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Volumn 17, Issue 24, 2011, Pages 2575-2591

Gene Therapy for Familial Hypercholesterolemia

Author keywords

Atherosclerosis; Familial hypercholesterolemia; Gene therapy; Low density lipoprotein receptor gene transfer

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

EID: 80053520295     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211797247550     Document Type: Review
Times cited : (33)

References (194)
  • 1
    • 84982342905 scopus 로고
    • Xanthomata, hypercholesterolemia, angina pectoris
    • Müller C. Xanthomata, hypercholesterolemia, angina pectoris. Acta Medica Scandinavia 1938; 89: 75-84.
    • (1938) Acta Medica Scandinavia , vol.89 , pp. 75-84
    • Müller, C.1
  • 2
    • 0001023903 scopus 로고
    • The Inheritance of Essential Familial Hypercholesterolemia
    • Khachadurian AK. The Inheritance of Essential Familial Hypercholesterolemia. The American journal of medicine 1964; 37: 402-7.
    • (1964) The American Journal of Medicine , vol.37 , pp. 402-407
    • Khachadurian, A.K.1
  • 3
    • 0013321009 scopus 로고
    • Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity
    • Brown MS and Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proceedings of the National Academy of Sciences of the United States of America 1974; 71: 788-92.
    • (1974) Proceedings of the National Academy of Sciences of the United States of America , vol.71 , pp. 788-792
    • Brown, M.S.1    Goldstein, J.L.2
  • 4
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown MS and Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232: 34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 5
    • 0015890890 scopus 로고
    • Familial hypercholesterolemia: Identification of a defect in the regulation of 3-hydroxy-3- methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol
    • Goldstein JL and Brown MS. Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3- methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc Natl Acad Sci USA 1973; 70: 2804-8.
    • (1973) Proc Natl Acad Sci USA , vol.70 , pp. 2804-2808
    • Goldstein, J.L.1    Brown, M.S.2
  • 6
    • 4444376916 scopus 로고    scopus 로고
    • Genetic causes of monogenic heterozygous familial hypercholesterolemia: A HuGE prevalence review
    • Austin MA, Hutter CM, Zimmern RL, and Humphries SE. Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review. American journal of epidemiology 2004; 160: 407-20.
    • (2004) American Journal of Epidemiology , vol.160 , pp. 407-420
    • Austin, M.A.1    Hutter, C.M.2    Zimmern, R.L.3    Humphries, S.E.4
  • 7
    • 0037541585 scopus 로고    scopus 로고
    • A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia
    • Marks D, Thorogood M, Neil HA, and Humphries SE. A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. Atherosclerosis 2003; 168: 1-14.
    • (2003) Atherosclerosis , vol.168 , pp. 1-14
    • Marks, D.1    Thorogood, M.2    Neil, H.A.3    Humphries, S.E.4
  • 8
    • 38849198546 scopus 로고    scopus 로고
    • Monogenic pediatric dyslipidemias: Classification, genetics and clinical spectrum
    • Rahalkar AR and Hegele RA. Monogenic pediatric dyslipidemias: classification, genetics and clinical spectrum. Molecular genetics and metabolism 2008; 93: 282-94.
    • (2008) Molecular Genetics and Metabolism , vol.93 , pp. 282-294
    • Rahalkar, A.R.1    Hegele, R.A.2
  • 9
    • 0016158546 scopus 로고
    • Familial hypercholesterolemia (one form of familial type II hyperlipoproteinemia)
    • A study of its biochemical, genetic and clinical presentation in childhood
    • Kwiterovich PO, Jr., Fredrickson DS, and Levy RI. Familial hypercholesterolemia (one form of familial type II hyperlipoproteinemia). A study of its biochemical, genetic and clinical presentation in childhood. The Journal of clinical investigation 1974; 53: 1237-49.
    • (1974) The Journal of Clinical Investigation , vol.53 , pp. 1237-1249
    • Kwiterovich Jr., P.O.1    Fredrickson, D.S.2    Levy, R.I.3
  • 11
    • 43549085271 scopus 로고    scopus 로고
    • Sitosterolaemia: Pathophysiology, clinical presentation and laboratory diagnosis
    • Kidambi S and Patel SB. Sitosterolaemia: pathophysiology, clinical presentation and laboratory diagnosis. Journal of clinical pathology 2008; 61: 588-94.
    • (2008) Journal of Clinical Pathology , vol.61 , pp. 588-594
    • Kidambi, S.1    Patel, S.B.2
  • 12
    • 0027301629 scopus 로고
    • Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics
    • Williams RR, Hunt SC, Schumacher MC, et al. Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. The American journal of cardiology 1993; 72: 171-6.
    • (1993) The American Journal of Cardiology , vol.72 , pp. 171-176
    • Williams, R.R.1    Hunt, S.C.2    Schumacher, M.C.3
  • 13
    • 0025944056 scopus 로고
    • Scientific Steering Committee on behalf of the Simon Broome Register Group
    • Risk of fatal coronary heart disease in familial hypercholesterolaemia
    • Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group. BMJ (Clinical research ed 1991; 303: 893-6.
    • (1991) BMJ (Clinical Research Ed , vol.303 , pp. 893-896
  • 15
    • 0032993468 scopus 로고    scopus 로고
    • The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia
    • Heath KE, Gudnason V, Humphries SE, and Seed M. The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia. Atherosclerosis 1999; 143: 41-54.
    • (1999) Atherosclerosis , vol.143 , pp. 41-54
    • Heath, K.E.1    Gudnason, V.2    Humphries, S.E.3    Seed, M.4
  • 16
    • 0036901111 scopus 로고    scopus 로고
    • Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands
    • Marang van de Mheen PJ, ten Asbroek AH, Bonneux L, Bonsel GJ, and Klazinga NS. Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands. European heart journal 2002; 23: 1922-30.
    • (2002) European Heart Journal , vol.23 , pp. 1922-1930
    • Marang van de Mheen, P.J.1    ten Asbroek, A.H.2    Bonneux, L.3    Bonsel, G.J.4    Klazinga, N.S.5
  • 17
    • 17044422041 scopus 로고    scopus 로고
    • Effect of lowdensity lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: A parent-offspring study
    • Koeijvoets KC, Wiegman A, Rodenburg J, et al. Effect of lowdensity lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study. Atherosclerosis 2005; 180: 93-9.
    • (2005) Atherosclerosis , vol.180 , pp. 93-99
    • Koeijvoets, K.C.1    Wiegman, A.2    Rodenburg, J.3
  • 18
    • 9644287995 scopus 로고    scopus 로고
    • The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: Data in 2400 patients
    • Jansen AC, van Aalst-Cohen ES, Tanck MW, et al. The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients. Journal of internal medicine 2004; 256: 482-90.
    • (2004) Journal of Internal Medicine , vol.256 , pp. 482-490
    • Jansen, A.C.1    van Aalst-Cohen, E.S.2    Tanck, M.W.3
  • 19
    • 0029791893 scopus 로고    scopus 로고
    • Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects
    • Tonstad S, Joakimsen O, Stensland-Bugge E, et al. Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. Arteriosclerosis, thrombosis, and vascular biology 1996; 16: 984-91.
    • (1996) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.16 , pp. 984-991
    • Tonstad, S.1    Joakimsen, O.2    Stensland-Bugge, E.3
  • 21
    • 0036016003 scopus 로고    scopus 로고
    • Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia
    • de Jongh S, Lilien MR, Bakker HD, et al. Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia. Atherosclerosis 2002; 163: 193-7.
    • (2002) Atherosclerosis , vol.163 , pp. 193-197
    • de Jongh, S.1    Lilien, M.R.2    Bakker, H.D.3
  • 23
    • 0034676774 scopus 로고    scopus 로고
    • Outcome of case finding among relatives of patients with known heterozygous familial hypercholesterolaemia
    • Bhatnagar D, Morgan J, Siddiq S, et al. Outcome of case finding among relatives of patients with known heterozygous familial hypercholesterolaemia. Bmj 2000; 321: 1497-500.
    • (2000) Bmj , vol.321 , pp. 1497-1500
    • Bhatnagar, D.1    Morgan, J.2    Siddiq, S.3
  • 24
    • 0014693152 scopus 로고
    • Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states
    • Slack J. Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states. Lancet 1969; 2: 1380-2.
    • (1969) Lancet , vol.2 , pp. 1380-1382
    • Slack, J.1
  • 25
    • 0032890205 scopus 로고    scopus 로고
    • Mortality in treated heterozygous familial hypercholesterolaemia: Implications for clinical management
    • Scientific Steering Committee on behalf of the Simon Broome Register Group
    • Mortality in treated heterozygous familial hypercholesterolaemia: implications for clinical management. Scientific Steering Committee on behalf of the Simon Broome Register Group. Atherosclerosis 1999; 142: 105-12.
    • (1999) Atherosclerosis , vol.142 , pp. 105-112
  • 26
    • 79959332777 scopus 로고    scopus 로고
    • Efficacy of statins in familial hypercholesterolaemia: A long term cohort study
    • Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: a long term cohort study. BMJ (Clinical research ed 2008; 337: a2423.
