Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

Nature

Volumn 418, Issue 6901, 2002, Pages 979-983

  Litingtung, Ying ^a   Li, Yina ^a   Fallon, John F ^b   Chiang, Chin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PROTEINS;

POLYDACTYLOUS;

MUSCULOSKELETAL SYSTEM;

GENE PRODUCT; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG;

LOCOMOTION;

ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CONTROLLED STUDY; FINGER; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; LIMB DEVELOPMENT; MESODERM; MOUSE; NONHUMAN; POLYDACTYLY; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, WESTERN; BODY PATTERNING; DNA-BINDING PROTEINS; EXTREMITIES; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; IN SITU HYBRIDIZATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LEG BONES; LIMB BUD; MICE; MICE, KNOCKOUT; MORPHOGENESIS; NERVE TISSUE PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA; ERINACEIDAE;

EID: 0037194765     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01033     Document Type: Article

References (30)

1. Hedgehog signaling in animal development: Paradigms and principles
2. A duplicated zone of polarizing activity in polydactylous mouse mutants
3. Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
4. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
5. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
6. An absolute requirement for Cubitus interruptus in Hedgehog signaling
7. Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
8. The molecular ZPA
9. Relationship between dose, distance and time in Sonic hedgehog-mediated regulation of anteroposterior polarity in the chick limb
10. Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by PtcI
11. Manifestation of the limb prepattern: Limb development in the absence of Sonic hedgehog function
12. Some distal limb structures develop in mice lacking Sonic hedgehog signaling
13. Fingering the vertebrate limb
14. Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
15. Gli/Zic factors pattern the neural plate by defining domains of cell differentiation
16. Gli2 functions in FGF signaling during antero-posterior patterning
17. GLI3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization
18. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
19. A mouse model of Greig cephalopolysyndactyly syndrome: The extra-toes mutation contains an intragenic deletion of the Gli 3 gene
20. Gli3 (Xt) and formin (Id) participate in the positioning of the polarising region and control of posterior limb-bud identity
21. Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling
22. Specification of neuronal cell types in the ventral spinal cord is mediated by antagonistic interaction between Shh and Gli3
23. 2: Shh-independent outgrowth and polarizing activity
24. The roles of FGFs in the early development of vertebrate limbs
25. Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds
26. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
27. Distinct regulatory elements govern Fgf4 expression in the mouse blastocyst, myotomes, and developing limb
28. Epidemiological analysis of rare polydactylies
29. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
30. The phenotypic spectrum of Gli3 morphopathies includes autosomal dominant preaxial polydactyly type IV and postaxial polydictyly type A/B