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Volumn 15, Issue 4, 2004, Pages 413-422

Current management of severe homozygous hypercholesterolaemias

Author keywords

Aortic valve; Atherosclerosis; Autosomal recessive hypercholesterolaemia; Coronary heart disease; Ezetimibe; Familial hypercholesterolaemia; LDL apheresis; Statins

Indexed keywords

ATORVASTATIN; AVASIMIBE; COMPACTIN; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN;

EID: 4043093508     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mol.0000137222.23784.2a     Document Type: Review
Times cited : (100)

References (98)
  • 1
    • 0001584433 scopus 로고
    • Angina pectoris in hereditary xanthomatosis
    • Muller C. Angina pectoris in hereditary xanthomatosis. Arch Intern Med 1939; 64:675-700.
    • (1939) Arch Intern Med , vol.64 , pp. 675-700
    • Muller, C.1
  • 2
    • 0017338846 scopus 로고
    • The metabolic lesion in familial hypercholesterolaemia
    • Myant NB. The metabolic lesion in familial hypercholesterolaemia. Expos Annu Biochim Med 1977; 33:39-52.
    • (1977) Expos Annu Biochim Med , vol.33 , pp. 39-52
    • Myant, N.B.1
  • 3
    • 0016241915 scopus 로고
    • Binding and degradation of low density lipoproteins by cultured human fibroblasts: Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia
    • Goldstein JL, Brown MS. Binding and degradation of low density lipoproteins by cultured human fibroblasts: comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem 1974; 249:5153-5162.
    • (1974) J Biol Chem , vol.249 , pp. 5153-5162
    • Goldstein, J.L.1    Brown, M.S.2
  • 4
    • 0018590304 scopus 로고
    • The LDL receptor locus and the genetics of familial hypercholesterolemia
    • Goldstein JL, Brown MS. The LDL receptor locus and the genetics of familial hypercholesterolemia. Annu Rev Genet 1979; 13:259-289.
    • (1979) Annu Rev Genet , vol.13 , pp. 259-289
    • Goldstein, J.L.1    Brown, M.S.2
  • 5
    • 0022981186 scopus 로고
    • In vivo evidence for reduced binding of low density lipoproteins to receptors as a cause of primary moderate hypercholesterolemia
    • Vega GL, Grundy SM. In vivo evidence for reduced binding of low density lipoproteins to receptors as a cause of primary moderate hypercholesterolemia. J Clin Invest 1986; 78:1410-1414.
    • (1986) J Clin Invest , vol.78 , pp. 1410-1414
    • Vega, G.L.1    Grundy, S.M.2
  • 6
    • 0025908365 scopus 로고
    • Clinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function
    • Myant NB, Gallagher JJ, Knight BL, et al. Clinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function. Arterioscler Thromb 1991; 11:691-703.
    • (1991) Arterioscler Thromb , vol.11 , pp. 691-703
    • Myant, N.B.1    Gallagher, J.J.2    Knight, B.L.3
  • 7
    • 0015546668 scopus 로고
    • Experiences with the homozygous cases of familial hypercholesterolemia: A report of 52 patients
    • Khachadurian AK, Uthman SM. Experiences with the homozygous cases of familial hypercholesterolemia: a report of 52 patients. Nutr Metab 1973; 15:132-140.
    • (1973) Nutr Metab , vol.15 , pp. 132-140
    • Khachadurian, A.K.1    Uthman, S.M.2
  • 8
    • 0035906961 scopus 로고    scopus 로고
    • Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein
    • Garcia CK, Wilund K, Arca M, et al. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science 2001; 292:1394-1398.
    • (2001) Science , vol.292 , pp. 1394-1398
    • Garcia, C.K.1    Wilund, K.2    Arca, M.3
  • 9
    • 0036897341 scopus 로고    scopus 로고
    • Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1
    • Eden ER, Patel DD, Sun XM, et al. Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1. J Clin Invest 2002; 110:1695-1702.
    • (2002) J Clin Invest , vol.110 , pp. 1695-1702
    • Eden, E.R.1    Patel, D.D.2    Sun, X.M.3
  • 11
    • 85047684249 scopus 로고    scopus 로고
    • Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
    • Pullinger CR, Eng C, Salen G, et al. Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest 2002; 110:109-117.
    • (2002) J Clin Invest , vol.110 , pp. 109-117
    • Pullinger, C.R.1    Eng, C.2    Salen, G.3
  • 12
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003; 34:154-156.
    • (2003) Nat Genet , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3
  • 13
    • 0024336424 scopus 로고
    • Identification of a point mutation in growth factor repeat C of the low density lipoprotein-receptor gene in a patient with homozygous familial hypercholesterolemia that affects ligand binding and intracellular movement of receptors
    • Soutar AK, Knight BL, Patel DD. Identification of a point mutation in growth factor repeat C of the low density lipoprotein-receptor gene in a patient with homozygous familial hypercholesterolemia that affects ligand binding and intracellular movement of receptors. Proc Natl Acad Sci U S A 1989; 86:4166-4170.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 4166-4170
    • Soutar, A.K.1    Knight, B.L.2    Patel, D.D.3
  • 14
    • 0026762461 scopus 로고
    • Characterization of two new point mutations in the low density lipoprotein receptor genes of an English patient with homozygous familial hypercholesterolemia
    • Webb JC, Sun XM, Patel DD, et al. Characterization of two new point mutations in the low density lipoprotein receptor genes of an English patient with homozygous familial hypercholesterolemia. J Lipid Res 1992; 33:689-698.
    • (1992) J Lipid Res , vol.33 , pp. 689-698
    • Webb, J.C.1    Sun, X.M.2    Patel, D.D.3
  • 15
    • 0029874084 scopus 로고    scopus 로고
    • Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom
    • Webb JC, Sun XM, McCarthy SN, et al. Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom. J Lipid Res 1996; 37:368-381.
    • (1996) J Lipid Res , vol.37 , pp. 368-381
    • Webb, J.C.1    Sun, X.M.2    McCarthy, S.N.3
  • 16
    • 0027495529 scopus 로고
    • Cholesterol-lowering drug therapy in a patient with receptor-negative homozygous familial hypercholesterolaemia
    • Feher MD, Webb JC, Patel DD, et al. Cholesterol-lowering drug therapy in a patient with receptor-negative homozygous familial hypercholesterolaemia. Atherosclerosis 1993; 103:171-180.