    • (2008) BMJ (Clinical Research Ed , vol.337
    • Versmissen, J.1    Oosterveer, D.M.2    Yazdanpanah, M.3
  • 27
    • 4444261091 scopus 로고    scopus 로고
    • Familial hypercholesterolemia, peripheral arterial disease, and stroke: A HuGE minireview
    • Hutter CM, Austin MA, and Humphries SE. Familial hypercholesterolemia, peripheral arterial disease, and stroke: a HuGE minireview. American journal of epidemiology 2004; 160: 430-5.
    • (2004) American Journal of Epidemiology , vol.160 , pp. 430-435
    • Hutter, C.M.1    Austin, M.A.2    Humphries, S.E.3
  • 31
    • 2942733215 scopus 로고    scopus 로고
    • Measurement of arterial wall thickness as a surrogate marker for atherosclerosis
    • de Groot E, Hovingh GK, Wiegman A, et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation 2004; 109: III33-8.
    • (2004) Circulation , vol.109
    • de Groot, E.1    Hovingh, G.K.2    Wiegman, A.3
  • 32
    • 0032845310 scopus 로고    scopus 로고
    • Differences in intimamedia thickness in the carotid and femoral arteries in familial hypercholesterolemic heterozygotes with and without clinical manifestations of cardiovascular disease
    • Wittekoek ME, de Groot E, Prins MH, et al. Differences in intimamedia thickness in the carotid and femoral arteries in familial hypercholesterolemic heterozygotes with and without clinical manifestations of cardiovascular disease. Atherosclerosis 1999; 146: 271-9.
    • (1999) Atherosclerosis , vol.146 , pp. 271-279
    • Wittekoek, M.E.1    de Groot, E.2    Prins, M.H.3
  • 33
    • 0035941786 scopus 로고    scopus 로고
    • Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): A prospective, randomised, double-blind trial
    • Smilde TJ, van Wissen S, Wollersheim H, et al. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 2001; 357: 577-81.
    • (2001) Lancet , vol.357 , pp. 577-581
    • Smilde, T.J.1    van Wissen, S.2    Wollersheim, H.3
  • 35
    • 0033044171 scopus 로고    scopus 로고
    • Characteristic cardiovascular manifestation in homozygous and heterozygous familial hypercholesterolemia
    • Kawaguchi A, Miyatake K, Yutani C, et al. Characteristic cardiovascular manifestation in homozygous and heterozygous familial hypercholesterolemia. American heart journal 1999; 137: 410-8.
    • (1999) American Heart Journal , vol.137 , pp. 410-418
    • Kawaguchi, A.1    Miyatake, K.2    Yutani, C.3
  • 37
    • 0042316738 scopus 로고    scopus 로고
    • Hypercholesterolemic valvulopathy: An aspect of malignant atherosclerosis
    • Kawaguchi A, Yutani C, and Yamamoto A. Hypercholesterolemic valvulopathy: an aspect of malignant atherosclerosis. Ther Apher Dial 2003; 7: 439-43.
    • (2003) Ther Apher Dial , vol.7 , pp. 439-443
    • Kawaguchi, A.1    Yutani, C.2    Yamamoto, A.3
  • 39
    • 56349147086 scopus 로고    scopus 로고
    • Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia
    • Kolansky DM, Cuchel M, Clark BJ, et al. Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia. The American journal of cardiology 2008; 102: 1438-43.
    • (2008) The American Journal of Cardiology , vol.102 , pp. 1438-1443
    • Kolansky, D.M.1    Cuchel, M.2    Clark, B.J.3
  • 40
    • 22244478077 scopus 로고    scopus 로고
    • Structure and physiologic function of the low-density lipoprotein receptor
    • Jeon H and Blacklow SC. Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem 2005; 74: 535-62.
    • (2005) Annu Rev Biochem , vol.74 , pp. 535-562
    • Jeon, H.1    Blacklow, S.C.2
  • 41
    • 0035292695 scopus 로고    scopus 로고
    • Structural, biochemical and signaling properties of the low-density lipoprotein receptor gene family
    • Hussain M. Structural, biochemical and signaling properties of the low-density lipoprotein receptor gene family. Front Biosci 2001; 6: D417-28.
    • (2001) Front Biosci , vol.6
    • Hussain, M.1
  • 42
    • 0032802253 scopus 로고    scopus 로고
    • The mammalian low-density lipoprotein receptor family
    • Hussain MM, Strickland DK, and Bakillah A. The mammalian low-density lipoprotein receptor family. Annu Rev Nutr 1999; 19: 141-72.
    • (1999) Annu Rev Nutr , vol.19 , pp. 141-172
    • Hussain, M.M.1    Strickland, D.K.2    Bakillah, A.3
  • 43
    • 0034672690 scopus 로고    scopus 로고
    • From cholesterol transport to signal transduction: Low density lipoprotein receptor, very low density lipoprotein receptor, and apolipoprotein E receptor-2
    • Nimpf J and Schneider WJ. From cholesterol transport to signal transduction: low density lipoprotein receptor, very low density lipoprotein receptor, and apolipoprotein E receptor-2. Biochim Biophys Acta 2000; 1529: 287-98.
    • (2000) Biochim Biophys Acta , vol.1529 , pp. 287-298
    • Nimpf, J.1    Schneider, W.J.2
  • 44
    • 0021742599 scopus 로고
    • The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
    • Yamamoto T, Davis CG, Brown MS, et al. The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell 1984; 39: 27-38.
    • (1984) Cell , vol.39 , pp. 27-38
    • Yamamoto, T.1    Davis, C.G.2    Brown, M.S.3
  • 45
    • 0037117749 scopus 로고    scopus 로고
    • Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants
    • Li Y, Lu W, Schwartz AL, and Bu G. Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants. Biochemistry 2002; 41: 4921-8.
    • (2002) Biochemistry , vol.41 , pp. 4921-4928
    • Li, Y.1    Lu, W.2    Schwartz, A.L.3    Bu, G.4
  • 47
    • 0017879170 scopus 로고
    • Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins
    • Innerarity TL and Mahley RW. Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins. Biochemistry 1978; 17: 1440-7.
    • (1978) Biochemistry , vol.17 , pp. 1440-1447
    • Innerarity, T.L.1    Mahley, R.W.2
  • 48
    • 0023664118 scopus 로고
    • The low density lipoprotein receptor
    • Identification of amino acids in cytoplasmic domain required for rapid endocytosis
    • Davis CG, van Driel IR, Russell DW, Brown MS, and Goldstein JL. The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis. The Journal of biological chemistry 1987; 262: 4075-82.
    • (1987) The Journal of Biological Chemistry , vol.262 , pp. 4075-4082
    • Davis, C.G.1    van Driel, I.R.2    Russell, D.W.3    Brown, M.S.4    Goldstein, J.L.5
  • 49
    • 0030758231 scopus 로고    scopus 로고
    • LDL-receptor structure
    • Calcium cages, acid baths and recycling receptors
    • Brown MS, Herz J, and Goldstein JL. LDL-receptor structure. Calcium cages, acid baths and recycling receptors. Nature 1997; 388: 629-30.
    • (1997) Nature , vol.388 , pp. 629-630
    • Brown, M.S.1    Herz, J.2    Goldstein, J.L.3
  • 50
    • 0031666905 scopus 로고    scopus 로고
    • Genotype/phenotype correlations in familial hypercholesterolaemia
    • Nicholls P, Young IS, and Graham CA. Genotype/phenotype correlations in familial hypercholesterolaemia. Curr Opin Lipidol 1998; 9: 313-7.
    • (1998) Curr Opin Lipidol , vol.9 , pp. 313-317
    • Nicholls, P.1    Young, I.S.2    Graham, C.A.3
  • 51
    • 0027026881 scopus 로고
    • Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
    • Hobbs HH, Brown MS, and Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat 1992; 1: 445-66.
    • (1992) Hum Mutat , vol.1 , pp. 445-466
    • Hobbs, H.H.1    Brown, M.S.2    Goldstein, J.L.3
  • 52
    • 0032526144 scopus 로고    scopus 로고
    • A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: Sequence-based, tabular, and direct submission data handling
    • Wilson DJ, Gahan M, Haddad L, et al. A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: sequence-based, tabular, and direct submission data handling. Am J Cardiol 1998; 81: 1509-11.
    • (1998) Am J Cardiol , vol.81 , pp. 1509-1511
    • Wilson, D.J.1    Gahan, M.2    Haddad, L.3
  • 53
    • 18444404884 scopus 로고    scopus 로고
    • The UMD-LDLR database: Additions to the software and 490 new entries to the database
    • Villeger L, Abifadel M, Allard D, et al. The UMD-LDLR database: additions to the software and 490 new entries to the database. Hum Mutat 2002; 20: 81-7.
    • (2002) Hum Mutat , vol.20 , pp. 81-87
    • Villeger, L.1    Abifadel, M.2    Allard, D.3
  • 54
    • 0023227574 scopus 로고
    • Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene
    • Sudhof TC, Van der Westhuyzen DR, Goldstein JL, Brown MS, and Russell DW. Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. J Biol Chem 1987; 262: 10773-9.
    • (1987) J Biol Chem , vol.262 , pp. 10773-10779
    • Sudhof, T.C.1    van der Westhuyzen, D.R.2    Goldstein, J.L.3    Brown, M.S.4    Russell, D.W.5
  • 55
    • 0032893494 scopus 로고    scopus 로고
    • An update on familial hypercholesterolaemia
    • L. An update on familial hypercholesterolaemia. Ann Med 1999; 31 Suppl 1: 13-8.
