Apolipoprotein A-I and lecithin: Cholesterol acyltransferase transfer induce cholesterol unloading in complex atherosclerotic lesions

Gene Therapy

Volumn 16, Issue 6, 2009, Pages 757-765

  Van Craeyveld, E ^a   Lievens, J ^a   Jacobs, F ^a   Feng, Y ^a   Snoeys, J ^a   De Geest, B ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DISEASE COURSE; DRUG MECHANISM; GENE THERAPY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; TARGET CELL; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; AORTA; APOLIPOPROTEIN A-I; ATHEROSCLEROSIS; AZO COMPOUNDS; BIOLOGICAL TRANSPORT; CHOLESTEROL, HDL; COLORING AGENTS; DIETARY FATS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LECITHIN ACYLTRANSFERASE DEFICIENCY; LIVER; PARTICLE SIZE; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; RABBITS; TIME FACTORS; TUNICA INTIMA;

ORYCTOLAGUS CUNICULUS;

EID: 67349153820     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2009.8     Document Type: Article

References (49)

1. Gordon DJ, Rifkind BM. High-density lipoprotein - the clinical implications of recent studies. N Eng J Med 1989; 321: 1311-1316.
2. Rubin EM, Krauss RM, Spangler EA, Verstuyft JG, Clift SM. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature 1991; 353: 265-267.
3. Duverger N, Kruth H, Emmanuel F, Caillaud JM, Viglietta C, Castro G et al. Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits. Circulation 1996; 94: 713-717.
4. Paszty C, Maeda N, Verstuyft J, Rubin EM. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest 1994; 94: 899-903.
5. Plump AS, Scott CJ, Breslow JL. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci USA 1994; 91: 9607-9611.
6. Badimon JJ, Badimon L, Fuster V. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest 1990; 85: 1234-1241.
7. Tangirala RK, Tsukamoto K, Chun SH, Usher D, Pure E, Rader DJ. Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation 1999; 100: 1816-1822.
8. Kosek AB, Durbin D, Jonas A. Binding affinity and reactivity of lecithin cholesterol acyltransferase with native lipoproteins. Biochem Biophys Res Commun 1999; 258: 548-551.
9. Greeve J, Altkemper I, Dieterich JH, Greten H, Windler E. Apolipoprotein B mRNA editing in 12 different mammalian species: Hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins. J Lipid Res 1993; 34: 1367-1383.
10. Nagashima M, McLean JW, Lawn RM. Cloning and mRNA tissue distribution of rabbit cholesteryl ester transfer protein. J Lipid Res 1988; 29 1643-1649.
11. Tall AR. Plasma cholesteryl ester transfer protein. J Lipid Res 1993; 34: 1255-1274.
12. Barter P, Rye KA. Cholesteryl ester transfer protein: Its role in plasma lipid transport. Clin Exp Pharmacol Physiol 1994; 21: 663-672.
13. Tall A. Plasma lipid transfer proteins. Annu Rev Biochem 1995; 64: 235-257.
14. Lievens J, Snoeys J, Vekemans K, Van Linthout S, de Zanger R, Collen D et al. The size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer. Gene Therapy 2004; 11: 1523-1531.
15. Snoeys J, Lievens J, Wisse E, Jacobs F, Duimel H, Collen D et al. Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae. Gene Therapy 2007; 14: 604-612.
16. Wisse E, Jacobs F, Topal B, Frederik P, De Geest B. The size of endothelial fenestrae in human liver sinusoids: Implications for hepatocyte-directed gene transfer. Gene Therapy 2008; 15: 1193-1199.
17. De Geest B, Van Linthout S, Collen D. Sustained expression of human apo A-I following adenoviral gene transfer in mice. Gene Therapy 2001; 8: 121-127.
18. De Geest BR, Van Linthout SA, Collen D. Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells. Blood 2003; 101: 2551-2556.
19. Mingozzi F, Liu YL, Dobrzynski E, Kaufhold A, Liu JH, Wang Y et al Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer. J Clin Invest 2003; 111: 1347-1356.
20. Van Linthout S, Collen D, De Geest B. Effect of promoters and enhancers on expression, transgene DNA persistence, and hepatotoxicity after adenoviral gene transfer of human apolipoprotein A-I. Hum Gene Ther 2002; 13: 829-840.
21. Van Linthout S, Lusky M, Collen D, De Geest B. Persistent hepatic expression of human apo A-I after transfer with a helper-virus independent adenoviral vector. Gene Therapy 2002; 9: 1520-1528.
22. Belalcazar LM, Merched A, Carr B, Oka K, Chen KH, Pastore L et al. Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia. Circulation 2003; 107: 2726-2732.
23. Brousseau ME, Kauffman RD, Herderick EE, Demosky Jr SJ, Evans W, Marcovina S et al. LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits. Arterioscler Thromb Vasc Biol 2000; 20: 450-458.
24. Shore VG, Shore B, Hart RG. Changes in apolipoproteins and properties of rabbit very low density lipoproteins on induction of cholesteremia. Biochemistry 1974; 13: 1579-1585.
