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Volumn 3, Issue 1, 2010, Pages

LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ADENOVIRUS VECTOR; ANION EXCHANGE RESIN; BILE ACID; CHOLESTEROL; EZETIMIBE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LENTIVIRUS VECTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; MIPOMERSEN; NICOTINIC ACID; PARVOVIRUS VECTOR; RETROVIRUS VECTOR; SQUALENE SYNTHASE INHIBITOR; STATIN;

EID: 78649942440     PISSN: None     EISSN: 17557682     Source Type: Journal    
DOI: 10.1186/1755-7682-3-36     Document Type: Review
Times cited : (47)

References (218)
  • 1
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • 10.1126/science.3513311
    • A receptor-mediated pathway for cholesterol homeostasis. MS Brown JL Goldstein, Science (New York, NY) 1986 232 4746 34 47 10.1126/science.3513311
    • (1986) Science (New York, NY) , vol.232 , Issue.4746 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 2
    • 44849108492 scopus 로고    scopus 로고
    • Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database
    • 10.1111/j.1469-1809.2008.00436.x. 18325082
    • Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database. SE Leigh AH Foster RA Whittall CS Hubbart SE Humphries, Annals of human genetics 2008 72 Pt 4 485 498 10.1111/j.1469-1809.2008.00436.x 18325082
    • (2008) Annals of Human Genetics , vol.72 , Issue.PART 4 , pp. 485-498
    • Leigh, S.E.1    Foster, A.H.2    Whittall, R.A.3    Hubbart, C.S.4    Humphries, S.E.5
  • 4
    • 4444328790 scopus 로고    scopus 로고
    • Familial hypercholesterolemia and coronary heart disease: A HuGE association review
    • 10.1093/aje/kwh237. 15321838
    • Familial hypercholesterolemia and coronary heart disease: a HuGE association review. MAHC Austin RL Zimmern SE Humphries, Am J Epidemiol 2004 160 421 429 10.1093/aje/kwh237 15321838
    • (2004) Am J Epidemiol , vol.160 , pp. 421-429
    • Mahc, A.1    Zimmern, R.L.2    Humphries, S.E.3
  • 5
    • 0022981186 scopus 로고
    • In vivo evidence for reduced binding of low density lipoproteins to receptors as a cause of primary moderate hypercholesterolemia
    • 10.1172/JCI112729. 3771801
    • In vivo evidence for reduced binding of low density lipoproteins to receptors as a cause of primary moderate hypercholesterolemia. GL Vega SM Grundy, The Journal of clinical investigation 1986 78 5 1410 1414 10.1172/JCI112729 3771801
    • (1986) The Journal of Clinical Investigation , vol.78 , Issue.5 , pp. 1410-1414
    • Vega, G.L.1    Grundy, S.M.2
  • 7
    • 4444376916 scopus 로고    scopus 로고
    • Genetic causes of monogenic heterozygous familial hypercholesterolemia: A HuGE prevalence review
    • 10.1093/aje/kwh236. 15321837
    • Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review. MAHC Austin RL Zimmern SE Humphries, Am J Epidemiol 2004 160 407 420 10.1093/aje/kwh236 15321837
    • (2004) Am J Epidemiol , vol.160 , pp. 407-420
    • Mahc, A.1    Zimmern, R.L.2    Humphries, S.E.3
  • 9
    • 0242660344 scopus 로고    scopus 로고
    • Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemia
    • 10.1161/01.ATV.0000094410.66558.9A. 12958046
    • Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemia. AK Soutar RP Naoumova LM Traub, Arteriosclerosis, thrombosis, and vascular biology 2003 23 11 1963 1970 10.1161/01.ATV.0000094410.66558.9A 12958046
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.11 , pp. 1963-1970
    • Soutar, A.K.1    Naoumova, R.P.2    Traub, L.M.3
  • 10
    • 33947679772 scopus 로고    scopus 로고
    • Mechanisms of disease: Genetic causes of familial hypercholesterolemia
    • 10.1038/ncpcardio0836. 17380167
    • Mechanisms of disease: genetic causes of familial hypercholesterolemia. AK Soutar RP Naoumova, Nature clinical practice 2007 4 4 214 225 10.1038/ncpcardio0836 17380167
    • (2007) Nature Clinical Practice , vol.4 , Issue.4 , pp. 214-225
    • Soutar, A.K.1    Naoumova, R.P.2
  • 11
    • 0019500525 scopus 로고
    • Hyperapobetalipoproteinaemia in two families with xanthomas and phytosterolaemia
    • 10.1016/S0140-6736(81)91850-X. 6110091
    • Hyperapobetalipoproteinaemia in two families with xanthomas and phytosterolaemia. PO Kwiterovich Jr PS Bachorik HH Smith VA McKusick WE Connor B Teng AD Sniderman, Lancet 1981 1 8218 466 469 10.1016/S0140-6736(81)91850-X 6110091
    • (1981) Lancet , vol.1 , Issue.8218 , pp. 466-469
    • Kwiterovich Jr., P.O.1    Bachorik, P.S.2    Smith, H.H.3    McKusick, V.A.4    Connor, W.E.5    Teng, B.6    Sniderman, A.D.7
  • 13
    • 0022355074 scopus 로고
    • Familial hypercholesterolemia: A genetic receptor disease
    • 45-36. 3932389
    • Familial hypercholesterolemia: a genetic receptor disease. JL Goldstein MS Brown, Hosp Pract (Off Ed) 1985 20 11 35 41 45-36 3932389
    • (1985) Hosp Pract (Off Ed) , vol.20 , Issue.11 , pp. 35-41
    • Goldstein, J.L.1    Brown, M.S.2
  • 14
    • 0031890146 scopus 로고    scopus 로고
    • Coronary heart disease risk factors in women
    • 9519343
    • Coronary heart disease risk factors in women. ML Brochier P Arwidson, European heart journal 1998 19 Suppl A 45 52 9519343
    • (1998) European Heart Journal , vol.19 , Issue.SUPPL. A , pp. 145-52
    • Brochier, M.L.1    Arwidson, P.2
  • 15
    • 0035197537 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor gene (LDLR) world-wide website in familial hypercholesterolaemia: Update, new features and mutation analysis
    • 10.1016/S0021-9150(00)00647-X. 11137106
    • Low-density lipoprotein receptor gene (LDLR) world-wide website in familial hypercholesterolaemia: update, new features and mutation analysis. KE Heath M Gahan RA Whittall SE Humphries, Atherosclerosis 2001 154 1 243 246 10.1016/S0021-9150(00)00647-X 11137106
    • (2001) Atherosclerosis , vol.154 , Issue.1 , pp. 243-246
    • Heath, K.E.1    Gahan, M.2    Whittall, R.A.3    Humphries, S.E.4
  • 17
    • 0024578914 scopus 로고
    • The use of low density lipoprotein receptor activity of lymphocytes to determine the prevalence of familial hypercholesterolaemia in a rural South African community
    • 10.1136/jmg.26.1.32. 2918524
    • The use of low density lipoprotein receptor activity of lymphocytes to determine the prevalence of familial hypercholesterolaemia in a rural South African community. K Steyn MJ Weight BR Dando KJ Christopher JE Rossouw, J Med Genet 1989 26 1 32 36 10.1136/jmg.26.1.32 2918524
    • (1989) J Med Genet , vol.26 , Issue.1 , pp. 32-36
    • Steyn, K.1    Weight, M.J.2    Dando, B.R.3    Christopher, K.J.4    Rossouw, J.E.5
  • 18
    • 0037541585 scopus 로고    scopus 로고
    • A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia
    • 10.1016/S0021-9150(02)00330-1. 12732381
    • A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. D Marks M Thorogood HA Neil SE Humphries, Atherosclerosis 2003 168 1 1 14 10.1016/S0021-9150(02)00330-1 12732381
    • (2003) Atherosclerosis , vol.168 , Issue.1 , pp. 1-14
    • Marks, D.1    Thorogood, M.2    Neil, H.A.3    Humphries, S.E.4
  • 19
    • 44049098596 scopus 로고
    • Lipid metabolism, hyper- and hypolipidaemias and atherosclerosis
    • Edinburgh,: Churchill Livingstone Marshall W, Bangert S
    • Lipid metabolism, hyper- and hypolipidaemias and atherosclerosis. C Marenah, Clinical biochemistry: metabolic and clinical aspects Edinburgh,: Churchill Livingstone, Marshall W, Bangert S, 1995 35 621 640
    • (1995) Clinical Biochemistry: Metabolic and Clinical Aspects , vol.35 , pp. 621-640
    • Marenah, C.1
  • 20
    • 0022021841 scopus 로고
    • The sequence and topology of human complement component C9
    • 4018030
    • The sequence and topology of human complement component C9. KK Stanley HP Kocher JP Luzio P Jackson J Tschopp, Embo J 1985 4 2 375 382 4018030
    • (1985) Embo J , vol.4 , Issue.2 , pp. 375-382
    • Stanley, K.K.1    Kocher, H.P.2    Luzio, J.P.3    Jackson, P.4    Tschopp, J.5
  • 21
    • 0021215312 scopus 로고
    • Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor
    • 10.1016/0092-8674(84)90388-X. 6327078
    • Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. DW Russell WJ Schneider T Yamamoto KL Luskey MS Brown JL Goldstein, Cell 1984 37 2 577 585 10.1016/0092-8674(84)90388-X 6327078
    • (1984) Cell , vol.37 , Issue.2 , pp. 577-585
    • Russell, D.W.1    Schneider, W.J.2    Yamamoto, T.3    Luskey, K.L.4    Brown, M.S.5    Goldstein, J.L.6
  • 22
    • 0022168951 scopus 로고
    • Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system
    • 10.1146/annurev.cb.01.110185.000245. 2881559
    • Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. JL Goldstein MS Brown RG Anderson DW Russell WJ Schneider, Annu Rev Cell Biol 1985 1 1 39 10.1146/annurev.cb.01.110185.000245 2881559
    • (1985) Annu Rev Cell Biol , vol.1 , pp. 1-39
    • Goldstein, J.L.1    Brown, M.S.2    Anderson, R.G.3    Russell, D.W.4    Schneider, W.J.5
  • 23
    • 0022259920 scopus 로고
    • The LDL receptor gene: A mosaic of exons shared with different proteins
    • 10.1126/science.2988123. 2988123
    • The LDL receptor gene: a mosaic of exons shared with different proteins. TC Sudhof JL Goldstein MS Brown DW Russell, Science 1985 228 4701 815 822 10.1126/science.2988123 2988123
    • (1985) Science , vol.228 , Issue.4701 , pp. 815-822