    • (1999) Ann Med , vol.31 , Issue.SUPPL. 1 , pp. 13-18
  • 56
    • 0025111798 scopus 로고
    • Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene
    • Smith JR, Osborne TF, Goldstein JL, and Brown MS. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J Biol Chem 1990; 265: 2306-10.
    • (1990) J Biol Chem , vol.265 , pp. 2306-2310
    • Smith, J.R.1    Osborne, T.F.2    Goldstein, J.L.3    Brown, M.S.4
  • 57
    • 30744466655 scopus 로고    scopus 로고
    • Human low-density lipoprotein receptor gene and its regulation
    • Kong WJ, Liu J, and Jiang JD. Human low-density lipoprotein receptor gene and its regulation. J Mol Med 2006; 84: 29-36.
    • (2006) J Mol Med , vol.84 , pp. 29-36
    • Kong, W.J.1    Liu, J.2    Jiang, J.D.3
  • 58
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, and Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-31.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 60
    • 34249848111 scopus 로고    scopus 로고
    • From the Cover: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
    • Radhakrishnan A, Ikeda Y, Kwon HJ, Brown MS, and Goldstein JL. From the Cover: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig. Proc Natl Acad Sci USA 2007; 104: 6511-8.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6511-6518
    • Radhakrishnan, A.1    Ikeda, Y.2    Kwon, H.J.3    Brown, M.S.4    Goldstein, J.L.5
  • 61
    • 34249861927 scopus 로고    scopus 로고
    • From the Cover: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
    • Sun LP, Seemann J, Goldstein JL, and Brown MS. From the Cover: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc Natl Acad Sci USA 2007; 104: 6519-26.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6519-6526
    • Sun, L.P.1    Seemann, J.2    Goldstein, J.L.3    Brown, M.S.4
  • 62
    • 0036892157 scopus 로고    scopus 로고
    • Minireview: Estrogen and mouse models of atherosclerosis
    • Hodgin JB and Maeda N. Minireview: estrogen and mouse models of atherosclerosis. Endocrinology 2002; 143: 4495-501.
    • (2002) Endocrinology , vol.143 , pp. 4495-4501
    • Hodgin, J.B.1    Maeda, N.2
  • 63
    • 0034448982 scopus 로고    scopus 로고
    • Estrogen markedly increases LDL-receptor activity in hypercholesterolemic patients
    • Inukai T, Takanashi K, Takebayashi K, et al. Estrogen markedly increases LDL-receptor activity in hypercholesterolemic patients. J Med 2000; 31: 247-61.
    • (2000) J Med , vol.31 , pp. 247-261
    • Inukai, T.1    Takanashi, K.2    Takebayashi, K.3
  • 64
    • 0141953288 scopus 로고    scopus 로고
    • Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoproteinreceptor
    • Bruning JC, Lingohr P, Gillette J, et al. Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoproteinreceptor. J Steroid Biochem Mol Biol 2003; 86: 113-21.
    • (2003) J Steroid Biochem Mol Biol , vol.86 , pp. 113-121
    • Bruning, J.C.1    Lingohr, P.2    Gillette, J.3
  • 65
    • 0034003980 scopus 로고    scopus 로고
    • The role of the LDL receptor in apolipoprotein B secretion
    • Twisk J, Gillian-Daniel DL, Tebon A, et al. The role of the LDL receptor in apolipoprotein B secretion. J Clin Invest 2000; 105: 521-32.
    • (2000) J Clin Invest , vol.105 , pp. 521-532
    • Twisk, J.1    Gillian-Daniel, D.L.2    Tebon, A.3
  • 67
    • 33747100291 scopus 로고    scopus 로고
    • Thematic review series: Patientoriented research
    • What we have learned about VLDL and LDL metabolism from human kinetics studies
    • Parhofer KG and Barrett PH. Thematic review series: patientoriented research. What we have learned about VLDL and LDL metabolism from human kinetics studies. Journal of lipid research 2006; 47: 1620-30.
    • (2006) Journal of Lipid Research , vol.47 , pp. 1620-1630
    • Parhofer, K.G.1    Barrett, P.H.2
  • 68
    • 0028819191 scopus 로고
    • Increased hepatic secretion of very-low-density-lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: A stable isotope study
    • Cummings MH, Watts GF, Umpleby M, et al. Increased hepatic secretion of very-low-density-lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: a stable isotope study. Atherosclerosis 1995; 113: 79-89.
    • (1995) Atherosclerosis , vol.113 , pp. 79-89
    • Cummings, M.H.1    Watts, G.F.2    Umpleby, M.3
  • 69
    • 2142713910 scopus 로고    scopus 로고
    • Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation
    • Tremblay AJ, Lamarche B, Ruel IL, et al. Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation. J Lipid Res 2004; 45: 866-72.
    • (2004) J Lipid Res , vol.45 , pp. 866-872
    • Tremblay, A.J.1    Lamarche, B.2    Ruel, I.L.3
  • 70
    • 0028179072 scopus 로고
    • ApoB metabolism in familial hypercholesterolemia
    • Inconsistencies with the LDL receptor paradigm
    • Fisher WR, Zech LA, and Stacpoole PW. ApoB metabolism in familial hypercholesterolemia. Inconsistencies with the LDL receptor paradigm. Arterioscler Thromb 1994; 14: 501-10.
    • (1994) Arterioscler Thromb , vol.14 , pp. 501-510
    • Fisher, W.R.1    Zech, L.A.2    Stacpoole, P.W.3
  • 71
    • 0024578744 scopus 로고
    • Apolipoprotein B metabolism in homozygous familial hypercholesterolemia
    • James RW, Martin B, Pometta D, et al. Apolipoprotein B metabolism in homozygous familial hypercholesterolemia. Journal of lipid research 1989; 30: 159-69.
    • (1989) Journal of Lipid Research , vol.30 , pp. 159-169
    • James, R.W.1    Martin, B.2    Pometta, D.3
  • 72
    • 20044387775 scopus 로고    scopus 로고
    • Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production
    • Millar JS, Maugeais C, Ikewaki K, et al. Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production. Arteriosclerosis, thrombosis, and vascular biology 2005; 25: 560-5.
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , pp. 560-565
    • Millar, J.S.1    Maugeais, C.2    Ikewaki, K.3
  • 73
    • 0035040325 scopus 로고    scopus 로고
    • Effect of low-density lipoprotein apheresis on kinetics of apolipoprotein B in heterozygous familial hypercholesterolemia
    • Maugeais C, Ouguerram K, Frenais R, et al. Effect of low-density lipoprotein apheresis on kinetics of apolipoprotein B in heterozygous familial hypercholesterolemia. J Clin Endocrinol Metab 2001; 86: 1679-86.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1679-1686
    • Maugeais, C.1    Ouguerram, K.2    Frenais, R.3
  • 74
    • 0021210499 scopus 로고
    • Abnormalities of high density lipoproteins in homozygous familial hypercholesterolemia
    • Goldberg RB, Fless GM, Baker SG, et al. Abnormalities of high density lipoproteins in homozygous familial hypercholesterolemia. Arteriosclerosis Dallas, Tex 1984; 4: 472-8.
    • (1984) Arteriosclerosis Dallas, Tex , vol.4 , pp. 472-478
    • Goldberg, R.B.1    Fless, G.M.2    Baker, S.G.3
  • 75
    • 0025187632 scopus 로고
    • Apolipoprotein E-rich HDL in patients with homozygous familial hypercholesterolemia
    • Keidar S, Ostlund RE, Jr., and Schonfeld G. Apolipoprotein E-rich HDL in patients with homozygous familial hypercholesterolemia. Atherosclerosis 1990; 84: 155-63.
    • (1990) Atherosclerosis , vol.84 , pp. 155-163
    • Keidar, S.1    Ostlund Jr., R.E.2    Schonfeld, G.3
  • 76
    • 10744233618 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
    • Civeira F. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis 2004; 173: 55-68.
    • (2004) Atherosclerosis , vol.173 , pp. 55-68
    • Civeira, F.1
  • 78
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383-9.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 79
    • 0032487931 scopus 로고    scopus 로고
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. The New England journal of medicine 1998; 339: 1349-57.
    • (1998) The New England Journal of Medicine , vol.339 , pp. 1349-1357
  • 80
    • 36549034768 scopus 로고    scopus 로고
    • Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
    • Lewington S, Whitlock G, Clarke R, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 2007; 370: 1829-39.
    • (2007) Lancet , vol.370 , pp. 1829-1839
    • Lewington, S.1    Whitlock, G.2    Clarke, R.3
  • 81
    • 0041743167 scopus 로고    scopus 로고
    • Monogenic hypercholesterolemia: New insights in pathogenesis and treatment
    • Rader DJ, Cohen J, and Hobbs HH. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. The Journal of clinical investigation 2003; 111: 1795-803.
    • (2003) The Journal of Clinical Investigation , vol.111 , pp. 1795-1803
    • Rader, D.J.1    Cohen, J.2    Hobbs, H.H.3
  • 82
    • 41649107358 scopus 로고    scopus 로고
    • Simvastatin with or without ezetimibe in familial hypercholesterolemia
    • Kastelein JJ, Akdim F, Stroes ES, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. The New England journal of medicine 2008; 358: 1431-43.