    • (1993) Atherosclerosis , vol.103 , pp. 171-180
    • Feher, M.D.1    Webb, J.C.2    Patel, D.D.3
  • 17
    • 0032747151 scopus 로고    scopus 로고
    • Inheritance of two different alleles of the low-density lipoprotein (LDL)-receptor gene carrying the recurrent Pro664Leu mutation in a patient with homozygous familial hypercholesterolaemia
    • Bourbon M, Fowler AM, Sun XM, Soutar AK. Inheritance of two different alleles of the low-density lipoprotein (LDL)-receptor gene carrying the recurrent Pro664Leu mutation in a patient with homozygous familial hypercholesterolaemia. Clin Genet 1999; 56:225-231.
    • (1999) Clin Genet , vol.56 , pp. 225-231
    • Bourbon, M.1    Fowler, A.M.2    Sun, X.M.3    Soutar, A.K.4
  • 18
    • 0000600880 scopus 로고    scopus 로고
    • Familial hypercholesterolemia
    • Valle D, Scriver CR, Beaudet A, et al., editors. New York: McGraw Hill
    • Goldstein J, Hobbs H, Brown M. Familial hypercholesterolemia. In: Valle D, Scriver CR, Beaudet A, et al., editors. The metabolic and molecular bases of inherited disease. 8th ed, vol 2. New York: McGraw Hill; 2001. pp. 2863-2913.
    • (2001) The Metabolic and Molecular Bases of Inherited Disease. 8th Ed , vol.2 , pp. 2863-2913
    • Goldstein, J.1    Hobbs, H.2    Brown, M.3
  • 19
    • 4043051429 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia
    • Wass JAH, Shalet SM, editors. Oxford: Oxford University Press
    • Thompson GR. Familial hypercholesterolaemia. In: Wass JAH, Shalet SM, editors. Oxford textbook of endocrinology and diabetes. Oxford: Oxford University Press; 2002. pp. 1545-1552.
    • (2002) Oxford Textbook of Endocrinology and Diabetes , pp. 1545-1552
    • Thompson, G.R.1
  • 20
    • 0042329251 scopus 로고    scopus 로고
    • Dyslipidaemia
    • Durrington P. Dyslipidaemia. Lancet 2003; 362:717-731. A comprehensive review, particularly aimed at clinical readership, summarizing the clinical manifestations of dyslipidaemia and its modern management.
    • (2003) Lancet , vol.362 , pp. 717-731
    • Durrington, P.1
  • 21
    • 0027768735 scopus 로고
    • Familial defective apolipoprotein B-100: A review, including some comparisons with familial hypercholesterolaemia
    • Myant NB. Familial defective apolipoprotein B-100: a review, including some comparisons with familial hypercholesterolaemia. Atherosclerosis 1993; 104:1-18.
    • (1993) Atherosclerosis , vol.104 , pp. 1-18
    • Myant, N.B.1
  • 22
    • 0031706072 scopus 로고    scopus 로고
    • Familial defective apolipoprotein B-100
    • Hansen PS. Familial defective apolipoprotein B-100. Dan Med Bull 1998; 45:370-382.
    • (1998) Dan Med Bull , vol.45 , pp. 370-382
    • Hansen, P.S.1
  • 23
    • 0242660344 scopus 로고    scopus 로고
    • Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemia
    • Soutar AK, Naoumova RP, Traub LM. Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol 2003; 23:1963-1970. This review provides useful information on the history of the genetics of ARH from the first clinical description of the condition, the recognition of a new cellular phenotype and mapping the gene on chromosome 1p35-36.1 to gene cloning. New insights into the role played by ARH protein in gathering the LDL receptor into forming endocytic carrier vesicles are discussed. The ARH clinical phenotype is critically compared to that of homozygous FH patients.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1963-1970
    • Soutar, A.K.1    Naoumova, R.P.2    Traub, L.M.3
  • 24
    • 0032728972 scopus 로고    scopus 로고
    • Characterization of a novel cellular defect in patients with phenotypic homozygous familial hypercholesterolemia
    • Norman D, Sun XM, Bourbon M, et al. Characterization of a novel cellular defect in patients with phenotypic homozygous familial hypercholesterolemia. J Clin Invest 1999; 104:619-628.
    • (1999) J Clin Invest , vol.104 , pp. 619-628
    • Norman, D.1    Sun, X.M.2    Bourbon, M.3
  • 25
    • 0037045847 scopus 로고    scopus 로고
    • Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: A clinical and molecular genetic analysis
    • Arca M, Zuliani G, Wilund K, et al. Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis. Lancet 2002; 359:841-847.
    • (2002) Lancet , vol.359 , pp. 841-847
    • Arca, M.1    Zuliani, G.2    Wilund, K.3
  • 26
    • 12244279036 scopus 로고    scopus 로고
    • Autosomal recessive hypercholesterolemia in a Sicilian kindred harboring the 432insA mutation of the ARH gene
    • Barbagallo CM, Emmanuele G, Cefalu AB, et al. Autosomal recessive hypercholesterolemia in a Sicilian kindred harboring the 432insA mutation of the ARH gene. Atherosclerosis 2003; 166:395-400.
    • (2003) Atherosclerosis , vol.166 , pp. 395-400
    • Barbagallo, C.M.1    Emmanuele, G.2    Cefalu, A.B.3
  • 27
    • 0037630245 scopus 로고    scopus 로고
    • Clinical features and genetic analysis of autosomal recessive hypercholesterolemia
    • Harada-Shiba M, Takagi A, Miyamoto Y, et al. Clinical features and genetic analysis of autosomal recessive hypercholesterolemia. J Clin Endocrinol Metab 2003; 88:2541-2547.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2541-2547
    • Harada-Shiba, M.1    Takagi, A.2    Miyamoto, Y.3
  • 28
    • 0037123969 scopus 로고    scopus 로고
    • Mutation in the ARH gene and a chromosome 13q locus influence cholesterol levels in a new form of digenic-recessive familial hypercholesterolemia
    • Al Kateb H, Bahring S, Hoffmann K, et al. Mutation in the ARH gene and a chromosome 13q locus influence cholesterol levels in a new form of digenic-recessive familial hypercholesterolemia. Circ Res 2002; 90:951-958.