    • Sudhof, T.C.1    Goldstein, J.L.2    Brown, M.S.3    Russell, D.W.4
  • 24
    • 0022262519 scopus 로고
    • Cassette of eight exons shared by genes for LDL receptor and EGF precursor
    • 10.1126/science.3873704. 3873704
    • Cassette of eight exons shared by genes for LDL receptor and EGF precursor. TC Sudhof DW Russell JL Goldstein MS Brown R Sanchez-Pescador GI Bell, Science 1985 228 4701 893 895 10.1126/science.3873704 3873704
    • (1985) Science , vol.228 , Issue.4701 , pp. 893-895
    • Sudhof, T.C.1    Russell, D.W.2    Goldstein, J.L.3    Brown, M.S.4    Sanchez-Pescador, R.5    Bell, G.I.6
  • 25
    • 0000600880 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia
    • New York: McGraw-Hill Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstien B
    • Familial hypercholesterolaemia. JL Goldstein HH Hobbs MS Brown, The Metabolic and Molecular Basis of Inherited Diseases New York: McGraw-Hill, Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstien B, 2001 2863 2913
    • (2001) The Metabolic and Molecular Basis of Inherited Diseases , pp. 2863-2913
    • Goldstein, J.L.1    Hobbs, H.H.2    Brown, M.S.3
  • 26
    • 0023227574 scopus 로고
    • Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene
    • 3611089
    • Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. TC Sudhof DR Van der Westhuyzen JL Goldstein MS Brown DW Russell, The Journal of biological chemistry 1987 262 22 10773 10779 3611089
    • (1987) The Journal of Biological Chemistry , vol.262 , Issue.22 , pp. 10773-10779
    • Sudhof, T.C.1    Van Der Westhuyzen, D.R.2    Goldstein, J.L.3    Brown, M.S.4    Russell, D.W.5
  • 27
  • 29
    • 0030725867 scopus 로고    scopus 로고
    • Long-term cholesterol-lowering effects of 4 fat-restricted diets in hypercholesterolemic and combined hyperlipidemic men. The Dietary Alternatives Study
    • 10.1001/jama.278.18.1509. 9363971
    • Long-term cholesterol-lowering effects of 4 fat-restricted diets in hypercholesterolemic and combined hyperlipidemic men. The Dietary Alternatives Study. RH Knopp CE Walden BM Retzlaff BS McCann AA Dowdy JJ Albers GO Gey MN Cooper, Jama 1997 278 18 1509 1515 10.1001/jama.278.18.1509 9363971
    • (1997) Jama , vol.278 , Issue.18 , pp. 1509-1515
    • Knopp, R.H.1    Walden, C.E.2    Retzlaff, B.M.3    McCann, B.S.4    Dowdy, A.A.5    Albers, J.J.6    Gey, G.O.7    Cooper, M.N.8
  • 30
    • 0031017286 scopus 로고    scopus 로고
    • Lipoprotein lipid response to the National Cholesterol Education Program step II diet by hypercholesterolemic and combined hyperlipidemic women and men
    • 9081694
    • Lipoprotein lipid response to the National Cholesterol Education Program step II diet by hypercholesterolemic and combined hyperlipidemic women and men. CE Walden BM Retzlaff BL Buck BS McCann RH Knopp, Arteriosclerosis, thrombosis, and vascular biology 1997 17 2 375 382 9081694
    • (1997) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.17 , Issue.2 , pp. 375-382
    • Walden, C.E.1    Retzlaff, B.M.2    Buck, B.L.3    McCann, B.S.4    Knopp, R.H.5
  • 31
    • 3142729178 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    • 10.1161/01.CIR.0000133317.49796.0E. 15249516
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. SM Grundy JI Cleeman CN Merz HB Brewer Jr LT Clark DB Hunninghake RC Pasternak SC Smith Jr NJ Stone, Circulation 2004 110 2 227 239 10.1161/01.CIR.0000133317.49796.0E 15249516
    • (2004) Circulation , vol.110 , Issue.2 , pp. 227-239
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3    Brewer Jr., H.B.4    Clark, L.T.5    Hunninghake, D.B.6    Pasternak, R.C.7    Smith Jr., S.C.8    Stone, N.J.9
  • 32
    • 0034068864 scopus 로고    scopus 로고
    • Statins: Effective antiatherosclerotic therapy
    • 10.1016/S0002-8703(00)90033-4. 10740137
    • Statins: effective antiatherosclerotic therapy. RS Blumenthal, Am Heart J 2000 139 4 577 583 10.1016/S0002-8703(00)90033-4 10740137
    • (2000) Am Heart J , vol.139 , Issue.4 , pp. 577-583
    • Blumenthal, R.S.1
  • 33
    • 0035020638 scopus 로고    scopus 로고
    • Poor adherence with hypolipidemic drugs: A lost opportunity
    • 10.1592/phco.21.6.576.34541. 11349746
    • Poor adherence with hypolipidemic drugs: a lost opportunity. RT Tsuyuki TJ Bungard, Pharmacotherapy 2001 21 5 576 582 10.1592/phco.21.6.576.34541 11349746
    • (2001) Pharmacotherapy , vol.21 , Issue.5 , pp. 576-582
    • Tsuyuki, R.T.1    Bungard, T.J.2
  • 34
    • 27744603554 scopus 로고    scopus 로고
    • Reducing residual risk for patients on statin therapy: The potential role of combination therapy
    • discussion 34K-35K. 10.1016/j.amjcard.2005.08.002. 16291008
    • Reducing residual risk for patients on statin therapy: the potential role of combination therapy. MH Davidson, The American journal of cardiology 2005 96 9A 3K 13K discussion 34K-35K 10.1016/j.amjcard.2005.08.002 16291008
    • (2005) The American Journal of Cardiology , vol.96 , Issue.9 A
    • Davidson, M.H.1
  • 35
    • 0033552130 scopus 로고    scopus 로고
    • Colesevelam hydrochloride (cholestagel): A new, potent bile acid sequestrant associated with a low incidence of gastrointestinal side effects
    • 10.1001/archinte.159.16.1893. 10493319
    • Colesevelam hydrochloride (cholestagel): a new, potent bile acid sequestrant associated with a low incidence of gastrointestinal side effects. MH Davidson MA Dillon B Gordon P Jones J Samuels S Weiss J Isaacsohn P Toth SK Burke, Arch Intern Med 1999 159 16 1893 1900 10.1001/archinte.159.16.1893 10493319
    • (1999) Arch Intern Med , vol.159 , Issue.16 , pp. 1893-1900
    • Davidson, M.H.1    Dillon, M.A.2    Gordon, B.3    Jones, P.4    Samuels, J.5    Weiss, S.6    Isaacsohn, J.7    Toth, P.8    Burke, S.K.9
  • 36
    • 0026021035 scopus 로고
    • Coronary drug project: Experience with niacin. Coronary Drug Project Research Group
    • 10.1007/BF01409409. 2044644
    • Coronary drug project: experience with niacin. Coronary Drug Project Research Group. KG Berge PL Canner, European journal of clinical pharmacology 1991 40 Suppl 1 49 51 10.1007/BF01409409 2044644
    • (1991) European Journal of Clinical Pharmacology , vol.40 , Issue.SUPPL. 1 , pp. 1949-51
    • Berge, K.G.1    Canner, P.L.2
  • 37
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • 10.1056/NEJM199908053410604. 10438259
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. HB Rubins SJ Robins D Collins CL Fye JW Anderson MB Elam FH Faas E Linares EJ Schaefer G Schectman TJ Wilt J Wittes, The New England journal of medicine 1999 341 6 410 418 10.1056/NEJM199908053410604 10438259
    • (1999) The New England Journal of Medicine , vol.341 , Issue.6 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6    Faas, F.H.7    Linares, E.8    Schaefer, E.J.9    Schectman, G.10    Wilt, T.J.11    Wittes, J.12
  • 38
  • 39
    • 0036910662 scopus 로고    scopus 로고
    • Management of dyslipidemia in the high-risk patient
    • 10.1067/mhj.2002.130302. 12486415
    • Management of dyslipidemia in the high-risk patient. EA Stein, Am Heart J 2002 144 6 Suppl 43 50 10.1067/mhj.2002.130302 12486415
    • (2002) Am Heart J , vol.144 , Issue.6 SUPPL. , pp. 1943-50
    • Stein, E.A.1
  • 40
    • 0037111924 scopus 로고    scopus 로고
    • Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia
    • 10.1016/S0002-9149(02)02798-4. 12423709
    • Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. CA Dujovne MP Ettinger JF McNeer LJ Lipka AP LeBeaut R Suresh B Yang EP Veltri, The American journal of cardiology 2002 90 10 1092 1097 10.1016/S0002-9149(02)02798- 4 12423709
    • (2002) The American Journal of Cardiology , vol.90 , Issue.10 , pp. 1092-1097
    • Dujovne, C.A.1    Ettinger, M.P.2    McNeer, J.F.3    Lipka, L.J.4    Lebeaut, A.P.5    Suresh, R.6    Yang, B.7    Veltri, E.P.8
  • 41
    • 0037395141 scopus 로고    scopus 로고
    • Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia
    • 10.1016/S0195-668X(02)00807-2. 12713767
    • Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. RH Knopp H Gitter T Truitt H Bays CV Manion LJ Lipka AP LeBeaut R Suresh B Yang EP Veltri, European heart journal 2003 24 8 729 741 10.1016/S0195-668X(02)00807-2 12713767
    • (2003) European Heart Journal , vol.24 , Issue.8 , pp. 729-741
    • Knopp, R.H.1    Gitter, H.2    Truitt, T.3    Bays, H.4    Manion, C.V.5    Lipka, L.J.6    Lebeaut, A.P.7    Suresh, R.8    Yang, B.9    Veltri, E.P.10
  • 42
    • 77954320146 scopus 로고    scopus 로고
    • Ezetimibe alone or in combination with simvastatin increases small dense low-density lipoproteins in healthy men: A randomized trial
    • 10.1093/eurheartj/ehq181. 20525999
    • Ezetimibe alone or in combination with simvastatin increases small dense low-density lipoproteins in healthy men: a randomized trial. K Berneis M Rizzo HK Berthold GA Spinas W Krone I Gouni-Berthold, European heart journal 2010 31 13 1633 1639 10.1093/eurheartj/ehq181 20525999
    • (2010) European Heart Journal , vol.31 , Issue.13 , pp. 1633-1639
    • Berneis, K.1    Rizzo, M.2    Berthold, H.K.3    Spinas, G.A.4    Krone, W.5    Gouni-Berthold, I.6
  • 44
    • 0034802407 scopus 로고    scopus 로고
    • Coadministration of colesevelam hydrochloride with atorvastatin lowers LDL cholesterol additively