    • (2008) The New England Journal of Medicine , vol.358 , pp. 1431-1443
    • Kastelein, J.J.1    Akdim, F.2    Stroes, E.S.3
  • 83
    • 0025993348 scopus 로고
    • Nutritional regulation of cholesterol synthesis and apolipoprotein B kinetics: Studies in patients with familial hypercholesterolemia and normal subjects treated with a high carbohydrate, low fat diet
    • Stacpoole PW, von Bergmann K, Kilgore LL, Zech LA, and Fisher WR. Nutritional regulation of cholesterol synthesis and apolipoprotein B kinetics: studies in patients with familial hypercholesterolemia and normal subjects treated with a high carbohydrate, low fat diet. Journal of lipid research 1991; 32: 1837-48.
    • (1991) Journal of Lipid Research , vol.32 , pp. 1837-1848
    • Stacpoole, P.W.1    von Bergmann, K.2    Kilgore, L.L.3    Zech, L.A.4    Fisher, W.R.5
  • 85
    • 44149123549 scopus 로고    scopus 로고
    • Recommendations for the use of LDL apheresis
    • Thompson GR. Recommendations for the use of LDL apheresis. Atherosclerosis 2008; 198: 247-55.
    • (2008) Atherosclerosis , vol.198 , pp. 247-255
    • Thompson, G.R.1
  • 86
    • 0037406314 scopus 로고    scopus 로고
    • Familial hypercholesterolemia--improving treatment and meeting guidelines
    • Hopkins PN. Familial hypercholesterolemia--improving treatment and meeting guidelines. International journal of cardiology 2003; 89: 13-23.
    • (2003) International Journal of Cardiology , vol.89 , pp. 13-23
    • Hopkins, P.N.1
  • 87
    • 0030716524 scopus 로고    scopus 로고
    • Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia
    • Marais AD, Naoumova RP, Firth JC, et al. Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia. Journal of lipid research 1997; 38: 2071-8.
    • (1997) Journal of Lipid Research , vol.38 , pp. 2071-2078
    • Marais, A.D.1    Naoumova, R.P.2    Firth, J.C.3
  • 88
    • 0037188567 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia
    • Gagne C, Gaudet D, and Bruckert E. Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia. Circulation 2002; 105: 2469-75.
    • (2002) Circulation , vol.105 , pp. 2469-2475
    • Gagne, C.1    Gaudet, D.2    Bruckert, E.3
  • 89
    • 33846151732 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
    • Cuchel M, Bloedon LT, Szapary PO, et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. The New England journal of medicine 2007; 356: 148-56.
    • (2007) The New England Journal of Medicine , vol.356 , pp. 148-156
    • Cuchel, M.1    Bloedon, L.T.2    Szapary, P.O.3
  • 90
    • 34250619179 scopus 로고    scopus 로고
    • Long-term outcome after living donor liver transplantation for two cases of homozygous familial hypercholesterolemia from a heterozygous donor
    • Kawagishi N, Satoh K, Akamatsu Y, et al. Long-term outcome after living donor liver transplantation for two cases of homozygous familial hypercholesterolemia from a heterozygous donor. Journal of atherosclerosis and thrombosis 2007; 14: 94-8.
    • (2007) Journal of Atherosclerosis and Thrombosis , vol.14 , pp. 94-98
    • Kawagishi, N.1    Satoh, K.2    Akamatsu, Y.3
  • 91
    • 0028793489 scopus 로고
    • A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia
    • Grossman M, Rader DJ, Muller DW, et al. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nature medicine 1995; 1: 1148-54.
    • (1995) Nature Medicine , vol.1 , pp. 1148-1154
    • Grossman, M.1    Rader, D.J.2    Muller, D.W.3
  • 92
    • 77952507205 scopus 로고    scopus 로고
    • Gene therapy to improve high-density lipoprotein metabolism and function
    • Van Craeyveld E, Gordts S, Jacobs F, and De Geest B. Gene therapy to improve high-density lipoprotein metabolism and function. Curr Pharm Des 2010; 16: 1531-44.
    • (2010) Curr Pharm Des , vol.16 , pp. 1531-1544
    • van Craeyveld, E.1    Gordts, S.2    Jacobs, F.3    de Geest, B.4
  • 93
    • 0027275449 scopus 로고
    • Plasma cholesteryl ester transfer protein
    • Tall AR. Plasma cholesteryl ester transfer protein. J Lipid Res 1993; 34: 1255-74.
    • (1993) J Lipid Res , vol.34 , pp. 1255-1274
    • Tall, A.R.1
  • 94
    • 0025273144 scopus 로고
    • Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice
    • Paigen B, Ishida BY, Verstuyft J, Winters RB, and Albee D. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 1990; 10: 316-23.
    • (1990) Arteriosclerosis , vol.10 , pp. 316-323
    • Paigen, B.1    Ishida, B.Y.2    Verstuyft, J.3    Winters, R.B.4    Albee, D.5
  • 95
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi S, Brown MS, Goldstein JL, et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993; 92: 883-93.
    • (1993) J Clin Invest , vol.92 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 96
    • 0035723938 scopus 로고    scopus 로고
    • Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice
    • Veniant MM, Withycombe S, and Young SG. Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice. Arterioscler Thromb Vasc Biol 2001; 21: 1567-70.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1567-1570
    • Veniant, M.M.1    Withycombe, S.2    Young, S.G.3
  • 97
    • 0028345073 scopus 로고
    • Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
    • Ishibashi S, Goldstein JL, Brown MS, Herz J, and Burns DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 1994; 93: 1885-93.
    • (1994) J Clin Invest , vol.93 , pp. 1885-1893
    • Ishibashi, S.1    Goldstein, J.L.2    Brown, M.S.3    Herz, J.4    Burns, D.K.5
  • 98
    • 0033827087 scopus 로고    scopus 로고
    • APOLIPOPROTEIN B: MRNA editing, lipoprotein assembly, and presecretory degradation
    • Davidson NO and Shelness GS. APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation. Annu Rev Nutr 2000; 20: 169-93.
    • (2000) Annu Rev Nutr , vol.20 , pp. 169-193
    • Davidson, N.O.1    Shelness, G.S.2
  • 99
    • 0028268018 scopus 로고
    • The two-receptor model of lipoprotein clearance: Tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins
    • Ishibashi S, Herz J, Maeda N, Goldstein JL, and Brown MS. The two-receptor model of lipoprotein clearance: tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci USA 1994; 91: 4431-5.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4431-4435
    • Ishibashi, S.1    Herz, J.2    Maeda, N.3    Goldstein, J.L.4    Brown, M.S.5
  • 100
    • 0028917252 scopus 로고
    • Lipoprotein and receptor interactions in vivo
    • Herz J and Willnow TE. Lipoprotein and receptor interactions in vivo. Curr Opin Lipidol 1995; 6: 97-103.
    • (1995) Curr Opin Lipidol , vol.6 , pp. 97-103
    • Herz, J.1    Willnow, T.E.2
  • 101
    • 0031927755 scopus 로고    scopus 로고
    • A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
    • Powell-Braxton L, Veniant M, Latvala RD, et al. A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet. Nat Med 1998; 4: 934-8.
    • (1998) Nat Med , vol.4 , pp. 934-938
    • Powell-Braxton, L.1    Veniant, M.2    Latvala, R.D.3
  • 102
    • 0242695290 scopus 로고    scopus 로고
    • Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100
    • Veniant MM, Pierotti V, Newland D, et al. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest 1997; 100: 180-8.
    • (1997) J Clin Invest , vol.100 , pp. 180-188
    • Veniant, M.M.1    Pierotti, V.2    Newland, D.3
  • 103
    • 0027172292 scopus 로고
    • Apolipoprotein B mRNA editing in 12 different mammalian species: Hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins
    • Greeve J, Altkemper I, Dieterich JH, Greten H, and Windler E. Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins. J Lipid Res 1993; 34: 1367-83.
    • (1993) J Lipid Res , vol.34 , pp. 1367-1383
    • Greeve, J.1    Altkemper, I.2    Dieterich, J.H.3    Greten, H.4    Windler, E.5
  • 104
    • 0024204966 scopus 로고
    • Cloning and mRNA tissue distribution of rabbit cholesteryl ester transfer protein
    • Nagashima M, McLean JW, and Lawn RM. Cloning and mRNA tissue distribution of rabbit cholesteryl ester transfer protein. J Lipid Res 1988; 29: 1643-9.
    • (1988) J Lipid Res , vol.29 , pp. 1643-1649
    • Nagashima, M.1    McLean, J.W.2    Lawn, R.M.3
  • 105
    • 0016909502 scopus 로고
    • Rabbits as a model for the study of hyperlipoproteinemia and atherosclerosis
    • Shore B and Shore V. Rabbits as a model for the study of hyperlipoproteinemia and atherosclerosis. Adv Exp Med Biol 1976; 67: 123-41.
    • (1976) Adv Exp Med Biol , vol.67 , pp. 123-141
    • Shore, B.1    Shore, V.2
  • 106
    • 0019162990 scopus 로고
    • Animal lipoproteins: Chemistry, structure, and comparative aspects
    • Chapman MJ. Animal lipoproteins: chemistry, structure, and comparative aspects. J Lipid Res 1980; 21: 789-853.