25. Roth RI, Gaubatz JW, Gotto Jr AM, Patsch JR. Effect of cholesterol feeding on the distribution of plasma lipoproteins and on the metabolism of apolipoprotein E in the rabbit. J Lipid Res 1983; 24: 1-11.
26. Chao YS, Yamin TT, Thompson GM, Kroon PA. Tissue-specific expression of genes encoding apolipoprotein E and apolipoprotein A-I in rabbits. J Biol Chem 1984; 259: 5306-5309.
27. Sun YP, Lu NC, Parmley WW, Hollenbeck CB. Effects of cholesterol diets on vascular function and atherogenesis in rabbits. Proc Soc Exp Biol Med 2000; 224: 166-171.
28. Kritchevsky D, Tepper SA, Vesselinovitch D, Wissler RW. Cholesterol vehicle in experimental atherosclerosis. 11. Peanut oil. Atherosclerosis 1971; 14: 53-64.
29. Adams CW, Miller NE, Morgan RS, Rao SN. Lipoprotein levels and tissue lipids in fatty-fibrous atherosclerosis induced in rabbits by two years' cholesterol feeding at a low level. Atherosclerosis 1982; 44 1-8.
30. Spagnoli LG, Orlandi A, Mauriello A, Santeusanio G, de Angelis C, Lucreziotti R et al. Aging and atherosclerosis in the rabbit. 1. Distribution, prevalence and morphology of atherosclerotic lesions. Atherosclerosis 1991; 89: 11-24.
31. Bocan TM, Mueller SB, Uhlendorf PD, Ferguson E, Newton RS. Dietary and mechanically induced rabbit iliac-femoral atherosclerotic lesions: A chemical and morphologic evaluation. Exp Mol Pathol 1991; 54 201-277.
32. Lupu F, Danaricu I, Simionescu N. Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions. A cytochemical and ultrastructural study. Atherosclerosis 1987; 67: 127-142.
33. Daley SJ, Klemp KF, Guyton JR, Rogers KA. Cholesterol-fed and casein-fed rabbit models of atherosclerosis. Part 2: Differing morphological severity of atherogenesis despite matched plasma cholesterol levels. Arterioscler Thromb 1994; 14: 105-141.
34. Kolodgie FD, Katocs Jr AS, Largis EE, Wrenn SM, Cornhill JF, Herderick EE et al. Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type. Arterioscler Thromb Vasc Biol 1996; 16: 1454-1464.
35. Atkinson JB, Hoover RL, Berry KK, Swift LL. Cholesterol-fed heterozygous Watanabe heritable hyperlipidemic rabbits: A new model for atherosclerosis. Atherosclerosis 1989; 78: 123-136.
36. Hoeg JM, Santamarina-Fojo S, Berard AM, Cornhill JF, Herderick EE, Feldman SH et al. Overexpression of lecithin:cHolesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis. Proc Natl Acad Sci USA 1996; 93: 11448-11453.
37. Berard AM, Foger B, Remaley A, Shamburek R, Vaisman BL, Talley G et al. High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase. Nat Med 1997; 3: 744-749.
38. Mehlum A, Muri M, Hagve TA, Solberg LA, Prydz H. Mice overexpressing human lecithin:cHolesterol acyltransferase are not protected against diet-induced atherosclerosis. APMIS 1997; 105: 861-868.
39. Mehlum A, Gjernes E, Solberg LA, Hagve TA, Prydz H. Overexpression of human lecithin:cHolesterol acyltransferase in mice offers no protection against diet-induced atherosclerosis. APMIS 2000; 108: 336-342.
40. Furbee Jr JW, Parks JS. Transgenic overexpression of human lecithin:cHolesterol acyltransferase (LCAT) in mice does not increase aortic cholesterol deposition. Atherosclerosis 2002; 165: 89-100.
41. Kondo T, Watanabe Y. [A heritable hyperlipemic rabbit (author's translation)]. Jikken Dobutsu 1975; 24: 89-94.
42. Watanabe Y. Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL- rabbit). Atherosclerosis 1980; 36: 261-268.
43. Sun H, Usui S, Shiomi M, Watanabe T, Fan J. A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits. J Atheroscler Thromb 2002; 9: 145-148.
44. Murata Y, Maeda E, Yoshino G, Kasuga M. Cloning of rabbit LCAT cDNA: increase in LCAT mRNA abundance in the liver of cholesterol-fed rabbits. J Lipid Res 1996; 37: 1616-1622.
45. Pan TC, Hao QL, Yamin TT, Dai PH, Chen BS, Chen SL et al. Rabbit apolipoprotein A-I mRNA and gene. Evidence that rabbit apolipoprotein A-I is synthesized in the intestine but not in the liver. Eur J Biochem 1987; 170: 99-104.
46. Feng Y, Jacobs F, Van Craeyveld E, Brunaud C, Snoeys J, Tjwa M et al Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008; 28: 278-283.
47. Chapman MJ, Goldstein S, Lagrange D, Laplaud PM. A density gradient ultracentrifugal procedure for the isolation of the major lipoprotein classes from human serum. J Lipid Res 1981; 22: 339-358.
48. Jacobs F, Van Craeyveld E, Feng Y, Snoeys J, De Geest B. Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia. Atherosclerosis 2008; 201: 289-297.
49. Junqueira LC, Bignolas G, Brentani RR. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 1979; 11: 447-455.