    • 10.1016/S0021-9150(01)00437-3. 11583720
    • Coadministration of colesevelam hydrochloride with atorvastatin lowers LDL cholesterol additively. D Hunninghake W Insull Jr P Toth D Davidson JM Donovan SK Burke, Atherosclerosis 2001 158 2 407 416 10.1016/S0021-9150(01) 00437-3 11583720
    • (2001) Atherosclerosis , vol.158 , Issue.2 , pp. 407-416
    • Hunninghake, D.1    Insull Jr., W.2    Toth, P.3    Davidson, D.4    Donovan, J.M.5    Burke, S.K.6
  • 45
    • 0024605192 scopus 로고
    • New horizons in combination drug therapy for hypercholesterolemia
    • discussion 94-100. 10.1159/000174550. 2653626
    • New horizons in combination drug therapy for hypercholesterolemia. DR Illingworth, Cardiology 1989 76 Suppl 1 83 94 discussion 94-100 10.1159/000174550 2653626
    • (1989) Cardiology , vol.76 , Issue.SUPPL. 1 , pp. 83-94
    • Illingworth, D.R.1
  • 46
    • 33750390318 scopus 로고    scopus 로고
    • Ezetimibe added to ongoing statin therapy improves LDL-C goal attainment and lipid profile in patients with diabetes or metabolic syndrome
    • 10.3132/dvdr.2006.020. 17058629
    • Ezetimibe added to ongoing statin therapy improves LDL-C goal attainment and lipid profile in patients with diabetes or metabolic syndrome. M Denke T Pearson P McBride RA Gazzara WE Brady AM Tershakovec, Diab Vasc Dis Res 2006 3 2 93 102 10.3132/dvdr.2006.020 17058629
    • (2006) Diab Vasc Dis Res , vol.3 , Issue.2 , pp. 93-102
    • Denke, M.1    Pearson, T.2    McBride, P.3    Gazzara, R.A.4    Brady, W.E.5    Tershakovec, A.M.6
  • 47
    • 0037188567 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia
    • 10.1161/01.CIR.0000018744.58460.62. 12034651
    • Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia. C Gagne D Gaudet E Bruckert, Circulation 2002 105 21 2469 2475 10.1161/01.CIR.0000018744. 58460.62 12034651
    • (2002) Circulation , vol.105 , Issue.21 , pp. 2469-2475
    • Gagne, C.1    Gaudet, D.2    Bruckert, E.3
  • 48
    • 0016753182 scopus 로고
    • Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia
    • 10.1172/JCI108223. 172531
    • Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia. DW Bilheimer JL Goldstein SM Grundy MS Brown, J Clin Invest 1975 56 6 1420 1430 10.1172/JCI108223 172531
    • (1975) J Clin Invest , vol.56 , Issue.6 , pp. 1420-1430
    • Bilheimer, D.W.1    Goldstein, J.L.2    Grundy, S.M.3    Brown, M.S.4
  • 49
    • 0026011275 scopus 로고
    • LDL-apheresis: Results of longterm treatment and vascular outcome
    • 10.1016/0021-9150(91)90093-I. 2064631
    • LDL-apheresis: results of longterm treatment and vascular outcome. C Keller, Atherosclerosis 1991 86 1 1 8 10.1016/0021-9150(91)90093-I 2064631
    • (1991) Atherosclerosis , vol.86 , Issue.1 , pp. 1-8
    • Keller, C.1
  • 50
    • 0035879864 scopus 로고    scopus 로고
    • Low-density lipoprotein apheresis in homozygous familial hypercholesterolemia
    • 10.1016/S0002-9149(01)01664-2. 11463060
    • Low-density lipoprotein apheresis in homozygous familial hypercholesterolemia. C Mora JL Teruel JF Navarro, The American journal of cardiology 2001 88 2 202 203 10.1016/S0002-9149(01)01664-2 11463060
    • (2001) The American Journal of Cardiology , vol.88 , Issue.2 , pp. 202-203
    • Mora, C.1    Teruel, J.L.2    Navarro, J.F.3
  • 51
    • 0029055583 scopus 로고
    • Pregnancy in a patient with homozygous familial hypercholesterolemia undergoing low-density lipoprotein apheresis by dextran sulfate adsorption
    • 10.1016/0026-0495(95)90247-3. 7616853
    • Pregnancy in a patient with homozygous familial hypercholesterolemia undergoing low-density lipoprotein apheresis by dextran sulfate adsorption. JL Teruel MA Lasuncion JF Navarro P Carrero J Ortuno, Metabolism 1995 44 7 929 933 10.1016/0026-0495(95)90247-3 7616853
    • (1995) Metabolism , vol.44 , Issue.7 , pp. 929-933
    • Teruel, J.L.1    Lasuncion, M.A.2    Navarro, J.F.3    Carrero, P.4    Ortuno, J.5
  • 52
    • 44149123549 scopus 로고    scopus 로고
    • Recommendations for the use of LDL apheresis
    • 10.1016/j.atherosclerosis.2008.02.009. 18371971
    • Recommendations for the use of LDL apheresis. GR Thompson, Atherosclerosis 2008 198 2 247 255 10.1016/j.atherosclerosis.2008.02.009 18371971
    • (2008) Atherosclerosis , vol.198 , Issue.2 , pp. 247-255
    • Thompson, G.R.1
  • 54
    • 0021717457 scopus 로고
    • Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia
    • 10.1056/NEJM198412273112603. 6390206
    • Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. DW Bilheimer JL Goldstein SM Grundy TE Starzl MS Brown, The New England journal of medicine 1984 311 26 1658 1664 10.1056/ NEJM198412273112603 6390206
    • (1984) The New England Journal of Medicine , vol.311 , Issue.26 , pp. 1658-1664
    • Bilheimer, D.W.1    Goldstein, J.L.2    Grundy, S.M.3    Starzl, T.E.4    Brown, M.S.5
  • 56
    • 0023130299 scopus 로고
    • Liver transplantation for treatment of cardiovascular disease: Comparison with medication and plasma exchange in homozygous familial hypercholesterolemia
    • 10.1016/0002-9149(87)91199-4. 3548303
    • Liver transplantation for treatment of cardiovascular disease: comparison with medication and plasma exchange in homozygous familial hypercholesterolemia. JM Hoeg TE Starzl HB Brewer Jr, Am J Cardiol 1987 59 6 705 707 10.1016/0002-9149(87)91199-4 3548303
    • (1987) Am J Cardiol , vol.59 , Issue.6 , pp. 705-707
    • Hoeg, J.M.1    Starzl, T.E.2    Brewer Jr., H.B.3
  • 57
    • 49449106497 scopus 로고    scopus 로고
    • Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins
    • 10.2165/00129784-200808040-00003. 18690757
    • Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins. K El Harchaoui F Akdim ES Stroes MD Trip JJ Kastelein, Am J Cardiovasc Drugs 2008 8 4 233 242 10.2165/00129784-200808040-00003 18690757
    • (2008) Am J Cardiovasc Drugs , vol.8 , Issue.4 , pp. 233-242
    • El Harchaoui, K.1    Akdim, F.2    Stroes, E.S.3    Trip, M.D.4    Kastelein, J.J.5
  • 59
    • 26844580001 scopus 로고    scopus 로고
    • JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs
    • 10.1186/1471-2261-5-30. 16188040
    • JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs. D Aggarwal KL West TL Zern S Shrestha M Vergara-Jimenez ML Fernandez, BMC cardiovascular disorders 2005 5 30 10.1186/1471-2261-5-30 16188040
    • (2005) BMC Cardiovascular Disorders , vol.5 , pp. 30
    • Aggarwal, D.1    West, K.L.2    Zern, T.L.3    Shrestha, S.4    Vergara-Jimenez, M.5    Fernandez, M.L.6
  • 63
    • 77956519356 scopus 로고    scopus 로고
    • A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo
    • 10.1371/journal.pone.0010682. 20498851
    • A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. N Gupta N Fisker MC Asselin M Lindholm C Rosenbohm H Orum J Elmen NG Seidah EM Straarup, PloS one 2010 5 5 10682 10.1371/journal.pone.0010682 20498851
    • (2010) PloS One , vol.5 , Issue.5 , pp. 510682
    • Gupta, N.1    Fisker, N.2    Asselin, M.C.3    Lindholm, M.4    Rosenbohm, C.5    Orum, H.6    Elmen, J.7    Seidah, N.G.8    Straarup, E.M.9
  • 64
    • 50349084487 scopus 로고    scopus 로고
    • Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice
    • 10.1161/CIRCULATIONAHA.108.786822. 18663084
    • Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. E Merki MJ Graham AE Mullick ER Miller RM Crooke RE Pitas JL Witztum S Tsimikas, Circulation 2008 118 7 743 753 10.1161/CIRCULATIONAHA.108.786822 18663084
    • (2008) Circulation , vol.118 , Issue.7 , pp. 743-753
    • Merki, E.1    Graham, M.J.2    Mullick, A.E.3    Miller, E.R.4    Crooke, R.M.5    Pitas, R.E.6    Witztum, J.L.7    Tsimikas, S.8
  • 65
    • 77949485460 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial
    • 10.1016/S0140-6736(10)60284-X. 20227758
    • Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. FJ Raal RD Santos DJ Blom AD Marais MJ Charng WC Cromwell RH Lachmann D Gaudet JL Tan S Chasan-Taber DL Tribble JD Flaim ST Crooke, Lancet 2010 375 9719 998 1006 10.1016/S0140-6736(10)60284-X 20227758
    • (2010) Lancet , vol.375 , Issue.9719 , pp. 998-1006
    • Raal, F.J.1    Santos, R.D.2    Blom, D.J.3    Marais, A.D.4    Charng, M.J.5    Cromwell, W.C.6    Lachmann, R.H.7    Gaudet, D.8    Tan, J.L.9    Chasan-Taber, S.10    Tribble, D.L.11    Flaim, J.D.12    Crooke, S.T.13
  • 66
    • 84864576548 scopus 로고    scopus 로고
    • The Medical News. http://www.news-medical.net/news/20100805/Genzyme-Isis- announce-results-of-two-mipomersen-phase-3-studies.aspx
    • The Medical News
  • 71
    • 0028834831 scopus 로고
    • Gene therapy for human liver disease
    • 9224503
    • Gene therapy for human liver disease. SE Raper JM Wilson, Prog Liver Dis 1995 13 201 230 9224503
    • (1995) Prog Liver Dis , vol.13 , pp. 201-230
    • Raper, S.E.1    Wilson, J.M.2
  • 72
    • 0029116596 scopus 로고
    • Prospects of therapy of liver diseases with foreign genes
    • 10.1055/s-2007-1007279. 7491505
    • Prospects of therapy of liver diseases with foreign genes. KK Kormis GY Wu, Semin Liver Dis 1995 15 3 257 267 10.1055/s-2007-1007279 7491505
    • (1995) Semin Liver Dis , vol.15 , Issue.3 , pp. 257-267
    • Kormis, K.K.1    Wu, G.Y.2
  • 73
    • 85134287629 scopus 로고    scopus 로고
    • The liver as a target for gene therapy
