-
1
-
-
33745161050
-
Structural biology and drug discovery
-
DOI 10.2174/138161206777585201
-
Scapin, G. Structural biology and drug discovery. Curr. Pharm. Des., 2006, 12, 2087-2097. (Pubitemid 43891405)
-
(2006)
Current Pharmaceutical Design
, vol.12
, Issue.17
, pp. 2087-2097
-
-
Scapin, G.1
-
2
-
-
33745199815
-
Virtual ligand screening: Strategies, perspectives and limitations
-
Klebe, G. Virtual ligand screening: strategies, perspectives and limitations.Drug Discov. Today, 2006, 11, 580-594.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 580-594
-
-
Klebe, G.1
-
3
-
-
0036717194
-
The druggable genome
-
Hopkins, A.L.; Groom, C.R. The druggable genome. Nat. Rev. Drug Discov., 2002, 1, 727-730. (Pubitemid 37361545)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.9
, pp. 727-730
-
-
Hopkins, A.L.1
Groom, C.R.2
-
4
-
-
84883035249
-
-
The Research Collaboratory for Structural Bioinformatics (RCSB). ProteinData Bank, Accessed February 16, 2011
-
The Research Collaboratory for Structural Bioinformatics (RCSB). ProteinData Bank. An Information Portal to Biological Macromolecular Structures.http://www.rcsb.org/pdb/home/home.do. (Accessed February 16, 2011
-
An Information Portal to Biological Macromolecular Structures
-
-
-
5
-
-
0034677966
-
Drug discovery: A historical perspective
-
DOI 10.1126/science.287.5460.1960
-
Drews, J. Drug discovery: a historical perspective. Science, 2000, 287, 1960-1964. (Pubitemid 30158662)
-
(2000)
Science
, vol.287
, Issue.5460
, pp. 1960-1964
-
-
Drews, J.1
-
7
-
-
79952737366
-
A new classification of membrane protein crystals
-
Schulz, G.E. A new classification of membrane protein crystals. J. Mol.Biol., 2011, 407(5), 640-646.
-
(2011)
J. Mol.Biol.
, vol.407
, Issue.5
, pp. 640-646
-
-
Schulz, G.E.1
-
8
-
-
28444488355
-
Solving the membrane protein folding problem
-
DOI 10.1038/nature04395
-
Bowie, J.U. Solving the membrane protein folding problem. Nature, 2005, 438, 581-589. (Pubitemid 41740561)
-
(2005)
Nature
, vol.438
, Issue.7068
, pp. 581-589
-
-
Bowie, J.U.1
-
9
-
-
0031954925
-
Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms
-
Wallin, E.; von Heijne, G. Genome-wide analysis of integral membraneproteins from eubacterial, archaean, and eukaryotic organisms. Protein Sci., 1998, 7, 1029-1038. (Pubitemid 28216544)
-
(1998)
Protein Science
, vol.7
, Issue.4
, pp. 1029-1038
-
-
Wallin, E.1
Von Heijne, G.2
-
10
-
-
4344586564
-
Homology-based modelling of targets for rational drug design
-
Wieman, H.; Tondel, K.; Anderssen, E.; Drablos, F. Homology- basedmodelling of targets for rational drug design. Mini Rev. Med. Chem., 2004, 4, 793-804. (Pubitemid 39149479)
-
(2004)
Mini-Reviews in Medicinal Chemistry
, vol.4
, Issue.7
, pp. 793-804
-
-
Wieman, H.1
Tondel, K.2
Anderssen, E.3
Drablos, F.4
-
11
-
-
76249105122
-
Mutational mapping and modeling of the binding site for(S)-citalopram in the human serotonin transporter
-
Andersen, J.; Olsen, L.; Hansen, K.B.; Taboureau, O.; Jorgensen, F.S.;Jorgensen, A.M.; Bang-Andersen, B.; Egebjerg, J.; Stromgaard, K.;Kristensen, A.S. Mutational mapping and modeling of the binding site for(S)-citalopram in the human serotonin transporter. J. Biol. Chem., 2010, 285, 2051-2063.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2051-2063
-
-
Andersen, J.1
Olsen, L.2
Hansen, K.B.3
Taboureau, O.4
Jorgensen, F.S.5
Jorgensen, A.M.6
Bang-Andersen, B.7
Egebjerg, J.8
Stromgaard, K.9
Kristensen, A.S.10
-
12
-
-
77950887681
-
Binding andorientation of tricyclic antidepressants within the central substrate site of thehuman serotonin transporter
-
Sinning, S.; Musgaard, M.; Jensen, M.; Severinsen, K.; Celik, L.; Koldso, H.;Meyer, T.; Bols, M.; Jensen, H.H.; Schiott, B.; Wiborg, O. Binding andorientation of tricyclic antidepressants within the central substrate site of thehuman serotonin transporter. J. Biol. Chem., 2010, 285, 8363-8374.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 8363-8374
-
-
Sinning, S.1
Musgaard, M.2
Jensen, M.3
Severinsen, K.4
Celik, L.5
Koldso, H.6
Meyer, T.7
Bols, M.8
Jensen, H.H.9
Schiott, B.10
Wiborg, O.11
-
13
-
-
77950058867
-
Thedevelopment and validation of a novel virtual screening cascade protocol toidentify potential serotonin 5-HT(7)R antagonists
-
Kurczab, R.; Nowak, M; Chilmonczyk, Z.; Sylte, I.; Bojarski A.J. Thedevelopment and validation of a novel virtual screening cascade protocol toidentify potential serotonin 5-HT(7)R antagonists. Bioorg. Med. Chem. Lett., 2010. 20(8), 2465-2468.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.8
, pp. 2465-2468
-
-
Kurczab, R.1
Nowak, M.2
Chilmonczyk, Z.3
Sylte, I.4
Bojarski, A.J.5
-
14
-
-
33751194447
-
A comprehensivestructure-based alignment of prokaryotic and eukaryoticneurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structureto probe NSS structure and function
-
Beuming, T.; Shi, L.; Javitch, J.A.; Weinstein, H. A comprehensivestructure-based alignment of prokaryotic and eukaryoticneurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structureto probe NSS structure and function. Mol. Pharmacol., 2006, 70, 1630-1642.
