Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

Journal of Virology

Volumn 71, Issue 1, 1997, Pages 624-629

  Wolff, Gerhard ^a   Worgall, Stefan ^a   Van Rooijen, Nico ^b   Song, Wen Ru ^a   Harvey, Ben Gary ^a   Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; CLODRONIC ACID; LIPOSOME; NEUTRALIZING ANTIBODY; VIRUS DNA; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DEPLETION; DNA DETERMINATION; ENZYME ASSAY; FEMALE; GENE EXPRESSION; GENE TRANSFER; HOST RESISTANCE; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; VIRUS GENOME; VIRUS IMMUNITY;

EID: 0031060294     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.1.624-629.1997     Document Type: Article

References (57)

1. Armentano, D., C. C. Sookdeo, K. M. Hehir, R. J. Gregory, J. A. St. George, G. A. Prince, S. C. Wadsworth, and A. E. Smith. 1995. Characterization of an adenovirus gene transfer vector containing an E4 deletion. Hum. Gene Ther. 6:1343-1353.
2. Austyn, J. M., and S. Gordon. 1981. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur. J. Immunol. 11:805-815.
3. Barr, D., J. Tubb, D. Ferguson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, and M. A. Kay. 1995. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompelent and immunodeficient inbred strains. Gene Ther. 2:151-155.
4. Biewenga, J., M. B. van der Ende, L. F. Krist, A. Borst, M. Ghufron, and N. Van Rooijen. 1995. Macrophage depletion in the rat after intraperitoneal administration of liposome-encapsulated clodronate: depletion kinetics and accelerated repopulation of peritoneal and omental macrophages by administration of Freund's adjuvant. Cell Tissue Res. 280:189-196.
5. Dai, Y., E. M. Schwarz, D. Gu, W.-W. Zhang, M. Sarvetnick, and I. M. Verma. 1995. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92:1401-1405.
6. Debus, E., K. Weber, and M. Osborn. 1983. Monoclonal antibodies specific for glial fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeplides. Differentiation 25:193-203.
7. de Leeuw, A. M., A. Brouwer, R. J. Barelds, and D. L. Knook. 1983. Maintenance cultures of Kupffer cells isolated from rats of various ages: ultra-structure, enzyme cytochemistry, and endocytosis. Hepatology 3:497-506.
8. Engelhardt, J. F., X. Ye, B. Doranz, and J. M. Wilson. 1994. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91:6196-6200.
9. Fearon, D. T., and R. M. Locksley. 1996. Elements of immunity - the instructive role of innate immunity in the acquired immune response. Science 272:50-54.
10. DP-liposome-mediated macrophage depletion. Blood 86:183-192.
11. Huitinga, I., S. R. Ruuls, S. Jung, N. Van Rooijen, H. P. Hartung, and C. D. Dijkstra. 1995. Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats. Clin. Exp. Immunol. 100:344-351.
12. Jaffe, H. A., C. Danel, G. Longenecker, M. Metzger, Y. Setoguchi, M. A. Rosenfeld, T. W. Gant, S. S. Thorgeirsson, L. D. Stratford-Perricaudet, M. Perricaudet, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1992. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat. Genet. 1:372-378.
13. Kass-Eisler, A., E. Falck-Pedersen, M. Alvira, J. Rivera, P. M. Buttrick, B. A. Wittenberg, L. Cipriani, and L. A. Leinwand. 1993. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc. Natl. Acad. Sci. USA 90:11498-11502.
14. Kass-Eisler, A., E. Falck-Pedersen, D. H. Elfenbein, M. Alvira, P. M. Buttrick, and L. A. Leinwand. 1994. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther. 1:395-402.
15. Kay, M. A., A. X. Holterman, L. Meuse, A. Gown, H. D. Ochs, P. S. Linsley, and C. B. Wilson. 1995. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4lg administration. Nat. Genet. 11:191-197.
16. Kolb-Bachofen, V. 1992. Uptake of toxic silica particles by isolated rat liver macrophages (Kupffer cells) is receptor mediated and can be blocked by competition. J. Clin. Invest. 90:1819-1824.
17. Laman, J. D., N. Kors, N. Van Rooijen, and E. Claassen. 1990. Mechanism of follicular trapping: localization of immune complexes and cell remnants after elimination and repopulation of different spleen cell populations. Immunology 71:57-62.
18. - adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector. Gene Ther. 2:256-262.
19. Mastrangeli, A., B.-G. Harvey, J. Yao, G. Wolff, I. Kovesdi, and R. G. Crystal. 1996. "Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Hum. Gene Ther. 7:79-87.
20. McCuskey, R. S., P. A. McCuskey, R. Urbaschek, and B. Urbaschek. 1987. Kupffer cell function in host defense. Rev. Infect. Dis. 9(Suppl. 5):S616-S619.
21. Miller, S. A., D. D. Dykes, and H. F. Polesky. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1215.
22. Mullbacher, A., A. J. Bellett, and R. T. Hla. 1989. The murine cellular immune response to adenovirus type 5. Immunol. Cell Biol. 67:31-39.
23. Neumann, J. R., C. A. Morency, and K. O. Russian. 1987. A novel rapid assay for chloramphenicol acelyltransferase gene expression. BioTechniques 5:444-447.
24. Pinto, A. J., D. Stewart, N. Van Rooijen, and P. S. Morahan. 1991. Selective depletion of liver and splenic macrophages using liposomes encapsulating the drug dichloromethylene diphosphonate: effects on antimicrobial resistance. J. Leukocyte Biol. 49:579-586.
25. Plosker, G. L., and K. L. Goa. 1994. Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs 47:945-982.