    • Berlin: Walter de Gruyter Strauss M, Barranger J
    • The liver as a target for gene therapy. G Cichon M Strauss, Concept in gene therapy Berlin: Walter de Gruyter, Strauss M, Barranger J, 1997 13 267 281
    • (1997) Concept in Gene Therapy , vol.13 , pp. 267-281
    • Cichon, G.1    Strauss, M.2
  • 74
    • 11144356061 scopus 로고    scopus 로고
    • A sensitive noninvasive method for monitoring successful liver-directed gene transfer of the low-density lipoprotein receptor in Watanabe hyperlipidemic rabbits in vivo
    • 10.1038/sj.gt.3302206. 14724675
    • A sensitive noninvasive method for monitoring successful liver-directed gene transfer of the low-density lipoprotein receptor in Watanabe hyperlipidemic rabbits in vivo. UJ Tietge G Cichon C Buttner J Genschel J Heeren P Gielow N Grewe M Dogar U Beisiegel MP Manns H Lochs W Burchert HH Schmidt, Gene Ther 2004 11 7 574 580 10.1038/sj.gt.3302206 14724675
    • (2004) Gene Ther , vol.11 , Issue.7 , pp. 574-580
    • Tietge, U.J.1    Cichon, G.2    Buttner, C.3    Genschel, J.4    Heeren, J.5    Gielow, P.6    Grewe, N.7    Dogar, M.8    Beisiegel, U.9    Manns, M.P.10    Lochs, H.11    Burchert, W.12    Schmidt, H.H.13
  • 75
    • 0021883888 scopus 로고
    • The effect of selective breeding on the development of coronary atherosclerosis in WHHL rabbits. An animal model for familial hypercholesterolemia
    • 10.1016/0021-9150(85)90085-1. 4026937
    • The effect of selective breeding on the development of coronary atherosclerosis in WHHL rabbits. An animal model for familial hypercholesterolemia. Y Watanabe T Ito M Shiomi, Atherosclerosis 1985 56 1 71 79 10.1016/0021-9150(85)90085-1 4026937
    • (1985) Atherosclerosis , vol.56 , Issue.1 , pp. 71-79
    • Watanabe, Y.1    Ito, T.2    Shiomi, M.3
  • 77
    • 0028345073 scopus 로고
    • Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
    • 10.1172/JCI117179. 8182121
    • Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. S Ishibashi JL Goldstein MS Brown J Herz DK Burns, The Journal of clinical investigation 1994 93 5 1885 1893 10.1172/JCI117179 8182121
    • (1994) The Journal of Clinical Investigation , vol.93 , Issue.5 , pp. 1885-1893
    • Ishibashi, S.1    Goldstein, J.L.2    Brown, M.S.3    Herz, J.4    Burns, D.K.5
  • 78
    • 0022482872 scopus 로고
    • Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit
    • 10.1126/science.3010466
    • Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. T Yamamoto RW Bishop MS Brown JL Goldstein DW Russell, Science (New York, NY) 1986 232 4755 1230 1237 10.1126/science.3010466
    • (1986) Science (New York, NY) , vol.232 , Issue.4755 , pp. 1230-1237
    • Yamamoto, T.1    Bishop, R.W.2    Brown, M.S.3    Goldstein, J.L.4    Russell, D.W.5
  • 79
    • 0020839091 scopus 로고
    • Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia
    • Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia. WJ Schneider MS Brown JL Goldstein, Molecular biology & medicine 1983 1 3 353 367
    • (1983) Molecular Biology & Medicine , vol.1 , Issue.3 , pp. 353-367
    • Schneider, W.J.1    Brown, M.S.2    Goldstein, J.L.3
  • 80
    • 70350573441 scopus 로고    scopus 로고
    • The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe
    • 10.1016/j.atherosclerosis.2009.03.024. 19389675
    • The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe. M Shiomi T Ito, Atherosclerosis 2009 207 1 1 7 10.1016/j.atherosclerosis.2009.03.024 19389675
    • (2009) Atherosclerosis , vol.207 , Issue.1 , pp. 1-7
    • Shiomi, M.1    Ito, T.2
  • 81
    • 0031833128 scopus 로고    scopus 로고
    • Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: Role of apoB mRNA editing in lipoprotein phenotype expression
    • 9598833
    • Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: role of apoB mRNA editing in lipoprotein phenotype expression. M Nakamuta S Taniguchi BY Ishida K Kobayashi L Chan, Arteriosclerosis, thrombosis, and vascular biology 1998 18 5 747 755 9598833
    • (1998) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.18 , Issue.5 , pp. 747-755
    • Nakamuta, M.1    Taniguchi, S.2    Ishida, B.Y.3    Kobayashi, K.4    Chan, L.5
  • 83
    • 0031850520 scopus 로고    scopus 로고
    • Methods of gene delivery
    • 10.1016/S0889-8588(05)70004-6. 9684094
    • Methods of gene delivery. NA Wivel JM Wilson, Hematol Oncol Clin North Am 1998 12 3 483 501 10.1016/S0889-8588(05)70004-6 9684094
    • (1998) Hematol Oncol Clin North Am , vol.12 , Issue.3 , pp. 483-501
    • Wivel, N.A.1    Wilson, J.M.2
  • 84
    • 0028962573 scopus 로고
    • Scope and limitations of gene therapy
    • 7767636
    • Scope and limitations of gene therapy. DJ Weatherall, Br Med Bull 1995 51 1 1 11 7767636
    • (1995) Br Med Bull , vol.51 , Issue.1 , pp. 1-11
    • Weatherall, D.J.1
  • 87
    • 0037294039 scopus 로고    scopus 로고
    • Non-viral and hybrid vectors in human gene therapy: An update
    • 10.1016/S1471-4914(03)00005-4. 12615040
    • Non-viral and hybrid vectors in human gene therapy: an update. GD Schmidt-Wolf IG Schmidt-Wolf, Trends Mol Med 2003 9 2 67 72 10.1016/S1471- 4914(03)00005-4 12615040
    • (2003) Trends Mol Med , vol.9 , Issue.2 , pp. 67-72
    • Schmidt-Wolf, G.D.1    Schmidt-Wolf, I.G.2
  • 88
    • 0036844766 scopus 로고    scopus 로고
    • In vivo characteristics of cationic liposomes as delivery vectors for gene therapy
    • 10.1023/A:1020989709019. 12458664
    • In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. SA Audouy LF de Leij D Hoekstra G Molema, Pharm Res 2002 19 11 1599 1605 10.1023/A:1020989709019 12458664
    • (2002) Pharm Res , vol.19 , Issue.11 , pp. 1599-1605
    • Audouy, S.A.1    De Leij, L.F.2    Hoekstra, D.3    Molema, G.4
  • 89
    • 0028863071 scopus 로고
    • Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes
    • 10.1002/jps.2600841102. 8587040
    • Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes. RI Mahato K Kawabata T Nomura Y Takakura M Hashida, J Pharm Sci 1995 84 11 1267 1271 10.1002/jps.2600841102 8587040
    • (1995) J Pharm Sci , vol.84 , Issue.11 , pp. 1267-1271
    • Mahato, R.I.1    Kawabata, K.2    Nomura, T.3    Takakura, Y.4    Hashida, M.5
  • 90
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • 10.1038/sj.gt.3300947. 10455434
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. F Liu Y Song D Liu, Gene therapy 1999 6 7 1258 1266 10.1038/sj.gt.3300947 10455434
    • (1999) Gene Therapy , vol.6 , Issue.7 , pp. 1258-1266
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 91
    • 14744292260 scopus 로고    scopus 로고
    • Low-density lipoprotein (LDL) receptor/transferrin fusion protein: In vivo production and functional evaluation as a potential therapeutic tool for lowering plasma LDL cholesterol
    • 10.1089/104303404323141980. 15212712
    • Low-density lipoprotein (LDL) receptor/transferrin fusion protein: in vivo production and functional evaluation as a potential therapeutic tool for lowering plasma LDL cholesterol. G Razzini F Parise D Calebiro R Battini B Bagni T Corazzari P Tarugi C Angelelli S Molinari L Falqui S Ferrari, Human gene therapy 2004 15 6 533 541 10.1089/104303404323141980 15212712
    • (2004) Human Gene Therapy , vol.15 , Issue.6 , pp. 533-541
    • Razzini, G.1    Parise, F.2    Calebiro, D.3    Battini, R.4    Bagni, B.5    Corazzari, T.6    Tarugi, P.7    Angelelli, C.8    Molinari, S.9    Falqui, L.10    Ferrari, S.11
  • 92
    • 0019860247 scopus 로고
    • Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein
    • 10.1016/0022-2836(81)90447-2. 6275086
    • Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein. M Krieger MS Brown JL Goldstein, J Mol Biol 1981 150 2 167 184 10.1016/0022-2836(81)90447-2 6275086
    • (1981) J Mol Biol , vol.150 , Issue.2 , pp. 167-184
    • Krieger, M.1    Brown, M.S.2    Goldstein, J.L.3
  • 93
    • 0038237520 scopus 로고    scopus 로고
    • Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells
    • 10.1016/S1525-0016(03)00060-1. 12718903
    • Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. R Wade-Martins Y Saeki EA Chiocca, Mol Ther 2003 7 5 Pt 1 604 612 10.1016/S1525-0016(03)00060-1 12718903
    • (2003) Mol Ther , vol.7 , Issue.5 PART 1 , pp. 604-612
    • Wade-Martins, R.1    Saeki, Y.2    Chiocca, E.A.3
  • 94
    • 34548569003 scopus 로고    scopus 로고
    • An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency
    • 10.1093/nar/gkm570. 17675302
    • An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency. MM Lufino R Manservigi R Wade-Martins, Nucleic acids research 2007 35 15 98 10.1093/nar/gkm570 17675302
    • (2007) Nucleic Acids Research , vol.35 , Issue.15 , pp. 598
    • Lufino, M.M.1    Manservigi, R.2    Wade-Martins, R.3
  • 96
    • 76349091597 scopus 로고    scopus 로고
    • Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs
    • 10.1038/mt.2009.249. 19861949
    • Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs. OC Hibbitt E McNeil MM Lufino L Seymour K Channon R Wade-Martins, Mol Ther 2010 18 2 317 326 10.1038/mt.2009.249 19861949
    • (2010) Mol Ther , vol.18 , Issue.2 , pp. 317-326
    • Hibbitt, O.C.1    McNeil, E.2    Lufino, M.M.3    Seymour, L.4    Channon, K.5    Wade-Martins, R.6
  • 97
    • 34447300969 scopus 로고    scopus 로고
    • Antisense apolipoprotein B therapy: Where do we stand?