    • (1980) J Lipid Res , vol.21 , pp. 789-853
    • Chapman, M.J.1
  • 107
    • 0025832067 scopus 로고
    • Rabbit hepatic lipase cDNA sequence: Low activity is associated with low messenger RNA levels
    • Warren RJ, Ebert DL, Mitchell A, and Barter PJ. Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels. J Lipid Res 1991; 32: 1333-9.
    • (1991) J Lipid Res , vol.32 , pp. 1333-1339
    • Warren, R.J.1    Ebert, D.L.2    Mitchell, A.3    Barter, P.J.4
  • 108
    • 0023097906 scopus 로고
    • Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit
    • Spady DK, Huettinger M, Bilheimer DW, and Dietschy JM. Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit. J Lipid Res 1987; 28: 32-41.
    • (1987) J Lipid Res , vol.28 , pp. 32-41
    • Spady, D.K.1    Huettinger, M.2    Bilheimer, D.W.3    Dietschy, J.M.4
  • 109
    • 0027418090 scopus 로고
    • Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits. I. The effects of aging and gender on plasma lipids and lipoproteins
    • Esper E, Chan EK, and Buchwald H. Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits. I. The effects of aging and gender on plasma lipids and lipoproteins. J Lab Clin Med 1993; 121: 97-102.
    • (1993) J Lab Clin Med , vol.121 , pp. 97-102
    • Esper, E.1    Chan, E.K.2    Buchwald, H.3
  • 110
    • 0027419602 scopus 로고
    • Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits. II. Morphologic evaluation of spontaneously occurring aortic and coronary lesions
    • Esper E, Runge WJ, Gunther R, and Buchwald H. Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits. II. Morphologic evaluation of spontaneously occurring aortic and coronary lesions. J Lab Clin Med 1993; 121: 103-10.
    • (1993) J Lab Clin Med , vol.121 , pp. 103-110
    • Esper, E.1    Runge, W.J.2    Gunther, R.3    Buchwald, H.4
  • 111
    • 67349153820 scopus 로고    scopus 로고
    • Apolipoprotein A-I and lecithin:Cholesterol acyltransferase transfer induce cholesterol unloading in complex atherosclerotic lesions
    • Van Craeyveld E, Lievens J, Jacobs F, et al. Apolipoprotein A-I and lecithin:cholesterol acyltransferase transfer induce cholesterol unloading in complex atherosclerotic lesions. Gene Ther 2009; 16: 757-65.
    • (2009) Gene Ther , vol.16 , pp. 757-765
    • van Craeyveld, E.1    Lievens, J.2    Jacobs, F.3
  • 112
    • 0024368979 scopus 로고
    • Cholesterol-fed heterozygous Watanabe heritable hyperlipidemic rabbits: A new model for atherosclerosis
    • Atkinson JB, Hoover RL, Berry KK, and Swift LL. Cholesterol-fed heterozygous Watanabe heritable hyperlipidemic rabbits: a new model for atherosclerosis. Atherosclerosis 1989; 78: 123-36.
    • (1989) Atherosclerosis , vol.78 , pp. 123-136
    • Atkinson, J.B.1    Hoover, R.L.2    Berry, K.K.3    Swift, L.L.4
  • 113
    • 77952710231 scopus 로고    scopus 로고
    • The relative atherogenicity of VLDL and LDL is dependent on the topographic site
    • Van Craeyveld E, Jacobs F, Feng Y, et al. The relative atherogenicity of VLDL and LDL is dependent on the topographic site. J Lipid Res 2010; 51: 1478-85.
    • (2010) J Lipid Res , vol.51 , pp. 1478-1485
    • van Craeyveld, E.1    Jacobs, F.2    Feng, Y.3
  • 114
    • 78650420101 scopus 로고    scopus 로고
    • The diameter of liver sinusoidal fenestrae is not a major determinant of lipoprotein levels and atherosclerosis in cholesterol-fed rabbits
    • Jacobs F, Van Craeyveld E, Feng Y, and De Geest B. The diameter of liver sinusoidal fenestrae is not a major determinant of lipoprotein levels and atherosclerosis in cholesterol-fed rabbits. Cardiovasc Pathol 2011; 20: 44-50.
    • (2011) Cardiovasc Pathol , vol.20 , pp. 44-50
    • Jacobs, F.1    van Craeyveld, E.2    Feng, Y.3    de Geest, B.4
  • 115
    • 0016523453 scopus 로고
    • A heritable hyperlipemic rabbit (author's transl)
    • Kondo T and Watanabe Y. A heritable hyperlipemic rabbit (author's transl)]. Jikken Dobutsu 1975; 24: 89-94.
    • (1975) Jikken Dobutsu , vol.24 , pp. 89-94
    • Kondo, T.1    Watanabe, Y.2
  • 116
    • 0018887237 scopus 로고
    • Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL- rabbit)
    • Watanabe Y. Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL- rabbit). Atherosclerosis 1980; 36: 261-8.
    • (1980) Atherosclerosis , vol.36 , pp. 261-268
    • Watanabe, Y.1
  • 117
    • 0022482872 scopus 로고
    • Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit
    • Yamamoto T, Bishop RW, Brown MS, Goldstein JL, and Russell DW. Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science 1986; 232: 1230-7.
    • (1986) Science , vol.232 , pp. 1230-1237
    • Yamamoto, T.1    Bishop, R.W.2    Brown, M.S.3    Goldstein, J.L.4    Russell, D.W.5
  • 118
    • 0034072413 scopus 로고    scopus 로고
    • Age-associated decrease in plasma cholesterol and changes in cholesterol metabolism in homozygous Watanabe heritable hyperlipidemic rabbits
    • Shiomi M, Ito T, Fujioka T, and Tsujita Y. Age-associated decrease in plasma cholesterol and changes in cholesterol metabolism in homozygous Watanabe heritable hyperlipidemic rabbits. Metabolism: clinical and experimental 2000; 49: 552-6.
    • (2000) Metabolism: Clinical and Experimental , vol.49 , pp. 552-556
    • Shiomi, M.1    Ito, T.2    Fujioka, T.3    Tsujita, Y.4
  • 119
    • 0023933504 scopus 로고
    • Biochemical and pathological features of a modified strain of Watanabe heritable hyperlipidaemic rabbits
    • Gallagher PJ, Nanjee MN, Richards T, Roche WR, and Miller NE. Biochemical and pathological features of a modified strain of Watanabe heritable hyperlipidaemic rabbits. Atherosclerosis 1988; 71: 173-83.
    • (1988) Atherosclerosis , vol.71 , pp. 173-183
    • Gallagher, P.J.1    Nanjee, M.N.2    Richards, T.3    Roche, W.R.4    Miller, N.E.5
  • 120
    • 0024440925 scopus 로고
    • Kinetics of HDL-apo A-I in the WHHL rabbit, an animal model of familial hypercholesterolemia
    • Saku K, Yamamoto K, Sakai T, et al. Kinetics of HDL-apo A-I in the WHHL rabbit, an animal model of familial hypercholesterolemia. Atherosclerosis 1989; 79: 225-30.
    • (1989) Atherosclerosis , vol.79 , pp. 225-230
    • Saku, K.1    Yamamoto, K.2    Sakai, T.3
  • 121
    • 0022497310 scopus 로고
    • Increased lipid transfer activities in hyperlipidemic rabbit plasma
    • Son YS and Zilversmit DB. Increased lipid transfer activities in hyperlipidemic rabbit plasma. Arteriosclerosis Dallas, Tex 1986; 6: 345-51.
    • (1986) Arteriosclerosis Dallas, Tex , vol.6 , pp. 345-351
    • Son, Y.S.1    Zilversmit, D.B.2
  • 122
    • 73949151839 scopus 로고    scopus 로고
    • The role of liver sinusoidal cells in hepatocyte-directed gene transfer
    • Jacobs F, Wisse E, and De Geest B. The role of liver sinusoidal cells in hepatocyte-directed gene transfer. Am J Pathol 2010; 176: 14-21.
    • (2010) Am J Pathol , vol.176 , pp. 14-21
    • Jacobs, F.1    Wisse, E.2    de Geest, B.3
  • 123
    • 0030943732 scopus 로고    scopus 로고
    • Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo
    • Kuzmin AI, Finegold MJ, and Eisensmith RC. Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo. Gene Ther 1997; 4: 309-16.
    • (1997) Gene Ther , vol.4 , pp. 309-316
    • Kuzmin, A.I.1    Finegold, M.J.2    Eisensmith, R.C.3
  • 124
    • 0031060294 scopus 로고    scopus 로고
    • Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ
    • Wolff G, Worgall S, van Rooijen N, et al. Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. J Virol 1997; 71: 624-9.
    • (1997) J Virol , vol.71 , pp. 624-629
    • Wolff, G.1    Worgall, S.2    van Rooijen, N.3
  • 125
    • 0037222389 scopus 로고    scopus 로고
    • Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors
    • Schiedner G, Hertel S, Johnston M, et al. Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors. Mol Ther 2003; 7: 35-43.
    • (2003) Mol Ther , vol.7 , pp. 35-43
    • Schiedner, G.1    Hertel, S.2    Johnston, M.3
  • 126
    • 28844493201 scopus 로고    scopus 로고
    • Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer
    • Snoeys J, Mertens G, Lievens J, et al. Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer. Mol Ther 2006; 13: 98-107.