    • (2002) Circ Res , vol.90 , pp. 951-958
    • Al Kateb, H.1    Bahring, S.2    Hoffmann, K.3
  • 29
    • 0038748336 scopus 로고    scopus 로고
    • A Q136Stop mutation in the ARH gene causing autosomal recessive hypercholesterolaemia with severely delayed LDL catabolism
    • Tietge UJ, Genschel J, Schmidt HH. A Q136Stop mutation in the ARH gene causing autosomal recessive hypercholesterolaemia with severely delayed LDL catabolism. J Intern Med 2003; 253:582-583.
    • (2003) J Intern Med , vol.253 , pp. 582-583
    • Tietge, U.J.1    Genschel, J.2    Schmidt, H.H.3
  • 30
    • 0242416622 scopus 로고    scopus 로고
    • Molecular mechanisms of autosomal recessive hypercholesterolemia
    • Cohen JC, Kimmel M, Polanski A, Hobbs HH. Molecular mechanisms of autosomal recessive hypercholesterolemia. Curr Opin Lipidol 2003; 14:121-127. A review article summarizing new findings into the pathophysiology and molecular genetics of ARH, concluding that ARH functions as an adaptor protein that couples the LDL receptor to the endocytic machinery.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 121-127
    • Cohen, J.C.1    Kimmel, M.2    Polanski, A.3    Hobbs, H.H.4
  • 31
    • 14444283887 scopus 로고    scopus 로고
    • Delayed low density lipoprotein (LDL) catabolism despite a functional intact LDL-apolipoprotein B particle and LDL-receptor in a subject with clinical homozygous familial hypercholesterolemia
    • Schmidt HH, Stuhrmann M, Shamburek R, et al. Delayed low density lipoprotein (LDL) catabolism despite a functional intact LDL-apolipoprotein B particle and LDL-receptor in a subject with clinical homozygous familial hypercholesterolemia. J Clin Endocrinol Metab 1998; 83:2167-2174.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2167-2174
    • Schmidt, H.H.1    Stuhrmann, M.2    Shamburek, R.3
  • 32
    • 2342454322 scopus 로고    scopus 로고
    • Autosomal recessive hypercholesterolaemia: Long-term follow up and response to treatment
    • Naoumova RP, Neuwirth C, Lee P, et al. Autosomal recessive hypercholesterolaemia: long-term follow up and response to treatment. Atherosclerosis 2004; 174:165-172.
    • (2004) Atherosclerosis , vol.174 , pp. 165-172
    • Naoumova, R.P.1    Neuwirth, C.2    Lee, P.3
  • 33
    • 0029794262 scopus 로고    scopus 로고
    • Aortic stenosis in homozygous familial hypercholesterolaemia
    • Rallidis L, Nihoyannopoulos P, Thompson GR. Aortic stenosis in homozygous familial hypercholesterolaemia. Heart 1996; 76:84-85.
    • (1996) Heart , vol.76 , pp. 84-85
    • Rallidis, L.1    Nihoyannopoulos, P.2    Thompson, G.R.3
  • 34
    • 0031743631 scopus 로고    scopus 로고
    • Extent and severity of atherosclerotic involvement of the aortic valve and root in familial hypercholesterolaemia
    • Rallidis L, Naoumova RP, Thompson GR, Nihoyannopoulos P. Extent and severity of atherosclerotic involvement of the aortic valve and root in familial hypercholesterolaemia. Heart 1998; 80:583-590.
    • (1998) Heart , vol.80 , pp. 583-590
    • Rallidis, L.1    Naoumova, R.P.2    Thompson, G.R.3    Nihoyannopoulos, P.4
  • 35
    • 0022407610 scopus 로고
    • Treatment of homozygous familial hypercholesterolaemia: An informative sibship
    • West R, Gibson P, Lloyd J. Treatment of homozygous familial hypercholesterolaemia: an informative sibship. BMJ (Clin Res Ed) 1985; 291:1079-1080.
    • (1985) BMJ (Clin Res Ed) , vol.291 , pp. 1079-1080
    • West, R.1    Gibson, P.2    Lloyd, J.3
  • 36
    • 0041815984 scopus 로고    scopus 로고
    • Long-term effect of low-density lipoprotein apheresis in patients with homozygous familial hypercholesterolemia
    • Makino H, Harada-Shiba M. Long-term effect of low-density lipoprotein apheresis in patients with homozygous familial hypercholesterolemia. Therap Apher Dial 2003; 7:397-401. A review article offering a wealth of clinical experience and answers to practical questions.
    • (2003) Therap Apher Dial , vol.7 , pp. 397-401
    • Makino, H.1    Harada-Shiba, M.2
  • 37
    • 0034957734 scopus 로고    scopus 로고
    • Low-density lipoprotein apheresis in a patient aged 3.5 years
    • Stefanutti C, Di Giacomo S, Vivenzio A, et al. Low-density lipoprotein apheresis in a patient aged 3.5 years. Acta Paediatr 2001; 90:694-701.
    • (2001) Acta Paediatr , vol.90 , pp. 694-701
    • Stefanutti, C.1    Di Giacomo, S.2    Vivenzio, A.3
  • 38
    • 0038148615 scopus 로고    scopus 로고
    • Indication of low-density lipoprotein apheresis in severe hypercholesterolemia and its atherosclerotic vascular complications: Dextran sulfate cellulose low-density lipoprotein apheresis
    • Keller C. Indication of low-density lipoprotein apheresis in severe hypercholesterolemia and its atherosclerotic vascular complications: dextran sulfate cellulose low-density lipoprotein apheresis. Therap Apher Dial 2003; 7:345-349. Review article which speculates that reductions in lipoprotein (a) and in LDL oxidation, improvement in procoagulatory state and decreases in adhesion molecules and cytokines induced by LDL apheresis may favourably influence regression of atherosclerosis.
