Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

Genes and Development

Volumn 16, Issue 4, 2002, Pages 421-426

  Te Welscher, Pascal ^a   Fernandez Teran, Marian ^b   Ros, Marian A ^b   Zeller, Rolf ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Alx4; DHAND; Gli3; Limb development; Polarizing region; SHH signalling

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; EMBRYO; EMBRYO POLARITY; GENE EXPRESSION REGULATION; LIMB BUD; LIMB DEVELOPMENT; MESENCHYME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DNA-BINDING PROTEINS; EXTREMITIES; FEEDBACK; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HELIX-LOOP-HELIX MOTIFS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MESODERM; MICE; MICE, KNOCKOUT; MORPHOGENESIS; NERVE TISSUE PROTEINS; PROTEINS; REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VERTEBRATES; XENOPUS PROTEINS; ZEBRAFISH PROTEINS; ZINC FINGERS;

VERTEBRATA;

EID: 0037083760     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.219202     Document Type: Article

References (29)

1. Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
2. Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
3. The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development
4. Manifestation of the limb prepattern: Limb development in the absence of Sonic hedgehog function
5. Giving limbs a hand
6. Role of dHAND in the anterior-posterior polarization of the limb bud: Implications for the Sonic hedgehog pathway
7. The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function
8. A series of normal stages in the development of the chick embryo
9. The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5′HoxD genes during limb pattern formation
10. A mouse model of greig cephalopolysyndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene
11. Molecular models for vertebrate limb development
12. Some distal limb structures develop in mice lacking Sonic hedgehog signaling
13. Retinoid signalling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation
14. Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development
15. A duplicated zone of polarizing activity in polydactylous mouse mutants
16. Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse
17. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
18. Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt)
19. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor dHAND
20. Sonic hedgehog signaling is essential for hair development
21. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
22. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development
23. Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly
24. Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes
25. Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes
26. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
27. The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development
28. Gli3 (Xt) and formin (d) participate in the positioning of the polarising region and control of posterior limb-bud identity
29. Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds