Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase-ganciclovir treatment

Gene Therapy

Volumn 6, Issue 1, 1999, Pages 34-41

  Pakkanen, T M ^a   Laitinen, M ^a   Hippelainen M ^a   Kallionpaa H ^a   Lehtolainen, P ^a   Leppanen P ^a   Luoma, J S ^a   Tarvainen, R ^a   Alhava, E ^a   Yla Herttuala S ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Familial hypercholesterolemia; Gene therapy; Proliferation; Thymidine kinase; Watanabe heritable hyperlipidemic rabbit

Indexed keywords

ALKALINE PHOSPHATASE; CHOLESTEROL; COMPLEMENTARY DNA; GANCICLOVIR; LIPOSOME; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; THYMIDINE KINASE; TRIACYLGLYCEROL;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE THERAPY; GENE TRANSFER; GENETIC TRANSCRIPTION; HYPERLIPIDEMIA; INTRAVENOUS CATHETER; LIVER CELL; LIVER FUNCTION TEST; LIVER RESECTION; MALE; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RABBIT; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURGICAL TECHNIQUE; TRANSGENE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTIMETABOLITES; CELL DIVISION; CHOLESTEROL; FEMALE; GANCICLOVIR; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HYPERLIPOPROTEINEMIA TYPE II; LIVER; MALE; RABBITS; RECEPTORS, LDL; RETROVIRIDAE; THYMIDINE KINASE; TRIGLYCERIDES;

ANIMALIA; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; ONCOVIRINAE; ORYCTOLAGUS CUNICULUS; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 6544243305     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300796     Document Type: Article

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