girkontaite I, Sakk V, Wagner M, Borggrefe T, Tedford K, Chun J, Fischer KD: The sphingosine-1-phosphate (s1p) lysophospholipid receptor s1p3 regulates madcam-1+ endothelial cells in splenic marginal sinus organization. J Exp Med 2004;200:1491-1501.
-
(2004)
J Exp Med
, vol.200
, pp. 1491-1501
-
-
Girkontaite, I.1
Sakk, V.2
Wagner, M.3
Borggrefe, T.4
Tedford, K.5
Chun, J.6
Fischer, K.D.7
-
54
-
-
11144356028
-
Hdl induces no-dependent vasorelaxation via the lysophospholipid receptor s1p3
-
Nofer JR, van der Giet M, Tolle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Godecke A, Ishii I, Kleuser B, Schafers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B: Hdl induces no-dependent vasorelaxation via the lysophospholipid receptor s1p3. J Clin Invest 2004;113:569-581.
-
(2004)
J Clin Invest
, vol.113
, pp. 569-581
-
-
Nofer, J.R.1
Van Der Giet, M.2
Tolle, M.3
Wolinska, I.4
Von Wnuck Lipinski, K.5
Baba, H.A.6
Tietge, U.J.7
Godecke, A.8
Ishii, I.9
Kleuser, B.10
Schafers, M.11
Fobker, M.12
Zidek, W.13
Assmann, G.14
Chun, J.15
Levkau, B.16
-
55
-
-
0032532764
-
Edg6, a novel g-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue
-
Gräler MH, Bernhardt G, Lipp M: Edg6, a novel g-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. Genomics 1998;53:164-169.
-
(1998)
Genomics
, vol.53
, pp. 164-169
-
-
Gräler, M.H.1
Bernhardt, G.2
Lipp, M.3
-
56
-
-
0037684739
-
The sphingo-sine 1-phosphate receptor s1p4 regulates cell shape and motility via coupling to gi and g12/13
-
Gräler MH, Grosse R, Kusch A, Kremmer E, Gudermann T, Lipp M: The sphingo-sine 1-phosphate receptor s1p4 regulates cell shape and motility via coupling to gi and g12/13. J Cell Biochem 2003;89:507-519.
-
(2003)
J Cell Biochem
, vol.89
, pp. 507-519
-
-
Gräler, M.H.1
Grosse, R.2
Kusch, A.3
Kremmer, E.4
Gudermann, T.5
Lipp, M.6
-
57
-
-
0035937165
-
Nrg-1 belongs to the endothelial differentiation gene family of g protein-coupled sphin-gosine-1-phosphate receptors
-
Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brocklyn JR, Milstien S, Spiegel S, Lee NH: Nrg-1 belongs to the endothelial differentiation gene family of g protein-coupled sphin-gosine-1-phosphate receptors. J Biol Chem 2001;276:5692-5699.
-
(2001)
J Biol Chem
, vol.276
, pp. 5692-5699
-
-
Malek, R.L.1
Toman, R.E.2
Edsall, L.C.3
Wong, S.4
Chiu, J.5
Letterle, C.A.6
Van Brocklyn, J.R.7
Milstien, S.8
Spiegel, S.9
Lee, N.H.10
|