    • (2006) Mol Ther , vol.13 , pp. 98-107
    • Snoeys, J.1    Mertens, G.2    Lievens, J.3
  • 127
    • 0014769772 scopus 로고
    • An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids
    • Wisse E. An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids. J Ultrastruct Res 1970; 31: 125-50.
    • (1970) J Ultrastruct Res , vol.31 , pp. 125-150
    • Wisse, E.1
  • 128
    • 0015308917 scopus 로고
    • An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells
    • Wisse E. An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. J Ultrastruct Res 1972; 38: 528-62.
    • (1972) J Ultrastruct Res , vol.38 , pp. 528-562
    • Wisse, E.1
  • 129
    • 65949109909 scopus 로고    scopus 로고
    • Species differences in hepatocyte-directed gene transfer: Implications for clinical translation
    • Jacobs F, Feng Y, Van Craeyveld E, et al. Species differences in hepatocyte-directed gene transfer: implications for clinical translation. Curr Gene Ther 2009; 9: 83-90.
    • (2009) Curr Gene Ther , vol.9 , pp. 83-90
    • Jacobs, F.1    Feng, Y.2    van Craeyveld, E.3
  • 130
    • 0021858187 scopus 로고
    • The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse
    • Wisse E, De Zanger RB, Charels K, Van Der Smissen P, and McCuskey RS. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 1985; 5: 683-92.
    • (1985) Hepatology , vol.5 , pp. 683-692
    • Wisse, E.1    de Zanger, R.B.2    Charels, K.3    van der Smissen, P.4    McCuskey, R.S.5
  • 131
    • 33947417327 scopus 로고    scopus 로고
    • Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae
    • Snoeys J, Lievens J, Wisse E, et al. Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae. Gene Ther 2007; 14: 604-12.
    • (2007) Gene Ther , vol.14 , pp. 604-612
    • Snoeys, J.1    Lievens, J.2    Wisse, E.3
  • 132
    • 5444276671 scopus 로고    scopus 로고
    • The size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer
    • Lievens J, Snoeys J, Vekemans K, et al. The size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer. Gene Ther 2004; 11: 1523-31.
    • (2004) Gene Ther , vol.11 , pp. 1523-1531
    • Lievens, J.1    Snoeys, J.2    Vekemans, K.3
  • 133
    • 50049136079 scopus 로고    scopus 로고
    • The size of endothelial fenestrae in human liver sinusoids: Implications for hepatocyte-directed gene transfer
    • Wisse E, Jacobs F, Topal B, Frederik P, and De Geest B. The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer. Gene Ther 2008; 15: 1193-9.
    • (2008) Gene Ther , vol.15 , pp. 1193-1199
    • Wisse, E.1    Jacobs, F.2    Topal, B.3    Frederik, P.4    de Geest, B.5
  • 134
    • 34948851811 scopus 로고    scopus 로고
    • Comparative observation of the recombinant adenoassociated virus 2 using transmission electron microscopy and atomic force microscopy
    • Chen H. Comparative observation of the recombinant adenoassociated virus 2 using transmission electron microscopy and atomic force microscopy. Microsc Microanal 2007; 13: 384-9.
    • (2007) Microsc Microanal , vol.13 , pp. 384-389
    • Chen, H.1
  • 135
    • 0028214173 scopus 로고
    • Herpes simplex virus L particles contain spherical membrane-enclosed inclusion vesicles
    • Szilagyi JF and Berriman J. Herpes simplex virus L particles contain spherical membrane-enclosed inclusion vesicles. J Gen Virol 1994; 75 (Pt 7): 1749-53.
    • (1994) J Gen Virol , vol.75 , Issue.PART 7 , pp. 1749-1753
    • Szilagyi, J.F.1    Berriman, J.2
  • 136
    • 79955681398 scopus 로고    scopus 로고
    • Why the diameter of sinusoidal fenestrae unlikely matters for lipoprotein metabolism and atherosclerosis susceptibility
    • Jacobs F, Van Craeyveld E, and De Geest B. Why the diameter of sinusoidal fenestrae unlikely matters for lipoprotein metabolism and atherosclerosis susceptibility. Cardiovasc Pathol 2011; 20: 193-4.
    • (2011) Cardiovasc Pathol , vol.20 , pp. 193-194
    • Jacobs, F.1    van Craeyveld, E.2    de Geest, B.3
  • 137
    • 0025188013 scopus 로고
    • Temporary amelioration of hyperlipidemia in low density lipoprotein receptordeficient rabbits transplanted with genetically modified hepatocytes
    • Wilson JM, Chowdhury NR, Grossman M, et al. Temporary amelioration of hyperlipidemia in low density lipoprotein receptordeficient rabbits transplanted with genetically modified hepatocytes. Proceedings of the National Academy of Sciences of the United States of America 1990; 87: 8437-41.
    • (1990) Proceedings of the National Academy of Sciences of the United States of America , vol.87 , pp. 8437-8441
    • Wilson, J.M.1    Chowdhury, N.R.2    Grossman, M.3
  • 138
    • 0026355641 scopus 로고
    • Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits
    • Chowdhury JR, Grossman M, Gupta S, et al. Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science New York, N.Y 1991; 254: 1802-5.
    • (1991) Science New York, N.Y , vol.254 , pp. 1802-1805
    • Chowdhury, J.R.1    Grossman, M.2    Gupta, S.3
  • 139
    • 0027534621 scopus 로고
    • A novel approach for introducing hepatocytes into the portal circulation
    • Grossman M, Wilson JM, and Raper SE. A novel approach for introducing hepatocytes into the portal circulation. J Lab Clin Med 1993; 121: 472-8.
    • (1993) J Lab Clin Med , vol.121 , pp. 472-478
    • Grossman, M.1    Wilson, J.M.2    Raper, S.E.3
  • 140
    • 0026938511 scopus 로고
    • Transplantation of genetically modified autologous hepatocytes into nonhuman primates: Feasibility and short-term toxicity
    • Grossman M, Raper SE, and Wilson JM. Transplantation of genetically modified autologous hepatocytes into nonhuman primates: feasibility and short-term toxicity. Hum Gene Ther 1992; 3: 501-10.
    • (1992) Hum Gene Ther , vol.3 , pp. 501-510
    • Grossman, M.1    Raper, S.E.2    Wilson, J.M.3
  • 141
    • 0026842933 scopus 로고
    • Ex vivo gene therapy of familial hypercholesterolemia
    • Wilson JM, Grossman M, Raper SE, et al. Ex vivo gene therapy of familial hypercholesterolemia. Hum Gene Ther 1992; 3: 179-222.
    • (1992) Hum Gene Ther , vol.3 , pp. 179-222
    • Wilson, J.M.1    Grossman, M.2    Raper, S.E.3
  • 142
    • 0026349396 scopus 로고
    • Towards liver-directed gene therapy: Retrovirus-mediated gene transfer into human hepatocytes
    • Grossman M, Raper SE, and Wilson JM. Towards liver-directed gene therapy: retrovirus-mediated gene transfer into human hepatocytes. Somat Cell Mol Genet 1991; 17: 601-7.
    • (1991) Somat Cell Mol Genet , vol.17 , pp. 601-607
    • Grossman, M.1    Raper, S.E.2    Wilson, J.M.3
  • 143
    • 0028292602 scopus 로고
    • Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia
    • Grossman M, Raper SE, Kozarsky K, et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet 1994; 6: 335-41.
    • (1994) Nat Genet , vol.6 , pp. 335-341
    • Grossman, M.1    Raper, S.E.2    Kozarsky, K.3
  • 144
    • 0030022230 scopus 로고    scopus 로고
    • Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia
    • Raper SE, Grossman M, Rader DJ, et al. Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Ann Surg 1996; 223: 116-26.
    • (1996) Ann Surg , vol.223 , pp. 116-126
    • Raper, S.E.1    Grossman, M.2    Rader, D.J.3
  • 145
    • 78649942440 scopus 로고    scopus 로고
    • LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives
    • Al-Allaf FA, Coutelle C, Waddington SN, et al. LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives. Int Arch Med; 3: 36.
    • Int Arch Med , vol.3 , pp. 36
    • Al-Allaf, F.A.1    Coutelle, C.2    Waddington, S.N.3
  • 146
    • 0026502766 scopus 로고
    • Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits
    • Wilson JM, Grossman M, Wu CH, et al. Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits. The Journal of biological chemistry 1992; 267: 963-7.
    • (1992) The Journal of Biological Chemistry , vol.267 , pp. 963-967
    • Wilson, J.M.1    Grossman, M.2    Wu, C.H.3
  • 147
    • 0028234357 scopus 로고
    • In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
    • Kozarsky KF, McKinley DR, Austin LL, et al. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem 1994; 269: 13695-702.
    • (1994) J Biol Chem , vol.269 , pp. 13695-13702
    • Kozarsky, K.F.1    McKinley, D.R.2    Austin, L.L.3
  • 148
    • 0028831356 scopus 로고
    • In vivo gene therapy for hyperlipidemia: Phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene
    • Li J, Fang B, Eisensmith RC, et al. In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene. J Clin Invest 1995; 95: 768-73.
