Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer

Molecular Therapy

Volumn 13, Issue 1, 2006, Pages 98-107

  Snoeys, Jan ^a   Mertens, Geertrui ^a   Lievens, Joke ^a   van Berkel, Theo ^b   Collen, Désiré ^a   Biessen, Erik A L ^b   De Geest, Bart ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Adenovirus; Clodronate; Endothelial cells; Gene therapy; Hepatocyte; Intravenous; Kupffer cells; Lipid emulsions; Liver; Mouse; Rag2 protein; Splenectomy

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN A1; CLODRONIC ACID; INTRALIPID; LIPID EMULSION; LIPOSOME; PHOSPHATIDYLCHOLINE; RAG1 PROTEIN; RAG2 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TRANSFER; HUMAN; KUPFFER CELL; LIVER CELL; LIVER SINUSOID; MOUSE; MOUSE STRAIN; NONHUMAN; RETICULOENDOTHELIAL SYSTEM; SPLENECTOMY; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; APOLIPOPROTEIN A-I; CLODRONIC ACID; DNA-BINDING PROTEINS; FAT EMULSIONS, INTRAVENOUS; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATOCYTES; HOMEODOMAIN PROTEINS; HUMANS; KUPFFER CELLS; LIPOSOMES; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHOSPHATIDYLCHOLINES; SPLENECTOMY; TRANSDUCTION, GENETIC; TRANSGENES;

ADENOVIRIDAE; ANIMALIA;

EID: 28844493201     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.06.477     Document Type: Article

References (36)

1. H. Do J.F. Healey E.K. Waller and P. Lollar Expression of factor VIII by murine liver sinusoidal endothelial cells J. Biol. Chem. 274 1999 19587-19592
2. D. Sasse U.M. Spornitz and I.P. Maly Liver architecture Enzyme 46 1992 8-32
3. A. Blouin R.P. Bolender and E.R. Weibel Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma: A stereological study J. Cell Biol. 72 1977 441-455
4. A.I. Kuzmin M.J. Finegold and R.C. Eisensmith Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo Gene Ther. 4 1997 309-316
5. G. Wolff et al. Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ J. Virol. 71 1997 624-629
6. G. Schiedner et al. Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors Mol. Ther. 7 2003 35-43
7. D.L. Knook and E.C. Sleyster Isolated parenchymal, Kupffer and endothelial rat liver cells characterized by their lysosomal enzyme content Biochem. Biophys. Res. Commun. 96 1980 250-257
8. D.L. Knook and E.C. Sleyster Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation Exp. Cell Res. 99 1976 444-449
9. P.A. Knolle and A. Limmer Neighborhood politics: The immunoregulatory function of organ-resident liver endothelial cells Trends Immunol. 22 2001 432-437
10. Y. Shiratori et al. Quantification of sinusoidal cell function in vivo Semin. Liver Dis. 13 1993 39-49
11. M. Niwano et al. Amelioration of sinusoidal endothelial cell damage by Kupffer cell blockade during cold preservation of rat liver J. Surg. Res. 72 1997 36-48
12. I.V. Deaciuc G.J. Bagby M.R. Niesman N. Skrepnik and J.J. Spitzer Modulation of hepatic sinusoidal endothelial cell function by Kupffer cells: An example of intercellular communication in the liver Hepatology 19 1994 464-470
13. B. De Geest S. Van Linthout and D. Collen Sustained expression of human apo A-I following adenoviral gene transfer in mice Gene Ther. 8 2001 121-127
14. B.R. De Geest S.A. Van Linthout and D. Collen Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells Blood 101 2003 2551-2556
15. I. Fichtner A. Kniest and D. Arndt Measurement of carbon clearance in mice as toxicity parameter for liposomal preparations In Vivo 6 1992 113-117
16. D.L. Waitzberg et al. Parenteral lipid emulsions and phagocytic systems Br. J. Nutr. 87 Suppl. 1 2002 S49-S57
17. G.L. Jensen et al. Parenteral infusion of long- and medium-chain triglycerides and reticuloendothelial system function in man J. Parenteral Enteral Nutr. 14 1990 467-471
18. G. Schiedner et al. A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells Hum. Gene Ther. 14 2003 1631-1641
19. D.M. Shayakhmetov Z.Y. Li S. Ni and A. Lieber Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors J. Virol. 78 2004 5368-5381
20. J. Dave and H.M. Patel Differentiation in hepatic and splenic phagocytic activity during reticuloendothelial blockade with cholesterol-free and cholesterol-rich liposomes Biochim. Biophys. Acta 888 1986 184-190
21. N. van Rooijen N. Kors and G. Kraal Macrophage subset repopulation in the spleen: Differential kinetics after liposome-mediated elimination J. Leukocyte Biol. 45 1989 97-104
22. N. Tao et al. Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver Mol. Ther. 3 2001 28-35
23. B. De Geest Z. Zhao D. Collen and P. Holvoet Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice Circulation 96 1997 4349-4356
24. M. Lusky et al. In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted J. Virol. 72 1998 2022-2032
25. N. Mittereder K.L. March and B.C. Trapnell Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy J. Virol. 70 1996 7498-7509
26. P. Mombaerts et al. RAG-1-deficient mice have no mature B and T lymphocytes Cell 68 1992 869-877
27. Y. Shinkai et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement Cell 68 1992 855-867
28. N. Van Rooijen and A. Sanders Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications J. Immunol. Methods 174 1994 83-93
29. N. van Rooijen and E. van Kesteren-Hendrikx "In vivo" depletion of macrophages by liposome-mediated "suicide" Methods Enzymol. 373 2003 3-16
30. E.A. Biessen H.F. Bakkeren D.M. Beuting J. Kuiper and T.J. Van Berkel Ligand size is a major determinant of high-affinity binding of fucose- and galactose-exposing (lipo)proteins by the hepatic fucose receptor Biochem. J. 299 1994 291-296
31. P.C. Rensen et al. Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo J. Biol. Chem. 276 2001 37577-37584
32. B. De Geest S. Van Linthout M. Lox D. Collen and P. Holvoet Sustained expression of human apolipoprotein A-I after adenoviral gene transfer in C57BL/6 mice: Role of apolipoprotein A-I promoter, apolipoprotein A-I introns, and human apolipoprotein E enhancer Hum. Gene Ther. 11 2000 101-112
33. J.M. Austyn and S. Gordon F4/80, a monoclonal antibody directed specifically against the mouse macrophage Eur. J. Immunol. 11 1981 805-815
34. P.O. Seglen Preparation of isolated rat liver cells Methods Cell Biol. 13 1976 29-83
35. J.F. Nagelkerke K.P. Barto and T.J. van Berkel In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells J. Biol. Chem. 258 1983 12221-12227
36. J. Lievens et al. The size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer Gene Ther. 11 2004 1523-1531