Apolipoprotein B: mRNA Editing, lipoprotein assembly, and presecretory degradation

Annual Review of Nutrition

Volumn 20, Issue , 2000, Pages 169-193

  Davidson, N O ^a   Shelness, G S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apobec 1; Microsomal triglyceride transfer protein; Proteasome; Protein turnover; Translocation; Ubiquitin

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN B100; APOLIPOPROTEIN B48; LIPID TRANSFER PROTEIN;

HUMAN; LIPOGENESIS; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN TARGETING; REVIEW; RNA EDITING; SMALL INTESTINE; TRANSCRIPTION REGULATION;

ANIMALS; APOLIPOPROTEINS B; BASE SEQUENCE; CHYLOMICRONS; GENE EXPRESSION REGULATION; HUMANS; INTESTINE, SMALL; LIPID METABOLISM; LIPIDS; LIVER; RNA EDITING; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER;

EID: 0033827087     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.20.1.169     Document Type: Review

References (156)

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5. Only cytidines 5' of the apolipoprotein B mRNA mooring sequence are edited
6. Apolipoprotein B mRNA sequences 3' of the editing site are necessary and sufficient for editing and editosome assembly
7. Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro
8. Specific 3' sequences flanking a minimal apolipoprotein B (apoB) mRNA editing 'cassette' are critical for efficient editing in vitro
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44. Distinct promoters induce APOBEC- 1 expression in rat liver and intestine
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51. Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol
52. Two efficiency elements flanking the editing site of cytidine 6666 in the apofipoprotein B mRNA support mooring-dependent editing
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58. Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48
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78. Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides co-translationally before translocation and fulMength apolipoprotein B after translocation into the endoplasmic reticulum
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80. Dexamethasone enhanced by insulin, but not by thyroid hormones stimulates apolipoprotein B mRNA editing in cultured rat hepatocytes depending on the developmental stage
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85. A sequence-specific RNA-binding protein complements apobec-1 to edit apolipoprotein B mRNA
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108. Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells
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129. Apolipoprotein B messenger RNA editing is developmentally regulated and widely expressed in human tissues
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156. Apoprotein B100, an inefficiently translocated secretory protein, is bound to the cytosolic chaperone, heat shock protein 70