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 1630-1642
-
-
Beuming, T.1
Shi, L.2
Javitch, J.A.3
Weinstein, H.4
-
15
-
-
12344250438
-
Structural genomics of GPCRs
-
DOI 10.1016/j.tibtech.2004.12.006, PII S0167779904003348
-
Lundstrom, K. Structural genomics of GPCRs. Trends Biotechnol., 2005, 23, 103-108. (Pubitemid 40127346)
-
(2005)
Trends in Biotechnology
, vol.23
, Issue.2
, pp. 103-108
-
-
Lundstrom, K.1
-
16
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
DOI 10.1126/science.289.5480.739
-
Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C.A.; Motoshima, H.; Fox, B.A.; Le Trong, I.; Teller, D.C.; Okada, T.; Stenkamp, R.E.; Yamamoto, M.;Miyano, M. Crystal structure of rhodopsin: A G protein-coupled receptor.Science, 2000, 289, 739-745. (Pubitemid 30650186)
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
17
-
-
36448995359
-
2-adrenergic G protein-coupled receptor
-
DOI 10.1126/science.1150577
-
Cherezov, V.; Rosenbaum, D.M.; Hanson, M.A.; Rasmussen, S.G.; Thian, F.S.; Kobilka, T.S.; Choi, H.J.; Kuhn, P.; Weis, W.I.; Kobilka, B.K.; Stevens, R.C. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science, 2007, 318, 1258-1265. (Pubitemid 350172884)
-
(2007)
Science
, vol.318
, Issue.5854
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.F.4
Foon, S.T.5
Kobilka, T.S.6
Choi, H.-J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
18
-
-
2442680282
-
Structures and models of transporterproteins
-
Dahl, S.G.; Sylte, I.; Ravna, A.W. Structures and models of transporterproteins. J. Pharmacol. Exp. Ther., 2004, 309, 853-860.
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.309
, pp. 853-860
-
-
Dahl, S.G.1
Sylte, I.2
Ravna, A.W.3
-
19
-
-
0036046157
-
Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders
-
DOI 10.1038/sj.tpj.6500106
-
Hahn, M.K.; Blakely, R.D. Monoamine transporter gene structure andpolymorphisms in relation to psychiatric and other complex disorders.Pharmacogenomics J., 2002, 2, 217-235. (Pubitemid 35023581)
-
(2002)
Pharmacogenomics Journal
, vol.2
, Issue.4
, pp. 217-235
-
-
Hahn, M.K.1
Blakely, R.D.2
-
20
-
-
0242576358
-
Monoamine transporters andpsychostimulant drugs
-
Rothman, R.B.; Baumann, M.H. Monoamine transporters andpsychostimulant drugs. Eur. J. Pharmacol., 2003, 479, 23-40.
-
(2003)
Eur. J. Pharmacol.
, vol.479
, pp. 23-40
-
-
Rothman, R.B.1
Baumann, M.H.2
-
21
-
-
33646649339
-
Regulation of monoamine transporters:influence of psychostimulants and therapeutic antidepressants
-
Jayanthi, L.D.; Ramamoorthy, S. Regulation of monoamine transporters:influence of psychostimulants and therapeutic antidepressants. AAPS J, 2005, 7, E728-E738.
-
(2005)
AAPS J
, vol.7
-
-
Jayanthi, L.D.1
Ramamoorthy, S.2
-
22
-
-
30544439942
-
Serotonin transporters: Implicationsfor antidepressant drug development
-
White, K.J.; Walline, C.C.; Barker, E.L. Serotonin transporters: implicationsfor antidepressant drug development. AAPS J, 2005, 7, E421-E433.
-
(2005)
AAPS J
, vol.7
-
-
White, K.J.1
Walline, C.C.2
Barker, E.L.3
-
23
-
-
75749140852
-
Brain serotonin transporteroccupancy by oral sibutramine dosed to steady state: A PET study using(11)C-DASB in healthy humans
-
Talbot, P.S.; Bradley, S.; Clarke, C.P.; Babalola, K.O.; Philipp, A.W.;Brown, G.; McMahon, A.W.; Matthews, J.C. Brain serotonin transporteroccupancy by oral sibutramine dosed to steady state: a PET study using(11)C-DASB in healthy humans. Neuropsychopharmacology, 2010, 35, 741-751.