    • (1995) J Clin Invest , vol.95 , pp. 768-773
    • Li, J.1    Fang, B.2    Eisensmith, R.C.3
  • 149
    • 0029962807 scopus 로고    scopus 로고
    • Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
    • Kobayashi K, Oka K, Forte T, et al. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J Biol Chem 1996; 271: 6852-60.
    • (1996) J Biol Chem , vol.271 , pp. 6852-6860
    • Kobayashi, K.1    Oka, K.2    Forte, T.3
  • 150
    • 0029988465 scopus 로고    scopus 로고
    • Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    • Kozarsky KF, Jooss K, Donahee M, Strauss JF, 3rd, and Wilson JM. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat Genet 1996; 13: 54-62.
    • (1996) Nat Genet , vol.13 , pp. 54-62
    • Kozarsky, K.F.1    Jooss, K.2    Donahee, M.3    Strauss 3rd, J.F.4    Wilson, J.M.5
  • 151
    • 0028484704 scopus 로고
    • MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
    • Yang Y, Ertl HC, and Wilson JM. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994; 1: 433-42.
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Ertl, H.C.2    Wilson, J.M.3
  • 152
    • 0028328261 scopus 로고
    • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
    • Yang Y, Nunes FA, Berencsi K, et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-11.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4407-4411
    • Yang, Y.1    Nunes, F.A.2    Berencsi, K.3
  • 153
    • 0034152718 scopus 로고    scopus 로고
    • Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector
    • O'Neal WK, Zhou H, Morral N, et al. Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector. Mol Med 2000; 6: 179-95.
    • (2000) Mol Med , vol.6 , pp. 179-195
    • O'Neal, W.K.1    Zhou, H.2    Morral, N.3
  • 154
    • 0033982331 scopus 로고    scopus 로고
    • Sustained expression of human apolipoprotein A-I after adenoviral gene transfer in C57BL/6 mice: Role of apolipoprotein A-I promoter, apolipoprotein A-I introns, and human apolipoprotein E enhancer
    • De Geest B, Van Linthout S, Lox M, Collen D, and Holvoet P. Sustained expression of human apolipoprotein A-I after adenoviral gene transfer in C57BL/6 mice: role of apolipoprotein A-I promoter, apolipoprotein A-I introns, and human apolipoprotein E enhancer. Hum Gene Ther 2000; 11: 101-12.
    • (2000) Hum Gene Ther , vol.11 , pp. 101-112
    • de Geest, B.1    van Linthout, S.2    Lox, M.3    Collen, D.4    Holvoet, P.5
  • 155
    • 0034746309 scopus 로고    scopus 로고
    • Sustained expression of human apo A-I following adenoviral gene transfer in mice
    • De Geest B, Van Linthout S, and Collen D. Sustained expression of human apo A-I following adenoviral gene transfer in mice. Gene Ther 2001; 8: 121-7.
    • (2001) Gene Ther , vol.8 , pp. 121-127
    • de Geest, B.1    van Linthout, S.2    Collen, D.3
  • 156
    • 0036252993 scopus 로고    scopus 로고
    • Effect of promoters and enhancers on expression, transgene DNA persistence, and hepatotoxicity after adenoviral gene transfer of human apolipoprotein A-I
    • Van Linthout S, Collen D, and De Geest B. Effect of promoters and enhancers on expression, transgene DNA persistence, and hepatotoxicity after adenoviral gene transfer of human apolipoprotein A-I. Hum Gene Ther 2002; 13: 829-40.
    • (2002) Hum Gene Ther , vol.13 , pp. 829-840
    • van Linthout, S.1    Collen, D.2    de Geest, B.3
  • 157
    • 18744364150 scopus 로고    scopus 로고
    • Persistent hepatic expression of human apo A-I after transfer with a helpervirus independent adenoviral vector
    • Van Linthout S, Lusky M, Collen D, and De Geest B. Persistent hepatic expression of human apo A-I after transfer with a helpervirus independent adenoviral vector. Gene Ther 2002; 9: 1520-8.
    • (2002) Gene Ther , vol.9 , pp. 1520-1528
    • van Linthout, S.1    Lusky, M.2    Collen, D.3    de Geest, B.4
  • 158
    • 6544243305 scopus 로고    scopus 로고
    • Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase--ganciclovir treatment
    • Pakkanen TM, Laitinen M, Hippelainen M, et al. Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase--ganciclovir treatment. Gene Ther 1999; 6: 34-41.
    • (1999) Gene Ther , vol.6 , pp. 34-41
    • Pakkanen, T.M.1    Laitinen, M.2    Hippelainen, M.3
  • 159
    • 0036673387 scopus 로고    scopus 로고
    • Therapeutic approach to familial hypercholesterolemia by HVJ-liposomes in LDL receptor knockout mouse
    • Tomita N, Morishita R, Koike H, et al. Therapeutic approach to familial hypercholesterolemia by HVJ-liposomes in LDL receptor knockout mouse. Int J Mol Med 2002; 10: 137-43.
    • (2002) Int J Mol Med , vol.10 , pp. 137-143
    • Tomita, N.1    Morishita, R.2    Koike, H.3
  • 160
    • 0038442874 scopus 로고    scopus 로고
    • Intravenous gene therapy for familial hypercholesterolemia using ligand-facilitated transfer of a liposome:LDL receptor gene complex
    • Shichiri M, Tanaka A, and Hirata Y. Intravenous gene therapy for familial hypercholesterolemia using ligand-facilitated transfer of a liposome:LDL receptor gene complex. Gene Ther 2003; 10: 827-31.
    • (2003) Gene Ther , vol.10 , pp. 827-831
    • Shichiri, M.1    Tanaka, A.2    Hirata, Y.3
  • 161
    • 56649109925 scopus 로고    scopus 로고
    • Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia
    • Jacobs F, Van Craeyveld E, Feng Y, Snoeys J, and De Geest B. Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia. Atherosclerosis 2008; 201: 289-97.
    • (2008) Atherosclerosis , vol.201 , pp. 289-297
    • Jacobs, F.1    van Craeyveld, E.2    Feng, Y.3    Snoeys, J.4    de Geest, B.5
  • 162
    • 4644247930 scopus 로고    scopus 로고
    • Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage
    • Cichon G, Willnow T, Herwig S, et al. Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage. J Gene Med 2004; 6: 166-75.
    • (2004) J Gene Med , vol.6 , pp. 166-175
    • Cichon, G.1    Willnow, T.2    Herwig, S.3
  • 163
    • 76349091597 scopus 로고    scopus 로고
    • Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs
    • Hibbitt OC, McNeil E, Lufino MM, et al. Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs. Mol Ther; 18: 317-26.
    • Mol Ther , vol.18 , pp. 317-326
    • Hibbitt, O.C.1    McNeil, E.2    Lufino, M.M.3
  • 164
    • 0038446697 scopus 로고    scopus 로고
    • Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigenpresenting cells
    • De Geest BR, Van Linthout SA, and Collen D. Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigenpresenting cells. Blood 2003; 101: 2551-6.
    • (2003) Blood , vol.101 , pp. 2551-2556
    • de Geest, B.R.1    van Linthout, S.A.2    Collen, D.3
  • 165
    • 0033587482 scopus 로고    scopus 로고
    • Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors
    • Pastore L, Morral N, Zhou H, et al. Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors. Hum Gene Ther 1999; 10: 1773-81.
    • (1999) Hum Gene Ther , vol.10 , pp. 1773-1781
    • Pastore, L.1    Morral, N.2    Zhou, H.3
  • 166
    • 0037988905 scopus 로고    scopus 로고
    • Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer
    • Mingozzi F, Liu YL, Dobrzynski E, et al. Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer. J Clin Invest 2003; 111: 1347-56.
    • (2003) J Clin Invest , vol.111 , pp. 1347-1356
    • Mingozzi, F.1    Liu, Y.L.2    Dobrzynski, E.3
  • 167
    • 27744533046 scopus 로고    scopus 로고
    • Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II
    • Franco LM, Sun B, Yang X, et al. Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. Mol Ther 2005; 12: 876-84.
    • (2005) Mol Ther , vol.12 , pp. 876-884
    • Franco, L.M.1    Sun, B.2    Yang, X.3
  • 168
    • 28444455678 scopus 로고    scopus 로고
    • Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver
    • Al-Dosari M, Zhang G, Knapp JE, and Liu D. Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver. Biochem Biophys Res Commun 2006; 339: 673-8.
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 673-678
    • Al-Dosari, M.1    Zhang, G.2    Knapp, J.E.3    Liu, D.4
  • 169
    • 0029834562 scopus 로고    scopus 로고
    • Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer
    • Guo ZS, Wang LH, Eisensmith RC, and Woo SL. Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer. Gene Ther 1996; 3: 802-10.
    • (1996) Gene Ther , vol.3 , pp. 802-810
    • Guo, Z.S.1    Wang, L.H.2    Eisensmith, R.C.3    Woo, S.L.4
  • 170
    • 2342619607 scopus 로고    scopus 로고
    • Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy
    • Kankkonen HM, Vahakangas E, Marr RA, et al. Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Mol Ther 2004; 9: 548-56.
    • (2004) Mol Ther , vol.9 , pp. 548-556
    • Kankkonen, H.M.1    Vahakangas, E.2    Marr, R.A.3
  • 171
    • 17044394814 scopus 로고    scopus 로고
    • Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy
    • Wang L, Calcedo R, Nichols TC, et al. Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy. Blood 2005; 105: 3079-86.
