Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae

Gene Therapy

Volumn 14, Issue 7, 2007, Pages 604-612

  Snoeys, J ^a   Lievens, J ^a   Wisse, E ^a,b   Jacobs, F ^a   Duimel, H ^b   Collen, D ^a   Frederik, P ^b   De Geest, B ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOVIRUS VECTOR; APOLIPOPROTEIN A1; DNA;

ANIMAL EXPERIMENT; ARTICLE; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DRUG BLOOD LEVEL; LIVER CELL; LIVER ISCHEMIA; LIVER SINUSOID; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; TRANSGENE; TRANSMISSION ELECTRON MICROSCOPY; VIRAL GENE DELIVERY SYSTEM; VITRIFICATION;

ALPHA 1-ANTITRYPSIN; ANIMALS; APOLIPOPROTEIN A-I; CRYOPRESERVATION; DNA; GENE THERAPY; GENOME, VIRAL; HEPATOCYTES; HUMANS; ISCHEMIA; LIVER DISEASES; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY; TRANSDUCTION, GENETIC; TRANSGENES; VESICULAR STOMATITIS-INDIANA VIRUS; VIREMIA;

MUS; ORYCTOLAGUS CUNICULUS;

EID: 33947417327     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302899     Document Type: Article

References (29)

1. Braet F, Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: A review. Comp Hepatol 2002; 1: 1.
2. Wisse E. An electron microscopic study of the fenestrated enclothelial lining of rat liver sinusoids. J Ultrastruct Res 1970; 31: 125-150.
3. Wisse E, De Zanger RB, Charels K, Van Der Smissen P, McCuskey RS. The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 1985; 5: 683-692.
4. Gatmaitan Z, Varticovski L, Ling L, Mikkelsen R, Steffan AM, Arias IM. Studies on fenestral contraction in rat liver endothelial cells in culture. Am J Pathol 1996; 148: 2027-2041.
5. Lievens J, Snoeys J, Vekemans K, Van Linthout S, de Zanger R, Collen D et al. The size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer. Gene Therapy 2004; 11: 1523-1531.
6. Van Linthout S, Lusky M, Collen D, De Geest B. Persistent hepatic expression of human apo A-I after transfer with a helper-virus independent adenoviral vector. Gene Therapy 2002; 9: 1520-1528.
7. Snoeys J, Mertens G, Lievens J, van Berkel T, Collen D, Biessen EA et al. Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer. Mol Ther 2006; 13: 98-107.
8. Tsurui Y, Sho M, Kuzumoto Y, Hamada K, Akashi S, Kashizuka H et al. Dual role of vascular endothelial growth factor in hepatic ischemia-reperfusion injury. Transplantation 2005; 79: 1110-1115.
9. De Geest BR, Van Linthout SA, Collen D. Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells. Blood 2003; 101: 2551-2556.
10. Saban SD, Nepomuceno RR, Gritton LD, Nemerow GR, Stewart PL CryoEM structure at 9A resolution of an adenovirus vector targeted to hematopoietic cells. J Mol Biol 2005; 349: 526-537.
11. Wu E, Pache L, Von Seggern DJ, Mullen TM, Mikyas Y, Stewart PL et al. Flexibility of the adenovirus fiber is required for efficient receptor interaction. J Virol 2003; 77: 7225-7235.
12. Chroboczek J, Ruigrok RW, Cusack S. Adenovirus fiber. Curr Top Microbiol Immunol 1995; 199 (Part 1): 163-200.
13. Zachary I, Mathur A, Yla-Herttuala S, Martin J. Vascular protection: A novel nonangiogenic cardiovascular role for vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 2000; 20: 1512-1520.
14. Dixon E, Vollmer Jr CM, Bathe OF, Sutherland F. Vascular occlusion todecrease blood loss during hepatic resection. Am J Surg 2005; 190: 75-86.
15. Kanoria S, Glantzounis G, Jalan R, Davies NA, Seifalian AM, Williams R et al. A model to study total hepatic ischemia-reperfusion injury. Transplant Proc 2004; 36: 2586-2589.
16. Fukuzawa K, Emre S, Senyuz O, Acarli K, Schwartz ME, Miller CM. N-acetylcysteine ameliorates reperfusion injury after warm hepatic ischemia. Transplantation 1995; 59: 6-9.
17. Atkinson MC. The use of N-acetylcysteine in intensive care. Crit Care Resusc 2002; 4: 21-27.
18. Higashi N, Ueda H, Yamada O, Oikawa S, Koiwa M, Tangkawattana P et al. Micromorphological characteristics of hepatic sinusoidal enclothelial cells and their basal laminae in five different animal species. Okajimas Folia Anat Jpn 2002; 79: 135-142.
19. Cichon G, Sclurddt HH, Benhidjeb T, Loser P, Ziemer S, Haas R et al. Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits. J Gene Med 1999; 1: 360-371.
20. De Geest B, Zhao Z, Collen D, Holvoet P. Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice. Circulation 1997; 96: 4349-4356.
21. Luskv M, Christ M, Rittner K, Dieterle A, Dreyer D, Mourot B et al. In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/ E2A, or E1/E4 deleted. J Virol 1998; 72: 2022-2032.
22. De Geest B, Van Linthout S, Lox M, Collen D, Holvoet P. Sustained expression of human apolipoprotein A-I after adenoviral gene transfer in C57BL/6 mice: Role of apolipoprotein A-I promoter, apolipoprotein A-I introns, and human apolipoprotein E enhancer. Hum Gene Ther 2000; 11: 101-112.
23. De Geest B, Van Linthout S, CoIlen D. Sustained expression of human apo A-I following adenoviral gene transfer in mice. Gene Therapy 2001; 8: 121-127.
24. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29-83.
25. Nagelkerke JF, Barto KP, van Berkel TJ. In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. J Biol Chem 1983; 258: 12221-12227.
26. Saulnier P, Vidaud M, Gautier E, Motte N, Bellet D, Escudier B et al. Development and validation of a real-time PCR assay for the detection and quantitation of p53 recombinant adenovirus in clinical samples from patients treated with Ad5CMV-p53 (INGN 201). J Virol Methods 2003; 114: 55-64.
27. Wisse E. An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. J Ultrastruct Res 1972; 38: 528-562.
28. Wisse E, De Zanger RB, Jacobs R, McCuskey RS. Scanning electron microscope observations on the structure of portal veins, sinusoids and central veins in rat liver. Scan Electron Microsc 1983: 1441-1452.
29. Frederik PK Hubert DH. Cryoelectron microscopy of liposomes. Methods Enzymol 2005; 391: 431-448.