-
(2010)
Neuropsychopharmacology
, vol.35
, pp. 741-751
-
-
Talbot, P.S.1
Bradley, S.2
Clarke, C.P.3
Babalola, K.O.4
Philipp, A.W.5
Brown, G.6
McMahon, A.W.7
Matthews, J.C.8
-
24
-
-
0035195373
-
A putative three-dimensional arrangement of the human serotonin transporter transmembrane helices: A tool to aid experimental studies
-
DOI 10.1016/S1093-3263(01)00112-7, PII S1093326301001127
-
Ravna, A.W.; Edvardsen, O. A putative three-dimensional arrangement ofthe human serotonin transporter transmembrane helices: a tool to aidexperimental studies. J. Mol. Graph. Model., 2001, 20, 133-144. (Pubitemid 33135510)
-
(2001)
Journal of Molecular Graphics and Modelling
, vol.20
, Issue.2
, pp. 133-144
-
-
Ravna, A.W.1
Edvardsen, O.2
-
25
-
-
33748786315
-
Aa template
-
DOI 10.1016/j.bmcl.2006.08.028, PII S0960894X06009188
-
Ravna, A.W.; Jaronczyk, M.; Sylte, I. A homology model of SERT based onthe LeuT(Aa) template. Bioorg. Med. Chem. Lett., 2006, 16, 5594-5597. (Pubitemid 44415450)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.21
, pp. 5594-5597
-
-
Ravna, A.W.1
Jaronczyk, M.2
Sylte, I.3
-
26
-
-
0242522301
-
Molecular model of the neural dopaminetransporter
-
Ravna, A.W.; Sylte, I.; Dahl, S.G. Molecular model of the neural dopaminetransporter. J. Comput. Aided Mol. Des., 2003, 17, 367-382.
-
(2003)
J. Comput. Aided Mol. Des.
, vol.17
, pp. 367-382
-
-
Ravna, A.W.1
Sylte, I.2
Dahl, S.G.3
-
27
-
-
0141519516
-
Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters
-
DOI 10.1124/jpet.103.054593
-
Ravna, A.W.; Sylte, I.; Dahl, S.G. Molecular mechanism of citalopram andcocaine interactions with neurotransmitter transporters. J. Pharmacol. Exp.Ther., 2003, 307, 34-41. (Pubitemid 37151889)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.307
, Issue.1
, pp. 34-41
-
-
Ravna, A.W.1
Sylte, I.2
Dahl, S.G.3
-
28
-
-
28844506362
-
Putative drug binding conformations of monoamine transporters
-
DOI 10.1016/j.bmc.2005.08.054, PII S0968089605008254
-
Ravna, A.W.; Sylte, I.; Kristiansen, K.; Dahl, S.G. Putative drug bindingconformations of monoamine transporters. Bioorg. Med. Chem., 2006, 14, 666-675. (Pubitemid 41767571)
-
(2006)
Bioorganic and Medicinal Chemistry
, vol.14
, Issue.3
, pp. 666-675
-
-
Ravna, A.W.1
Sylte, I.2
Kristiansen, K.3
Dahl, S.G.4
-
30
-
-
0028116546
-
A putative model of the dopamine transporter
-
DOI 10.1016/0169-328X(94)90009-4
-
Edvardsen, O.; Dahl, S.G. A putative model of the dopamine transporter.Brain Res Mol. Brain Res., 1994, 27, 265-274. (Pubitemid 24379209)
-
(1994)
Molecular Brain Research
, vol.27
, Issue.2
, pp. 265-274
-
-
Edvardsen, O.1
Dahl, S.G.2
-
31
-
-
0032524637
-
Determination of external loop topology in the serotonin transporter by site-directed chemical labeling
-
DOI 10.1074/jbc.273.20.12675
-
Chen, J.G.; Liu-Chen, S.; Rudnick, G. Determination of external looptopology in the serotonin transporter by site-directed chemical labeling. J. Biol. Chem., 1998, 273, 12675-12681. (Pubitemid 28240647)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.20
, pp. 12675-12681
-
-
Chen, J.-G.1
Liu-Chen, S.2
Rudnick, G.3
-
32
-
-
0028239439
-
A functional superfamily ofsodium/solute symporters
-
Reizer, J.; Reizer, A.; Saier, M.H., Jr. A functional superfamily ofsodium/solute symporters. Biochim. Biophys. Acta, 1994, 1197, 133-166.
-
(1994)
Biochim. Biophys. Acta
, vol.1197
, pp. 133-166
-
-
Reizer, J.1
Reizer, A.2
Saier Jr., M.H.3
-
33
-
-
0026722234
-
Dopamine transporter site-directed mutations differentially alter substratetransport and cocaine binding
-
Kitayama, S.; Shimada, S.; Xu, H.; Markham, L.; Donovan, D.M.; Uhl, G.R.Dopamine transporter site-directed mutations differentially alter substratetransport and cocaine binding. Proc. Natl. Acad. Sci. U S A, 1992, 89, 7782-7785.
-
(1992)
Proc. Natl. Acad. Sci. U S A
, vol.89
, pp. 7782-7785
-
-
Kitayama, S.1
Shimada, S.2
Xu, H.3
Markham, L.4
Donovan, D.M.5
Uhl, G.R.6
-
34
-
-
33646073783
-
Comparison of the monoamine transporters fromhuman and mouse in their sensitivities to psychostimulant drugs
-
Han, D.D.; Gu, H.H. Comparison of the monoamine transporters fromhuman and mouse in their sensitivities to psychostimulant drugs. BMCPharmacology, 2006. 6(6).
-
(2006)
BMCPharmacology
, vol.6
, pp. 6
-
-
Han, D.D.1
Gu, H.H.2
-
35
-
-
0032584587
-
High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol
-
DOI 10.1074/jbc.273.31.19459
-
Barker, E.L.; Perlman, M.A.; Adkins, E.M.; Houlihan, W.J.; Pristupa, Z.B.;Niznik, H.B.; Blakely, R.D. High affinity recognition of serotonin transporterantagonists defined by species-scanning mutagenesis. An aromatic residue intransmembrane domain I dictates species-selective recognition of citalopramand mazindol. J. Biol. Chem., 1998, 273, 19459-19468. (Pubitemid 28366995)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.31
, pp. 19459-19468
-
-
Barker, E.L.1
Perlman, M.A.2
Adkins, E.M.3
Houlihan, W.J.4
Pristupa, Z.B.5
Niznik, H.B.6
Blakely, R.D.7
-
36
-
-
0033981373
-
Permeation and gating residues in serotonintransporter
-
Chen, J.G.; Rudnick, G. Permeation and gating residues in serotonintransporter. Proc. Natl. Acad. Sci. USA, 2000, 97, 1044-1049.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1044-1049
-
-
Chen, J.G.1
Rudnick, G.2
-
37
-
-
0030692041
-
The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding
-
DOI 10.1074/jbc.272.45.28321
-
Chen, J.G.; Sachpatzidis, A.; Rudnick, G. The third transmembrane domainof the serotonin transporter contains residues associated with substrate andcocaine binding. J. Biol. Chem., 1997, 272, 28321-28327. (Pubitemid 27517776)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.45
, pp. 28321-28327
-
-
Chen, J.-G.1
Sachpatzidis, A.2
Rudnick, G.3
-
38
-
-
0030608258
-
Dissection of dopamine acid cocaine binding sites on the rat dopamine transporter expressed in COS cells
-
DOI 10.1111/j.1749-6632.1996.tb17460.x
-
Kitayama, S.; Morita, K.; Dohi, T.; Wang, J.B.; Davis, S.C.; Uhl, G.R.Dissection of dopamine and cocaine binding sites on the rat dopaminetransporter expressed in COS cells. Ann. N. Y. Acad. Sci., 1996, 801, 388-393. (Pubitemid 27030984)
-
(1996)
Annals of the New York Academy of Sciences
, vol.801
, pp. 388-393
-
-
Kitayama, S.1
Morita, K.2
Dohi, T.3
Wang, J.-B.4
Davis, S.C.5
Uhl, G.R.6
-
39
-
-
0032078412
-
Tyrosine-533 of rat dopamine transporter: Involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine
-
DOI 10.1016/S0169-328X(98)00032-1, PII S0169328X98000321
-
Mitsuhata, C.; Kitayama, S.; Morita, K.; Vandenbergh, D.; Uhl, G.R.; Dohi, T. Tyrosine-533 of rat dopamine transporter: involvement in interactionswith 1-methyl-4-phenylpyridinium and cocaine. Brain Res. Mol. Brain Res., 1998, 56, 84-88. (Pubitemid 28271664)
-
(1998)
Molecular Brain Research
, vol.56
, Issue.1-2
, pp. 84-88
-
-
Mitsuhata, C.1
Kitayama, S.2
Morita, K.3
Vandenbergh, D.4
Uhl, G.R.5
Dohi, T.6
-
40
-
-
0029860223
-
Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter
-
Barker, E.L.; Blakely, R.D. Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions oftricyclic antidepressants with the human serotonin transporter. Mol. Pharmacol., 1996, 50, 957-965. (Pubitemid 26347717)
-
(1996)
Molecular Pharmacology
, vol.50
, Issue.4
, pp. 957-965
-
-
Barker, E.L.1
Blakely, R.D.2
-
41
-
-
0027318006
-
+ transport
-
Kitayama, S.; Wang, J.B.; Uhl, G.R. Dopamine transporter mutantsselectively enhance MPP+ transport. Synapse, 1993, 15, 58-62. (Pubitemid 23262756)
-
(1993)
Synapse
, vol.15
, Issue.1
, pp. 58-62
-
-
Kitayama, S.1
Wang, J.-B.2
Uhl, G.R.3
-
42
-
-
0027532379
-
Only one of the charged amino acids located in the transmembrane α- helices of the γ-aminobutyric acid transporter (subtype A) is essential for its activity
-
Pantanowitz, S.; Bendahan, A.; Kanner, B.I. Only one of the charged aminoacids located in the transmembrane alpha-helices of the gamma-aminobutyricacid transporter (subtype A) is essential for its activity. J. Biol. Chem., 1993, 268, 3222-3225. (Pubitemid 23070948)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.5
, pp. 3222-3225
-
-
Pantanowitz, S.1
Bendahan, A.2
Kanner, B.I.3
-
43
-
-
0030739445
-
A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter
-
DOI 10.1073/pnas.94.14.7639
-
Sur, C.; Betz, H.; Schloss, P. A single serine residue controls the cationdependence of substrate transport by the rat serotonin transporter. Proc. Natl. Acad. Sci. USA, 1997, 94, 7639-7644. (Pubitemid 27345369)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.14
, pp. 7639-7644
-
-
Sur, C.1
Betz, H.2
Schloss, P.3
-
44
-
-
0031560438
-
The rat serotonin transporter: Identification of cysteine residues important for substrate transport
-
DOI 10.1006/bbrc.1997.7771
-
Sur, C.; Schloss, P.; Betz, H. The rat serotonin transporter: identification ofcysteine residues important for substrate transport. Biochem. Biophys. Res.Commun., 1997, 241, 68-72. (Pubitemid 28033540)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.241
, Issue.1
, pp. 68-72
-
-
Sur, C.1
Schloss, P.2
Betz, H.3
-
46
-
-
0034610788
-
Three-dimensional structure of the ion-coupled transport protein NhaA
-
DOI 10.1038/47534
-
Williams, K.A. Three-dimensional structure of the ion-coupled transportprotein NhaA. Nature, 2000, 403, 112-115. (Pubitemid 30038532)
-
(2000)
Nature
, vol.403
, Issue.6765
, pp. 112-115
-
-
Williams, K.A.1
-
47
-
-
0041353145
-
Structure and mechanism of the lactose permease of Escherichia coli
-
DOI 10.1126/science.1088196
-
Abramson, J.; Smirnova, I.; Kasho, V.; Verner, G.; Kaback, H.R.; Iwata, S.Structure and mechanism of the lactose permease of Escherichia coli.Science, 2003, 301, 610-615. (Pubitemid 36927939)
-
(2003)
Science
, vol.301
, Issue.5633
, pp. 610-615
-
-
Abramson, J.1
Smirnova, I.2
Kasho, V.3
Verner, G.4
Kaback, H.R.5
Iwata, S.6
-
48
-
-
0033564765
-
Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter
-
Barker, E.L.; Moore, K.R.; Rakhshan, F.; Blakely, R.D. Transmembranedomain I contributes to the permeation pathway for serotonin and ions in theserotonin transporter. J. Neurosci., 1999, 19, 4705-4717. (Pubitemid 29270106)
-
(1999)
Journal of Neuroscience
, vol.19
, Issue.12
, pp. 4705-4717
-
-
Barker, E.L.1
Moore, K.R.2
Rakhshan, F.3
Blakely, R.D.4
-
49
-
-
0028849881
-
Homology modeling by the ICMmethod
-
Cardozo, T.; Totrov, M.; Abagyan, R. Homology modeling by the ICMmethod. Proteins, 1995, 23, 403-414.
-
(1995)
Proteins
, vol.23
, pp. 403-414
-
-
Cardozo, T.1
Totrov, M.2
Abagyan, R.3
-
50
-
-
24644470065
-
--dependent neurotransmitter transporters
-
DOI 10.1038/nature03978
-
Yamashita, A.; Singh, S.K.; Kawate, T.; Jin, Y.; Gouaux, E. Crystal structureof a bacterial homologue of Na+/Cl-dependent neurotransmittertransporters. Nature, 2005, 437, 215-223. (Pubitemid 41294479)
-
(2005)
Nature
, vol.437
, Issue.7056
, pp. 215-223
-
-
Yamashita, A.1
Singh, S.K.2
Kawate, T.3
Jin, Y.4
Gouaux, E.5
-
51
-
-
65649109333
-
Location of the antidepressant binding sitein the serotonin transporter: Importance of Ser-438 in recognition ofcitalopram and tricyclic antidepressants
-
Andersen, J.; Taboureau, O.; Hansen, K.B.; Olsen, L.; Egebjerg, J.;Stromgaard, K.; Kristensen, A.S. Location of the antidepressant binding sitein the serotonin transporter: importance of Ser-438 in recognition ofcitalopram and tricyclic antidepressants. J. Biol. Chem., 2009, 284, 10276-10284.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 10276-10284
-
-
Andersen, J.1
Taboureau, O.2
Hansen, K.B.3
Olsen, L.4
Egebjerg, J.5
Stromgaard, K.6
Kristensen, A.S.7
-
52
-
-
41149175461
-
Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation
-
DOI 10.1021/ja076403h
-
Celik, L.; Sinning, S.; Severinsen, K.; Hansen, C.G.; Moller, M.S.; Bols, M.;Wiborg, O.; Schiott, B. Binding of serotonin to the human serotonintransporter. Molecular modeling and experimental validation. J. Am. Chem.Soc., 2008, 130, 3853-3865. (Pubitemid 351429851)
-
(2008)
Journal of the American Chemical Society
, vol.130
, Issue.12
, pp. 3853-3865
-
-
Celik, L.1
Sinning, S.2
Severinsen, K.3
Hansen, C.G.4
Moller, M.S.5
Bols, M.6
Wiborg, O.7
Schiott, B.8
-
53
-
-
59849093622
-
Structural determinants of species-selective substrate recognitionin human and Drosophila serotonin transporters revealed throughcomputational docking studies
-
Kaufmann, K.W.; Dawson, E.S.; Henry, L.K.; Field, J.R.; Blakely, R.D.;Meiler, J. Structural determinants of species-selective substrate recognitionin human and Drosophila serotonin transporters revealed throughcomputational docking studies. Proteins, 2009, 74, 630-642.