26. Qian, Q., M. A. Jutila, N. Van Rooijen, and J. E. Cutler. 1994. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J. Immunol. 152:5000-5008.
27. Ralph, E. D., K. R. Barber, and C. W. Grant. 1993. Clinical experience with multilamellar liposomal amphotericin b in patients with proven and suspected fungal infections. Scand. J. Infect. Dis. 25:487-496.
28. Rosenfeld, M. A., W. Siegfried, K. Yoshimura, K. Yoneyama, M. Fukayama, L. E. Stier, P. K. Paakko, P. Gilardi, L. D. Stratford-Perricaudet, M. Perricaudet, S. Jallat, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1991. Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science 252:431-434.
29. Rosenfeld, M. A., K. Yoshimura, B. C. Trapnell, K. Yoneyama, E. R. Rosenthal, W. Dalemans, M. Fukayama, J. Bargon, L. E. Stier, L. Stratford-Perricaudet, M. Perricaudet, W. B. Guggino, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1992. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68:143-155.
30. Saba, T. M. 1970. Physiology and physiopathology of the reticuloendothelial system. Arch. Intern. Med. 126:1031-1052.
31. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
32. Song, W., E. W. Collisson, P. M. Billingsley, and W. C. Brown. 1992. Induction of feline immunodeficiency virus-specific cytolytic T-cell responses from experimentally infected cats. J. Virol. 66:5409-5417.
33. Thepen, T., N. Van Rooijen, and G. Kraal. 1989. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J. Exp. Med. 170:499-509.
34. Tschaikowsky, K., and J. D. Brain. 1994. Effects of liposome-encapsulated dichloromethylene diphosphonate on macrophage function and endotoxin-induced mortality. Biochim. Biophys. Acta 1222:323-330.
35. Van Rooijen, N. 1989. The liposome-mediated macrophage "suicide" technique. J. Immunol. Methods 124:1-6.
36. Van Rooijen, N., N. Kors, and G. Kraal. 1989. Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. J. Leukocyte Biol. 45:97-104.
37. Van Rooijen, N., N. Kors, M. van der Ende, and C. D. Dijkstra. 1990. Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate. Cell Tissue Res. 260:215-222.
38. Van Rooijen, N., and A. Sanders. 1994. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J. Immunol. Methods 174:83-93.
39. Van Rooijen, N., and A. Sanders. 1996. Kupffer cell depletion by liposomedelivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid. Hepatology 23:1239-1243.
40. Van Rooijen, N., A. Sanders, and T. K. Van den Berg. 1996. Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. J. Immunol. Methods 193:93-99.
41. Van Rooijen, N., R. van Nieuwmegen, and E. W. Kamperdijk. 1985. Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. Ultrastructural aspects of elimination of marginal zone macrophages. Virchows Arch. B Cell. Pathol. Incl. Mol. Pathol. 49:375-383.
42. Vreden, S. G. S., R. W. Sauerwein, J. P. Verhave, N. Van Rooijen, J. H. E. T. Meuwissen, and M. F. Van Den Broek. 1993. Kupffer cell elimination enhances development of liver schizonts of Plasmodium berghei in rats. Infect. Immun. 61:1936-1939.
43. Wake, K., K. Decker, A. Kirn, D. L. Knook, R. S. McCuskey, L. Bouwens, and E. Wisse. 1989. Cell biology and kinetics of Kupffer cells in the liver. Int. Rev. Cytol. 118:173-229.
44. Whitton, J. L., and M. B. A. Oldstone. 1996. Immune response to viruses, p. 345-374. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology. Lippincott-Raven Publishers, Philadelphia, Penn.
45. Wijffels, J. F., Z. de Rover, R. H. Beelen, G. Kraal, and N. Van Rooijen. 1994. Macrophage subpopulations in the mouse spleen renewed by local proliferation. Immunobiology 191:52-64.
46. Worgall, S., G. Wolff, E. Falck-Pedersen, and R. G. Crystal. 1996. Non-immune mechanisms dominate elimination of adenovirus vectors following in vivo administration. Pediatr. Pulmonol. 20:419.
47. Yang, Y., H. C. Ertl, and J. M. Wilson. 1994. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1:433-442.
48. Yang, Y., Q. Li, H. C. J. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.
49. Yang, Y., F. A. Nunes, K. Berencsi, E. E. Furth, E. Gonczol, and J. M. Wilson. 1994. Cellular immunity to viral antigens limits E1-deleted adeno-viruses for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407-4411.
50. Yang, Y., F. A. Nunes, K. Berencsi, E. Gonczol, J. F. Engelhardt, and J. M. Wilson. 1994. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat. Genet. 7:362-369.
51. Yang, Y., G. Trinchieri, and J. M. Wilson. 1995. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nat. Med. 1:890-893.
52. + CTLs in vivo. J. Immunol. 155:2564-2570.
53. Yang, Y., Z. Xiang, H. C. Ertl, and J. M. Wilson. 1995. Upregulation of class major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc. Natl. Acad. Sci. USA 92:7257-7261.
54. Zabner, J., D. M. Petersen, A. P. Puga, S. M. Graham, L. A. Couture, L. D. Keyes, M. J. Lukason, J. A. St. George, R. J. Gregory, A. E. Smith, and M. J. Welsh. 1994. Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nat. Genet. 6:75-83.
55. Zinkernagel, R. M. 1993. Immunity to viruses, p. 1211-1250. In W. E. Paul (ed.), Fudamental immunology. Raven Press, Ltd., New York, N.Y.
56. Zinkernagel, R. M. 1996. Immunology taught by viruses. Science 271:173-178.
57. Zsengeller, Z. K., S. E. Wert, W. M. Hull, X. Hu, S. Yei, B. C. Trapnell, and J. A. Whitsett. 1995. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6:457-467.