    • (2003) Therap Apher Dial , vol.7 , pp. 345-349
    • Keller, C.1
  • 39
    • 0041743167 scopus 로고    scopus 로고
    • Monogenic hypercholesterolemia: New insights in pathogenesis and treatment
    • Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest 2003; 111:1795-1803. This review focuses on recent developments in the understanding of the molecular pathogenesis and treatment of monogenic forms of severe hypercholesterolaemia, and some of the implications of these findings for the management of common forms of hypercholesterolaemia.
    • (2003) J Clin Invest , vol.111 , pp. 1795-1803
    • Rader, D.J.1    Cohen, J.2    Hobbs, H.H.3
  • 40
    • 0037371166 scopus 로고    scopus 로고
    • LDL apheresis
    • Thompson GR. LDL apheresis. Atherosclerosis 2003; 167:1-13. This comprehensive review summarizes current knowledge on LDL apheresis starting from the history of the procedure and its application as safe and reliable treatment for patients with homozygous FH, where there is clear evidence of benefit. The possibility of widening the indications for LDL apheresis to include patients with post-transplant donor disease, stroke and prevention of re-stenosis after coronary angioplasty is examined and the need for evidence from controlled trials is also discussed.
    • (2003) Atherosclerosis , vol.167 , pp. 1-13
    • Thompson, G.R.1
  • 41
    • 0042817880 scopus 로고    scopus 로고
    • Long-term effect of low-density lipoprotein apheresis in patients with heterozygous familial hypercholesterolemia
    • Higashikata T, Mabuchi H. Long-term effect of low-density lipoprotein apheresis in patients with heterozygous familial hypercholesterolemia. Therap Apher Dial 2003; 7:402-407. The authors stress the need for clarification of treatment goals for LDL cholesterol during long-term LDL apheresis.
    • (2003) Therap Apher Dial , vol.7 , pp. 402-407
    • Higashikata, T.1    Mabuchi, H.2
  • 42
    • 0014207423 scopus 로고
    • Homozygous cutaneotendinous forms of hypercholesteremic xanthomatosis in an exemplary familial case. Trial of plasmapheresis and heroic treatment
    • de Gennes JL, Touraine R, Maunand B, et al. [Homozygous cutaneotendinous forms of hypercholesteremic xanthomatosis in an exemplary familial case. Trial of plasmapheresis and heroic treatment]. Bull Mem Soc Med Hop Paris 1967; 118:1377-1402.
    • (1967) Bull Mem Soc Med Hop Paris , vol.118 , pp. 1377-1402
    • De Gennes, J.L.1    Touraine, R.2    Maunand, B.3
  • 43
    • 0016704825 scopus 로고
    • Plasma exchange in the management of homozygous familial hypercholesterolaemia
    • Thompson GR, Lowenthal R, Myant NB. Plasma exchange in the management of homozygous familial hypercholesterolaemia. Lancet 1975; 1:1208-1211.
    • (1975) Lancet , vol.1 , pp. 1208-1211
    • Thompson, G.R.1    Lowenthal, R.2    Myant, N.B.3
  • 44
    • 0018822386 scopus 로고
    • Assessment of long-term plasma exchange for familial hypercholesterolaemia
    • Thompson GR, Myant NB, Kilpatrick D, et al. Assessment of long-term plasma exchange for familial hypercholesterolaemia. Br Heart J 1980; 43:680-688.
    • (1980) Br Heart J , vol.43 , pp. 680-688
    • Thompson, G.R.1    Myant, N.B.2    Kilpatrick, D.3
  • 45
    • 0022345240 scopus 로고
    • Improved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange
    • Thompson GR, Miller JP, Breslow JL. Improved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange. BMJ (Clin Res Ed) 1985; 291:1671-1673.
    • (1985) BMJ (Clin Res Ed) , vol.291 , pp. 1671-1673
    • Thompson, G.R.1    Miller, J.P.2    Breslow, J.L.3
  • 46
    • 0017121743 scopus 로고
    • A new approach to the management of familial hypercholesterolaemia: Removal of plasma-cholesterol based on the principle of affinity chromatography
    • Lupien PJ, Moorjani S, Awad J. A new approach to the management of familial hypercholesterolaemia: removal of plasma-cholesterol based on the principle of affinity chromatography. Lancet 1976; 1:1261-1265.
    • (1976) Lancet , vol.1 , pp. 1261-1265
    • Lupien, P.J.1    Moorjani, S.2    Awad, J.3
  • 47
    • 0019477889 scopus 로고
    • Application of specific extracorporeal removal of low density lipoprotein in familial hypercholesterolaemia
    • Stoffel W, Borberg H, Greve V. Application of specific extracorporeal removal of low density lipoprotein in familial hypercholesterolaemia. Lancet 1981; 2:1005-1007.
    • (1981) Lancet , vol.2 , pp. 1005-1007
    • Stoffel, W.1    Borberg, H.2    Greve, V.3
  • 48
    • 0028122413 scopus 로고
    • Comparative long-term experience with immunoadsorption and dextran sulfate cellulose adsorption for extracorporeal elimination of low-density lipoproteins
    • Knisel W, Pfohl M, Muller M, et al. Comparative long-term experience with immunoadsorption and dextran sulfate cellulose adsorption for extracorporeal elimination of low-density lipoproteins. Clin Invest 1994; 72:660-668.
    • (1994) Clin Invest , vol.72 , pp. 660-668
    • Knisel, W.1    Pfohl, M.2    Muller, M.3
  • 49
    • 0029961935 scopus 로고    scopus 로고
    • Prospective cross-over comparisons of three low-density lipoprotein (LDL)-apheresis methods in patients with familial hypercholesterolaemia
    • Schaumann D, Welch-Wichary M, Voss A, et al. Prospective cross-over comparisons of three low-density lipoprotein (LDL)-apheresis methods in patients with familial hypercholesterolaemia. Eur J Clin Invest 1996; 26:1033-1038.