-
(2009)
Proteins
, vol.74
, pp. 630-642
-
-
Kaufmann, K.W.1
Dawson, E.S.2
Henry, L.K.3
Field, J.R.4
Blakely, R.D.5
Meiler, J.6
-
54
-
-
44249099473
-
Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition
-
DOI 10.1124/jpet.108.136200
-
Walline, C.C.; Nichols, D.E.; Carroll, F.I.; Barker, E.L. Comparativemolecular field analysis using selectivity fields reveals residues in the thirdtransmembrane helix of the serotonin transporter associated with substrateand antagonist recognition. J. Pharmacol. Exp. Ther., 2008, 325, 791-800. (Pubitemid 351724338)
-
(2008)
Journal of Pharmacology and Experimental Therapeutics
, vol.325
, Issue.3
, pp. 791-800
-
-
Walline, C.C.1
Nichols, D.E.2
Carroll, F.I.3
Barker, E.L.4
-
55
-
-
34548178234
-
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
-
DOI 10.1038/nature06038, PII NATURE06038
-
Singh, S.K.; Yamashita, A.; Gouaux, E. Antidepressant binding site in abacterial homologue of neurotransmitter transporters. Nature, 2007, 448, 952-956. (Pubitemid 47312772)
-
(2007)
Nature
, vol.448
, Issue.7156
, pp. 952-956
-
-
Singh, S.K.1
Yamashita, A.2
Gouaux, E.3
-
56
-
-
34548684744
-
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
-
DOI 10.1126/science.1147614
-
Zhou, Z.; Zhen, J.; Karpowich, N.K.; Goetz, R.M.; Law, C.J.; Reith, M.E.;Wang, D.N. LeuT-desipramine structure reveals how antidepressants blockneurotransmitter reuptake. Science, 2007, 317, 1390-1393. (Pubitemid 47417479)
-
(2007)
Science
, vol.317
, Issue.5843
, pp. 1390-1393
-
-
Zhou, Z.1
Zhen, J.2
Karpowich, N.K.3
Goetz, R.M.4
Law, C.J.5
Reith, M.E.A.6
Wang, D.-N.7
-
57
-
-
67349282342
-
Antidepressant specificity of serotonin transporter suggested by three LeuTSSRIstructures
-
Zhou, Z.; Zhen, J.; Karpowich, N.K.; Law, C.J.; Reith, M.E.; Wang, D.N.Antidepressant specificity of serotonin transporter suggested by three LeuTSSRIstructures. Nat. Struct. Mol. Biol., 2009, 16, 652-657.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 652-657
-
-
Zhou, Z.1
Zhen, J.2
Karpowich, N.K.3
Law, C.J.4
Reith, M.E.5
Wang, D.N.6
-
58
-
-
0035122827
-
Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition
-
Adkins, E.M.; Barker, E.L.; Blakely, R.D. Interactions of tryptaminederivatives with serotonin transporter species variants implicatetransmembrane domain I in substrate recognition. Mol. Pharmacol., 2001.59(3), 514-523. (Pubitemid 32179931)
-
(2001)
Molecular Pharmacology
, vol.59
, Issue.3
, pp. 514-523
-
-
Adkins, E.M.1
Barker, E.L.2
Blakely, R.D.3
-
59
-
-
33644856545
-
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants
-
DOI 10.1074/jbc.M505055200
-
Henry, L.K.; Field, J.R.; Adkins, M.L.; Parnas, M.L.; Vaughan, R.A.; Zou, M.F.; Newman, A.H.; Blakely, R.D. Tyr-95 and Ile-172 in transmembranesegments 1 and 3 of human serotonin transporters interact to establish highaffinity recognition of antidepressants. J. Biol. Chem., 2006. 281, 2012-2023. (Pubitemid 43845789)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.4
, pp. 2012-2023
-
-
Henry, L.K.1
Field, J.R.2
Adkins, E.M.3
Parnas, M.L.4
Vaughan, R.A.5
Zou, M.-F.6
Newman, A.H.7
Blakely, R.D.8
-
60
-
-
44949086583
-
+ and Substrate Is Triggered by Substrate in a Second Binding Site
-
DOI 10.1016/j.molcel.2008.05.008, PII S1097276508003596
-
Shi, L.; Quick, M.; Zhao, Y.; Weinstein, H.; Javitch, J.A. The mechanism ofa neurotransmitter:sodium symporter-inward release of Na+ and substrate istriggered by substrate in a second binding site. Mol. Cell, 2008. 30, 667-677. (Pubitemid 351815131)
-
(2008)
Molecular Cell
, vol.30
, Issue.6
, pp. 667-677
-
-
Shi, L.1
Quick, M.2
Zhao, Y.3
Weinstein, H.4
Javitch, J.A.5
-
61
-
-
58149233796
-
A competitiveinhibitor traps LeuT in an open-to-out conformation
-
Singh, S.K.; Piscitelli, C.L.; Yamashita, A.; Gouaux, E. A competitiveinhibitor traps LeuT in an open-to-out conformation. Science, 2008, 322, 1655-16561.
-
(2008)
Science
, vol.322
, pp. 1655-16561
-
-
Singh, S.K.1
Piscitelli, C.L.2
Yamashita, A.3
Gouaux, E.4
-
62
-
-
69249136609
-
Structure and function of Na(+)-symporters withinverted repeats
-
Abramson, J.; E.M. Wright, Structure and function of Na(+)-symporters withinverted repeats. Curr. Opin. Struct. Biol., 2009. 19, 425-432.
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, pp. 425-432
-
-
Abramson, J.1
Wright, E.M.2
-
63
-
-
48749106109
-
The crystal structure of a sodium galactosetransporter reveals mechanistic insights into Na+/sugar symport
-
Faham, S.; Watanabe A.; Besserer G.M., Cascio, D.; Specht, A.; Hirayama, B.A.; Wright, E.M.; Abramson, J. The crystal structure of a sodium galactosetransporter reveals mechanistic insights into Na+/sugar symport. Science, 2008. 321, 810-814.
-
(2008)
Science
, vol.321
, pp. 810-814
-
-
Faham, S.1
Watanabe, A.2
Besserer, G.M.3
Cascio, D.4
Specht, A.5
Hirayama, B.A.6
Wright, E.M.7
Abramson, J.8
-
64
-
-
78049427382
-
Modeling and dynamics of the inward-facingstate of a Na+/Cl- dependent neurotransmitter transporter homologue
-
Shaikh, S.A.; Tajkhorshid E. Modeling and dynamics of the inward-facingstate of a Na+/Cl- dependent neurotransmitter transporter homologue. PLoSComp. Biol., 2010. 6(8).
-
(2010)
PLoSComp. Biol.
, vol.6
, pp. 8
-
-
Shaikh, S.A.1
Tajkhorshid, E.2
-
65
-
-
68949176654
-
Structure and localisation of drug bindingsites on neurotransmitter transporters
-
Ravna, A.W.; Sylte, I.; Dahl, S.G. Structure and localisation of drug bindingsites on neurotransmitter transporters. J. Mol. Model., 2009, 15, 1155-1164.
-
(2009)
J. Mol. Model.
, vol.15
, pp. 1155-1164
-
-
Ravna, A.W.1
Sylte, I.2
Dahl, S.G.3
-
66
-
-
0032801143
-
Dopamine transporter: Transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition
-
Lin, Z.; Wang, W.; Kopajtic, T.; Revay, R.S.; Uhl, G.R. Dopaminetransporter: transmembrane phenylalanine mutations can selectivelyinfluence dopamine uptake and cocaine analog recognition. Mol. Pharmacol., 1999, 56, 434-447. (Pubitemid 29347622)
-
(1999)
Molecular Pharmacology
, vol.56
, Issue.2
, pp. 434-447
-
-
Lin, Z.1
Wang, W.2
Kopajtic, T.3
Revay, R.S.4
Uhl, G.R.5
-
67
-
-
4744348862
-
The chicken serotonin transporter discriminates between serotonin-selective reuptake inhibitors: A species-scanning mutagenesis study
-
DOI 10.1074/jbc.M405579200
-
Larsen, M.B.; Elfving, B.; Wiborg, O. The chicken serotonin transporterdiscriminates between serotonin-selective reuptake inhibitors. A speciesscanningmutagenesis study. J. Biol. Chem., 2004, 279, 42147-42156. (Pubitemid 39313664)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.40
, pp. 42147-42156
-
-
Larsen, M.B.1
Elfving, B.2
Wiborg, O.3
-
68
-
-
0034015391
-
Importance of valine at position 152 for the substrate transport and 2β-carbomethoxy-3β-(4-fluorophenyl)tropane binding of dopamine transporter
-
Lee, S.H.; Chang, M.Y.; Lee, K.H.; Park, B.S.; Lee, Y.S.; Chin, H.R.Importance of valine at position 152 for the substrate transport and 2betacarbomethoxy-3beta-(4-fluorophenyl)tropane binding of dopaminetransporter. Mol. Pharmacol., 2000, 57, 883-889. (Pubitemid 30253370)
-
(2000)
Molecular Pharmacology
, vol.57
, Issue.5
, pp. 883-889
-
-
Lee, S.-H.1
Chang, M.-Y.2
Lee, K.-H.3
Park, B.S.4
Lee, Y.-S.5
Chin, H.R.6
Lee, Y.-S.7
-
69
-
-
0034780661
-
Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants
-
DOI 10.1046/j.1471-4159.2001.00587.x
-
Mortensen, O.V.; Kristensen, A.S.; Wiborg, O. Species-scanningmutagenesis of the serotonin transporter reveals residues essential inselective, high-affinity recognition of antidepressants. J. Neurochem., 2001, 79, 237-247. (Pubitemid 32988939)
-
(2001)
Journal of Neurochemistry
, vol.79
, Issue.2
, pp. 237-247
-
-
Mortensen, O.V.1
Kristensen, A.S.2
Wiborg, O.3
-
70
-
-
0035896596
-
Determination of residues in the norepinephrine transporter that are criticalfor tricyclic antidepressant affinity
-
Roubert, C.; Cox, P.J.; Bruss, M.; Hamon, M.; Bonisch, H.; Giros, B.Determination of residues in the norepinephrine transporter that are criticalfor tricyclic antidepressant affinity. J. Biol. Chem., 2001, 276, 8254-8260.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8254-8260
-
-
Roubert, C.1
Cox, P.J.2
Bruss, M.3
Hamon, M.4
Bonisch, H.5
Giros, B.6
-
71
-
-
0033669731
-
Dopamine transporter tryptophan mutantshighlight candidate dopamine-and cocaine-selective domains
-
Lin, Z.; Wang, W.; Uhl, G.R. Dopamine transporter tryptophan mutantshighlight candidate dopamine- and cocaine-selective domains. Mol. Pharmacol., 2000, 58, 1581-1592.
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1581-1592
-
-
Lin, Z.1
Wang, W.2
Uhl, G.R.3
-
72
-
-
33744948233
-
136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle
-
DOI 10.1074/jbc.M511382200
-
Korkhov, V.M.; Holy, M.; Freissmuth, M.; Sitte, H.H. The conservedglutamate (Glu136) in transmembrane domain 2 of the serotonin transporteris required for the conformational switch in the transport cycle. J. Biol. Chem., 2006, 281, 13439-13448. (Pubitemid 43855256)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.19
, pp. 13439-13448
-
-
Korkhov, V.M.1
Holy, M.2
Freissmuth, M.3
Sitte, H.H.4
-
73
-
-
0034094557
-
Dopamine transporter transmembrane domain polar mutants: δG and δδG values implicate regions important for transporter functions
-
Itokawa, M.; Lin, Z.; Cai, N.S.; Wu, C.; Kitayama, S.; Wang, J.B.; Uhl, G.R.Dopamine transporter transmembrane domain polar mutants: DeltaG andDeltaDeltaG values implicate regions important for transporter functions.Mol. Pharmacol., 2000, 57, 1093-1103. (Pubitemid 30354381)
-
(2000)
Molecular Pharmacology
, vol.57
, Issue.6
, pp. 1093-1103
-
-
Itokawa, M.1
Lin, Z.2
Cai, N.-S.3
Wu, C.4
Kitayama, S.5
Wang, J.-B.6
Uhl, G.R.7
-
74
-
-
35148815052
-
Mechanism of chloride interaction with neurotransmitter:sodium symporters
-
DOI 10.1038/nature06133, PII NATURE06133
-
Zomot, E.; Bendahan, A.; Quick, M.; Zhao, Y.; Javitch, J.A.; Kanner, B.I.Mechanism of chloride interaction with neurotransmitter:sodium symporters.Nature, 2007, 449, 726-730. (Pubitemid 47552085)
-
(2007)
Nature
, vol.449
, Issue.7163
, pp. 726-730
-
-
Zomot, E.1
Bendahan, A.2
Quick, M.3
Zhao, Y.4
Javitch, J.A.5
Kanner, B.I.6
-
75
-
-
34547875396
-
--dependent transporters
-
DOI 10.1073/pnas.0705600104
-
Forrest, L.R.; Tavoulari, S.; Zhang, Y.W.; Rudnick, G.; Honig, B.Identification of a chloride ion binding site in Na+/Cl - dependenttransporters. Proc. Natl. Acad. Sci. USA, 2007, 104, 12761-12766. (Pubitemid 47255228)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.31
, pp. 12761-12766
-
-
Forrest, L.R.1
Tavoulari, S.2
Zhang, Y.-W.3
Rudnick, G.4
Honig, B.5
-
76
-
-
77951246287
-
Transmembrane domain 6 of thehuman serotonin transporter contributes to an aqueously accessible bindingpocket for serotonin and the psychostimulant 3, 4-methylenedioxymethamphetamine
-
Field, J.R.; Henry, L.K.; Blakely, R.D. Transmembrane domain 6 of thehuman serotonin transporter contributes to an aqueously accessible bindingpocket for serotonin and the psychostimulant 3, 4- methylenedioxymethamphetamine. J. Biol. Chem., 2010, 285, 11270-11280.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 11270-11280
-
-
Field, J.R.1
Henry, L.K.2
Blakely, R.D.3
-
77
-
-
33845966416
-
The cytoplasmic substrate permeation pathway of serotonin transporter
-
DOI 10.1074/jbc.M605468200
-
Zhang, Y.W.; Rudnick, G. The cytoplasmic substrate permeation pathway ofserotonin transporter. J. Biol. Chem., 2006, 281, 36213-36220. (Pubitemid 46043244)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.47
, pp. 36213-36220
-
-
Zhang, Y.-W.1
Rudnick, G.2
-
78
-
-
21744436321
-
+ antiporter and insights into mechanism of action and regulation by pH
-
DOI 10.1038/nature03692
-
+ antiporter and insights into mechanism of action andregulation by pH. Nature, 2005, 435, 1197-1202. (Pubitemid 40943079)
-
(2005)
Nature
, vol.435
, Issue.7046
, pp. 1197-1202
-
-
Hunte, C.1
Screpanti, E.2
Venturi, M.3
Rimon, A.4
Padan, E.5
Michel, H.6
|