    • 10.1097/MOL.0b013e328248b4ad. 17620855
    • Antisense apolipoprotein B therapy: where do we stand? F Akdim ES Stroes JJ Kastelein, Current opinion in lipidology 2007 18 4 397 400 10.1097/MOL.0b013e328248b4ad 17620855
    • (2007) Current Opinion in Lipidology , vol.18 , Issue.4 , pp. 397-400
    • Akdim, F.1    Stroes, E.S.2    Kastelein, J.J.3
  • 99
    • 20544474017 scopus 로고    scopus 로고
    • An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
    • 10.1194/jlr.M400492-JLR200. 15716585
    • An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis. RM Crooke MJ Graham KM Lemonidis CP Whipple S Koo RJ Perera, Journal of lipid research 2005 46 5 872 884 10.1194/jlr.M400492-JLR200 15716585
    • (2005) Journal of Lipid Research , vol.46 , Issue.5 , pp. 872-884
    • Crooke, R.M.1    Graham, M.J.2    Lemonidis, K.M.3    Whipple, C.P.4    Koo, S.5    Perera, R.J.6
  • 100
    • 34748859659 scopus 로고    scopus 로고
    • ISIS 301012 gene therapy for hypercholesterolemia: Sense, antisense, or nonsense?
    • 10.1345/aph.1K065. 17848425
    • ISIS 301012 gene therapy for hypercholesterolemia: sense, antisense, or nonsense? MK Ito, The Annals of pharmacotherapy 2007 41 10 1669 1678 10.1345/aph.1K065 17848425
    • (2007) The Annals of Pharmacotherapy , vol.41 , Issue.10 , pp. 1669-1678
    • Ito, M.K.1
  • 101
    • 33750207033 scopus 로고    scopus 로고
    • Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    • 10.1161/CIRCULATIONAHA.105.606442. 17030687
    • Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. JJ Kastelein MK Wedel BF Baker J Su JD Bradley RZ Yu E Chuang MJ Graham RM Crooke, Circulation 2006 114 16 1729 1735 10.1161/CIRCULATIONAHA. 105.606442 17030687
    • (2006) Circulation , vol.114 , Issue.16 , pp. 1729-1735
    • Kastelein, J.J.1    Wedel, M.K.2    Baker, B.F.3    Su, J.4    Bradley, J.D.5    Yu, R.Z.6    Chuang, E.7    Graham, M.J.8    Crooke, R.M.9
  • 102
    • 42049088250 scopus 로고    scopus 로고
    • Novel molecules targeting dyslipidemia and atherosclerosis
    • 10.2174/092986708783955482. 18393849
    • Novel molecules targeting dyslipidemia and atherosclerosis. A Tavridou VG Manolopoulos, Current medicinal chemistry 2008 15 8 792 802 10.2174/092986708783955482 18393849
    • (2008) Current Medicinal Chemistry , vol.15 , Issue.8 , pp. 792-802
    • Tavridou, A.1    Manolopoulos, V.G.2
  • 103
    • 0030928619 scopus 로고    scopus 로고
    • Gene therapy - Promises, problems and prospects
    • 10.1038/38410. 9305836
    • Gene therapy - promises, problems and prospects. IM Verma N Somia, Nature 1997 389 6648 239 242 10.1038/38410 9305836
    • (1997) Nature , vol.389 , Issue.6648 , pp. 239-242
    • Verma, I.M.1    Somia, N.2
  • 105
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • 10.1038/nrg1066. 12728277
    • Progress and problems with the use of viral vectors for gene therapy. CE Thomas A Ehrhardt MA Kay, Nat Rev Genet 2003 4 5 346 358 10.1038/nrg1066 12728277
    • (2003) Nat Rev Genet , vol.4 , Issue.5 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 106
    • 2642545574 scopus 로고    scopus 로고
    • Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells
    • 10.1128/JVI.78.12.6556-6566.2004. 15163748
    • Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells. O Dorigo JS Gil SD Gallaher BT Tan MG Castro PR Lowenstein MP Calos AJ Berk, J Virol 2004 78 12 6556 6566 10.1128/JVI.78.12.6556-6566.2004 15163748
    • (2004) J Virol , vol.78 , Issue.12 , pp. 6556-6566
    • Dorigo, O.1    Gil, J.S.2    Gallaher, S.D.3    Tan, B.T.4    Castro, M.G.5    Lowenstein, P.R.6    Calos, M.P.7    Berk, A.J.8
  • 108
    • 0020582124 scopus 로고
    • Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus
    • 10.1016/0092-8674(83)90344-6. 6678608
    • Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. R Mann RC Mulligan D Baltimore, Cell 1983 33 1 153 159 10.1016/0092-8674(83)90344-6 6678608
    • (1983) Cell , vol.33 , Issue.1 , pp. 153-159
    • Mann, R.1    Mulligan, R.C.2    Baltimore, D.3
  • 109
    • 0006093983 scopus 로고    scopus 로고
    • Retroviral vectors
    • Oxford: BIOS Scientific Publishers Limited Lemoine NR, Cooper DN First
    • Retroviral vectors. WH Gunzburg B Salmons, Gene Therapy Oxford: BIOS Scientific Publishers Limited, Lemoine NR, Cooper DN, First 1996 1 72 102
    • (1996) Gene Therapy , vol.1 , pp. 72-102
    • Gunzburg, W.H.1    Salmons, B.2
  • 110
    • 0030770490 scopus 로고    scopus 로고
    • Retroviral particles produced from a stable human-derived packaging cell line transduce target cells with very high efficiencies
    • 10.1089/hum.1997.8.12-1459. 9287146
    • Retroviral particles produced from a stable human-derived packaging cell line transduce target cells with very high efficiencies. JL Davis RM Witt PR Gross CA Hokanson S Jungles LK Cohen O Danos SK Spratt, Human gene therapy 1997 8 12 1459 1467 10.1089/hum.1997.8.12-1459 9287146
    • (1997) Human Gene Therapy , vol.8 , Issue.12 , pp. 1459-1467
    • Davis, J.L.1    Witt, R.M.2    Gross, P.R.3    Hokanson, C.A.4    Jungles, S.5    Cohen, L.K.6    Danos, O.7    Spratt, S.K.8
  • 111
    • 0032798686 scopus 로고    scopus 로고
    • The resistance of retroviral vectors produced from human cells to serum inactivation in vivo and in vitro is primate species dependent
    • 10400768
    • The resistance of retroviral vectors produced from human cells to serum inactivation in vivo and in vitro is primate species dependent. NJ DePolo CE Harkleroad M Bodner AT Watt CG Anderson JS Greengard KK Murthy TW Dubensky Jr DJ Jolly, J Virol 1999 73 8 6708 6714 10400768
    • (1999) J Virol , vol.73 , Issue.8 , pp. 6708-6714
    • Depolo, N.J.1    Harkleroad, C.E.2    Bodner, M.3    Watt, A.T.4    Anderson, C.G.5    Greengard, J.S.6    Murthy, K.K.7    Jolly, D.J.8
  • 112
    • 0342463159 scopus 로고
    • Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges
    • 10.1073/pnas.85.17.6460. 3413107
    • Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. O Danos RC Mulligan, Proc Natl Acad Sci USA 1988 85 17 6460 6464 10.1073/pnas.85.17.6460 3413107
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.17 , pp. 6460-6464
    • Danos, O.1    Mulligan, R.C.2
  • 113
    • 0027228422 scopus 로고
    • Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
    • 10.1073/pnas.90.17.8033
    • Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. JC Burns F T W Driever M Burrascano JK Yee, Proc Natl Acad Sci USA 1993 1;90 17 8033 8037 10.1073/pnas.90.17.8033
    • (1993) Proc Natl Acad Sci USA , vol.190 , Issue.17 , pp. 8033-8037
    • Burns, J.C.1    Driever, W.2    Burrascano, M.3    Yee, J.K.4
  • 114
    • 0023177629 scopus 로고
    • Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region
    • 3502707
    • Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region. MA Bender TD Palmer RE Gelinas AD Miller, J Virol 1987 61 5 1639 1646 3502707
    • (1987) J Virol , vol.61 , Issue.5 , pp. 1639-1646
    • Bender, M.A.1    Palmer, T.D.2    Gelinas, R.E.3    Miller, A.D.4
  • 116
    • 0026355641 scopus 로고
    • Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits
    • 10.1126/science.1722351
    • Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. JR Chowdhury M Grossman S Gupta NR Chowdhury JR Baker Jr JM Wilson, Science (New York, NY) 1991 254 5039 1802 1805 10.1126/science.1722351
    • (1991) Science (New York, NY) , vol.254 , Issue.5039 , pp. 1802-1805
    • Chowdhury, J.R.1    Grossman, M.2    Gupta, S.3    Chowdhury, N.R.4    Wilson, J.M.5
  • 117
    • 0026938511 scopus 로고
    • Transplantation of genetically modified autologous hepatocytes into nonhuman primates: Feasibility and short-term toxicity
    • 10.1089/hum.1992.3.5-501. 1420448
    • Transplantation of genetically modified autologous hepatocytes into nonhuman primates: feasibility and short-term toxicity. M Grossman SE Raper JM Wilson, Human gene therapy 1992 3 5 501 510 10.1089/hum.1992.3.5-501 1420448
    • (1992) Human Gene Therapy , vol.3 , Issue.5 , pp. 501-510
    • Grossman, M.1    Raper, S.E.2    Wilson, J.M.3
  • 118
    • 0027534621 scopus 로고
    • A novel approach for introducing hepatocytes into the portal circulation
    • 8445295
    • A novel approach for introducing hepatocytes into the portal circulation. M Grossman JM Wilson SE Raper, J Lab Clin Med 1993 121 3 472 478 8445295
    • (1993) J Lab Clin Med , vol.121 , Issue.3 , pp. 472-478
    • Grossman, M.1    Wilson, J.M.2    Raper, S.E.3
  • 119
    • 0028292602 scopus 로고
    • Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia
    • 10.1038/ng0494-335. 8054972
    • Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. M Grossman SE Raper K Kozarsky EA Stein JF Engelhardt D Muller PJ Lupien JM Wilson, Nat Genet 1994 6 4 335 341 10.1038/ng0494-335 8054972
    • (1994) Nat Genet , vol.6 , Issue.4 , pp. 335-341
    • Grossman, M.1    Raper, S.E.2    Kozarsky, K.3    Stein, E.A.4    Engelhardt, J.F.5    Muller, D.6    Lupien, P.J.7    Wilson, J.M.8
  • 122
    • 0000800331 scopus 로고    scopus 로고
    • Adenoviridae, the viruses and their replication
    • Philadelphia: Lippincott-William and Wilkins Fields B, Knipe D, Howley P 4
    • Adenoviridae, The viruses and their replication. T Shenk, Fields Virology Philadelphia: Lippincott-William and Wilkins, Fields B, Knipe D, Howley P, 4 1999 2 2265 2300
    • (1999) Fields Virology , vol.2 , pp. 2265-2300
    • Shenk, T.1
  • 123
    • 0027723616 scopus 로고
    • Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia
    • 10.1007/BF01233250. 8291022
    • Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia. K Kozarsky M Grossman JM Wilson, Somatic cell and molecular genetics 1993 19 5 449 458 10.1007/BF01233250 8291022
    • (1993) Somatic Cell and Molecular Genetics , vol.19 , Issue.5 , pp. 449-458
    • Kozarsky, K.1    Grossman, M.2    Wilson, J.M.3
  • 124
    • 0029988465 scopus 로고    scopus 로고
    • Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    • 10.1038/ng0596-54. 8673104
    • Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. KF Kozarsky K Jooss M Donahee JF Strauss JM Wilson, Nat Genet 1996 13 1 54 62 10.1038/ng0596-54 8673104
    • (1996) Nat Genet , vol.13 , Issue.1 , pp. 54-62
    • Kozarsky, K.F.1    Jooss, K.2    Donahee, M.3    Strauss, J.F.4    Wilson, J.M.5
  • 125
    • 0033533669 scopus 로고    scopus 로고
    • Virus treatment questioned after gene therapy death
    • 10.1038/43977. 10524611
    • Virus treatment questioned after gene therapy death. S Lehrman, Nature 1999 401 6753 517 518 10.1038/43977 10524611
    • (1999) Nature , vol.401 , Issue.6753 , pp. 517-518
    • Lehrman, S.1
  • 127
    • 0027166647 scopus 로고
    • Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment
    • 10.1016/0092-8674(93)90231-E. 8477447
    • Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. TJ Wickham P Mathias DA Cheresh GR Nemerow, Cell 1993 73 2 309 319 10.1016/0092-8674(93)90231-E 8477447
    • (1993) Cell , vol.73 , Issue.2 , pp. 309-319
    • Wickham, T.J.1    Mathias, P.2    Cheresh, D.A.3    Nemerow, G.R.4
  • 128
    • 0021100062 scopus 로고
    • Generation of adenovirus by transfection of plasmids
    • 10.1093/nar/11.17.6003. 6310523
    • Generation of adenovirus by transfection of plasmids. KL Berkner PA Sharp, Nucleic acids research 1983 11 17 6003 6020 10.1093/nar/11.17.6003 6310523
    • (1983) Nucleic Acids Research , vol.11 , Issue.17 , pp. 6003-6020
    • Berkner, K.L.1    Sharp, P.A.2
  • 129
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. S Ishibashi MS Brown JL Goldstein RD Gerard RE Hammer J Herz, J Clin Invest 1993 92 2 883 893 10.1172/JCI116663 8349823 (Pubitemid 23262411)
    • (1993) Journal of Clinical Investigation , vol.92 , Issue.2 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 130
    • 0028234357 scopus 로고
    • In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
    • 8175805
    • In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. KF Kozarsky DR McKinley LL Austin SE Raper LD Stratford-Perricaudet JM Wilson, J Biol Chem 1994 269 18 13695 13702 8175805
    • (1994) J Biol Chem , vol.269 , Issue.18 , pp. 13695-13702
    • Kozarsky, K.F.1    McKinley, D.R.2    Austin, L.L.3    Raper, S.E.4    Stratford-Perricaudet, L.D.5    Wilson, J.M.6
  • 132
    • 0030460117 scopus 로고    scopus 로고
    • Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: Receptor expression modulates high-density lipoproteins
    • 10.1016/S0026-0495(96)90172-9. 8969276
    • Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: receptor expression modulates high-density lipoproteins. DR Brown ME Brousseau RD Shamburek GD Talley S Meyn SJ Demosky Jr S Santamarina-Fojo HB Brewer Jr JM Hoeg, Metabolism 1996 45 12 1447 1457 10.1016/S0026-0495(96)90172-9 8969276
    • (1996) Metabolism , vol.45 , Issue.12 , pp. 1447-1457
    • Brown, D.R.1    Brousseau, M.E.2    Shamburek, R.D.3    Talley, G.D.4    Meyn, S.5
  • 133
    • 0032751795 scopus 로고    scopus 로고
    • Nonphysiological overexpression of low-density lipoprotein receptors causes pathological intracellular lipid accumulation and the formation of cholesterol and cholesteryl ester crystals in vitro
    • 10.1007/s001099900045. 10606209
    • Nonphysiological overexpression of low-density lipoprotein receptors causes pathological intracellular lipid accumulation and the formation of cholesterol and cholesteryl ester crystals in vitro. J Heeren DS Steinwaerder F Schnieders G Cichon M Strauss U Beisiegel, J Mol Med 1999 77 10 735 743 10.1007/s001099900045 10606209
    • (1999) J Mol Med , vol.77 , Issue.10 , pp. 735-743
    • Heeren, J.1    Steinwaerder, D.S.2    Schnieders, F.3    Cichon, G.4    Strauss, M.5    Beisiegel, U.6
  • 135
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • 10.1073/pnas.92.5.1401. 7877990
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Y Dai EM Schwarz D Gu WW Zhang N Sarvetnick IM Verma, Proc Natl Acad Sci USA 1995 92 5 1401 1405 10.1073/pnas.92.5.1401 7877990
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.5 , pp. 1401-1405
    • Dai, Y.1    Schwarz, E.M.2    Gu, D.3    Zhang, W.W.4    Sarvetnick, N.5    Verma, I.M.6
  • 136
    • 0028914687 scopus 로고
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
    • 7719932
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. D Barr J Tubb D Ferguson A Scaria A Lieber C Wilson J Perkins MA Kay, Gene Ther 1995 2 2 151 155 7719932
    • (1995) Gene Ther , vol.2 , Issue.2 , pp. 151-155
    • Barr, D.1    Tubb, J.2    Ferguson, D.3    Scaria, A.4    Lieber, A.5    Wilson, C.6    Perkins, J.7    Kay, M.A.8
  • 137
    • 0033644454 scopus 로고    scopus 로고
    • Long-term reversal of hypercholesterolemia in low density lipoprotein receptor (LDLR)-deficient mice by adenovirus-mediated LDLR gene transfer combined with CD154 blockade
    • 10.10 02/(SICI)152 1-2254(200001/02)2: 1<41::AID-JGM 79>3.0.CO;2-P. 10765504
    • Long-term reversal of hypercholesterolemia in low density lipoprotein receptor (LDLR)-deficient mice by adenovirus-mediated LDLR gene transfer combined with CD154 blockade. CS Stein I Martins BL Davidson, J Gene Med 2000 2 1 41 51 10.1002/(SICI)1521-2254(200001/02)2:1<41::AID-JGM79>3.0.CO;2-P 10765504
    • (2000) J Gene Med , vol.2 , Issue.1 , pp. 41-51
    • Stein, C.S.1    Martins, I.2    Davidson, B.L.3
  • 138
    • 0030161017 scopus 로고    scopus 로고
    • Second-generation adenovirus vectors
    • 10.1038/nm0696-714. 8640568
    • Second-generation adenovirus vectors. Q Wang MH Finer, Nature medicine 1996 2 6 714 716 10.1038/nm0696-714 8640568
    • (1996) Nature Medicine , vol.2 , Issue.6 , pp. 714-716
    • Wang, Q.1    Finer, M.H.2
  • 139
    • 5444276005 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia
    • 10.1038/sj.gt.3302310. 15269711
    • Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. S Nomura A Merched E Nour C Dieker K Oka L Chan, Gene therapy 2004 11 20 1540 1548 10.1038/sj.gt.3302310 15269711
    • (2004) Gene Therapy , vol.11 , Issue.20 , pp. 1540-1548
    • Nomura, S.1    Merched, A.2    Nour, E.3    Dieker, C.4    Oka, K.5    Chan, L.6
  • 140
    • 56649109925 scopus 로고    scopus 로고
    • Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia
    • 10.1016/j.atherosclerosis.2008.02.023. 18378244
    • Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia. F Jacobs E Van Craeyveld Y Feng J Snoeys B De Geest, Atherosclerosis 2008 201 2 289 297 10.1016/j.atherosclerosis.2008.02.023 18378244
    • (2008) Atherosclerosis , vol.201 , Issue.2 , pp. 289-297
    • Jacobs, F.1    Van Craeyveld, E.2    Feng, Y.3    Snoeys, J.4    De Geest, B.5
  • 141
    • 0035814955 scopus 로고    scopus 로고
    • Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor
    • 11238273
    • Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor. K Oka L Pastore IH Kim A Merched S Nomura HJ Lee M Merched-Sauvage C Arden-Riley B Lee M Finegold A Beaudet L Chan, Circulation 2001 103 9 1274 1281 11238273
    • (2001) Circulation , vol.103 , Issue.9 , pp. 1274-1281
    • Oka, K.1    Pastore, L.2    Kim, I.H.3    Merched, A.4    Nomura, S.5    Lee, H.J.6    Merched-Sauvage, M.7    Arden-Riley, C.8    Lee, B.9    Finegold, M.10    Beaudet, A.11    Chan, L.12
  • 142
    • 0033134604 scopus 로고    scopus 로고
    • Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization
    • 10.1172/JCI6889. 10225965
    • Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. JM Isner T Asahara, The Journal of clinical investigation 1999 103 9 1231 1236 10.1172/JCI6889 10225965
    • (1999) The Journal of Clinical Investigation , vol.103 , Issue.9 , pp. 1231-1236
    • Isner, J.M.1    Asahara, T.2
  • 143
  • 145
    • 0001142644 scopus 로고    scopus 로고
    • Parvoviridae, the viruses and their replication
    • Philadelphia: Lippincott-William and Wilkins Fields B, Knipe D, Howley P 4
    • Parvoviridae, The viruses and their replication. N Muzyczka KI Berns, Fields Virology Philadelphia: Lippincott-William and Wilkins, Fields B, Knipe D, Howley P, 4 1999 2 2327 2379
    • (1999) Fields Virology , vol.2 , pp. 2327-2379
    • Muzyczka, N.1    Berns, K.I.2
  • 146
    • 19444365150 scopus 로고    scopus 로고
    • Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models
    • 10.1016/j.ymthe.2004.12.022. 15922958
    • Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models. AM Davidoff JT Gray CY Ng Y Zhang J Zhou Y Spence Y Bakar AC Nathwani, Mol Ther 2005 11 6 875 888 10.1016/j.ymthe.2004.12.022 15922958
    • (2005) Mol Ther , vol.11 , Issue.6 , pp. 875-888
    • Davidoff, A.M.1    Gray, J.T.2    Ng, C.Y.3    Zhang, Y.4    Zhou, J.5    Spence, Y.6    Bakar, Y.7    Nathwani, A.C.8
  • 147
    • 0037818636 scopus 로고    scopus 로고
    • Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway
    • 10.1182/blood-2002-09-2889. 12637328
    • Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. AM Davidoff CY Ng J Zhou Y Spence AC Nathwani, Blood 2003 102 2 480 488 10.1182/blood-2002-09-2889 12637328
    • (2003) Blood , vol.102 , Issue.2 , pp. 480-488
    • Davidoff, A.M.1    Ng, C.Y.2    Zhou, J.3    Spence, Y.4    Nathwani, A.C.5
  • 148
    • 0034091579 scopus 로고    scopus 로고
    • Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus
    • 10.1172/JCI8317. 10841516
    • Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus. D Duan Y Yue Z Yan J Yang JF Engelhardt, The Journal of clinical investigation 2000 105 11 1573 1587 10.1172/JCI8317 10841516
    • (2000) The Journal of Clinical Investigation , vol.105 , Issue.11 , pp. 1573-1587
    • Duan, D.1    Yue, Y.2    Yan, Z.3    Yang, J.4    Engelhardt, J.F.5
  • 150
    • 0029655894 scopus 로고    scopus 로고
    • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
    • 8523565
    • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. KJ Fisher GP Gao MD Weitzman R DeMatteo JF Burda JM Wilson, Journal of virology 1996 70 1 520 532 8523565
    • (1996) Journal of Virology , vol.70 , Issue.1 , pp. 520-532
    • Fisher, K.J.1    Gao, G.P.2    Weitzman, M.D.3    Dematteo, R.4    Burda, J.F.5    Wilson, J.M.6
  • 151
    • 0348038748 scopus 로고    scopus 로고
    • Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo
    • 10.1038/sj.gt.3302133. 14625564
    • Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo. Z Wang HI Ma J Li L Sun J Zhang X Xiao, Gene therapy 2003 10 26 2105 2111 10.1038/sj.gt.3302133 14625564
    • (2003) Gene Therapy , vol.10 , Issue.26 , pp. 2105-2111
    • Wang, Z.1    Ma, H.I.2    Li, J.3    Sun, L.4    Zhang, J.5    Xiao, X.6
  • 152
    • 33645528206 scopus 로고    scopus 로고
    • Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver
    • 10.1182/blood-2005-10-4035. 16322469
    • Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver. AC Nathwani JT Gray CY Ng J Zhou Y Spence SN Waddington EG Tuddenham G Kemball-Cook J McIntosh M Boon-Spijker K Mertens AM Davidoff, Blood 2006 107 7 2653 2661 10.1182/blood-2005-10-4035 16322469
    • (2006) Blood , vol.107 , Issue.7 , pp. 2653-2661
    • Nathwani, A.C.1    Gray, J.T.2    Ng, C.Y.3    Zhou, J.4    Spence, Y.5    Waddington, S.N.6    Tuddenham, E.G.7    Kemball-Cook, G.8    McIntosh, J.9    Boon-Spijker, M.10    Mertens, K.11    Davidoff, A.M.12
  • 153
    • 0034264614 scopus 로고    scopus 로고
    • Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor
    • 10.1006/mthe.2000.0122. 10985956
    • Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor. SJ Chen DJ Rader J Tazelaar M Kawashiri G Gao JM Wilson, Mol Ther 2000 2 3 256 261 10.1006/mthe.2000.0122 10985956
    • (2000) Mol Ther , vol.2 , Issue.3 , pp. 256-261
    • Chen, S.J.1    Rader, D.J.2    Tazelaar, J.3    Kawashiri, M.4    Gao, G.5    Wilson, J.M.6
  • 154
    • 6344275675 scopus 로고    scopus 로고
    • Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia
    • 10.1002/jgm.554. 15170737
    • Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia. C Lebherz G Gao JP Louboutin J Millar D Rader JM Wilson, J Gene Med 2004 6 6 663 672 10.1002/jgm.554 15170737
    • (2004) J Gene Med , vol.6 , Issue.6 , pp. 663-672
    • Lebherz, C.1    Gao, G.2    Louboutin, J.P.3    Millar, J.4    Rader, D.5    Wilson, J.M.6
  • 155
    • 0037015049 scopus 로고    scopus 로고
    • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
    • 10.1073/pnas.182412299. 12192090
    • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. GP Gao MR Alvira L Wang R Calcedo J Johnston JM Wilson, Proc Natl Acad Sci USA 2002 99 18 11854 11859 10.1073/pnas.182412299 12192090
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.18 , pp. 11854-11859
    • Gao, G.P.1    Alvira, M.R.2    Wang, L.3    Calcedo, R.4    Johnston, J.5    Wilson, J.M.6
  • 156
    • 33746840266 scopus 로고    scopus 로고
    • Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8
    • 10.1161/01.ATV.0000231520.26490.54. 16763161
    • Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8. K Kitajima DH Marchadier GC Miller GP Gao JM Wilson DJ Rader, Arteriosclerosis, thrombosis, and vascular biology 2006 26 8 1852 1857 10.1161/01.ATV.0000231520. 26490.54 16763161
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.8 , pp. 1852-1857
    • Kitajima, K.1    Marchadier, D.H.2    Miller, G.C.3    Gao, G.P.4    Wilson, J.M.5    Rader, D.J.6
  • 157
    • 33746700195 scopus 로고    scopus 로고
    • Inhibition of atherogenesis in LDLR knockout mice by systemic delivery of adeno-associated virus type 2-hIL-10
    • 10.1016/j.atherosclerosis.2005.10.029. 16300768
    • Inhibition of atherogenesis in LDLR knockout mice by systemic delivery of adeno-associated virus type 2-hIL-10. Y Liu D Li J Chen J Xie S Bandyopadhyay D Zhang AR Nemarkommula H Liu JL Mehta PL Hermonat, Atherosclerosis 2006 188 1 19 27 10.1016/j.atherosclerosis.2005.10.029 16300768
    • (2006) Atherosclerosis , vol.188 , Issue.1 , pp. 19-27
    • Liu, Y.1    Li, D.2    Chen, J.3    Xie, J.4    Bandyopadhyay, S.5    Zhang, D.6    Nemarkommula, A.R.7    Liu, H.8    Mehta, J.L.9    Hermonat, P.L.10
  • 160
    • 44049094771 scopus 로고    scopus 로고
    • Clinical gene therapy using recombinant adeno-associated virus vectors
    • 10.1038/gt.2008.68. 18418415
    • Clinical gene therapy using recombinant adeno-associated virus vectors. C Mueller T Flotte, Gene Ther 2008 15 11 858 863 10.1038/gt.2008.68 18418415
    • (2008) Gene Ther , vol.15 , Issue.11 , pp. 858-863
    • Mueller, C.1    Flotte, T.2
  • 161
    • 0035135747 scopus 로고    scopus 로고
    • Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics
    • 10.1038/83324. 11135613
    • Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. MA Kay JC Glorioso L Naldini, Nature medicine 2001 7 1 33 40 10.1038/83324 11135613
    • (2001) Nature Medicine , vol.7 , Issue.1 , pp. 33-40
    • Kay, M.A.1    Glorioso, J.C.2    Naldini, L.3
  • 165
    • 0028055281 scopus 로고
    • Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
    • 8254763
    • Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. PF Lewis M Emerman, J Virol 1994 68 1 510 516 8254763
    • (1994) J Virol , vol.68 , Issue.1 , pp. 510-516
    • Lewis, P.F.1    Emerman, M.2
  • 166
    • 76749152709 scopus 로고    scopus 로고
    • Integrase-defective lentiviral vectors: Progress and applications
    • 10.1038/gt.2009.135. 19847206
    • Integrase-defective lentiviral vectors: progress and applications. MB Banasik PB McCray Jr, Gene therapy 2010 17 2 150 157 10.1038/gt.2009.135 19847206
    • (2010) Gene Therapy , vol.17 , Issue.2 , pp. 150-157
    • Banasik, M.B.1
  • 167
    • 0028137215 scopus 로고
    • 2-LTR circular viral DNA as a marker for human immunodeficiency virus type 1 infection in vivo
    • 10.1006/viro.1994.1667. 7975248
    • 2-LTR circular viral DNA as a marker for human immunodeficiency virus type 1 infection in vivo. CD Pauza P Trivedi TS McKechnie DD Richman FM Graziano, Virology 1994 205 2 470 478 10.1006/viro.1994.1667 7975248
    • (1994) Virology , vol.205 , Issue.2 , pp. 470-478
    • Pauza, C.D.1    Trivedi, P.2    McKechnie, T.S.3    Richman, D.D.4    Graziano, F.M.5
  • 168
    • 0025719637 scopus 로고
    • Circularization of human immunodeficiency virus type 1 DNA in vitro
    • 1834863
    • Circularization of human immunodeficiency virus type 1 DNA in vitro. CM Farnet WA Haseltine, Journal of virology 1991 65 12 6942 6952 1834863
    • (1991) Journal of Virology , vol.65 , Issue.12 , pp. 6942-6952
    • Farnet, C.M.1    Haseltine, W.A.2
  • 169
    • 0036247444 scopus 로고    scopus 로고
    • Characterization of lentiviral vector-mediated gene transfer in adult mouse brain
    • 10.1089/10430340252899019. 11975850
    • Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. V Baekelandt A Claeys K Eggermont E Lauwers B De Strooper B Nuttin Z Debyser, Hum Gene Ther 2002 13 7 841 853 10.1089/10430340252899019 11975850
    • (2002) Hum Gene Ther , vol.13 , Issue.7 , pp. 841-853
    • Baekelandt, V.1    Claeys, A.2    Eggermont, K.3    Lauwers, E.4    De Strooper, B.5    Nuttin, B.6    Debyser, Z.7
  • 170
    • 0242382679 scopus 로고    scopus 로고
    • Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain
    • 10.1038/sj.gt.3302094. 14528317
    • Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain. V Baekelandt K Eggermont M Michiels B Nuttin Z Debyser, Gene Ther 2003 10 23 1933 1940 10.1038/sj.gt.3302094 14528317
    • (2003) Gene Ther , vol.10 , Issue.23 , pp. 1933-1940
    • Baekelandt, V.1    Eggermont, K.2    Michiels, M.3    Nuttin, B.4    Debyser, Z.5
  • 171
    • 0037853149 scopus 로고    scopus 로고
    • Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors
    • 12718906
    • Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors. JP O'Rourke H Hiraragi K Urban M Patel JC Olsen BA Bunnell, Mol Ther 2003 7 5 Pt 1 632 639 12718906
    • (2003) Mol Ther , vol.7 , Issue.5 PART 1 , pp. 632-639
    • O'Rourke, J.P.1    Hiraragi, H.2    Urban, K.3    Patel, M.4    Olsen, J.C.5    Bunnell, B.A.6
  • 172
    • 0034254320 scopus 로고    scopus 로고
    • Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver
    • 10910939
    • Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver. F Park K Ohashi MA Kay, Blood 2000 96 3 1173 1176 10910939
    • (2000) Blood , vol.96 , Issue.3 , pp. 1173-1176