    • (1996) Eur J Clin Invest , vol.26 , pp. 1033-1038
    • Schaumann, D.1    Welch-Wichary, M.2    Voss, A.3
  • 50
    • 0032790486 scopus 로고    scopus 로고
    • Three low density lipoprotein apheresis techniques in treatment of patients with familial hypercholesterolemia: A long-term evaluation
    • Richter WO, Donner MG, Schwandt P. Three low density lipoprotein apheresis techniques in treatment of patients with familial hypercholesterolemia: a long-term evaluation. Ther Apher 1999; 3:203-208.
    • (1999) Ther Apher , vol.3 , pp. 203-208
    • Richter, W.O.1    Donner, M.G.2    Schwandt, P.3
  • 51
    • 0033868129 scopus 로고    scopus 로고
    • Prospective randomised cross-over comparison of three LDL-apheresis systems in statin pretreated patients with familial hypercholesterolaemia
    • Schmaldienst S, Banyai S, Stulnig TM, et al. Prospective randomised cross-over comparison of three LDL-apheresis systems in statin pretreated patients with familial hypercholesterolaemia. Atherosclerosis 2000; 151:493-499.
    • (2000) Atherosclerosis , vol.151 , pp. 493-499
    • Schmaldienst, S.1    Banyai, S.2    Stulnig, T.M.3
  • 52
    • 0033749351 scopus 로고    scopus 로고
    • Efficacy of different low-density lipoprotein apheresis methods
    • Parhofer KG, Geiss HC, Schwandt P. Efficacy of different low-density lipoprotein apheresis methods. Ther Apher 2000; 4:382-385.
    • (2000) Ther Apher , vol.4 , pp. 382-385
    • Parhofer, K.G.1    Geiss, H.C.2    Schwandt, P.3
  • 53
    • 0042817882 scopus 로고    scopus 로고
    • Low density lipoprotein apheresis: An overview
    • Bambauer R, Schiel R, Latza R. Low density lipoprotein apheresis: an overview. Ther Apher Dial 2003; 7:382-390. The authors summarize 14 years of experience and more than 4000 apheresis procedures performed on 45 patients with dyslipidaemia and conclude that all currently available systems for LDL apheresis are safe and very effective and have similar frequency of minor (10.9%) and serious - but not life-threatening - (0.3%) side effects.
    • (2003) Ther Apher Dial , vol.7 , pp. 382-390
    • Bambauer, R.1    Schiel, R.2    Latza, R.3
  • 54
    • 0033380221 scopus 로고    scopus 로고
    • Therapeutic effects of LDL apheresis in the prevention of atherosclerosis
    • Kajinami K, Mabuchi H. Therapeutic effects of LDL apheresis in the prevention of atherosclerosis. Curr Opin Lipidol 1999; 10:401-406.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 401-406
    • Kajinami, K.1    Mabuchi, H.2
  • 55
    • 0042271714 scopus 로고    scopus 로고
    • Efficacy and safety of a new whole-blood low-density lipoprotein apheresis system (Liposorber D) in severe hypercholesterolemia
    • Otto C, Kern P, Bambauer R, et al. Efficacy and safety of a new whole-blood low-density lipoprotein apheresis system (Liposorber D) in severe hypercholesterolemia. Artif Organs 2003; 27:1116-1122. This study demonstrates that the newest whole-blood LDL apheresis system (Liposorber D) is a safe, simple to use and useful modality to reduce LDL cholesterol.
    • (2003) Artif Organs , vol.27 , pp. 1116-1122
    • Otto, C.1    Kern, P.2    Bambauer, R.3
  • 56
    • 0034723431 scopus 로고    scopus 로고
    • Direct adsorption of lipoproteins (DALI) from whole blood: First long-term clinical experience with a new LDL-apheresis system for the treatment of familial hypercholesterolaemia
    • Jansen M, Banyai S, Schmaldienst S, et al. Direct adsorption of lipoproteins (DALI) from whole blood: first long-term clinical experience with a new LDL-apheresis system for the treatment of familial hypercholesterolaemia. Wien Klin Wochenschr 2000; 112:61-69.
    • (2000) Wien Klin Wochenschr , vol.112 , pp. 61-69
    • Jansen, M.1    Banyai, S.2    Schmaldienst, S.3
  • 57
    • 0030901838 scopus 로고    scopus 로고
    • Decreased low-density lipoprotein oxidation after repeated selective apheresis in homozygous familial hypercholesterolemia
    • Napoli C, Ambrosio G, Scarpato N, et al. Decreased low-density lipoprotein oxidation after repeated selective apheresis in homozygous familial hypercholesterolemia. Am Heart J 1997; 133:585-595.
    • (1997) Am Heart J , vol.133 , pp. 585-595
    • Napoli, C.1    Ambrosio, G.2    Scarpato, N.3
  • 58
    • 0032869002 scopus 로고    scopus 로고
    • Does the production of nitric oxide contribute to the early improvement after a single low-density lipoprotein apheresis in patients with peripheral arterial obstructive disease?
    • Kizaki Y, Ueki Y, Yoshida K, et al. Does the production of nitric oxide contribute to the early improvement after a single low-density lipoprotein apheresis in patients with peripheral arterial obstructive disease? Blood Coagul Fibrinolysis 1999; 10:341-349.
    • (1999) Blood Coagul Fibrinolysis , vol.10 , pp. 341-349
    • Kizaki, Y.1    Ueki, Y.2    Yoshida, K.3
  • 59
    • 0030478362 scopus 로고    scopus 로고
    • Low density lipoprotein apheresis improves regional myocardial perfusion in patients with hypercholesterolemia and extensive coronary artery disease. LDL-Apheresis Atherosclerosis Regression Study (LAARS)
    • Aengevaeren WR, Kroon AA, Stalenhoef AF, et al. Low density lipoprotein apheresis improves regional myocardial perfusion in patients with hypercholesterolemia and extensive coronary artery disease. LDL-Apheresis Atherosclerosis Regression Study (LAARS). J Am Coll Cardiol 1996; 28:1696-1704.
    • (1996) J Am Coll Cardiol , vol.28 , pp. 1696-1704
    • Aengevaeren, W.R.1    Kroon, A.A.2    Stalenhoef, A.F.3
  • 60
    • 0024563258 scopus 로고
    • Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin-induced extracorporeal LDL precipitation (HELP)
    • Schuff-Werner P, Schutz E, Seyde WC, et al. Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin-induced extracorporeal LDL precipitation (HELP). Eur J Clin Invest 1989; 19:30-37.
    • (1989) Eur J Clin Invest , vol.19 , pp. 30-37
    • Schuff-Werner, P.1    Schutz, E.2    Seyde, W.C.3
  • 61
    • 0033997057 scopus 로고    scopus 로고
    • Intraindividual comparison of the impact of two selective apheresis methods (DALI and HELP) on the coagulation system
    • Julius U, Siegert G, Gromeier S. Intraindividual comparison of the impact of two selective apheresis methods (DALI and HELP) on the coagulation system. Int J Artif Organs 2000; 23:199-206.
    • (2000) Int J Artif Organs , vol.23 , pp. 199-206
    • Julius, U.1    Siegert, G.2    Gromeier, S.3
  • 62
    • 0036229904 scopus 로고    scopus 로고
    • The effects of three different LDL-apheresis methods on the plasma concentrations of E-selectin, VCAM-1, and ICAM-1
    • Empen K, Otto C, Brodl UC, Parhofer KG. The effects of three different LDL-apheresis methods on the plasma concentrations of E-selectin, VCAM-1, and ICAM-1. J Clin Apheresis 2002; 17:38-43.
    • (2002) J Clin Apheresis , vol.17 , pp. 38-43
    • Empen, K.1    Otto, C.2    Brodl, U.C.3    Parhofer, K.G.4
  • 63
    • 0042817875 scopus 로고    scopus 로고
    • The effect of apheresis on adhesion molecules
    • Motohashi K, Yamane S. The effect of apheresis on adhesion molecules. Therap Apher Dial 2003; 7:425-430.
    • (2003) Therap Apher Dial , vol.7 , pp. 425-430
    • Motohashi, K.1    Yamane, S.2
  • 64
    • 0042316778 scopus 로고    scopus 로고
    • Changes in C-reactive protein plasma levels during low-density lipoprotein apheresis
    • Kojima S, Shida M, Yokoyama H. Changes in C-reactive protein plasma levels during low-density lipoprotein apheresis. Therap Apher Dial 2003; 7:431-434. This small study demonstrates that DSA apheresis reduces the pre-apheresis serum C-reactive protein by more than 50% after repeated treatment. Post-apheresis C-reactive levels were decreased to undetectable levels.
    • (2003) Therap Apher Dial , vol.7 , pp. 431-434
    • Kojima, S.1    Shida, M.2    Yokoyama, H.3
  • 65
    • 0041815982 scopus 로고    scopus 로고
    • Low-density lipoprotein apheresis in the prevention of recurrent coronary heart disease: A review
    • Tasaki H. Low-density lipoprotein apheresis in the prevention of recurrent coronary heart disease: a review. Therap Apher Dial 2003; 7:408-412. The author discusses the role of LDL apheresis in CHD prevention and more specifically the role of changes in lipid and non-lipid parameters ('pleiotropic effects') induced by this procedure.
    • (2003) Therap Apher Dial , vol.7 , pp. 408-412
    • Tasaki, H.1
  • 66
    • 0026779525 scopus 로고
    • Effective reduction of plasma LDL levels by LDL apheresis in familial defective apolipoprotein B-100
    • Maher VM, Kitano Y, Neuwirth C, et al. Effective reduction of plasma LDL levels by LDL apheresis in familial defective apolipoprotein B-100. Atherosclerosis 1992; 95:231-234.
    • (1992) Atherosclerosis , vol.95 , pp. 231-234
    • Maher, V.M.1    Kitano, Y.2    Neuwirth, C.3
  • 67
    • 0026656115 scopus 로고
    • Siblings with normal LDL receptor activity and severe hypercholesterolemia
    • Harada-Shiba M, Tajima S, Yokoyama S, et al. Siblings with normal LDL receptor activity and severe hypercholesterolemia. Arterioscler Thromb 1992; 12:1071-1078.
    • (1992) Arterioscler Thromb , vol.12 , pp. 1071-1078
    • Harada-Shiba, M.1    Tajima, S.2    Yokoyama, S.3
  • 68
    • 0036516789 scopus 로고    scopus 로고
    • Impact of the characteristics of patients and their clinical management on outcomes in children with homozygous familial hypercholesterolemia
    • Al Shaikh AM, Abdullah MH, Barclay A, et al. Impact of the characteristics of patients and their clinical management on outcomes in children with homozygous familial hypercholesterolemia. Cardiol Young 2002; 12:105-112.
    • (2002) Cardiol Young , vol.12 , pp. 105-112
    • Al Shaikh, A.M.1    Abdullah, M.H.2    Barclay, A.3
  • 69
    • 0018901408 scopus 로고
    • Therapeutic effects of ML-236B in primary hypercholesterolemia
    • Yamamoto A, Sudo H, Endo A. Therapeutic effects of ML-236B in primary hypercholesterolemia. Atherosclerosis 1980; 35:259-266.
    • (1980) Atherosclerosis , vol.35 , pp. 259-266
    • Yamamoto, A.1    Sudo, H.2    Endo, A.3
  • 70
    • 0034111843 scopus 로고    scopus 로고
    • Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia
    • Raal FJ, Pappu AS, Illingworth DR, et al. Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. Atherosclerosis 2000; 150:421-428.
    • (2000) Atherosclerosis , vol.150 , pp. 421-428
    • Raal, F.J.1    Pappu, A.S.2    Illingworth, D.R.3
  • 71
    • 0030716524 scopus 로고    scopus 로고
    • Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia
    • Marais AD, Naoumova RP, Firth JC, et al. Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia. J Lipid Res 1997; 38:2071-2078.
    • (1997) J Lipid Res , vol.38 , pp. 2071-2078
    • Marais, A.D.1    Naoumova, R.P.2    Firth, J.C.3
  • 73
    • 0003141815 scopus 로고    scopus 로고
    • Effect of rosuvastatin on LDL-cholesterol, melavonic acid, and other lipid measurements in patients with homozygous familial hypercholesterolaemia
    • Posters and abstracts of the 73rd European Atherosclerosis Society Congress
    • Marais D, Raal F, Stein E, et al. Effect of rosuvastatin on LDL-cholesterol, melavonic acid, and other lipid measurements in patients with homozygous familial hypercholesterolaemia. In: Posters and abstracts of the 73rd European Atherosclerosis Society Congress. Atherosclerosis Supplements 2002; 3:159.
    • (2002) Atherosclerosis Supplements , vol.3 , pp. 159
    • Marais, D.1    Raal, F.2    Stein, E.3
  • 74
    • 0037188567 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia
    • Gagne C, Gaudet D, Bruckert E. Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia. Circulation 2002; 105:2469-2475.
    • (2002) Circulation , vol.105 , pp. 2469-2475
    • Gagne, C.1    Gaudet, D.2    Bruckert, E.3
  • 75
    • 0344896639 scopus 로고    scopus 로고
    • Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygous familial hypercholesterolemia
    • Raal FJ, Marais AD, Klepack E, et al. Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygous familial hypercholesterolemia. Atherosclerosis 2003; 171:273-279. This randomized, double-blind, cross-over trial involving 27 patients with homozygous FH showed that avasimibe, an acyl coenzyme A-cholesterol acyltransferase inhibitor, only modestly (by around 4%) enhances the lipid-lowering effect of atorvastatin 80 mg. No significant lipid changes resulted from monotherapy with avasimibe.
    • (2003) Atherosclerosis , vol.171 , pp. 273-279
    • Raal, F.J.1    Marais, A.D.2    Klepack, E.3
  • 76
    • 0038291655 scopus 로고    scopus 로고
    • Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats
    • van Heek M, Farley C, Compton DS, et al. Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats. Br J Pharmacol 2003; 138:1459-1464.
    • (2003) Br J Pharmacol , vol.138 , pp. 1459-1464
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3
  • 77
    • 0030472785 scopus 로고    scopus 로고
    • Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. Cl-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets
    • Lee HT, Sliskovic DR, Picard JA, et al. Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. Cl-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J Med Chem 1996; 39:5031-5034.
    • (1996) J Med Chem , vol.39 , pp. 5031-5034
    • Lee, H.T.1    Sliskovic, D.R.2    Picard, J.A.3
  • 79
    • 0029039253 scopus 로고
    • Treatment of homozygous and double heterozygous familial hypercholesterolemic children with LDL-apheresis
    • Stefanutti C, Vivenzio A, Colombo C, et al. Treatment of homozygous and double heterozygous familial hypercholesterolemic children with LDL-apheresis. Int J Artif Organs 1995; 18:103-110.
    • (1995) Int J Artif Organs , vol.18 , pp. 103-110
    • Stefanutti, C.1    Vivenzio, A.2    Colombo, C.3
  • 80
    • 0021911744 scopus 로고
    • Pregnancy complicated by homozygous hypercholesterolemia
    • Barss V, Phillippe M, Greene MF, Covell L. Pregnancy complicated by homozygous hypercholesterolemia. Obstet Gynecol 1985; 65:756-757.
    • (1985) Obstet Gynecol , vol.65 , pp. 756-757
    • Barss, V.1    Phillippe, M.2    Greene, M.F.3    Covell, L.4
  • 81
    • 0025121985 scopus 로고
    • Pregnancy in a homozygous familial hypercholesterolemic patient treated with long-term plasma exchange
    • Beigel Y, Hod M, Fuchs J, et al. Pregnancy in a homozygous familial hypercholesterolemic patient treated with long-term plasma exchange. Am J Obstet Gynecol 1990; 162:77-78.
    • (1990) Am J Obstet Gynecol , vol.162 , pp. 77-78
    • Beigel, Y.1    Hod, M.2    Fuchs, J.3
  • 82
    • 0028136240 scopus 로고
    • Pregnancy in a patient with homozygous familial hypercholesterolemia treated with long-term low-density lipoprotein apheresis
    • Kroon AA, Swinkels DW, van Dongen PW, Stalenhoef AF. Pregnancy in a patient with homozygous familial hypercholesterolemia treated with long-term low-density lipoprotein apheresis. Metabolism 1994; 43:1164-1170.
    • (1994) Metabolism , vol.43 , pp. 1164-1170
    • Kroon, A.A.1    Swinkels, D.W.2    Van Dongen, P.W.3    Stalenhoef, A.F.4
  • 83
    • 0038487270 scopus 로고    scopus 로고
    • Differential indication of lipoprotein apheresis during pregnancy
    • Klingel R, Gohlen B, Schwarting A, et al. Differential indication of lipoprotein apheresis during pregnancy. Therap Apher Dial 2003; 7:359-364. This article summarizes the experience with patients who become pregnant during chronic apheresis (LDL apheresis or plasma exchange), or who were treated during pregnancy by apheresis because of acute disorders of lipid metabolism.
    • (2003) Therap Apher Dial , vol.7 , pp. 359-364
    • Klingel, R.1    Gohlen, B.2    Schwarting, A.3
  • 84
    • 0029055583 scopus 로고
    • Pregnancy in a patient with homozygous familial hypercholesterolemia undergoing low-density lipoprotein apheresis by dextran sulfate adsorption
    • Teruel JL, Lasuncion MA, Navarro JF, et al. Pregnancy in a patient with homozygous familial hypercholesterolemia undergoing low-density lipoprotein apheresis by dextran sulfate adsorption. Metabolism 1995; 44:929-933.
    • (1995) Metabolism , vol.44 , pp. 929-933
    • Teruel, J.L.1    Lasuncion, M.A.2    Navarro, J.F.3
  • 85
    • 0021262841 scopus 로고
    • Heart-liver transplantation in a patient with familial hyperoholesterolaemia
    • Starzl TE, Bilheimer DW, Bahnson HT, et al. Heart-liver transplantation in a patient with familial hyperoholesterolaemia. Lancet 1984; 1:1382-1383.
    • (1984) Lancet , vol.1 , pp. 1382-1383
    • Starzl, T.E.1    Bilheimer, D.W.2    Bahnson, H.T.3
  • 86
    • 0027096986 scopus 로고
    • Normal levels of lipoproteins including lipoprotein(a) after liver-heart transplantation in a patient with homozygous familial hypercholesterolaemia
    • Barbir M, Khaghani A, Kehely A, et al. Normal levels of lipoproteins including lipoprotein(a) after liver-heart transplantation in a patient with homozygous familial hypercholesterolaemia. Q J Med 1992; 85:807-812.
