Suppressor of fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

Development

Volumn 127, Issue 18, 2000, Pages 4001-4010

  Methot, N ^a   Basler, K ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cubitus interruptus; Drosophila; Hedgehog signaling; Nuclear entry; Transcriptional regulation

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE INDUCTION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMAL; CELL NUCLEUS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; IMMUNOHISTOCHEMISTRY; INSECT PROTEINS; KINESIN; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0033789068     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Drosophila CBP is a co-activator of Cubitus interruptus in hedgehog signaling
2. Hedgehog and its Patched-Smoothened receptor complex: A novel signaling mechanism at the cell surface
3. Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs
4. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
5. Ci: A complex transducer of the hedgehog signal
6. A new member of the frizzled family from Drosophila functions as a Wingless receptor
7. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
8. Visualization of gene expression in living adult Drosophila
9. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
10. Protein kinase A directly regulates the activity and proteolysis of Cubitus interruptus
11. Dual roles for Patched in sequestering and transducing Hedgehog
12. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
13. Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein Cubitus interruptus
14. Genetic analysis of hedgehog signaling in the Drosophila embryo
15. Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes
16. Transducing Hedgehog: The story so far
17. Protein Kinase A and Hedgehog signaling in Drosophila Limb Development
18. Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb
19. Mammalian Suppressor-of-Fused modulates nuclear cytoplasmic shuttling of GLI-1
20. Genetic investigation of cAMP-dependent protein kinase function in Drosophila Development
21. Morphogens, compartments, and pattern: Lessons from Drosophila?
22. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
23. Function of Protein Kinase A in Hedgehog signal transduction and Drosophila imaginal disc development
24. More surprises in the hedgehog signaling pathway
25. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
26. Molecular interactions between three members of the Drosophila Hedgehog signaling pathway: Supressor of fused links the ser-thr kinase Fused and the transcription factor Cubitus interruptus
27. Direct and long-range action of a DPP morphogen gradient
28. Morphogens and pattern formation
29. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster I Zigotic loci on the second chromosome
30. Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos
31. Hedgehog stimulates the maturation of Cubitus interruptus into a labile transcriptional activator
32. Cloning and characterization of the segment polarity gene Cubitus interruptus Dominant of Drosophila
33. Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A
34. Induction of Drosophila eye development by decapentaplegic
35. A putative serine/threonine protein kinase encoded by the segment polarity fused gene of Drosophila
36. Characterization of Supressor of fused, a complete supressor of the fused segment polarity gene of Drosophila melanogaster
37. Segmental polarity in Drosophila melanogaster: Genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2
38. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2
39. Gli proteins and Hedgehog signaling in development and cancer
40. Drawing a stripe in Drosophila imaginal disks: Negative regulation of decapentaplegic and patched expression by engrailed
41. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
42. Formation of morphogen gradients in the Drosophila wing
43. Functional domains of Fused, a serine-threonine kinase required for signaling in Drosophila
44. Differential requirements of the Fused kinase for Hedgehog signaling in the Drosophila embryo
45. Protein Kinase A antagonized Hedgehog signaling by regulating both activator and repressor forms of Cubitus interruptus
46. The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
47. Analysis of genetic mosaics in developing and adult Drosophila tissues
48. Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing