Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor

Circulation

Volumn 103, Issue 9, 2001, Pages 1274-1281

  Oka, Kazuhiro ^a   Pastore, Lucio ^a   Kim, In Hoo ^a   Merched, Aksam ^a   Nomura, Shuichi ^a   Lee, Hye Jeong ^a   Merched Sauvage, Maria ^a   Arden Riley, Celeste ^a   Lee, Brendan ^a   Finegold, Milton ^a   Beaudet, Arthur ^a   Chan, Lawrence ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Adenovirus; Genes; Hypercholesterolemia; Lipoproteins; Receptors

Indexed keywords

LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN RECEPTOR; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; DIALYSIS; FAMILIAL HYPERCHOLESTEROLEMIA; GENE MUTATION; GENE THERAPY; IMMUNOFLUORESCENCE TEST; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; WESTERN BLOTTING;

EID: 0035814955     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.9.1274     Document Type: Article

References (33)

1. Familial hypercholesterolemia
2. A receptor-mediated pathway for cholesterol homeostasis
3. Therapeutic effects of LDL apheresis in the prevention of atherosclerosis
4. A pilot study of ex-vivo gene therapy for homozygous familial hypercholesterolaemia
5. Hypercholesterolemia in LDL receptor knockout mice and its reversal by adenovirus-mediated gene delivery
6. In-vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenovirus
7. In-vivo gene therapy for hyperlipidemia: Phenotype correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene
8. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
9. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
10. Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism
11. Rabbit very low density lipoprotein receptor: A low density lipoprotein receptor-like protein with distinct ligand specificity
12. MHC class 1-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with El-deleted recombinant adenoviruses
13. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy
14. High-capacity adenoviral vectors for gene transfer and somatic gene therapy
15. In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes
16. A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
17. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
18. 1-antitrypsin with negligible toxicity
19. Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons
20. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice
21. A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging
22. Redistribution of U-snRNPs during mitosis
23. Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy
24. Absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
25. Serial inbreeding of rabbits with hereditary hyperlipidemia
26. Very low density lipoprotein receptor binds apolipoprotein E2/2 as well as apolipoprotein E3/3
27. Reversal of hypereholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
28. Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors
29. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
30. Frequency and stability of chromosomal integration of adenovirus vectors
31. Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
32. Gene therapy death prompts review of adenovirus vector
33. Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor