Inclusion of the hepatic locus control region, an Intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro

Molecular Therapy

Volumn 1, Issue 6, 2000, Pages 522-532

  Miao, Carol H ^a   Ohashi, Kazuo ^b   Patijn, Gijsbert A ^a   Meuse, Leonard ^b   Ye, Xin ^a   Thompson, Arthur R ^a   Kay, Mark A ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Hemophilia; Liver gene therapy; Nonviral and viral vectors

Indexed keywords

BOVINAE;

BLOOD CLOTTING FACTOR 9;

3' UNTRANSLATED REGION; ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; CATTLE; CELL LINE; COMPARATIVE STUDY; GENE EXPRESSION; GENE THERAPY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HEMOPHILIA B; HUMAN; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; INTRON; LIVER; METABOLISM; METHODOLOGY; MOUSE; PLASMID; PORTAL VEIN; REGULATOR GENE;

3' UNTRANSLATED REGIONS; ANIMALS; CATTLE; CELL LINE; FACTOR IX; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HEMOPHILIA B; HUMANS; INJECTIONS, INTRAVENOUS; INTRONS; LIVER; LOCUS CONTROL REGION; MICE; MICE, INBRED C57BL; PLASMIDS; PORTAL VEIN; TRANSFECTION;

EID: 0034202522     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0075     Document Type: Article

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