    • (1992) Q J Med , vol.85 , pp. 807-812
    • Barbir, M.1    Khaghani, A.2    Kehely, A.3
  • 87
    • 0035179398 scopus 로고    scopus 로고
    • Plasma exchange and heart-liver transplantation in a patient with homozygous familial hypercholesterolemia
    • Offstad J, Schrumpf E, Geiran O, et al. Plasma exchange and heart-liver transplantation in a patient with homozygous familial hypercholesterolemia. Clin Transplant 2001; 15:432-436.
    • (2001) Clin Transplant , vol.15 , pp. 432-436
    • Offstad, J.1    Schrumpf, E.2    Geiran, O.3
  • 88
    • 0037641223 scopus 로고    scopus 로고
    • Living-donor liver transplantation for homozygous familial hypercholesterolemia from a donor with heterozygous hypercholesterolemia
    • Shirahata Y, Ohkohchi N, Kawagishi N, et al. Living-donor liver transplantation for homozygous familial hypercholesterolemia from a donor with heterozygous hypercholesterolemia. Transpl Int 2003; 16:276-279.
    • (2003) Transpl Int , vol.16 , pp. 276-279
    • Shirahata, Y.1    Ohkohchi, N.2    Kawagishi, N.3
  • 89
    • 0035109768 scopus 로고    scopus 로고
    • Liver transplantation: Current status and novel approaches to liver replacement
    • Keeffe EB. Liver transplantation: current status and novel approaches to liver replacement. Gastroenterology 2001; 120:749-762.
    • (2001) Gastroenterology , vol.120 , pp. 749-762
    • Keeffe, E.B.1
  • 90
    • 0034898388 scopus 로고    scopus 로고
    • Advances in hepatocyte transplantation: A myth becomes reality
    • Lee LA. Advances in hepatocyte transplantation: a myth becomes reality. J Clin Invest 2001; 108:367-369.
    • (2001) J Clin Invest , vol.108 , pp. 367-369
    • Lee, L.A.1
  • 91
    • 0028292602 scopus 로고
    • Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia
    • Grossman M, Raper SE, Kozarsky K, et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet 1994; 6:335-341.
    • (1994) Nat Genet , vol.6 , pp. 335-341
    • Grossman, M.1    Raper, S.E.2    Kozarsky, K.3
  • 92
    • 0028793489 scopus 로고
    • A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia
    • Grossman M, Rader DJ, Muller DW, et al. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat Med 1995; 1:1148-1154.
    • (1995) Nat Med , vol.1 , pp. 1148-1154
    • Grossman, M.1    Rader, D.J.2    Muller, D.W.3
  • 93
    • 18544393448 scopus 로고    scopus 로고
    • Gene therapy for familial hypercholesterolemia
    • Rader DJ. Gene therapy for familial hypercholesterolemia. Nutr Metab Cardiovasc Dis 2001; 11 (Suppl 5):40-44.
    • (2001) Nutr Metab Cardiovasc Dis , vol.11 , Issue.5 SUPPL. , pp. 40-44
    • Rader, D.J.1
  • 94
    • 0029882605 scopus 로고    scopus 로고
    • The extracranial carotid artery in familial hypercholesterolaemia: Relationship of intimal-medial thickness and plaque morphology with plasma lipids and coronary heart disease
    • Sidhu PS, Naoumova RP, Maher VM, et al. The extracranial carotid artery in familial hypercholesterolaemia: relationship of intimal-medial thickness and plaque morphology with plasma lipids and coronary heart disease. J Cardiovasc Risk 1996; 3:61-67.
    • (1996) J Cardiovasc Risk , vol.3 , pp. 61-67
    • Sidhu, P.S.1    Naoumova, R.P.2    Maher, V.M.3
  • 95
    • 0028358075 scopus 로고
    • Detection and quantitation of calcific atherosclerosis by ultrafast computed tomography in children and young adults with homozygous familial hypercholesterolemia
    • Hoeg JM, Feuerstein IM, Tucker EE. Detection and quantitation of calcific atherosclerosis by ultrafast computed tomography in children and young adults with homozygous familial hypercholesterolemia. Arterioscler Thromb 1994; 14:1066-1074.
    • (1994) Arterioscler Thromb , vol.14 , pp. 1066-1074
    • Hoeg, J.M.1    Feuerstein, I.M.2    Tucker, E.E.3
  • 96
    • 0036065554 scopus 로고    scopus 로고
    • Long-term prevention of premature coronary atherosclerosis in homozygous familial hypercholesterolemia
    • Jaeger BR, Tsobanelis T, Bengel F, et al. Long-term prevention of premature coronary atherosclerosis in homozygous familial hypercholesterolemia. J Pediatr 2002; 141:125-128.
    • (2002) J Pediatr , vol.141 , pp. 125-128
    • Jaeger, B.R.1    Tsobanelis, T.2    Bengel, F.3
  • 97
    • 0034744238 scopus 로고    scopus 로고
    • MR virtual angioscopy of thoracic aortic atherosclerosis in homozygous familial hypercholesterolemia
    • Summers RM, Choyke PL, Patronas NJ, et al. MR virtual angioscopy of thoracic aortic atherosclerosis in homozygous familial hypercholesterolemia. J Comput Assist Tomogr 2001; 25:371-377.
    • (2001) J Comput Assist Tomogr , vol.25 , pp. 371-377
    • Summers, R.M.1    Choyke, P.L.2    Patronas, N.J.3
  • 98
    • 0025316858 scopus 로고
    • Fatal outcome of homozygous familial hypercholesterolaemia in a black patient: A case report
    • Marais AD, Firth JC, Rose AG, Berger GM. Fatal outcome of homozygous familial hypercholesterolaemia in a black patient: a case report. S Afr Med J 1990; 77:588-590.
    • (1990) S Afr Med J , vol.77 , pp. 588-590
    • Marais, A.D.1    Firth, J.C.2    Rose, A.G.3    Berger, G.M.4


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