    • (2005) Blood , vol.105 , pp. 3079-3086
    • Wang, L.1    Calcedo, R.2    Nichols, T.C.3
  • 173
    • 0029127002 scopus 로고
    • Rat growth hormone gene introns stimulate nucleosome alignment in vitro and in transgenic mice
    • Liu K, Sandgren EP, Palmiter RD, and Stein A. Rat growth hormone gene introns stimulate nucleosome alignment in vitro and in transgenic mice. Proc Natl Acad Sci USA 1995; 92: 7724-8.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7724-7728
    • Liu, K.1    Sandgren, E.P.2    Palmiter, R.D.3    Stein, A.4
  • 174
    • 0034202522 scopus 로고    scopus 로고
    • Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro
    • Miao CH, Ohashi K, Patijn GA, et al. Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro. Mol Ther 2000; 1: 522-32.
    • (2000) Mol Ther , vol.1 , pp. 522-532
    • Miao, C.H.1    Ohashi, K.2    Patijn, G.A.3
  • 176
    • 0031958593 scopus 로고    scopus 로고
    • Scaffold attachment region-mediated enhancement of retroviral vector expression in primary T cells
    • Agarwal M, Austin TW, Morel F, et al. Scaffold attachment region-mediated enhancement of retroviral vector expression in primary T cells. J Virol 1998; 72: 3720-8.
    • (1998) J Virol , vol.72 , pp. 3720-3728
    • Agarwal, M.1    Austin, T.W.2    Morel, F.3
  • 177
    • 0033587191 scopus 로고    scopus 로고
    • Effect of scaffold attachment region on transgene expression in retrovirus vector-transduced primary T cells and macrophages
    • Auten J, Agarwal M, Chen J, Sutton R, and Plavec I. Effect of scaffold attachment region on transgene expression in retrovirus vector-transduced primary T cells and macrophages. Hum Gene Ther 1999; 10: 1389-99.
    • (1999) Hum Gene Ther , vol.10 , pp. 1389-1399
    • Auten, J.1    Agarwal, M.2    Chen, J.3    Sutton, R.4    Plavec, I.5
  • 178
    • 0034088115 scopus 로고    scopus 로고
    • Human beta interferon scaffold attachment region inhibits de novo methylation and confers longterm, copy number-dependent expression to a retroviral vector
    • Dang Q, Auten J, and Plavec I. Human beta interferon scaffold attachment region inhibits de novo methylation and confers longterm, copy number-dependent expression to a retroviral vector. J Virol 2000; 74: 2671-8.
    • (2000) J Virol , vol.74 , pp. 2671-2678
    • Dang, Q.1    Auten, J.2    Plavec, I.3
  • 179
    • 0034950612 scopus 로고    scopus 로고
    • Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo
    • Miao CH, Thompson AR, Loeb K, and Ye X. Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo. Mol Ther 2001; 3: 947-57.
    • (2001) Mol Ther , vol.3 , pp. 947-957
    • Miao, C.H.1    Thompson, A.R.2    Loeb, K.3    Ye, X.4
  • 180
    • 0036148167 scopus 로고    scopus 로고
    • Variables affecting in vivo performance of high-capacity adenovirus vectors
    • Schiedner G, Hertel S, Johnston M, et al. Variables affecting in vivo performance of high-capacity adenovirus vectors. J Virol 2002; 76: 1600-9.
    • (2002) J Virol , vol.76 , pp. 1600-1609
    • Schiedner, G.1    Hertel, S.2    Johnston, M.3
  • 181
    • 0031471857 scopus 로고    scopus 로고
    • Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice
    • De Geest B, Zhao Z, Collen D, and Holvoet P. Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice. Circulation 1997; 96: 4349-56.
    • (1997) Circulation , vol.96 , pp. 4349-4356
    • de Geest, B.1    Zhao, Z.2    Collen, D.3    Holvoet, P.4
  • 182
    • 43049180252 scopus 로고    scopus 로고
    • Direct comparison of hepatocytespecific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer
    • Jacobs F, Snoeys J, Feng Y, et al. Direct comparison of hepatocytespecific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer. Gene Ther 2008; 15: 594-603.
    • (2008) Gene Ther , vol.15 , pp. 594-603
    • Jacobs, F.1    Snoeys, J.2    Feng, Y.3
  • 183
    • 0034264614 scopus 로고    scopus 로고
    • Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor
    • Chen SJ, Rader DJ, Tazelaar J, et al. Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor. Mol Ther 2000; 2: 256-61.
    • (2000) Mol Ther , vol.2 , pp. 256-261
    • Chen, S.J.1    Rader, D.J.2    Tazelaar, J.3
  • 184
    • 0035814955 scopus 로고    scopus 로고
    • Long-term stable correction of low-density lipoprotein receptor- deficient mice with a helperdependent adenoviral vector expressing the very low-density lipoprotein receptor
    • Oka K, Pastore L, Kim IH, et al. Long-term stable correction of low-density lipoprotein receptor- deficient mice with a helperdependent adenoviral vector expressing the very low-density lipoprotein receptor. Circulation 2001; 103: 1274-81.
    • (2001) Circulation , vol.103 , pp. 1274-1281
    • Oka, K.1    Pastore, L.2    Kim, I.H.3
  • 185
    • 5444276005 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia
    • Nomura S, Merched A, Nour E, et al. Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. Gene Ther 2004; 11: 1540-8.
    • (2004) Gene Ther , vol.11 , pp. 1540-1548
    • Nomura, S.1    Merched, A.2    Nour, E.3
  • 186
    • 6344275675 scopus 로고    scopus 로고
    • Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia
    • Lebherz C, Gao G, Louboutin JP, et al. Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia. J Gene Med 2004; 6: 663-72.
    • (2004) J Gene Med , vol.6 , pp. 663-672
    • Lebherz, C.1    Gao, G.2    Louboutin, J.P.3
  • 187
    • 0037566365 scopus 로고    scopus 로고
    • Long-term stable expression of human apolipoprotein A-I mediated by helperdependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia
    • Belalcazar LM, Merched A, Carr B, et al. Long-term stable expression of human apolipoprotein A-I mediated by helperdependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia. Circulation 2003; 107: 2726-32.
    • (2003) Circulation , vol.107 , pp. 2726-2732
    • Belalcazar, L.M.1    Merched, A.2    Carr, B.3
  • 188
    • 38549109764 scopus 로고    scopus 로고
    • Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells
    • Feng Y, Jacobs F, Van Craeyveld E, et al. Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008; 28: 278-83.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 278-283
    • Feng, Y.1    Jacobs, F.2    van Craeyveld, E.3
  • 189
    • 60249097216 scopus 로고    scopus 로고
    • Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer
    • Feng Y, van Eck M, Van Craeyveld E, et al. Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer. Blood 2009; 113: 755-64.
    • (2009) Blood , vol.113 , pp. 755-764
    • Feng, Y.1    van Eck, M.2    van Craeyveld, E.3
  • 190
    • 60549100304 scopus 로고    scopus 로고
    • Wild-type apo A-I and apo A-I(Milano) gene transfer reduce native and transplant arteriosclerosis to a similar extent
    • Feng Y, Van Craeyveld E, Jacobs F, et al. Wild-type apo A-I and apo A-I(Milano) gene transfer reduce native and transplant arteriosclerosis to a similar extent. J Mol Med 2009; 87: 287-97.
    • (2009) J Mol Med , vol.87 , pp. 287-297
    • Feng, Y.1    van Craeyveld, E.2    Jacobs, F.3
  • 191
    • 79151485904 scopus 로고    scopus 로고
    • Topical HDL administration reduces vein graft atherosclerosis in apo E deficient mice
    • Feng Y, Gordts SC, Chen F, et al. Topical HDL administration reduces vein graft atherosclerosis in apo E deficient mice. Atherosclerosis 2010; 214: 271-8.
    • (2010) Atherosclerosis , vol.214 , pp. 271-278
    • Feng, Y.1    Gordts, S.C.2    Chen, F.3
  • 192
    • 78149421771 scopus 로고    scopus 로고
    • Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis
    • Kassim SH, Li H, Vandenberghe LH, et al. Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis. PLoS One; 5: e13424.
    • PLoS One , vol.5
    • Kassim, S.H.1    Li, H.2    Vandenberghe, L.H.3
  • 193
    • 79959982293 scopus 로고    scopus 로고
    • Regression and stabilization of advanced murine atherosclerotic lesions: A comparison of LDL lowering and HDL raising gene transfer strategies
    • Van Craeyveld E, Gordts SC, Nefyodova E, Jacobs F, and De Geest B. Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies. J Mol Med 2011; 89: 555-67.
    • (2011) J Mol Med , vol.89 , pp. 555-567
    • van Craeyveld, E.1    Gordts, S.C.2    Nefyodova, E.3    Jacobs, F.4    de Geest, B.5
  • 194
    • 33744776646 scopus 로고    scopus 로고
    • Aggressive very lowdensity lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice
    • MacDougall ED, Kramer F, Polinsky P, et al. Aggressive very lowdensity lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice. Am J Pathol 2006; 168: 2064-73.
    • (2006) Am J Pathol , vol.168 , pp. 2064-2073
    • Macdougall, E.D.1    Kramer, F.2    Polinsky, P.3


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