    • Park, F.1    Ohashi, K.2    Kay, M.A.3
  • 175
    • 34447134838 scopus 로고    scopus 로고
    • Use of nonintegrating lentiviral vectors for gene therapy
    • 10.1089/hum.2007.013. 17523890
    • Use of nonintegrating lentiviral vectors for gene therapy. NJ Philpott AJ Thrasher, Human gene therapy 2007 18 6 483 489 10.1089/hum.2007.013 17523890
    • (2007) Human Gene Therapy , vol.18 , Issue.6 , pp. 483-489
    • Philpott, N.J.1    Thrasher, A.J.2
  • 177
    • 3042730820 scopus 로고    scopus 로고
    • Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation
    • 10.1023/B:MOLE.0000031363.35839.46. 15293783
    • Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation. AC Jenke MF Scinteie IM Stehle HJ Lipps, Molecular biology reports 2004 31 2 85 90 10.1023/B:MOLE. 0000031363.35839.46 15293783
    • (2004) Molecular Biology Reports , vol.31 , Issue.2 , pp. 85-90
    • Jenke, A.C.1    Scinteie, M.F.2    Stehle, I.M.3    Lipps, H.J.4
  • 178
    • 68249112926 scopus 로고    scopus 로고
    • Integration-deficient lentiviral vectors: A slow coming of age
    • 10.1038/mt.2009.122. 19491821
    • Integration-deficient lentiviral vectors: a slow coming of age. K Wanisch RJ Yanez-Munoz, Mol Ther 2009 17 8 1316 1332 10.1038/mt.2009.122 19491821
    • (2009) Mol Ther , vol.17 , Issue.8 , pp. 1316-1332
    • Wanisch, K.1    Yanez-Munoz, R.J.2
  • 181
    • 56749185598 scopus 로고    scopus 로고
    • A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector
    • 10.1038/mt.2008.199. 18797449
    • A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector. M Bayer B Kantor A Cockrell H Ma B Zeithaml X Li T McCown T Kafri, Mol Ther 2008 16 12 1968 1976 10.1038/mt.2008.199 18797449
    • (2008) Mol Ther , vol.16 , Issue.12 , pp. 1968-1976
    • Bayer, M.1    Kantor, B.2    Cockrell, A.3    Ma, H.4    Zeithaml, B.5    Li, X.6    McCown, T.7    Kafri, T.8
  • 186
    • 0023152463 scopus 로고
    • Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites
    • 3027365
    • Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites. H Rohdewohld H Weiher W Reik R Jaenisch M Breindl, Journal of virology 1987 61 2 336 343 3027365
    • (1987) Journal of Virology , vol.61 , Issue.2 , pp. 336-343
    • Rohdewohld, H.1    Weiher, H.2    Reik, W.3    Jaenisch, R.4    Breindl, M.5
  • 187
    • 0017664865 scopus 로고
    • Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA
    • 10.1016/0092-8674(77)90047-2. 196759
    • Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. HE Varmus T Padgett S Heasley G Simon JM Bishop, Cell 1977 11 2 307 319 10.1016/0092-8674(77)90047-2 196759
    • (1977) Cell , vol.11 , Issue.2 , pp. 307-319
    • Varmus, H.E.1    Padgett, T.2    Heasley, S.3    Simon, G.4    Bishop, J.M.5
  • 188
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • DOI 10.1126/science.1083413
    • Transcription start regions in the human genome are favored targets for MLV integration. X Wu Y Li B Crise SM Burgess, Science (New York, NY) 2003 300 5626 1749 1751 10.1126/science.1083413 (Pubitemid 36712571)
    • (2003) Science , vol.300 , Issue.5626 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 190
    • 0037162715 scopus 로고    scopus 로고
    • HIV-1 integration in the human genome favors active genes and local hotspots
    • 10.1016/S0092-8674(02)00864-4. 12202041
    • HIV-1 integration in the human genome favors active genes and local hotspots. AR Schroder P Shinn H Chen C Berry JR Ecker F Bushman, Cell 2002 110 4 521 529 10.1016/S0092-8674(02)00864-4 12202041
    • (2002) Cell , vol.110 , Issue.4 , pp. 521-529
    • Schroder, A.R.1    Shinn, P.2    Chen, H.3    Berry, C.4    Ecker, J.R.5    Bushman, F.6
  • 191
    • 0027373134 scopus 로고
    • Insertional inactivation of the tk locus in a human B lymphoblastoid cell line by a retroviral shuttle vector
    • 7690899
    • Insertional inactivation of the tk locus in a human B lymphoblastoid cell line by a retroviral shuttle vector. AJ Grosovsky A Skandalis L Hasegawa BN Walter, Mutation research 1993 289 2 297 308 7690899
    • (1993) Mutation Research , vol.289 , Issue.2 , pp. 297-308
    • Grosovsky, A.J.1    Skandalis, A.2    Hasegawa, L.3    Walter, B.N.4
  • 192
    • 0021835658 scopus 로고
    • Insertion mutagenesis of embryonal carcinoma cells by retroviruses
    • 10.1126/science.3838595
    • Insertion mutagenesis of embryonal carcinoma cells by retroviruses. W King MD Patel LI Lobel SP Goff MC Nguyen-Huu, Science (New York, NY) 1985 228 4699 554 558 10.1126/science.3838595
    • (1985) Science (New York, NY) , vol.228 , Issue.4699 , pp. 554-558
    • King, W.1    Patel, M.D.2    Lobel, L.I.3    Goff, S.P.4    Nguyen-Huu, M.C.5
  • 194
    • 0041410142 scopus 로고    scopus 로고
    • Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: Implications for gene therapy
    • 10.1038/sj.gt.3302059. 12923569
    • Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: implications for gene therapy. M Themis D May C Coutelle RF Newbold, Gene therapy 2003 10 19 1703 1711 10.1038/sj.gt.3302059 12923569
    • (2003) Gene Therapy , vol.10 , Issue.19 , pp. 1703-1711
    • Themis, M.1    May, D.2    Coutelle, C.3    Newbold, R.F.4
  • 201
    • 0037443457 scopus 로고    scopus 로고
    • Side effects of retroviral gene transfer into hematopoietic stem cells
    • DOI 10.1182/blood-2002-07-2314
    • Side effects of retroviral gene transfer into hematopoietic stem cells. C Baum J Dullmann Z Li B Fehse J Meyer DA Williams C von Kalle, Blood 2003 101 6 2099 2114 10.1182/blood-2002-07-2314 12511419 (Pubitemid 36302043)
    • (2003) Blood , vol.101 , Issue.6 , pp. 2099-2114
    • Baum, C.1    Dullmann, J.2    Li, Z.3    Fehse, B.4    Meyer, J.5    Williams, D.A.6    Von Kalle, C.7
  • 205
    • 33646887376 scopus 로고    scopus 로고
    • Genotoxicity of retroviral integration in hematopoietic cells
    • 10.1016/j.ymthe.2006.03.001. 16624621
    • Genotoxicity of retroviral integration in hematopoietic cells. AW Nienhuis CE Dunbar BP Sorrentino, Mol Ther 2006 13 6 1031 1049 10.1016/j.ymthe.2006.03.001 16624621
    • (2006) Mol Ther , vol.13 , Issue.6 , pp. 1031-1049
    • Nienhuis, A.W.1    Dunbar, C.E.2    Sorrentino, B.P.3
  • 207
  • 211
    • 33846952869 scopus 로고    scopus 로고
    • Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
    • 10.1186/1471-2199-8-3. 17233885
    • Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB. B Khoo X Roca SL Chew AR Krainer, BMC molecular biology 2007 8 3 10.1186/1471-2199-8-3 17233885
    • (2007) BMC Molecular Biology , vol.8 , pp. 3
    • Khoo, B.1    Roca, X.2    Chew, S.L.3    Krainer, A.R.4
  • 213
    • 7044228128 scopus 로고    scopus 로고
    • Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns
    • 10.1016/j.ymthe.2004.08.001. 15509505
    • Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns. S Laufs KZ Nagy FA Giordano A Hotz-Wagenblatt WJ Zeller S Fruehauf, Mol Ther 2004 10 5 874 881 10.1016/j.ymthe.2004.08.001 15509505
    • (2004) Mol Ther , vol.10 , Issue.5 , pp. 874-881
    • Laufs, S.1    Nagy, K.Z.2    Giordano, F.A.3    Hotz-Wagenblatt, A.4    Zeller, W.J.5    Fruehauf, S.6
  • 214
    • 33646863928 scopus 로고    scopus 로고
    • Inadvertent germline transmission of AAV2 vector: Findings in a rabbit model correlate with those in a human clinical trial
    • 10.1016/j.ymthe.2006.03.002. 16631412
    • Inadvertent germline transmission of AAV2 vector: findings in a rabbit model correlate with those in a human clinical trial. J Schuettrumpf JH Liu LB Couto K Addya DG Leonard Z Zhen J Sommer VR Arruda, Mol Ther 2006 13 6 1064 1073 10.1016/j.ymthe.2006.03.002 16631412
    • (2006) Mol Ther , vol.13 , Issue.6 , pp. 1064-1073
    • Schuettrumpf, J.1    Liu, J.H.2    Couto, L.B.3    Addya, K.4    Leonard, D.G.5    Zhen, Z.6    Sommer, J.7    Arruda, V.R.8
  • 216
    • 0029962807 scopus 로고    scopus 로고
    • Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
    • 10.1074/jbc.271.12.6852. 8636110
    • Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. K Kobayashi K Oka T Forte B Ishida B Teng K Ishimura-Oka M Nakamuta L Chan, The Journal of biological chemistry 1996 271 12 6852 6860 10.1074/jbc.271.12.6852 8636110
    • (1996) The Journal of Biological Chemistry , vol.271 , Issue.12 , pp. 6852-6860
    • Kobayashi, K.1    Oka, K.2    Forte, T.3    Ishida, B.4    Teng, B.5    Ishimura-Oka, K.6    Nakamuta, M.7    Chan, L.8
  • 217
    • 0031743610 scopus 로고    scopus 로고
    • Very-low-density lipoprotein receptor fragment shed from HeLa cells inhibits human rhinovirus infection
    • Very-low-density lipoprotein receptor fragment shed from HeLa cells inhibits human rhinovirus infection. TC Marlovits C Abrahamsberg D Blaas, Journal of virology 1998 72 12 10246 10250 9811769 (Pubitemid 28520899)
    • (1998) Journal of Virology , vol.72 , Issue.12 , pp. 10246-10250
    • Marlovits, T.C.1    Abrahamsberg, C.2    Blaas, D.3
  • 218
    • 77649273815 scopus 로고    scopus 로고
    • Recent Advances in Lentiviral Vector Development and Applications
    • 10.1038/mt.2009.319. 20087315
    • Recent Advances in Lentiviral Vector Development and Applications. J Matri M Chuah T VandenDriessche, Mol Ther 2010 18 5 477 490 10.1038/mt.2009.319 20087315
    • (2010) Mol Ther , vol.18 , Issue.5 , pp. 477-490
    • Matri, J.1    Chuah, M.2    Vandendriessche, T.3


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